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Systemic Sclerosis and Skin Histology Changes

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Systemic Sclerosis and Skin Histology Changes

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Questions and Answers

What is the characteristic feature of skin fibrosis in late systemic sclerosis?

Increased number of rete pegs

Thickening of the epidermis

Absence of inflammation (correct)

Presence of perivascular mononuclear cell infiltrates

Which of the following is true about the dermis in systemic sclerosis?

Collagen bundles are oriented perpendicular to the epithelium (correct)

Adnexal glands are hypertrophic

There is an increase in white adipose tissue

The dermis is atrophic

What happens to the adnexal glands in systemic sclerosis?

They become hyperpigmented

They become hypertrophic

They show increased inflammation

They atrophy (correct)

What is the main cellular component found in early perivascular infiltrates in systemic sclerosis?

Lymphocytes Signup and view all the answers

What is the state of rete pegs in systemic sclerosis compared to normal skin?

They are effaced Signup and view all the answers

What is the result of progressive thickening of alveolar septae in lung disease?

Obliteration of airspaces and honeycombing Signup and view all the answers

Which of the following cell types is NOT typically found in the early disease stage of lung involvement?

Neutrophils Signup and view all the answers

What is the consequence of vascular damage in the progression of lung disease?

Enhanced pulmonary artery hypertension (PAH) Signup and view all the answers

What happens as a result of the loss of pulmonary vessels in the context of lung involvement?

Impaired gas exchange Signup and view all the answers

What is the ultimate consequence of the obliteration of airspaces and honeycombing in lung disease?

Worsening of PAH Signup and view all the answers