Manufacturing of Semisolid Dosage Forms Issues
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Questions and Answers

Which tablet processing method involves suspending materials in air while spraying a liquid binder?

  • Direct Compression
  • Fluid Bed Coater
  • Dry Granulation
  • Fluid Bed Granulation (correct)

What is the primary purpose of the sub-coating step in tableting?

  • To improve flowability of excipients
  • To separate the top and bottom crown
  • To improve tablet hardness
  • To build up the tablet size (correct)

Which tablet coating method involves successive coating of a sucrose-based solution?

  • Fluid Bed Coater
  • Dry Granulation
  • Sugar Coating (correct)
  • Direct Compression

In tableting, what is the purpose of double compression in Dry Granulation?

<p>To compact the powder mixture into large pieces (A)</p> Signup and view all the answers

Which excipient type is critical for Direct Compression tablet processing?

<p>Avicel® (B)</p> Signup and view all the answers

What is the major disadvantage of Sugar Coating as a tablet coating method?

<p>Leads to a large increase in tablet weight and is time-consuming (B)</p> Signup and view all the answers

What is the recommended remedy for flaking in tablet manufacturing?

<p>Add a polysorbate surfactant (C)</p> Signup and view all the answers

Which type of capsules are manufactured separately from the filling operation?

<p>Hard Gelatin Capsules (B)</p> Signup and view all the answers

What method is used to mix heat-sensitive ointment bases during the manufacturing process?

<p>Unguator® Electric Mortar and Pestle (D)</p> Signup and view all the answers

What type of film surface is characterized by rough, non-glossy appearance in tablet manufacturing?

<p>Orange Peel (B)</p> Signup and view all the answers

Which substance is NOT considered a gelling agent according to the text?

<p>Magnesium Aluminum Silicate (C)</p> Signup and view all the answers

What is the purpose of using ointment roller mills in the manufacturing of ointments?

<p>To mix heat-sensitive ointment bases (C)</p> Signup and view all the answers

What is the purpose of the volatile solvent/vehicle in tablet manufacturing?

<p>To improve spreadability of the film (A)</p> Signup and view all the answers

Which substance is responsible for providing water solubility/permeability to the film in tablet manufacturing?

<p>Cellulose acetate phthalate (CAP) (D)</p> Signup and view all the answers

What is the main function of impression coating in tablet manufacturing?

<p>Separates the tablet core from water (D)</p> Signup and view all the answers

Which component is responsible for enhancing the spreadability of the film in tablet manufacturing?

<p>Polysorbates (Tween) (B)</p> Signup and view all the answers

What is the main advantage of sealcoating agents in tablet manufacturing?

<p>Minimal increase in tablet weight (D)</p> Signup and view all the answers

What is the primary function of bridging in tablet manufacturing?

<p>Obscuring logo markings on tablets (D)</p> Signup and view all the answers

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