Lecture 15 multiple chocie quiz- immunology
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Questions and Answers

Which step is NOT involved in the T helper cell immune response?

  • Proliferation
  • Migration
  • Activation
  • Apoptosis (correct)

    • What induces the differentiation of Th1, Th2, and Th17 subsets according to the text?

  • Interaction with B cells
  • Chemokines expressed by APCs
  • Cytokines present during antigen presentation (correct)
  • Types of antigens encountered

    • Which cytokine is crucial for the development of Th1 subset of CD4+ T cells?

  • IL-4
  • IL-17
  • IFN-γ (correct)
  • IL-10

    • Which immune-mediated disease is characterized by chronic inflammation?

    <p>Rheumatoid arthritis</p> Signup and view all the answers

    What drives the development of Th cell subsets according to the text?

    <p>Cytokines generated early in immune response</p> Signup and view all the answers

    Which chemokine receptor is expressed by Th1 cells to guide them to sites of viral or intracellular bacterial infections?

    <p>CXCR3</p> Signup and view all the answers

    What is the primary cytokine produced by Th1 cells?

    <p>Interferon-gamma (IFN-γ)</p> Signup and view all the answers

    Which chemokine receptor is expressed by Th2 cells to enable migration to sites of allergic inflammation or helminth infections?

    <p>CCR4</p> Signup and view all the answers

    What is the role of Th17 cells concerning specific pathogens?

    <p>Combat extracellular bacteria and fungi</p> Signup and view all the answers

    How are the Th1, Th2, and Th17 subsets of CD4+ T cells regulated?

    <p>By manipulation of cytokine signals</p> Signup and view all the answers

    What is the primary function of Th1 cells?

    <p>Promote phagocyte-mediated elimination of intracellular pathogens</p> Signup and view all the answers

    Which cytokines are produced by Th1 cells?

    <p>Interferon-gamma (IFN-γ) and Tumor Necrosis Factor-alpha (TNF-α)</p> Signup and view all the answers

    Which immune responses are coordinated by Th1 cells?

    <p>Regulation of cellular immunity and innate immunity</p> Signup and view all the answers

    What is the main function of Th17 cells?

    <p>Regulate cellular immunity against extracellular pathogens</p> Signup and view all the answers

    Which of the following is NOT a cytokine produced by Th1 cells?

    <p>Interleukin-4 (IL-4)</p> Signup and view all the answers

    What role do Th1 cells play in the immune response?

    <p>Defense against intracellular pathogens</p> Signup and view all the answers

    Which cytokine is involved in reinforcing Th1 differentiation?

    <p>IFN-γ</p> Signup and view all the answers

    What is the function of Th17 cells in the immune response?

    <p>Defense against extracellular bacteria and fungi</p> Signup and view all the answers

    What is the role of Th17 cells in defense against extracellular bacteria and fungi?

    <p>Stimulating the production of antimicrobial peptides</p> Signup and view all the answers

    Which condition can arise from excessive Th17 responses?

    <p>Psoriasis</p> Signup and view all the answers

    Which type of cells produce the cytokines necessary for driving Th cell subset differentiation?

    <p>Antigen-presenting cells</p> Signup and view all the answers

    What is the impact of autocrine regulation by CD4+ T cells?

    <p>Suppressing the development of other subsets</p> Signup and view all the answers

    What is the function of Th1 cells in the immune response?

    <p>Activating macrophages to destroy intracellular microbes</p> Signup and view all the answers

    Which cytokine is typically associated with Th1 cells' function?

    <p>Interferon-gamma (IFN-γ)</p> Signup and view all the answers

    In which context is an excessive Th17 response more likely to cause damage?

    <p>Contributing to chronic inflammation and tissue damage</p> Signup and view all the answers

    Which effector function of CD4+ Th cells involves the release of cytokines like interferon-gamma and tumor necrosis factor-alpha to activate macrophages and promote inflammation?

    <p>Inducing inflammation</p> Signup and view all the answers

    What is the primary role of T follicular helper (Tfh) cells in the immune response?

    <p>Providing help to B cells for antibody production</p> Signup and view all the answers

    Which subset of CD4+ T cells can cause tissue damage in delayed-type hypersensitivity reactions?

    <p>Th1 cells</p> Signup and view all the answers

    Which immune-mediated disease is characterized by chronic inflammation?

    <p>Rheumatoid Arthritis</p> Signup and view all the answers

    In the immune response, what do Th1 cells specifically target?

    <p>Tissue damage induction in delayed-type hypersensitivity reactions</p> Signup and view all the answers

    What is the primary function of costimulatory blockade in manipulating the B7/CD28 interaction for therapeutic purposes?

    <p>Suppress T cell activation</p> Signup and view all the answers

    Which molecule competes with CD28 for binding to B7-1 and B7-2, acting as an inhibitory molecule to dampen T cell activation?

    <p>CTLA-4</p> Signup and view all the answers

    What is the goal of therapeutic intervention in blocking the CD28 co-stimulatory pathway for T cell activation?

    <p>Prevent T cell activation</p> Signup and view all the answers

    Which cell receptor on T cells binds to B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells (APCs) for full T cell activation?

    <p>CD28</p> Signup and view all the answers

    What role does CTLA-4 play in the manipulation of the B7/CD28 interaction for therapeutic purposes?

    <p>Dampens T cell activation by binding to B7-1 and B7-2</p> Signup and view all the answers

    In the context of immune-related disorders, how does inhibition of the CD28 pathway affect T cell activation?

    <p>Reduces inflammation and tissue damage</p> Signup and view all the answers

    What is the effect of blocked CD28 co-stimulation on T cell activity?

    <p>Suppresses T cell activation</p> Signup and view all the answers

    Which molecule competes with CD28 for binding to B7-1 and B7-2, thereby inhibiting T cell activation?

    <p>CTLA-4</p> Signup and view all the answers

    What is the essential function of CTLA-4 in the manipulation of the B7/CD28 interaction for therapeutic purposes?

    <p>Dampen T cell activation</p> Signup and view all the answers

    In immune-related disorders, what is the impact of costimulatory blockade on T cell activation?

    <p>Suppresses T cell activation</p> Signup and view all the answers

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