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MHC class I molecules present peptides derived from extracellular proteins to CD4 T cells.
MHC class I molecules present peptides derived from extracellular proteins to CD4 T cells.
False
There are three main classes of MHC cell surface proteins.
There are three main classes of MHC cell surface proteins.
False
The peptide-binding cleft of MHC molecules contains few polymorphic amino acids.
The peptide-binding cleft of MHC molecules contains few polymorphic amino acids.
False
MHC gene loci were identified in research on immune responses related to allergies.
MHC gene loci were identified in research on immune responses related to allergies.
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Class II HLA gene loci encode for alpha and gamma chains.
Class II HLA gene loci encode for alpha and gamma chains.
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MHC class I molecules are primarily expressed on the surface of antigen-presenting cells.
MHC class I molecules are primarily expressed on the surface of antigen-presenting cells.
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Class II MHC molecules present peptides derived from intracellular proteins.
Class II MHC molecules present peptides derived from intracellular proteins.
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Peptide binding in the cleft of MHC molecules involves nonpolymorphic amino acids.
Peptide binding in the cleft of MHC molecules involves nonpolymorphic amino acids.
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Dendritic cells, macrophages, and B cells play a minimal role in antigen capture and presentation.
Dendritic cells, macrophages, and B cells play a minimal role in antigen capture and presentation.
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MHC gene loci were not identified through work on tissue transplantation.
MHC gene loci were not identified through work on tissue transplantation.
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The peptide-binding cleft contains many polymorphic amino acids.
The peptide-binding cleft contains many polymorphic amino acids.
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Antigen-presenting cells activate CD4 T lymphocytes.
Antigen-presenting cells activate CD4 T lymphocytes.
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MHC gene loci were identified in work on tissue transplantation.
MHC gene loci were identified in work on tissue transplantation.
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There are two main classes of MHC cell surface proteins.
There are two main classes of MHC cell surface proteins.
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Class II HLA gene loci code for alpha and gamma chains.
Class II HLA gene loci code for alpha and gamma chains.
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Class I MHC molecules are recognized by CD4+ helper T cells.
Class I MHC molecules are recognized by CD4+ helper T cells.
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Polymorphic genes encode for the antigen-binding regions of MHC molecules.
Polymorphic genes encode for the antigen-binding regions of MHC molecules.
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MHC haplotypes refer to the complete set of MHC alleles present on both chromosomes inherited from a single parent.
MHC haplotypes refer to the complete set of MHC alleles present on both chromosomes inherited from a single parent.
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There are nonpolymorphic genes encoded at the MHC locus that solely regulate immune responses and antigen processing.
There are nonpolymorphic genes encoded at the MHC locus that solely regulate immune responses and antigen processing.
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The peptide-binding cleft of MHC molecules contains few polymorphic amino acids.
The peptide-binding cleft of MHC molecules contains few polymorphic amino acids.
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Class II MHC molecules are primarily expressed on the surface of dendritic cells, macrophages, and T cells.
Class II MHC molecules are primarily expressed on the surface of dendritic cells, macrophages, and T cells.
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Class I MHC molecules are composed of an alpha chain and a gamma-2 microglobulin chain.
Class I MHC molecules are composed of an alpha chain and a gamma-2 microglobulin chain.
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Class I MHC molecules are expressed on the surface of almost all nucleated cells in the body.
Class I MHC molecules are expressed on the surface of almost all nucleated cells in the body.
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The peptide binding cleft of Class II MHC molecules is formed by the alpha1 and beta2 domains.
The peptide binding cleft of Class II MHC molecules is formed by the alpha1 and beta2 domains.
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MHC gene loci were identified in work on tissue transplantation.
MHC gene loci were identified in work on tissue transplantation.
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T Cell Receptors (TCRs) consist of two protein chains: α and β for γδ T cells.
T Cell Receptors (TCRs) consist of two protein chains: α and β for γδ T cells.
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Peptides presented by MHC molecules on the cell surface are usually 15-20 amino acids in length.
Peptides presented by MHC molecules on the cell surface are usually 15-20 amino acids in length.
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Dendritic cells, macrophages, and B cells are examples of T cell receptors (TCRs).
Dendritic cells, macrophages, and B cells are examples of T cell receptors (TCRs).
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MHC class I molecules present peptides derived from intracellular proteins to CD4 T cells.
MHC class I molecules present peptides derived from intracellular proteins to CD4 T cells.
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The peptide-binding cleft of MHC molecules contains few polymorphic amino acids.
The peptide-binding cleft of MHC molecules contains few polymorphic amino acids.
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The peptide binding cleft of Class II MHC molecules allows longer peptides to bind compared to Class I MHC molecules.
The peptide binding cleft of Class II MHC molecules allows longer peptides to bind compared to Class I MHC molecules.
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Peptides derived from extracellular proteins are taken up by dendritic cells for processing and loading onto Class II MHC molecules.
Peptides derived from extracellular proteins are taken up by dendritic cells for processing and loading onto Class II MHC molecules.
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The peptide binding cleft of Class I MHC molecules is open at both ends.
The peptide binding cleft of Class I MHC molecules is open at both ends.
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MHC class I molecules primarily present peptides derived from intracellular proteins to CD4+ helper T cells.
MHC class I molecules primarily present peptides derived from intracellular proteins to CD4+ helper T cells.
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Peptides bind to the peptide binding cleft of MHC molecules via interactions with nonpolymorphic amino acids.
Peptides bind to the peptide binding cleft of MHC molecules via interactions with nonpolymorphic amino acids.
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MHC gene loci were identified through research on allergic responses.
MHC gene loci were identified through research on allergic responses.
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There are three main classes of MHC cell surface proteins.
There are three main classes of MHC cell surface proteins.
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Class II HLA gene loci encode for alpha and gamma chains.
Class II HLA gene loci encode for alpha and gamma chains.
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Antigen-presenting cells play a minimal role in activating CD4+ helper T cells.
Antigen-presenting cells play a minimal role in activating CD4+ helper T cells.
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MHC cell surface proteins present peptide antigens to B cell receptors for immune response initiation.
MHC cell surface proteins present peptide antigens to B cell receptors for immune response initiation.
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