Tablet Dosage Forms and Advantages
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Tablet Dosage Forms and Advantages

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Questions and Answers

What is the primary advantage of Gelcap over traditional capsules?

  • Gelcap is about one-third smaller than a capsule with the same powder content. (correct)
  • Gelcap allows for a faster release of medication.
  • Gelcap contains a special coating for delayed release.
  • Gelcap is more effective in treating gastrointestinal disorders.

    • Which type of tablet is characterized by disintegrating or dissolving in the mouth within 1 minute?

  • Rapidly Disintegrating Tablets (correct)
  • Immediate Release Tablets
  • Modified Release Tablets
  • Effervescent Tablets

    • What defines Modified Release Tablets?

  • They are designed only for pediatric patients.
  • They disintegrate instantly upon ingestion.
  • They are meant to be absorbed solely in the stomach.
  • They are coated with polymers to control the release rate. (correct)

    • What is the purpose of effervescent tablets?

    <p>To enhance the absorption of poorly soluble drugs.</p> Signup and view all the answers

    What has happened to the use of multilayered tablets in recent years?

    <p>Their use has decreased.</p> Signup and view all the answers

    What purpose does the second coat serve in the tablet manufacturing process?

    <p>To create a constant mass around the tablet</p> Signup and view all the answers

    Multiple compressed tablets can be used to prevent which of the following issues?

    <p>Incompatibility of drugs in single-layer tablets</p> Signup and view all the answers

    What is a primary benefit of enteric-coated tablets?

    <p>They protect drugs from degradation in acidic conditions</p> Signup and view all the answers

    Which of the following is true about the polymers used for enteric coatings?

    <p>They allow drug dissolution at alkaline conditions in the small intestine</p> Signup and view all the answers

    Which property does hydroxypropylmethyl cellulose succinate provide for enteric-coated tablets?

    <p>Dissolves within the intestines</p> Signup and view all the answers

    What is the purpose of including polymeric excipients in drug layers of multiple compressed tablets?

    <p>They control the drug dissolution or diffusion rates</p> Signup and view all the answers

    What is a key characteristic of the polymers used in enteric coatings such as cellulose acetate phthalate?

    <p>Insoluble below pH 6</p> Signup and view all the answers

    Which statement about the complexity of manufacturing tablets is correct?

    <p>It increases as the number of drug layers increases</p> Signup and view all the answers

    What is one disadvantage of tablet manufacturing?

    <p>The absorption of drugs from tablets varies among patients.</p> Signup and view all the answers

    Which type of tablet is designed for quick disintegration and drug release?

    <p>Conventional compressed tablets</p> Signup and view all the answers

    What is a characteristic of multiple compressed tablets?

    <p>They can contain multiple layers of compressed material.</p> Signup and view all the answers

    Which type of tablet might be used to assist patients who have difficulty swallowing?

    <p>Chewable tablets</p> Signup and view all the answers

    Why may certain therapeutic agents pose challenges in tablet formulation?

    <p>Their compression properties may be poor.</p> Signup and view all the answers

    Which type of tablet is specifically designed to dissolve in the gastrointestinal tract while avoiding effects from gastric acid?

    <p>Enteric-coated tablets</p> Signup and view all the answers

    What is a significant factor that affects the absorption of drugs from tablets?

    <p>Gastric emptying rate</p> Signup and view all the answers

    What advantage do effervescent tablets offer compared to conventional tablets?

    <p>They provide a faster disintegration for better absorption.</p> Signup and view all the answers

    What is one advantage of tablets in drug administration?

    <p>They can be designed for rapid or controlled drug release.</p> Signup and view all the answers

    Which characteristic of tablets contributes to their convenience and elegance as a dosage form?

    <p>They often come with colorful coatings.</p> Signup and view all the answers

    What property allows tablets to be formulated with multiple therapeutic agents?

    <p>Tablet formulation can control the release of incompatible agents.</p> Signup and view all the answers

    Why might tablets be preferred for administering drugs that are typically bitter?

    <p>Tablets can effectively mask the taste of bitter drugs.</p> Signup and view all the answers

    How do tablets compare in terms of stability to other dosage forms?

    <p>Tablets have superior physical, chemical, and microbiological stability.</p> Signup and view all the answers

    What makes it possible for tablets to target drug release at specific sites in the gastrointestinal tract?

    <p>The manufacturing process allows for tailored release mechanisms.</p> Signup and view all the answers

    What is a key factor in the formulation of tablets that ensures better patient compliance?

    <p>Controlled drug release formulations reduce the number of doses needed.</p> Signup and view all the answers

    What limitation is associated with the use of tablets compared to other dosage forms?

    <p>Tablets cannot deliver proteins effectively.</p> Signup and view all the answers

    What is one main advantage of using effervescent tablets?

    <p>They allow the therapeutic agent to be absorbed rapidly.</p> Signup and view all the answers

    What is a primary disadvantage of effervescent tablets?

    <p>They require moisture-impermeable packaging.</p> Signup and view all the answers

    Where are buccal tablets positioned during administration?

    <p>Between the cheek and the gingiva.</p> Signup and view all the answers

    Why is it important for buccal and sublingual tablets to dissolve slowly?

    <p>To avoid stimulating saliva production.</p> Signup and view all the answers

    What type of effect do vaginal tablets primarily provide?

    <p>Local pharmacological effects.</p> Signup and view all the answers

    What is a critical aspect of the formulation of vaginal tablets?

    <p>They must retain at the site of application.</p> Signup and view all the answers

    What is the benefit of drug absorption across the buccal mucosa?

    <p>It avoids first-pass metabolism.</p> Signup and view all the answers

    What is a common application for buccal and sublingual tablets?

    <p>For rapid absorption of drugs.</p> Signup and view all the answers

    Study Notes

    Tablet Dosage Forms

    • Tablets are solid dosage forms that are easy to administer and versatile in their design.
    • Tablets are prepared with excipients (inert ingredients) to help with the manufacturing, stability and drug release.
    • Tablets are typically used for oral administration of medication.

    Advantages of Tablets

    • Convenient and elegant dosage form.
    • Offer a wide range of controlled and modified release options, influencing drug release rate and duration of effect.
    • Can be designed for rapid or controlled drug release.
    • Can be formulated to release the drug at a specific site within the GI tract, reducing side effects and improving absorption.
    • Can be designed to incorporate multiple therapeutic agents, even those with physical or chemical incompatibilities.
    • Release of each agent can be controlled with formulation and design.
    • Can be used to administer all types of medications except proteins.
    • Effective in masking bitter tastes compared to other dosage forms.
    • Generally inexpensive to manufacture.
    • Can be easily manufactured to show product identification (markings on the surface).
    • Offer superior chemical, physical, and microbiological stability compared to other dosage forms.

    Disadvantages of Tablets

    • Manufacturing requires a series of steps, potentially leading to product loss at each stage.
    • Absorption of therapeutic agents from tablets can vary significantly between individuals due to physiological factors like gastric emptying rate.
    • Some drugs have poor compression properties, making it difficult to formulate and manufacture them as tablets.
    • Administration to certain groups, such as children and the elderly, can be challenging due to swallowing difficulties.

    Types of Tablets

    • Conventional Compressed Tablets: Disintegrate rapidly and release the drug quickly. Common type for oral administration.
    • Multiple Compressed Tablets: Consist of two or more layers, enabling:
      • Separation of incompatible drugs.
      • Delivery of different therapeutic agents at different rates or to different GI tract sites.
      • Controlled release of drugs through the use of polymeric excipients.
      • Coating to mask taste, protect the stomach, or stabilize chemically unstable drugs.
    • Enteric-Coated Tablets: Coated with a polymer that dissolves in the small intestine (alkaline environment), but not the stomach (acidic environment). Protects the drug from degradation, irritation, or chemical instability.
    • Sugar-Coated Tablets: Coated with sugar to mask taste, protect the drug from degradation, and improve appearance.
    • Film-Coated Tablets: Covered with a thin layer of polymer for taste masking, faster disintegration, and improved appearance.
    • Chewable Tablets: Designed to be chewed before swallowing for taste masking, faster disintegration, and easier administration to children and the elderly.
    • Effervescent Tablets: React with water to produce carbon dioxide, which aids in tablet disintegration and enhances drug absorption.
    • Buccal and Sublingual Tablets: Dissolve slowly in the mouth for systemic absorption, avoiding first-pass metabolism.
    • Vaginal Tablets: Inserted into the vagina for local therapeutic effects or systemic absorption.
    • Gelatin-Coated Tablets (Gelcaps): Capsule-shaped tablets coated with gelatin for easier swallowing and smaller size compared to capsules.

    Tablet Release Profiles

    • Immediate Release Tablets (IR Tablets): Designed for rapid disintegration and drug release.
    • Modified Release Tablets (MR Tablets) or Controlled Release Tablets (CR Tablets): Have special coatings or techniques to modify drug release rate.
      • Sustained/Extended Release (SR/XR Tablets): Provide a prolonged effect, reducing the frequency of administration.
      • Delayed Release (Enteric Coated Tablets): Release the drug in the small intestine, protecting the stomach and optimizing absorption.
    • Rapidly Disintegrating or Dissolving Tablets (RD Tablets): Disintegrate or dissolve quickly in the mouth, often within 1 minute.
    • Rapid-release Tablets or Oro-Dispersible Tablets (ODT): Liquefy on the tongue, suitable for patients with difficulty swallowing tablets.

    Key Points Summary

    • Different tablet types offer flexible delivery options for medications within the GI tract.
    • Polymer coatings allow control over drug release at specific locations in the GI tract.
    • Effervescent tablets enhance absorption of poorly soluble drugs.
    • While multilayered tablets were prevalent, their use has declined in recent years.

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    Description

    Explore the essential characteristics and benefits of tablet dosage forms in this quiz. Learn about their design, manufacturing, and how they can improve drug delivery and efficacy. Discover the various release mechanisms and their applications in medication administration.

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