Lecture 15 multiple chocie quiz- immunology
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Lecture 15 multiple chocie quiz- immunology

Explore the key steps involved in the T helper cell immune response, including activation, proliferation, differentiation, migration, and effector functions. Learn how dysregulated responses can lead to immune-mediated diseases like delayed-type hypersensitivity reactions.

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@LuxuryOrphism

Questions and Answers

Which step is NOT involved in the T helper cell immune response?

Apoptosis

What induces the differentiation of Th1, Th2, and Th17 subsets according to the text?

Cytokines present during antigen presentation

Which cytokine is crucial for the development of Th1 subset of CD4+ T cells?

IFN-γ

Which immune-mediated disease is characterized by chronic inflammation?

<p>Rheumatoid arthritis</p> Signup and view all the answers

What drives the development of Th cell subsets according to the text?

<p>Cytokines generated early in immune response</p> Signup and view all the answers

Which chemokine receptor is expressed by Th1 cells to guide them to sites of viral or intracellular bacterial infections?

<p>CXCR3</p> Signup and view all the answers

What is the primary cytokine produced by Th1 cells?

<p>Interferon-gamma (IFN-γ)</p> Signup and view all the answers

Which chemokine receptor is expressed by Th2 cells to enable migration to sites of allergic inflammation or helminth infections?

<p>CCR4</p> Signup and view all the answers

What is the role of Th17 cells concerning specific pathogens?

<p>Combat extracellular bacteria and fungi</p> Signup and view all the answers

How are the Th1, Th2, and Th17 subsets of CD4+ T cells regulated?

<p>By manipulation of cytokine signals</p> Signup and view all the answers

What is the primary function of Th1 cells?

<p>Promote phagocyte-mediated elimination of intracellular pathogens</p> Signup and view all the answers

Which cytokines are produced by Th1 cells?

<p>Interferon-gamma (IFN-γ) and Tumor Necrosis Factor-alpha (TNF-α)</p> Signup and view all the answers

Which immune responses are coordinated by Th1 cells?

<p>Regulation of cellular immunity and innate immunity</p> Signup and view all the answers

What is the main function of Th17 cells?

<p>Regulate cellular immunity against extracellular pathogens</p> Signup and view all the answers

Which of the following is NOT a cytokine produced by Th1 cells?

<p>Interleukin-4 (IL-4)</p> Signup and view all the answers

What role do Th1 cells play in the immune response?

<p>Defense against intracellular pathogens</p> Signup and view all the answers

Which cytokine is involved in reinforcing Th1 differentiation?

<p>IFN-γ</p> Signup and view all the answers

What is the function of Th17 cells in the immune response?

<p>Defense against extracellular bacteria and fungi</p> Signup and view all the answers

What is the role of Th17 cells in defense against extracellular bacteria and fungi?

<p>Stimulating the production of antimicrobial peptides</p> Signup and view all the answers

Which condition can arise from excessive Th17 responses?

<p>Psoriasis</p> Signup and view all the answers

Which type of cells produce the cytokines necessary for driving Th cell subset differentiation?

<p>Antigen-presenting cells</p> Signup and view all the answers

What is the impact of autocrine regulation by CD4+ T cells?

<p>Suppressing the development of other subsets</p> Signup and view all the answers

What is the function of Th1 cells in the immune response?

<p>Activating macrophages to destroy intracellular microbes</p> Signup and view all the answers

Which cytokine is typically associated with Th1 cells' function?

<p>Interferon-gamma (IFN-γ)</p> Signup and view all the answers

In which context is an excessive Th17 response more likely to cause damage?

<p>Contributing to chronic inflammation and tissue damage</p> Signup and view all the answers

Which effector function of CD4+ Th cells involves the release of cytokines like interferon-gamma and tumor necrosis factor-alpha to activate macrophages and promote inflammation?

<p>Inducing inflammation</p> Signup and view all the answers

What is the primary role of T follicular helper (Tfh) cells in the immune response?

<p>Providing help to B cells for antibody production</p> Signup and view all the answers

Which subset of CD4+ T cells can cause tissue damage in delayed-type hypersensitivity reactions?

<p>Th1 cells</p> Signup and view all the answers

Which immune-mediated disease is characterized by chronic inflammation?

<p>Rheumatoid Arthritis</p> Signup and view all the answers

In the immune response, what do Th1 cells specifically target?

<p>Tissue damage induction in delayed-type hypersensitivity reactions</p> Signup and view all the answers

What is the primary function of costimulatory blockade in manipulating the B7/CD28 interaction for therapeutic purposes?

<p>Suppress T cell activation</p> Signup and view all the answers

Which molecule competes with CD28 for binding to B7-1 and B7-2, acting as an inhibitory molecule to dampen T cell activation?

<p>CTLA-4</p> Signup and view all the answers

What is the goal of therapeutic intervention in blocking the CD28 co-stimulatory pathway for T cell activation?

<p>Prevent T cell activation</p> Signup and view all the answers

Which cell receptor on T cells binds to B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells (APCs) for full T cell activation?

<p>CD28</p> Signup and view all the answers

What role does CTLA-4 play in the manipulation of the B7/CD28 interaction for therapeutic purposes?

<p>Dampens T cell activation by binding to B7-1 and B7-2</p> Signup and view all the answers

In the context of immune-related disorders, how does inhibition of the CD28 pathway affect T cell activation?

<p>Reduces inflammation and tissue damage</p> Signup and view all the answers

What is the effect of blocked CD28 co-stimulation on T cell activity?

<p>Suppresses T cell activation</p> Signup and view all the answers

Which molecule competes with CD28 for binding to B7-1 and B7-2, thereby inhibiting T cell activation?

<p>CTLA-4</p> Signup and view all the answers

What is the essential function of CTLA-4 in the manipulation of the B7/CD28 interaction for therapeutic purposes?

<p>Dampen T cell activation</p> Signup and view all the answers

In immune-related disorders, what is the impact of costimulatory blockade on T cell activation?

<p>Suppresses T cell activation</p> Signup and view all the answers

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