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What is the primary advantage of Gelcap over traditional capsules?
What is the primary advantage of Gelcap over traditional capsules?
Which type of tablet is characterized by disintegrating or dissolving in the mouth within 1 minute?
Which type of tablet is characterized by disintegrating or dissolving in the mouth within 1 minute?
What defines Modified Release Tablets?
What defines Modified Release Tablets?
What is the purpose of effervescent tablets?
What is the purpose of effervescent tablets?
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What has happened to the use of multilayered tablets in recent years?
What has happened to the use of multilayered tablets in recent years?
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What purpose does the second coat serve in the tablet manufacturing process?
What purpose does the second coat serve in the tablet manufacturing process?
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Multiple compressed tablets can be used to prevent which of the following issues?
Multiple compressed tablets can be used to prevent which of the following issues?
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What is a primary benefit of enteric-coated tablets?
What is a primary benefit of enteric-coated tablets?
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Which of the following is true about the polymers used for enteric coatings?
Which of the following is true about the polymers used for enteric coatings?
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Which property does hydroxypropylmethyl cellulose succinate provide for enteric-coated tablets?
Which property does hydroxypropylmethyl cellulose succinate provide for enteric-coated tablets?
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What is the purpose of including polymeric excipients in drug layers of multiple compressed tablets?
What is the purpose of including polymeric excipients in drug layers of multiple compressed tablets?
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What is a key characteristic of the polymers used in enteric coatings such as cellulose acetate phthalate?
What is a key characteristic of the polymers used in enteric coatings such as cellulose acetate phthalate?
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Which statement about the complexity of manufacturing tablets is correct?
Which statement about the complexity of manufacturing tablets is correct?
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What is one disadvantage of tablet manufacturing?
What is one disadvantage of tablet manufacturing?
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Which type of tablet is designed for quick disintegration and drug release?
Which type of tablet is designed for quick disintegration and drug release?
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What is a characteristic of multiple compressed tablets?
What is a characteristic of multiple compressed tablets?
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Which type of tablet might be used to assist patients who have difficulty swallowing?
Which type of tablet might be used to assist patients who have difficulty swallowing?
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Why may certain therapeutic agents pose challenges in tablet formulation?
Why may certain therapeutic agents pose challenges in tablet formulation?
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Which type of tablet is specifically designed to dissolve in the gastrointestinal tract while avoiding effects from gastric acid?
Which type of tablet is specifically designed to dissolve in the gastrointestinal tract while avoiding effects from gastric acid?
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What is a significant factor that affects the absorption of drugs from tablets?
What is a significant factor that affects the absorption of drugs from tablets?
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What advantage do effervescent tablets offer compared to conventional tablets?
What advantage do effervescent tablets offer compared to conventional tablets?
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What is one advantage of tablets in drug administration?
What is one advantage of tablets in drug administration?
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Which characteristic of tablets contributes to their convenience and elegance as a dosage form?
Which characteristic of tablets contributes to their convenience and elegance as a dosage form?
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What property allows tablets to be formulated with multiple therapeutic agents?
What property allows tablets to be formulated with multiple therapeutic agents?
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Why might tablets be preferred for administering drugs that are typically bitter?
Why might tablets be preferred for administering drugs that are typically bitter?
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How do tablets compare in terms of stability to other dosage forms?
How do tablets compare in terms of stability to other dosage forms?
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What makes it possible for tablets to target drug release at specific sites in the gastrointestinal tract?
What makes it possible for tablets to target drug release at specific sites in the gastrointestinal tract?
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What is a key factor in the formulation of tablets that ensures better patient compliance?
What is a key factor in the formulation of tablets that ensures better patient compliance?
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What limitation is associated with the use of tablets compared to other dosage forms?
What limitation is associated with the use of tablets compared to other dosage forms?
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What is one main advantage of using effervescent tablets?
What is one main advantage of using effervescent tablets?
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What is a primary disadvantage of effervescent tablets?
What is a primary disadvantage of effervescent tablets?
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Where are buccal tablets positioned during administration?
Where are buccal tablets positioned during administration?
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Why is it important for buccal and sublingual tablets to dissolve slowly?
Why is it important for buccal and sublingual tablets to dissolve slowly?
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What type of effect do vaginal tablets primarily provide?
What type of effect do vaginal tablets primarily provide?
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What is a critical aspect of the formulation of vaginal tablets?
What is a critical aspect of the formulation of vaginal tablets?
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What is the benefit of drug absorption across the buccal mucosa?
What is the benefit of drug absorption across the buccal mucosa?
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What is a common application for buccal and sublingual tablets?
What is a common application for buccal and sublingual tablets?
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Study Notes
Tablet Dosage Forms
- Tablets are solid dosage forms that are easy to administer and versatile in their design.
- Tablets are prepared with excipients (inert ingredients) to help with the manufacturing, stability and drug release.
- Tablets are typically used for oral administration of medication.
Advantages of Tablets
- Convenient and elegant dosage form.
- Offer a wide range of controlled and modified release options, influencing drug release rate and duration of effect.
- Can be designed for rapid or controlled drug release.
- Can be formulated to release the drug at a specific site within the GI tract, reducing side effects and improving absorption.
- Can be designed to incorporate multiple therapeutic agents, even those with physical or chemical incompatibilities.
- Release of each agent can be controlled with formulation and design.
- Can be used to administer all types of medications except proteins.
- Effective in masking bitter tastes compared to other dosage forms.
- Generally inexpensive to manufacture.
- Can be easily manufactured to show product identification (markings on the surface).
- Offer superior chemical, physical, and microbiological stability compared to other dosage forms.
Disadvantages of Tablets
- Manufacturing requires a series of steps, potentially leading to product loss at each stage.
- Absorption of therapeutic agents from tablets can vary significantly between individuals due to physiological factors like gastric emptying rate.
- Some drugs have poor compression properties, making it difficult to formulate and manufacture them as tablets.
- Administration to certain groups, such as children and the elderly, can be challenging due to swallowing difficulties.
Types of Tablets
- Conventional Compressed Tablets: Disintegrate rapidly and release the drug quickly. Common type for oral administration.
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Multiple Compressed Tablets: Consist of two or more layers, enabling:
- Separation of incompatible drugs.
- Delivery of different therapeutic agents at different rates or to different GI tract sites.
- Controlled release of drugs through the use of polymeric excipients.
- Coating to mask taste, protect the stomach, or stabilize chemically unstable drugs.
- Enteric-Coated Tablets: Coated with a polymer that dissolves in the small intestine (alkaline environment), but not the stomach (acidic environment). Protects the drug from degradation, irritation, or chemical instability.
- Sugar-Coated Tablets: Coated with sugar to mask taste, protect the drug from degradation, and improve appearance.
- Film-Coated Tablets: Covered with a thin layer of polymer for taste masking, faster disintegration, and improved appearance.
- Chewable Tablets: Designed to be chewed before swallowing for taste masking, faster disintegration, and easier administration to children and the elderly.
- Effervescent Tablets: React with water to produce carbon dioxide, which aids in tablet disintegration and enhances drug absorption.
- Buccal and Sublingual Tablets: Dissolve slowly in the mouth for systemic absorption, avoiding first-pass metabolism.
- Vaginal Tablets: Inserted into the vagina for local therapeutic effects or systemic absorption.
- Gelatin-Coated Tablets (Gelcaps): Capsule-shaped tablets coated with gelatin for easier swallowing and smaller size compared to capsules.
Tablet Release Profiles
- Immediate Release Tablets (IR Tablets): Designed for rapid disintegration and drug release.
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Modified Release Tablets (MR Tablets) or Controlled Release Tablets (CR Tablets): Have special coatings or techniques to modify drug release rate.
- Sustained/Extended Release (SR/XR Tablets): Provide a prolonged effect, reducing the frequency of administration.
- Delayed Release (Enteric Coated Tablets): Release the drug in the small intestine, protecting the stomach and optimizing absorption.
- Rapidly Disintegrating or Dissolving Tablets (RD Tablets): Disintegrate or dissolve quickly in the mouth, often within 1 minute.
- Rapid-release Tablets or Oro-Dispersible Tablets (ODT): Liquefy on the tongue, suitable for patients with difficulty swallowing tablets.
Key Points Summary
- Different tablet types offer flexible delivery options for medications within the GI tract.
- Polymer coatings allow control over drug release at specific locations in the GI tract.
- Effervescent tablets enhance absorption of poorly soluble drugs.
- While multilayered tablets were prevalent, their use has declined in recent years.
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Description
Explore the essential characteristics and benefits of tablet dosage forms in this quiz. Learn about their design, manufacturing, and how they can improve drug delivery and efficacy. Discover the various release mechanisms and their applications in medication administration.
