10 Questions
What is the characteristic feature of skin fibrosis in late systemic sclerosis?
Absence of inflammation
Which of the following is true about the dermis in systemic sclerosis?
Collagen bundles are oriented perpendicular to the epithelium
What happens to the adnexal glands in systemic sclerosis?
They atrophy
What is the main cellular component found in early perivascular infiltrates in systemic sclerosis?
Lymphocytes
What is the state of rete pegs in systemic sclerosis compared to normal skin?
They are effaced
What is the result of progressive thickening of alveolar septae in lung disease?
Obliteration of airspaces and honeycombing
Which of the following cell types is NOT typically found in the early disease stage of lung involvement?
Neutrophils
What is the consequence of vascular damage in the progression of lung disease?
Enhanced pulmonary artery hypertension (PAH)
What happens as a result of the loss of pulmonary vessels in the context of lung involvement?
Impaired gas exchange
What is the ultimate consequence of the obliteration of airspaces and honeycombing in lung disease?
Worsening of PAH
Learn about the histological changes in skin associated with systemic sclerosis, including thickening of the dermis, collagen accumulation, atrophy of adnexal glands, and more. Understand the differences between early and late-stage skin fibrosis.
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