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What is a benefit of tablets as an oral dosage form?
Which of the following are types of Compressed Tablets (CT)? (Select all that apply)
Enteric-Coated Tablets dissolve in the gastric fluid.
False
What is one disadvantage of tablets?
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The drug in Enteric-Coated Tablets is protected from __________.
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Which type of tablet is used to release medication in a controlled manner?
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Match the type of tablet with its characteristic:
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Name one essential component in tablet formulations.
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What are molded tablets also referred to as?
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Give an example of a tablet that is meant for solution.
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Study Notes
Tablet Types
- Solid preparations containing one or more active ingredients obtained by compressing uniform volumes of particles.
- Advantages include precision dosing, compact nature, stability, and ease of administration.
- Disadvantages include difficult formulation for certain drugs and issues with taste, odor, and sensitivity to air.
Compressed Tablets (CT)
- Types of CT include:
- Sugar-coated tablets (SCT)
- Film-coated Tablets (FCT)
- Enteric-Coated Tablets (ECT)
- Multiple Compressed Tablets (MCT)
- Layered Tablets
- Press-Coated Tablets
- Controlled-Release Tablets (CRT)
- Tablets For Solution
- Effervescent Tablets
- Compressed Suppositories or Inserts
- Buccal or Sublingual Tablets
Sugar-Coated Tablets (SCT)
- Beneficial in covering-up taste/odor of drugs or protecting sensitive materials from oxidation.
Film-Coated Tablets (FCT)
- Covered with a thin layer of water-soluble film.
- Various polymeric substances with film-forming properties are used.
Enteric-Coated Tablets (ECT)
- Resist dissolving in gastric fluid but disintegrate in the intestine.
- Used for drugs inactive/destroyed in the stomach, those irritating the mucosa, or for delayed release medication.
Multiple Compressed Tablets (MCT)
- Layered Tablets: Prepared by compressing tablet granulations repeatedly to create multilayered tablets.
- Press-Coated Tablets (Dry-coated): Precompressed tablets are further compressed with another granulation layer.
Controlled-Release Tablets (CRT)
- Prolonged or Sustained release
- Three types:
- Release triggered by physiological conditions (e.g., enteric coating).
- Steady, controlled drug release.
- Combined mechanisms for "pulse" drug release (e.g., repeat action tablets).
Tablets for Solution
- Not for swallowing, but for preparing solutions.
- Examples: Halazone Tablets for Solutions or Potassium Permanganate Tablet for solution.
Effervescent Tablets
- Release gas upon contact with water, facilitating dissolving.
Compressed Suppositories or Inserts
- Vaginal suppositories.
- Example: Metronidazole Tablets.
Buccal and Sublingual Tablets
- Small, flat oval tablets.
- Buccal: Inserted in the buccal pouch for slow dissolving/erosion.
- Sublingual: Placed under the tongue.
- Examples:
- Progesterone Tablets (Buccal)
- Nitroglycerine, Isoproterenol HCl, Erythrityl Tetranitrate (Sublingual)
Molded Tablets or Tablet Triturates (TT)
- Made from moist materials using a triturate mold.
- Types:
- Dispensing Tablets (DT)
- Hypodermic Tablets (HT)
Tablet Properties
- Freedom from defects (chips, cracks, discoloration, contamination).
- Strength to withstand production, packaging, and handling.
- Chemical and physical stability.
- Reproducible and predictable drug release.
Tablet Components
- Essential Components
- Diluents or bulking agents (e.g., Lactose USP)
- Fillers for tablet volume and compression
- Lactose USP (Hydrous, Anhydrous)
- Coarse Granular: 60-80 mesh
- Regular: 80-100 mesh
- Spray-dried: 100- 120 mesh
- Advantages of Lactose:
- Inexpensive
- Readily Soluble
- Stable and Inert
- Not softened by compression forces
- Binders
- Hold tablet components together during compression.
- Examples: Starch, Gelatin, Acacia, PVP.
- Disintegrators
- Promote tablet disintegration in the GI tract to release the drug.
- Examples: Starch, CrosscarmelloseSodium (CCS), Crospovidone (CP).
- Lubricants (e.g., Stearic Acid, Magnesium Stearate)
- Reduce friction during compression, facilitating tablet ejection.
- Diluents or bulking agents (e.g., Lactose USP)
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Description
Explore the various types of tablets, including compressed and coated formulations. This quiz covers the advantages and disadvantages of different tablet types, along with their specific applications. Test your knowledge on solid preparations in the pharmaceutical field.
