Diaphragm & Pleura

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Questions and Answers

A patient presents with an asymptomatic elevated hemidiaphragm on chest X-ray. Which of the following is the MOST likely next step in confirming the diagnosis of unilateral diaphragmatic paralysis?

  • Pulmonary function testing (PFTs)
  • Fluoroscopy (correct)
  • Arterial blood gas (ABG) analysis
  • Measuring forced vital capacity (FVC)

A patient who recently underwent a coronary artery bypass graft (CABG) presents with sternal wound drainage, increasing sternal pain, and fever. Which of the following is the MOST likely diagnosis?

  • Pericarditis
  • Mediastinitis (correct)
  • Costochondritis
  • Pneumonia

Which of the following is the MOST common cause of mediastinitis in the United States?

  • Eroding carcinoma
  • Post-operative coronary artery bypass graft (CABG) (correct)
  • Tracheal disruption during bronchoscopy
  • Esophageal perforation

A patient experiencing marked dyspnea and difficulty sleeping lying down should be evaluated for which of the following conditions?

<p>Bilateral diaphragmatic paralysis (B)</p> Signup and view all the answers

Which of the following diagnostic findings is MOST suggestive of esophageal perforation?

<p>Subcutaneous emphysema (D)</p> Signup and view all the answers

A chest X-ray of a patient with suspected esophageal rupture reveals mediastinal widening, air in the mediastinum, and hydropneumothorax. Which of the following is the MOST likely diagnosis?

<p>Pneumomediastinum secondary to ruptured esophagus (C)</p> Signup and view all the answers

Which of the following is a common clinical finding in patients with mediastinitis following cardiac surgery?

<p>Sternum pain that has increased since surgery (A)</p> Signup and view all the answers

What is the MOST appropriate initial treatment for mediastinitis following a coronary artery bypass graft (CABG)?

<p>Surgical debridement and broad-spectrum IV antibiotics (A)</p> Signup and view all the answers

Which of the following conditions is MOST likely to cause bilateral diaphragmatic paralysis?

<p>Guillain-Barré syndrome (A)</p> Signup and view all the answers

The '5 T's' are a helpful differential for anterior mediastinal masses. Which of the following is NOT one of the '5 T's'?

<p>Tuberculosis (B)</p> Signup and view all the answers

A patient presents with new-onset neck pain and subcutaneous emphysema. Which of the following is the MOST likely underlying cause?

<p>Esophageal perforation (D)</p> Signup and view all the answers

A patient with a history of postpolio syndrome presents with progressive dyspnea. Which of the following is the MOST likely underlying cause of their respiratory compromise?

<p>Bilateral diaphragmatic paralysis (B)</p> Signup and view all the answers

A patient has been diagnosed with mediastinitis following cardiac surgery. Cultures reveal the presence of Staphylococcus aureus and Staphylococcus epidermidis. Which of the following antibiotic regimens is MOST appropriate for initial empiric therapy?

<p>Vancomycin (C)</p> Signup and view all the answers

Which of the following is the MOST common type of mass found in the posterior mediastinum?

<p>Neurogenic tumor (schwannoma, neurofibroma) (B)</p> Signup and view all the answers

Following instrumentation of the esophagus for a therapeutic procedure, a patient develops signs and symptoms consistent with esophageal perforation. Where is the MOST likely location of this perforation?

<p>Proximal esophagus at the level of the cricopharyngeus muscle (A)</p> Signup and view all the answers

A patient diagnosed with unilateral diaphragmatic paralysis undergoes fluoroscopy. Which of the following findings would be MOST consistent with the diagnosis?

<p>Paradoxical upward movement of the affected hemidiaphragm during inspiration (A)</p> Signup and view all the answers

A patient being evaluated for a mediastinal mass is found to have myasthenia gravis. Which of the following anterior mediastinal masses is MOST strongly associated with this presentation?

<p>Thymoma (C)</p> Signup and view all the answers

In the management of mediastinitis following cardiac surgery, after initial surgical debridement and broad-spectrum antibiotics, definitive wound closure is being considered. Which of the following factors is MOST critical to ensure before proceeding with definitive closure?

<p>Negative intraoperative cultures and adequate infection control (A)</p> Signup and view all the answers

A patient presents with esophageal perforation secondary to Boerhaave syndrome. Which radiographic finding would STRONGLY suggest the presence of a pneumo-mediastinum?

<p>The presence of a continuous diaphragm sign (A)</p> Signup and view all the answers

A patient has undergone a chest X-ray for dyspnea, which reveals an elevated hemidiaphragm. Further investigation reveals that the cause is phrenic nerve injury. Which of the following is the MOST likely etiology of phrenic nerve injury leading to diaphragmatic paralysis?

<p>Mediastinal tumor (B)</p> Signup and view all the answers

A patient is diagnosed with mediastinitis and undergoes surgical debridement. Post-operative cultures confirm the presence of MRSA. What is the MOST appropriate antibiotic treatment?

<p>Vancomycin (C)</p> Signup and view all the answers

A CXR reveals an anterior mediastinal mass. The patient denies any symptoms of hyperthyroidism. Which of the following anterior mediastinal masses is LEAST likely?

<p>Lymphoma (A)</p> Signup and view all the answers

A patient with a history of cardiac surgery is admitted with suspected mediastinitis. Which of the following clinical findings, if present, would have the HIGHEST specificity for diagnosing mediastinitis?

<p>Wound dehiscence with purulent drainage (B)</p> Signup and view all the answers

During the evaluation of a patient with a suspected mediastinal mass, a contrasted CT scan of the chest is performed. The scan reveals a well-encapsulated mass containing elements of all three germ cell layers (ectoderm, mesoderm, and endoderm). Which of the following is the MOST likely diagnosis?

<p>Teratoma (C)</p> Signup and view all the answers

A 65-year old male, post CABG presents with a complaint of substernal pain radiating to the back, fever, and chills. On examination, crepitus is palpated near the sternal border. You suspect mediastinitis. Further questioning reveals the patient is allergic to vancomycin, what is your next line treatment?

<p>Linezolid (C)</p> Signup and view all the answers

Which of the following procedures involves a small incision in the chest wall to remove air or fluid from the pleural space, and can be performed using either a needle or a tube?

<p>Thoracostomy (B)</p> Signup and view all the answers

A patient with a recurrent pneumothorax is being considered for a procedure to obliterate the pleural space. Which of the following terms BEST describes this procedure?

<p>Pleurodesis (A)</p> Signup and view all the answers

Inflammation of the pleura, often characterized by pleuritic chest pain, is best described by which term?

<p>Pleuritis (A)</p> Signup and view all the answers

Which of the following conditions is characterized by a pleural effusion with milky fluid and elevated pleural triglyceride levels?

<p>Chylothorax (B)</p> Signup and view all the answers

A patient presents with dyspnea and chest heaviness three days post-coronary artery bypass grafting. A milky white fluid is drained from the chest. This fluid is MOST likely indicative of:

<p>Chylothorax (B)</p> Signup and view all the answers

Which of the following pathophysiological mechanisms is MOST directly associated with the formation of a transudative pleural effusion?

<p>Elevation of hydrostatic pressure (B)</p> Signup and view all the answers

Cirrhosis of the liver typically leads to pleural effusions through which mechanism?

<p>Decreased plasma oncotic pressure (D)</p> Signup and view all the answers

Infection and neoplasm are MOST likely to cause pleural effusions through which pathophysiological process?

<p>Increased capillary permeability (D)</p> Signup and view all the answers

Which of the following physical exam findings is typically associated with a pleural effusion?

<p>Diminished breath sounds (B)</p> Signup and view all the answers

A chest X-ray finding suggestive of pleural effusion is:

<p>Blunting of the costophrenic angle (A)</p> Signup and view all the answers

In a right lateral decubitus chest X-ray, free pleural fluid will:

<p>Layer out along the dependent pleura (D)</p> Signup and view all the answers

What is the recommended maximum volume of pleural fluid to remove during a single thoracentesis procedure to minimize the risk of pulmonary edema?

<p>1500 mL (C)</p> Signup and view all the answers

Which of the following pleural fluid analysis results is consistent with an exudative effusion based on Light's criteria?

<p>Pleural fluid protein greater than 3 g/dL (D)</p> Signup and view all the answers

Which of the following conditions is MOST likely to cause a transudative pleural effusion?

<p>Congestive heart failure (A)</p> Signup and view all the answers

Empyema, a purulent pleural effusion, is MOST frequently a complication of:

<p>Pneumonia (C)</p> Signup and view all the answers

What is the MOST appropriate initial management for an empyema?

<p>Chest tube drainage (C)</p> Signup and view all the answers

Hemothorax is defined as:

<p>Blood in the pleural space (A)</p> Signup and view all the answers

The MOST common cause of hemothorax is:

<p>Blunt or penetrating trauma (B)</p> Signup and view all the answers

Which size chest tube is typically recommended for drainage of a hemothorax to prevent fibrothorax and trapped lung?

<p>16-22 French (A)</p> Signup and view all the answers

Pneumothorax is characterized by:

<p>Air in the pleural space (A)</p> Signup and view all the answers

A tall, thin, 25-year-old male smoker presents with sudden onset sharp chest pain and dyspnea. This clinical presentation is MOST suggestive of:

<p>Primary spontaneous pneumothorax (B)</p> Signup and view all the answers

Which of the following is a typical symptom of pneumothorax?

<p>Sudden, sharp chest pain and dyspnea (A)</p> Signup and view all the answers

Physical examination findings in a patient with pneumothorax typically include:

<p>Absent breath sounds on the affected side (C)</p> Signup and view all the answers

A patient with a small primary spontaneous pneumothorax who is clinically stable may be initially managed with:

<p>Observation and oxygen (B)</p> Signup and view all the answers

For a large primary spontaneous pneumothorax (>2-3cm rim of air) in a stable patient, the FIRST line of management is typically:

<p>Needle aspiration (B)</p> Signup and view all the answers

Secondary pneumothorax is characterized by:

<p>Developing in the presence of underlying lung pathology (C)</p> Signup and view all the answers

Which of the following underlying conditions is a common cause of secondary pneumothorax?

<p>Chronic obstructive pulmonary disease (COPD) (B)</p> Signup and view all the answers

Traumatic pneumothorax can be caused by:

<p>Mechanical ventilation (B)</p> Signup and view all the answers

In a tension pneumothorax, the clinical diagnosis is paramount and requires immediate intervention, which is:

<p>Immediate needle decompression followed by chest tube (C)</p> Signup and view all the answers

Which of the following is a LATE sign of tension pneumothorax?

<p>Deviation of trachea away from the affected side (C)</p> Signup and view all the answers

The INITIAL step in the emergency treatment of a tension pneumothorax is:

<p>Needle thoracostomy/decompression (C)</p> Signup and view all the answers

Needle decompression for tension pneumothorax is typically performed at which intercostal space and location?

<p>2nd intercostal space, midclavicular line (B)</p> Signup and view all the answers

Mesothelioma is a rare tumor MOST strongly associated with exposure to:

<p>Asbestos (D)</p> Signup and view all the answers

Which of the following is TRUE regarding mesothelioma?

<p>It often presents as a large, bulky tumor filling the chest cavity. (C)</p> Signup and view all the answers

A patient presents with pleuritic chest pain, dyspnea, and asymmetric chest expansion with decreased breath sounds on the left side. Percussion reveals hyper-resonance on the left. Which of the following is the MOST likely diagnosis?

<p>Pneumothorax (D)</p> Signup and view all the answers

A patient with known congestive heart failure presents with dyspnea. A chest X-ray reveals bilateral pleural effusions. Which type of pleural effusion is MOST likely in this clinical context?

<p>Transudative (A)</p> Signup and view all the answers

A patient develops a pneumothorax following a subclavian central line insertion. This is best classified as what type of pneumothorax?

<p>Traumatic (iatrogenic) (B)</p> Signup and view all the answers

Which of the following laboratory findings in pleural fluid would STRONGLY suggest an exudative effusion over a transudative effusion?

<p>Pleural fluid cholesterol of 60 mg/dL (A)</p> Signup and view all the answers

Which of the following statements BEST differentiates needle thoracostomy from tube thoracostomy?

<p>Needle thoracostomy uses a smaller gauge catheter and is often used in emergency situations for tension pneumothorax, while tube thoracostomy uses a larger tube for more definitive and continuous drainage. (D)</p> Signup and view all the answers

A patient with a history of asbestos exposure presents with a pleural effusion and pleural thickening seen on chest imaging. Which of the following diagnoses is MOST concerning given the exposure history?

<p>Mesothelioma (D)</p> Signup and view all the answers

A patient with a known pneumothorax shows visceral pleural lines on chest X-ray. What does the presence of these lines indicate?

<p>Separation of the visceral and parietal pleura due to air in the pleural space (A)</p> Signup and view all the answers

Which condition is suggested by the physical exam finding of hyper-resonance to percussion over a lung field?

<p>Pneumothorax (A)</p> Signup and view all the answers

In managing a secondary pneumothorax, what is the MOST critical difference in approach compared to a primary spontaneous pneumothorax?

<p>Secondary pneumothoraces usually require more aggressive intervention and hospitalization due to underlying lung disease. (D)</p> Signup and view all the answers

Which of the following best describes the primary goal of a thoracentesis?

<p>To remove excess fluid in the pleural space for diagnosis or symptom relief. (C)</p> Signup and view all the answers

A patient presents with dyspnea, non-productive cough, and pleuritic chest pain. Auscultation reveals diminished breath sounds on the left side. Which of the following is the MOST likely underlying condition?

<p>Pleural effusion. (D)</p> Signup and view all the answers

According to Light's criteria, which of the following pleural fluid analysis results suggests an exudative pleural effusion?

<p>Pleural fluid protein to serum protein ratio of 0.6. (A)</p> Signup and view all the answers

A patient with a known history of cirrhosis presents with increasing dyspnea. A chest X-ray reveals a moderate pleural effusion. What is the MOST likely mechanism causing this effusion?

<p>Decreased plasma oncotic pressure. (A)</p> Signup and view all the answers

What is the MOST appropriate initial step in managing a patient suspected of having a tension pneumothorax?

<p>Perform needle decompression. (C)</p> Signup and view all the answers

A 25-year-old male with Marfan's syndrome presents to the emergency department complaining of acute onset shortness of breath and right-sided chest pain. On physical exam, you note decreased breath sounds and hyperresonance to percussion on the right side. Which of the following is the MOST likely diagnosis?

<p>Primary spontaneous pneumothorax. (C)</p> Signup and view all the answers

Following a motor vehicle accident, a patient is diagnosed with a hemothorax. Which of the following is the MOST important step in managing this condition to prevent long-term complications?

<p>Adequate drainage of the pleural space. (B)</p> Signup and view all the answers

A patient with known asbestos exposure presents with a large pleural effusion and significant pleural thickening on imaging. Which of the following diagnoses should be of HIGHEST concern?

<p>Mesothelioma. (B)</p> Signup and view all the answers

A patient with a history of COPD develops a secondary spontaneous pneumothorax. Why are secondary pneumothoraces generally considered more serious than primary spontaneous pneumothoraces?

<p>They occur in patients with already compromised lung function. (A)</p> Signup and view all the answers

A researcher is investigating novel biomarkers in pleural fluid to differentiate between transudative and exudative effusions with greater accuracy than Light's criteria. Which of the following biomarkers, if elevated in exudative effusions compared to transudative effusions, would BEST support the hypothesis that increased vascular permeability is a key factor in exudate formation?

<p>Vascular endothelial growth factor (VEGF). (D)</p> Signup and view all the answers

A 72-year-old male with congestive heart failure (CHF) presents with progressive dyspnea. Chest X-ray shows a bilateral pleural effusion. What is the most likely type of effusion?

<p>Transudative effusion (D)</p> Signup and view all the answers

A patient with bacterial pneumonia develops a unilateral pleural effusion. Thoracentesis shows pleural fluid with LDH > 200 IU/L and protein ratio > 0.5. What is the most likely classification?

<p>Exudative effusion (A)</p> Signup and view all the answers

Which of the following findings on pleural fluid analysis is most suggestive of a malignant pleural effusion?

<p>Pleural fluid pH &lt; 7.2 (C)</p> Signup and view all the answers

Which of the following is most characteristic of a chylothorax?

<p>Milky pleural fluid with triglycerides &gt; 110 mg/dL (C)</p> Signup and view all the answers

A patient with empyema presents with fever, pleuritic chest pain, and dyspnea. What is the best initial treatment?

<p>Chest tube drainage + IV antibiotics (D)</p> Signup and view all the answers

Which of the following is the most common cause of unilateral diaphragmatic paralysis?

<p>Phrenic nerve injury (A)</p> Signup and view all the answers

Which test is most useful for confirming diaphragmatic paralysis?

<p>Fluoroscopy (&quot;Sniff Test&quot;) (B)</p> Signup and view all the answers

A patient with Guillain-Barré syndrome (GBS) develops bilateral diaphragmatic paralysis. Which of the following is the most appropriate management?

<p>Intubation with mechanical ventilation (C)</p> Signup and view all the answers

A patient presents with chest pain and subcutaneous emphysema after forceful vomiting. Which of the following is the most likely diagnosis?

<p>Boerhaave syndrome (esophageal perforation) (B)</p> Signup and view all the answers

Which of the following is most strongly associated with anterior mediastinal masses?

<p>Thymoma, Teratoma, Thyroid tumor, &quot;Terrible&quot; Lymphoma (C)</p> Signup and view all the answers

A 55-year-old man presents with chronic cough, weight loss, and facial swelling. Exam shows distended neck veins and upper extremity swelling. What is the most likely diagnosis?

<p>Superior vena cava (SVC) syndrome (D)</p> Signup and view all the answers

A patient with a recent coronary artery bypass graft (CABG) surgery presents with sternal pain, fever, and wound drainage. What is the most likely diagnosis?

<p>Mediastinitis (D)</p> Signup and view all the answers

A 45-year-old man with cirrhosis presents with dyspnea and right-sided pleural effusion. Thoracentesis reveals a transudative effusion with no signs of infection. What is the most likely diagnosis?

<p>Hepatic hydrothorax (D)</p> Signup and view all the answers

A patient with a known history of tuberculosis (TB) presents with fever, night sweats, and a unilateral pleural effusion. What is the most likely finding on pleural fluid analysis?

<p>pH &lt; 7.2, low glucose, lymphocytic predominance (D)</p> Signup and view all the answers

A 75-year-old male with lung cancer presents with dyspnea and a large malignant pleural effusion. He has recurrent symptomatic effusions despite repeated thoracentesis. What is the best next step?

<p>Pleurodesis with talc or doxycycline (C)</p> Signup and view all the answers

A patient with suspected pneumothorax presents with sudden dyspnea and pleuritic chest pain. Which of the following CXR findings is most consistent with tension pneumothorax?

<p>Tracheal deviation away from affected side (B)</p> Signup and view all the answers

A patient with amyotrophic lateral sclerosis (ALS) develops progressive dyspnea, especially when lying flat. Which of the following is the most likely cause?

<p>Bilateral diaphragmatic paralysis (D)</p> Signup and view all the answers

A 50-year-old male with severe cervical spine trauma is found to have elevated hemidiaphragm on CXR and paradoxical breathing on inspiration. What is the most likely diagnosis?

<p>Unilateral diaphragmatic paralysis due to phrenic nerve injury (D)</p> Signup and view all the answers

A patient with Guillain-Barré syndrome (GBS) develops progressive hypoventilation and hypercapnia. Which test is best to monitor for impending respiratory failure?

<p>Negative inspiratory force (NIF) (D)</p> Signup and view all the answers

A 50-year-old male with myasthenia gravis undergoes a CT scan of the chest, which shows an anterior mediastinal mass. What is the most likely diagnosis?

<p>Thymoma (C)</p> Signup and view all the answers

A patient with Boerhaave syndrome (esophageal rupture) is at risk for developing which life-threatening complication?

<p>Mediastinitis (D)</p> Signup and view all the answers

A patient with a history of lymphoma presents with progressive facial swelling, dyspnea, and distended neck veins. What is the most likely diagnosis?

<p>Superior vena cava (SVC) syndrome (D)</p> Signup and view all the answers

Which of the following mediastinal mass locations is most commonly associated with neurogenic tumors (e.g., schwannomas, neurofibromas)?

<p>Posterior mediastinum (C)</p> Signup and view all the answers

Flashcards

Unilateral Diaphragmatic Paralysis

Phrenic nerve injury that may be caused by trauma or mediastinal tumor; nearly half are unexplained.

Bilateral Diaphragmatic Paralysis

Generalized neuromuscular disease that may require mechanical ventilation.

Mediastinitis

Inflammation of the mediastinum, often infectious.

Operative Risk Factors for Mediastinitis

Emergency surgery, external cardiac compression, obesity.

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Clinical Findings of Mediastinitis

Sternum pain, fever & chills, SOB, back pain, drainage from wound site, progressive erythema.

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Clinical Findings of Mediastinitis

Chest wall tenderness, wound drainage, and unstable chest wall.

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Treatment for Mediastinitis

Surgical debridement and broad-spectrum IV antibiotics.

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Etiologies of Esophageal Perforation

Erosion by malignancy, foreign bodies, instrumentation from endoscopes, spontaneous rupture (Boerhaave syndrome).

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Presentation of Esophageal Perforation

Neck pain and subcutaneous emphysema.

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Pneumomediastinum due to Ruptured Esophagus

Radiographic hallmarks include mediastinal widening, air in mediastinal, pneumo- or hydropneumothorax.

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Anterior Mediastinal Mass DDX

Thymoma, Teratoma, Thyroid Tumor, Terrible Lymphoma, mesenchymal Tumors.

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Middle Mediastinal Mass

Structures of trachea, esophagus, aortic arch/great vessels, pulmonary arteries, and lymph nodes.

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Posterior Mediastinal Mass

Schwannomas or neurofibroma

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Thoracotomy

An incision in the pleural space to access thoracic organs.

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VATS

Video-assisted surgery, less invasive than a thoracotomy.

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Thoracostomy

A small incision in the chest wall to remove air or fluid.

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Needle Thoracostomy

Needle decompression used for a tension pneumothorax.

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Tube Thoracostomy

A chest tube used for treating pneumothorax, empyema, etc.

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Thoracentesis

Needle-based procedure to remove excess fluid for diagnosis or relief.

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Pleurodesis

Artificial obliteration of the pleural space.

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Pleuritis

Inflammation of the pleura.

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Pleurodynia

Viral inflammation that causes pleuritic chest pain.

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Pleural Effusion

Fluid collection between parietal and visceral pleura.

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Chylothorax

Pleural effusion characterized by milky fluid; high triglycerides.

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Hemothorax

Blood in the pleural space.

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Pneumothorax

Air in the pleural space.

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Empyema

Pus in the pleural space.

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Transudative Effusion

Increased pleural fluid due to increased hydrostatic pressure.

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Exudative Effusion

Increased pleural fluid due to increased capillary permeability.

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Pleural Effusion CXR Finding

Blunting of costophrenic angles on CXR.

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Lateral Decubitus Views

Determines free vs. loculated fluid.

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Thoracentesis Use

Diagnostic and therapeutic aspiration of pleural fluid.

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Exudative Effusion Analysis

Elevated protein and LDH.

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Transudative Effusion Causes

Heart failure, nephrotic syndrome, and cirrhosis.

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Exudative Effusion Causes

Malignancy, infection, and trauma.

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Empyema

Purulent pleural effusion.

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Hemothorax Etiology

Blunt or penetrating trauma.

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Pneumothorax Exam Findings

Asymmetric chest expansion, absent breath sounds.

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Primary Pneumothorax

No underlying lung disease is present.

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Secondary Pneumothorax

An underlying lung pathology is present.

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Traumatic Pneumothorax

Stab wound or gunshot wound.

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Iatrogenic Pneumothorax

Increased peak airway pressure or post-procedures.

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Pneumothorax Treatment

Needle aspiration or chest tube insertion.

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Tension Pneumothorax

Severe respiratory distress, shock, tracheal deviation.

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Tension Pneumothorax Treatment

EMERGENT Needle thoracostomy/Needle decompression

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Mesothelioma

Very rare tumor, linked to asbestos exposure.

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Malignant Pleural Effusion

A type of exudative effusion often associated with malignancy, indicated by a pH less than 7.2 and positive cytology.

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Characteristics of Chylothorax

Milky-appearing pleural fluid with elevated triglycerides (>110 mg/dL).

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Treatment for an empyema

Drainage and IV antibiotics; without proper drainage there can be persistent infection.

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Diagnosis of Diaphragmatic Paralysis

Fluoroscopy assesses diaphragm movement when the patient "sniffs".

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Bilateral Diaphragmatic Paralysis Management

High risk for respiratory failure and requires intubation.

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Boerhaave Syndrome

Characterized by vomiting, subcutaneous emphysema, and pneumomediastinum.

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Superior Vena Cava (SVC) Syndrome

Facial swelling, distended neck veins caused by a mediastinal mass.

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Study Notes

Pleural Effusion Types

  • Congestive heart failure (CHF) often leads to transudative pleural effusion due to increased hydrostatic pressure and decreased oncotic pressure.
  • Bacterial pneumonia can lead to exudative pleural effusion. The fluid will have LDH >200 IU/L and a protein ratio > 0.5 due to increased capillary permeability from the infection.
  • Malignant pleural effusions are exudative and typically present with a pH < 7.2 and may have positive cytology.
  • Chylothorax is characterized by a milky pleural fluid with triglycerides > 110 mg/dL.

Empyema Treatment

  • Empyema is best treated with drainage and IV antibiotics; persistent infection may occur without drainage.

Diaphragmatic Paralysis

  • Phrenic nerve injury is the most common cause of unilateral diaphragmatic paralysis.
  • Fluoroscopy ("Sniff Test") is most useful for confirming diaphragmatic paralysis.
  • Bilateral diaphragmatic paralysis, as seen in Guillain-Barré syndrome (GBS), can lead to respiratory failure and often requires intubation with mechanical ventilation.
  • Cervical trauma with elevated hemidiaphragm suggests phrenic nerve injury as the cause of unilateral diaphragmatic paralysis.
  • Elevated hemidiaphragm on CXR and paradoxical breathing suggests unilateral diaphragmatic paralysis due to phrenic nerve injury.
  • Amyotrophic lateral sclerosis (ALS) can cause bilateral diaphragmatic paralysis, leading to orthopnea.

Disorders of the Mediastinum

  • Boerhaave syndrome (esophageal perforation) presents with vomiting, subcutaneous emphysema, and pneumomediastinum. Esophageal perforation can lead to mediastinitis.
  • Anterior mediastinal masses are associated with the "4 T's": Thymoma, Teratoma, Thyroid tumor, and "Terrible" Lymphoma.
  • Mediastinal masses + facial swelling + JVD is indicative of Superior Vena Cava (SVC) syndrome.
  • SVC Syndrome presents with facial swelling and distended neck veins. The symptoms are typically caused by a mediastinal mass.
  • Posterior mediastinal masses are commonly associated with neurogenic tumors like schwannomas and neurofibromas.

Mediastinitis

  • Recent CABG surgery with fever, sternal pain, and wound drainage is suggestive of mediastinitis.
  • Post-CABG is the most common cause of mediastinitis due to sternal wound infections.

Pleural Effusion Characteristics

  • Cirrhosis with right-sided pleural effusion indicates hepatic hydrothorax (a transudative effusion).
  • Tuberculosis (TB) effusions are exudative, with lymphocytic predominance, low glucose, and low pH.
  • For recurrent malignant pleural effusions, pleurodesis is indicated to prevent fluid reaccumulation.

Tension Pneumothorax Diagnosis

  • Tension pneumothorax is consistent with tracheal deviation away from the affected side and absent breath sounds.

Monitoring Respiratory Failure

  • In Guillain-Barré syndrome (GBS) with progressive hypoventilation and hypercapnia, use negative inspiratory force (NIF) to monitor for respiratory decline; intubation may be necessary.

Anterior Mediastinal Masses

  • Myasthenia gravis with an anterior mediastinal mass points to thymoma as the likely diagnosis.

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