T Cell Differentiation and Memory

Which of the following is NOT a typical phase in the kinetic response of T cells to an antigen?

Effector T cells are characterized by their exclusive presence in lymphoid tissues, enabling them to efficiently survey for antigens.

What immunological process is characterized by long-lived memory, surveillance, and rapid recall?

Following activation, naive T cells undergo metabolic changes, including increased ______ to meet the energetic demands of proliferation and augmented motility.

Match the following T cell types with their corresponding homing capabilities or migratory patterns:

In the context of T cell activation, what is the primary function of CD25 (IL2Ra)?

The process of T cell differentiation exclusively leads to the formation of effector cells, with no capacity for forming memory cells.

What term describes the phenomenon where the progeny of a singular CD62Lhi T cell can confer protection against bacterial challenge, demonstrating the potential of these cells to expand robustly?

When considering memory T cell development, short-lived effector cells are called ______, while memory precursor effector cells are called MPECs.

Match the following qualities with their respective T cell subsets:

What is the primary function or purpose of specialized effector T cells?

The strength of signals received by a T cell during antigen presentation does not influence its differentiation pathway.

What are the two key goals that a T cell response must achieve to effectively control an infection?

The ______ model proposes that T cell diversity is determined by the strength of signals received during antigen presentation.

Match each of the below memory T cell subsets to whether they express the marker in their name:

What is the primary function of the proteomic profiling used in the study of T cell differentiation?

T cell exhaustion primarily occurs during acute infections when the immune system is overwhelmed by pathogens.

What is the main characteristic that differentiates Tcm cells from Tem cells in terms of migratory capacity and chemokine receptor expression?

The persistence of memory T cells over long periods, even years, is related to their capacity for ______ proliferation, allowing for maintenance of the memory pool.

Match each T cell state with its primary attribute or marker:

Which type of T cells would be classified as central memory T cells?

T cell responses are uniform, meaning that all T cells respond identically to the same antigen.

What is the significance of measuring deuterium incorporation in T cells following vaccination, as demonstrated by Akondy et al.?

According to the research, persistence of autoimmune CD4+ T cells relies on fine-tuning a transcription factor known as ______ to balance function and survival during ongoing antigen exposure.

Match the term with its primary function or characteristic.

Which of the following is NOT a characteristic of T cell exhaustion?

Natural history studies of T cell responses provide insights that are not obtainable through animal challenge models or vaccine studies.

What are the functions of the TOX transcription factor in programming CD8+ T cells relative to exhaustion?

The efficacy of T-cell based vaccines in tackling infections is limited by the lack of clear T-cell ______ of protection.

Match each T cell function with its primary influence on adaptive immunity:

According to the information, which of the following factors is known to promote terminally differentiated exhausted CD8+ T cells?

The immediate goal of a T cell response is only to produce enough effector T cells to clear an infection.

What term is directly related to the capacity of memory T cells to divide and proliferate at an accelerated rate compared to naïve T cells?

In T cell differentiation, ______ refers to the process where T cells adapt to new functions.

Match each T cell component with the related function:

Based on the reading from Janeway's Immunobiology, which of the following topics is most likely covered in Chapter 10/11?

All memory T cells are fundamentally the same, differing only in their duration of survival.

According to the research, what is most important regarding types of T cell memory?

In a T cell response, for protection on future exposure, in addition to clearing the infection, it is key to lay down ______ .

Match the T cell types with the vaccine they are most closely associated with:

Which of the following is NOT one of the three key phases of T cell differentiation?

Naïve T cells differentiate into specialized effectors with identical properties.

What is the main function of T helper 17 cells (Th17) in adaptive immune response?

Within 24 hours of activation, naïve T cells increase their ______ content by threefold.

In the context of T cell responses, what is typically considered a correlate of protection (COP) for antibody-based vaccines?

The presence of short-lived effector cells (SLECs) is crucial for long-term immunological memory.

What chemokine receptor and selectin are associated with naïve T cell homing to lymph nodes?

Memory T cells can be broadly classified as central (Tcm, Tscm) and ______.

Which of the following is a characteristic of exhausted T cells?

T cell exhaustion is primarily regulated by genetic factors alone.

What types of signals or cues can drive differentiation of T effector cells?

A key hallmark of memory T cells is their ______ activation threshold compared to naïve T cells.

Match the T cell characteristic with the location:

Central Memory T cells (Tcm) Terminal Effector Memory T cells (Temra)

What is the primary difference between Memory Precursor Effector Cells (MPECs) and Short-Lived Effector Cells (SLECs)?

Deuterium, incorporated into T cells, is diluted out quickly as the cells proliferate.