17 Questions
What do Natural Killer T cells recognize?
Lipids displayed by class I–like CD1 molecules
What is a characteristic of MAIT cells?
Recognition of bacterial-derived vitamin B metabolites displayed by class I–like MR1 molecules
What is a feature of γδ T cells?
Recognition of a wide variety of molecules
What molecules do MHC-restricted CD4+ and CD8+ T cells recognize?
Peptides displayed by MHC molecules
What is not described as a function of the mentioned T cell types?
Participation in the ubiquitin-proteasome pathway
What is the primary function of MHC molecules?
To display peptides derived from protein antigens
What type of T cells recognize lipid and other nonpeptide antigens?
Small populations of T cells
Which cells are responsible for capturing microbial antigens and displaying them for recognition by T lymphocytes?
Antigen-presenting cells (APCs)
What is required for T cell recognition of peptide antigens?
Both the peptide antigen and the MHC molecule
What is the result of naive T lymphocytes seeing protein antigens presented by dendritic cells?
Initiation of clonal expansion and differentiation of the T cells into effector and memory cells
How do peptides bind to MHC molecules?
By anchor residues, which attach the peptides to pockets in the MHC molecules
What is the primary function of dendritic cells in the process of cross-presentation?
To present antigens from other infected or dying cells to CD8+ T cells
Where are the antigenic peptides generated in the process of cross-presentation?
Cytosol
What is the role of the proteasome in the process of cross-presentation?
To generate antigenic peptides from ingested antigens
What is the function of the endoplasmic reticulum in the process of cross-presentation?
To bind antigenic peptides to MHC class I molecules
What is the role of MHC class I molecules in the process of cross-presentation?
To bind antigenic peptides and display them on the surface of dendritic cells
What is the outcome of CD8+ T cell recognition of antigen presented by dendritic cells?
Killing of infected host cells or tumor cells
This quiz covers the different types of T cells, including CD4+, CD8+, NK-T cells, and MAIT cells, and their recognition of various antigens, including peptides, lipids, and bacterial-derived metabolites. It also touches on the role of MHC and CD1 molecules in antigen presentation. Test your knowledge of the immune system!
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