T Cell Recognition and Antigens

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What do Natural Killer T cells recognize?

Proteins from the endoplasmic reticulum

Lipids displayed by class I–like CD1 molecules (correct)

Peptides displayed by MHC molecules

Bacterial-derived vitamin B metabolites

What is a characteristic of MAIT cells?

Involvement in cross-presentation

Recognition of peptides displayed by MHC class I molecules

Recognition of bacterial-derived vitamin B metabolites displayed by class I–like MR1 molecules (correct)

Participation in the ubiquitin-proteasome pathway

What is a feature of γδ T cells?

Involvement in cross-presentation

Recognition of peptides displayed by MHC class II molecules

Recognition of a wide variety of molecules (correct)

Participation in the ubiquitin-proteasome pathway

What molecules do MHC-restricted CD4+ and CD8+ T cells recognize?

Peptides displayed by MHC molecules Signup and view all the answers

What is not described as a function of the mentioned T cell types?

Participation in the ubiquitin-proteasome pathway Signup and view all the answers

What is the primary function of MHC molecules?

To display peptides derived from protein antigens Signup and view all the answers

What type of T cells recognize lipid and other nonpeptide antigens?

Small populations of T cells Signup and view all the answers

Which cells are responsible for capturing microbial antigens and displaying them for recognition by T lymphocytes?

Antigen-presenting cells (APCs) Signup and view all the answers

What is required for T cell recognition of peptide antigens?

Both the peptide antigen and the MHC molecule Signup and view all the answers

What is the result of naive T lymphocytes seeing protein antigens presented by dendritic cells?

Initiation of clonal expansion and differentiation of the T cells into effector and memory cells Signup and view all the answers

How do peptides bind to MHC molecules?

By anchor residues, which attach the peptides to pockets in the MHC molecules Signup and view all the answers

What is the primary function of dendritic cells in the process of cross-presentation?

To present antigens from other infected or dying cells to CD8+ T cells Signup and view all the answers

Where are the antigenic peptides generated in the process of cross-presentation?

Cytosol Signup and view all the answers

What is the role of the proteasome in the process of cross-presentation?

To generate antigenic peptides from ingested antigens Signup and view all the answers

What is the function of the endoplasmic reticulum in the process of cross-presentation?

To bind antigenic peptides to MHC class I molecules Signup and view all the answers

What is the role of MHC class I molecules in the process of cross-presentation?

To bind antigenic peptides and display them on the surface of dendritic cells Signup and view all the answers

What is the outcome of CD8+ T cell recognition of antigen presented by dendritic cells?

Killing of infected host cells or tumor cells Signup and view all the answers

T Cell Recognition and Antigens

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