Podcast
Questions and Answers
What is the role of CD4 or CD8 co-receptor in the T cell intracellular signaling pathway?
What is the role of CD4 or CD8 co-receptor in the T cell intracellular signaling pathway?
- Enhances the stability of TCR-MHC-peptide interaction (correct)
- Inhibits TCR-MHC-peptide interaction
- Halts transcription factor activation
- Triggers activation of CTLs
What initiates the formation of an increasingly stable immune synapse in the T cell signaling pathway?
What initiates the formation of an increasingly stable immune synapse in the T cell signaling pathway?
- CD4 or CD8 co-receptor binding
- Activation of transcription factors
- CD4/CD8-associated Lck phosphorylation
- TCR binding to MHC-peptide complex (correct)
Which proteins act as recruitment sites for other signaling proteins once phosphorylated in the T cell intracellular signaling pathway?
Which proteins act as recruitment sites for other signaling proteins once phosphorylated in the T cell intracellular signaling pathway?
- TCR-MHC complexes
- CD4/CD8-associated Lck
- P-Tyr residues on CD3 & zeta chains (correct)
- Ligands
What is the main function of the immune synapse in coordinating immune responses?
What is the main function of the immune synapse in coordinating immune responses?
Which event occurs first in the T cell intracellular signal pathway?
Which event occurs first in the T cell intracellular signal pathway?
Which components make up the TCR complex?
Which components make up the TCR complex?
What is the composition of the TCR itself?
What is the composition of the TCR itself?
Which part of the TCR complex serves as a sensor for the T cell?
Which part of the TCR complex serves as a sensor for the T cell?
Which region of the TCR is the most variable and critical for antigen recognition?
Which region of the TCR is the most variable and critical for antigen recognition?
What initiates signaling in the TCR complex upon binding to MHC presenting an antigen peptide?
What initiates signaling in the TCR complex upon binding to MHC presenting an antigen peptide?
Which part of the TCR complex contains ITAMs in their cytoplasmic tails?
Which part of the TCR complex contains ITAMs in their cytoplasmic tails?
What type of bonds contribute to the stability and proper folding of the TCR chains?
What type of bonds contribute to the stability and proper folding of the TCR chains?
Which domain is characteristic of proteins in the immunoglobulin superfamily and is involved in antigen recognition?
Which domain is characteristic of proteins in the immunoglobulin superfamily and is involved in antigen recognition?
Which structure enables T cells to recognize a wide range of antigens and initiate immune responses?
Which structure enables T cells to recognize a wide range of antigens and initiate immune responses?
What is the primary function of the TCR complex in signal transduction?
What is the primary function of the TCR complex in signal transduction?
Which protein is primarily expressed on CD4+ T cells and serves as a co-receptor for helper T lymphocytes?
Which protein is primarily expressed on CD4+ T cells and serves as a co-receptor for helper T lymphocytes?
What is the main role of CD8 as a co-receptor in T cells?
What is the main role of CD8 as a co-receptor in T cells?
Which type of cells primarily express CD8 as a co-receptor?
Which type of cells primarily express CD8 as a co-receptor?
What is the function of CD4 in the context of T cell activation?
What is the function of CD4 in the context of T cell activation?
When a CD4+ T cell encounters an antigen-presenting cell displaying a peptide bound to class II MHC molecules, what does the CD4 co-receptor bind to?
When a CD4+ T cell encounters an antigen-presenting cell displaying a peptide bound to class II MHC molecules, what does the CD4 co-receptor bind to?
What is the role of CD8 co-receptor in T cell activation?
What is the role of CD8 co-receptor in T cell activation?
Which molecules do CD8 co-receptors bind to during T cell activation?
Which molecules do CD8 co-receptors bind to during T cell activation?
What is the key defining feature of CD4+ helper T cells?
What is the key defining feature of CD4+ helper T cells?
How do CD4 and CD8 co-receptors contribute to T cell activation?
How do CD4 and CD8 co-receptors contribute to T cell activation?
Which molecules are recognized by TCRs on T cells?
Which molecules are recognized by TCRs on T cells?
What is the composition of the TCR with respect to chains?
What is the composition of the TCR with respect to chains?
Which region of the TCR is responsible for recognizing specific antigens?
Which region of the TCR is responsible for recognizing specific antigens?
What is the structure of the TCR when considering the heterodimer formation?
What is the structure of the TCR when considering the heterodimer formation?
Which event leads to the formation of an increasingly stable immune synapse in the T cell signaling pathway?
Which event leads to the formation of an increasingly stable immune synapse in the T cell signaling pathway?
What is the function of CD4 and CD8 co-receptors in the T cell signaling pathway?
What is the function of CD4 and CD8 co-receptors in the T cell signaling pathway?
Which protein kinase phosphorylates tyrosine residues within the ITAMs upon TCR engagement?
Which protein kinase phosphorylates tyrosine residues within the ITAMs upon TCR engagement?
What is the main function of phosphorylated tyrosine residues within the ITAMs in the TCR signaling pathway?
What is the main function of phosphorylated tyrosine residues within the ITAMs in the TCR signaling pathway?
Following activation of transcription factors, what is the next step in the T cell signal pathway cascade?
Following activation of transcription factors, what is the next step in the T cell signal pathway cascade?
Which transcription factor is NOT activated by the downstream signaling proteins in the TCR signaling pathway?
Which transcription factor is NOT activated by the downstream signaling proteins in the TCR signaling pathway?
What is the role of phosphorylated tyrosine residues within the ITAMs in recruiting other signaling proteins?
What is the role of phosphorylated tyrosine residues within the ITAMs in recruiting other signaling proteins?
Which molecules translocate to the nucleus and bind to specific DNA sequences in the T cell signal pathway?
Which molecules translocate to the nucleus and bind to specific DNA sequences in the T cell signal pathway?
What do the expressed proteins contribute to in the T cell signal pathway?
What do the expressed proteins contribute to in the T cell signal pathway?
Which proteins initiate a signaling cascade that amplifies and propagates the TCR signaling pathway?
Which proteins initiate a signaling cascade that amplifies and propagates the TCR signaling pathway?
What event follows the binding of TCR and co-receptor to MHC antigen in the formation of an immune synapse?
What event follows the binding of TCR and co-receptor to MHC antigen in the formation of an immune synapse?
What is the function of ZAP-70 in the T cell intracellular signaling pathway?
What is the function of ZAP-70 in the T cell intracellular signaling pathway?
