Opioids
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Questions and Answers

Which opioid has a longer context-sensitive half-time for infusions up to 8 hours in duration?

  • Fentanyl
  • Sufentanil
  • Morphine
  • Alfentanil (correct)

Is alfentanil a superior choice to sufentanil for ambulatory sedation techniques?

  • No (correct)
  • It depends
  • Not mentioned
  • Yes

What is the onset and offset characteristic of alfentanil?

  • Slow onset and rapid offset
  • Rapid onset and slow offset
  • Slow onset and offset
  • Rapid onset and offset (correct)

What is the recommended dose of alfentanil for acute but transient analgesia?

<p>15 g/kg IV (A)</p> Signup and view all the answers

Which opioid is associated with a lower incidence of postoperative nausea and vomiting in outpatients?

<p>Alfentanil (B)</p> Signup and view all the answers

Which opioid has a shorter elimination half-time compared to alfentanil and sufentanil?

<p>Morphine (D)</p> Signup and view all the answers

Which opioid is structurally unique due to its ester linkage structure?

<p>Remifentanil (B)</p> Signup and view all the answers

What is the analgesic potency of remifentanil compared to alfentanil?

<p>More potent (D)</p> Signup and view all the answers

What is the characteristic of remifentanil's metabolism pathway?

<p>It is rapidly hydrolyzed to inactive metabolites (A)</p> Signup and view all the answers

Which opioid has a blood-brain equilibration time similar to that of alfentanil?

<p>Remifentanil (B)</p> Signup and view all the answers

What are the advantages of remifentanil's unique metabolism pathway?

<p>Rapid onset and offset (C)</p> Signup and view all the answers

Which of the following statements about remifentanil's pharmacokinetics is true?

<p>Remifentanil has a small volume of distribution and rapid clearance compared to other opioids. (A)</p> Signup and view all the answers

What advantage does remifentanil's rapid systemic clearance provide in clinical situations?

<p>Predictable termination of drug effect. (D)</p> Signup and view all the answers

What is the effect of remifentanil's small volume of distribution and rapid clearance?

<p>It produces a drug with a transient effect. (B)</p> Signup and view all the answers

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