T Cell Recognition and Antigens

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Questions and Answers

What do Natural Killer T cells recognize?

  • Proteins from the endoplasmic reticulum
  • Lipids displayed by class I–like CD1 molecules (correct)
  • Peptides displayed by MHC molecules
  • Bacterial-derived vitamin B metabolites

What is a characteristic of MAIT cells?

  • Involvement in cross-presentation
  • Recognition of peptides displayed by MHC class I molecules
  • Recognition of bacterial-derived vitamin B metabolites displayed by class I–like MR1 molecules (correct)
  • Participation in the ubiquitin-proteasome pathway

What is a feature of γδ T cells?

  • Involvement in cross-presentation
  • Recognition of peptides displayed by MHC class II molecules
  • Recognition of a wide variety of molecules (correct)
  • Participation in the ubiquitin-proteasome pathway

What molecules do MHC-restricted CD4+ and CD8+ T cells recognize?

<p>Peptides displayed by MHC molecules (C)</p> Signup and view all the answers

What is not described as a function of the mentioned T cell types?

<p>Participation in the ubiquitin-proteasome pathway (B)</p> Signup and view all the answers

What is the primary function of MHC molecules?

<p>To display peptides derived from protein antigens (B)</p> Signup and view all the answers

What type of T cells recognize lipid and other nonpeptide antigens?

<p>Small populations of T cells (D)</p> Signup and view all the answers

Which cells are responsible for capturing microbial antigens and displaying them for recognition by T lymphocytes?

<p>Antigen-presenting cells (APCs) (B)</p> Signup and view all the answers

What is required for T cell recognition of peptide antigens?

<p>Both the peptide antigen and the MHC molecule (A)</p> Signup and view all the answers

What is the result of naive T lymphocytes seeing protein antigens presented by dendritic cells?

<p>Initiation of clonal expansion and differentiation of the T cells into effector and memory cells (C)</p> Signup and view all the answers

How do peptides bind to MHC molecules?

<p>By anchor residues, which attach the peptides to pockets in the MHC molecules (D)</p> Signup and view all the answers

What is the primary function of dendritic cells in the process of cross-presentation?

<p>To present antigens from other infected or dying cells to CD8+ T cells (C)</p> Signup and view all the answers

Where are the antigenic peptides generated in the process of cross-presentation?

<p>Cytosol (D)</p> Signup and view all the answers

What is the role of the proteasome in the process of cross-presentation?

<p>To generate antigenic peptides from ingested antigens (B)</p> Signup and view all the answers

What is the function of the endoplasmic reticulum in the process of cross-presentation?

<p>To bind antigenic peptides to MHC class I molecules (D)</p> Signup and view all the answers

What is the role of MHC class I molecules in the process of cross-presentation?

<p>To bind antigenic peptides and display them on the surface of dendritic cells (A)</p> Signup and view all the answers

What is the outcome of CD8+ T cell recognition of antigen presented by dendritic cells?

<p>Killing of infected host cells or tumor cells (C)</p> Signup and view all the answers

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