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Explain the role of costimulation in T cell activation and how it prevents accidental immune responses.
Explain the role of costimulation in T cell activation and how it prevents accidental immune responses.
Costimulation is necessary for T cell activation as it ensures that T cells are only activated when both the T cell receptor recognizes a specific antigen presented with MHC complexes and receives costimulatory signals. This prevents accidental immune responses from occurring. Recognition of the antigen without costimulation results in anergy, a prolonged state of inactivity in both B and T cells.
Where does the activation, proliferation, and differentiation of T cells occur?
Where does the activation, proliferation, and differentiation of T cells occur?
The activation, proliferation, and differentiation of T cells occur in secondary lymphatic organs and tissues.
Describe the process of T cell activation, proliferation, and differentiation.
Describe the process of T cell activation, proliferation, and differentiation.
T cell activation involves binding of the T cell receptor to a specific antigen presented with MHC complexes, along with receiving costimulatory signals. Once activated, the T cell proliferates and differentiates to form more highly specialized cells.
What happens if a T cell only recognizes the antigen but does not receive costimulation?
What happens if a T cell only recognizes the antigen but does not receive costimulation?
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