40 Questions
MHC class I molecules present peptides derived from extracellular proteins to CD4 T cells.
False
There are three main classes of MHC cell surface proteins.
False
The peptide-binding cleft of MHC molecules contains few polymorphic amino acids.
False
MHC gene loci were identified in research on immune responses related to allergies.
False
Class II HLA gene loci encode for alpha and gamma chains.
False
MHC class I molecules are primarily expressed on the surface of antigen-presenting cells.
False
Class II MHC molecules present peptides derived from intracellular proteins.
False
Peptide binding in the cleft of MHC molecules involves nonpolymorphic amino acids.
False
Dendritic cells, macrophages, and B cells play a minimal role in antigen capture and presentation.
False
MHC gene loci were not identified through work on tissue transplantation.
False
The peptide-binding cleft contains many polymorphic amino acids.
True
Antigen-presenting cells activate CD4 T lymphocytes.
True
MHC gene loci were identified in work on tissue transplantation.
True
There are two main classes of MHC cell surface proteins.
True
Class II HLA gene loci code for alpha and gamma chains.
False
Class I MHC molecules are recognized by CD4+ helper T cells.
False
Polymorphic genes encode for the antigen-binding regions of MHC molecules.
True
MHC haplotypes refer to the complete set of MHC alleles present on both chromosomes inherited from a single parent.
False
There are nonpolymorphic genes encoded at the MHC locus that solely regulate immune responses and antigen processing.
False
The peptide-binding cleft of MHC molecules contains few polymorphic amino acids.
False
Class II MHC molecules are primarily expressed on the surface of dendritic cells, macrophages, and T cells.
False
Class I MHC molecules are composed of an alpha chain and a gamma-2 microglobulin chain.
False
Class I MHC molecules are expressed on the surface of almost all nucleated cells in the body.
True
The peptide binding cleft of Class II MHC molecules is formed by the alpha1 and beta2 domains.
False
MHC gene loci were identified in work on tissue transplantation.
True
T Cell Receptors (TCRs) consist of two protein chains: α and β for γδ T cells.
True
Peptides presented by MHC molecules on the cell surface are usually 15-20 amino acids in length.
False
Dendritic cells, macrophages, and B cells are examples of T cell receptors (TCRs).
False
MHC class I molecules present peptides derived from intracellular proteins to CD4 T cells.
False
The peptide-binding cleft of MHC molecules contains few polymorphic amino acids.
False
The peptide binding cleft of Class II MHC molecules allows longer peptides to bind compared to Class I MHC molecules.
True
Peptides derived from extracellular proteins are taken up by dendritic cells for processing and loading onto Class II MHC molecules.
True
The peptide binding cleft of Class I MHC molecules is open at both ends.
False
MHC class I molecules primarily present peptides derived from intracellular proteins to CD4+ helper T cells.
False
Peptides bind to the peptide binding cleft of MHC molecules via interactions with nonpolymorphic amino acids.
False
MHC gene loci were identified through research on allergic responses.
False
There are three main classes of MHC cell surface proteins.
False
Class II HLA gene loci encode for alpha and gamma chains.
False
Antigen-presenting cells play a minimal role in activating CD4+ helper T cells.
False
MHC cell surface proteins present peptide antigens to B cell receptors for immune response initiation.
False
Explore the components involved in the interaction between a T cell receptor (TCR) and the peptide-Major Histocompatibility Complex (MHC) complex. Learn about the role of T cell receptors and MHC cell surface proteins in presenting peptide antigens to T cells.
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