Podcast
Questions and Answers
What is the advantage of using tablets as an oral dosage form?
What is the advantage of using tablets as an oral dosage form?
- Easy and convenient to use (correct)
- Greater chemical mobility for drug molecules
- Unstable drug molecule due to limited mobility
- Rapid absorption in the gastrointestinal tract
What is the function of the crystal lattice structure in tablet formulation?
What is the function of the crystal lattice structure in tablet formulation?
- Enhances the solubility of drug molecules
- Promotes rapid drug absorption in the gastrointestinal tract
- Increases the chemical reactivity of drug molecules
- Restricts the mobility of drug molecules, reducing the likelihood of chemical reactions (correct)
In what ways can tablets be consumed other than swallowing them whole?
In what ways can tablets be consumed other than swallowing them whole?
- Chewing or dissolving in water (correct)
- Inhaling as a powder
- Mixing with liquid for injection
- Applying topically on the skin
Why are drug molecules in a solid-state tablet more stable compared to those in liquid form?
Why are drug molecules in a solid-state tablet more stable compared to those in liquid form?
What is the disintegration time requirement for uncoated tablets in water?
What is the disintegration time requirement for uncoated tablets in water?
How many tablets are taken at random for the disintegration test?
How many tablets are taken at random for the disintegration test?
What is the minimum percentage of the drug that should be released within 45 minutes in the dissolution test?
What is the minimum percentage of the drug that should be released within 45 minutes in the dissolution test?
For which type of tablet is the dissolution test not required?
For which type of tablet is the dissolution test not required?
For a tablet weighing 220mg, what is the maximum allowable deviation from the average mass according to the pharmacopeial quality control tests?
For a tablet weighing 220mg, what is the maximum allowable deviation from the average mass according to the pharmacopeial quality control tests?
If the average weight of 20 tablets is $95.2 mg$, which tablet deviates the most from the average mass according to the pharmacopeial quality control tests?
If the average weight of 20 tablets is $95.2 mg$, which tablet deviates the most from the average mass according to the pharmacopeial quality control tests?
What is the acceptable range of active ingredient content for registered tablets according to the pharmacopeial quality control tests?
What is the acceptable range of active ingredient content for registered tablets according to the pharmacopeial quality control tests?
What is the maximum allowable deviation for active ingredient content in listed tablets according to the pharmacopeial quality control tests?
What is the maximum allowable deviation for active ingredient content in listed tablets according to the pharmacopeial quality control tests?
Study Notes
Advantages of Tablets as Oral Dosage Forms
- Convenient for dosing and easy to handle
- Stable and have a longer shelf-life compared to liquids
- Precise dosage control and manufacturing efficiency
- Can be formulated for controlled release of medications
Crystal Lattice Structure in Tablet Formulation
- Provides stability and integrity to the tablet
- Helps control the release rate of the active ingredient
- Affects physical properties like hardness, dissolution rate, and compressibility
Alternative Consumption Methods for Tablets
- Tablets can be crushed and mixed with food or liquids
- Some can be dissolved in water to create a suspension
- Effervescent tablets can be consumed by dissolving in water
Stability of Drug Molecules in Solid-States
- Solid-state prevents degradation from hydrolysis or oxidation that occurs more readily in liquids
- Offers better protection from environmental factors such as moisture and light
- Solid forms provide consistent performance in terms of dosage release
Disintegration Time Requirement for Uncoated Tablets
- Required to disintegrate within 15 minutes when tested in water
Random Tablet Selection for Disintegration Test
- A total of six tablets are taken for the disintegration test
Drug Release in Dissolution Test
- At least 80% of the drug must be released within 45 minutes in the dissolution test
Tablets Exempt from Dissolution Test
- Sublingual tablets do not require a dissolution test due to their route of absorption
Maximum Allowable Deviation for Tablet Mass
- For a 220 mg tablet, the maximum allowable deviation is ±10% of the average mass
Deviation from Average Mass Based on 20 Tablet Sample
- If the average weight of 20 tablets is 95.2 mg, deviations exceeding ±7.5 mg should be noted (a 7.5% deviation)
Acceptable Range for Active Ingredient Content
- Active ingredient content should be within 90-110% of the labeled claim for registered tablets
Maximum Allowable Deviation for Active Ingredient in Listed Tablets
- Maximum allowable deviation is ±10% of the active ingredient content
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Description
Test your knowledge of tablet formulations with this quiz! Explore the advantages and limitations of using tablets as an oral dosage form for patients. Learn about the features of tablets, including their ease of use and potential for different administration methods such as chewing and dissolving.
