Podcast
Questions and Answers
What is the primary purpose of appraising evidence in a systematic review?
What is the primary purpose of appraising evidence in a systematic review?
- To identify publication bias
- To collect evidence from relevant databases
- To synthesize evidence from multiple studies
- To assess the risk of bias in individual studies (correct)
What type of bias is most likely to occur when studies with significant results are more likely to be published than studies with non-significant results?
What type of bias is most likely to occur when studies with significant results are more likely to be published than studies with non-significant results?
- Selection bias
- Information bias
- Confounding bias
- Publication bias (correct)
What is the primary goal of synthesizing evidence in a systematic review?
What is the primary goal of synthesizing evidence in a systematic review?
- To identify sources of heterogeneity
- To appraise the quality of individual studies
- To estimate the overall effect of an intervention (correct)
- To identify the most effective treatment
Which of the following is a type of bias that can occur when the outcome of interest is not measured or reported consistently across studies?
Which of the following is a type of bias that can occur when the outcome of interest is not measured or reported consistently across studies?
What is the primary purpose of using a systematic review methodology?
What is the primary purpose of using a systematic review methodology?
What tool is commonly used to assess the risk of bias in individual studies within a systematic review?
What tool is commonly used to assess the risk of bias in individual studies within a systematic review?
What is the primary goal of the evidence to decision framework?
What is the primary goal of the evidence to decision framework?
What is the primary purpose of considering the acceptability of an intervention in the evidence to decision framework?
What is the primary purpose of considering the acceptability of an intervention in the evidence to decision framework?
What is the primary goal of using a clear and precise recommendation in the evidence to decision framework?
What is the primary goal of using a clear and precise recommendation in the evidence to decision framework?
What is the primary purpose of considering the feasibility of an intervention in the evidence to decision framework?
What is the primary purpose of considering the feasibility of an intervention in the evidence to decision framework?
What is the primary purpose of a systematic review?
What is the primary purpose of a systematic review?
Which of the following is NOT a component of the PICO framework?
Which of the following is NOT a component of the PICO framework?
What is the primary goal of bias assessment in a systematic review?
What is the primary goal of bias assessment in a systematic review?
Which tool is used to assess the risk of bias in randomized controlled trials?
Which tool is used to assess the risk of bias in randomized controlled trials?
What is the purpose of meta-analysis in a systematic review?
What is the purpose of meta-analysis in a systematic review?
Which type of meta-analysis is used to compare multiple interventions?
Which type of meta-analysis is used to compare multiple interventions?
What is the purpose of the GRADE approach in a systematic review?
What is the purpose of the GRADE approach in a systematic review?
What is the purpose of visual inspection in a systematic review?
What is the purpose of visual inspection in a systematic review?
Which of the following is a type of study design?
Which of the following is a type of study design?
What is the purpose of appraising the evidence in a systematic review?
What is the purpose of appraising the evidence in a systematic review?
What is the most suitable type of study to use in this scenario?
What is the most suitable type of study to use in this scenario?
What is the primary purpose of using a systematic review in this case?
What is the primary purpose of using a systematic review in this case?
What is the primary advantage of using a search strategy like (pregnan* AND appendicit*) AND (treatment OR management)?
What is the primary advantage of using a search strategy like (pregnan* AND appendicit*) AND (treatment OR management)?
What is a potential limitation of relying on a single consultant's opinion in this scenario?
What is a potential limitation of relying on a single consultant's opinion in this scenario?
What is the primary purpose of using a risk of bias tool in this scenario?
What is the primary purpose of using a risk of bias tool in this scenario?
What is the primary advantage of using an artificial intelligence (AI) system in this scenario?
What is the primary advantage of using an artificial intelligence (AI) system in this scenario?
What is the primary limitation of relying on a textbook in this scenario?
What is the primary limitation of relying on a textbook in this scenario?
What is the primary advantage of using a systematic review in informing treatment decisions?
What is the primary advantage of using a systematic review in informing treatment decisions?
What is the primary purpose of assessing the quality of individual studies in a systematic review?
What is the primary purpose of assessing the quality of individual studies in a systematic review?
What is the primary advantage of using a systematic search strategy in this scenario?
What is the primary advantage of using a systematic search strategy in this scenario?
Flashcards
Appraising Evidence
Appraising Evidence
Assess the risk of bias in individual studies.
Publication Bias
Publication Bias
Studies with significant results are more likely to be published.
Synthesizing Evidence
Synthesizing Evidence
To estimate the overall effect of an intervention.
Indirectness Bias
Indirectness Bias
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Systematic Review Purpose
Systematic Review Purpose
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Cochrane Risk of Bias Tool
Cochrane Risk of Bias Tool
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Evidence to Decision Framework Goal
Evidence to Decision Framework Goal
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Acceptability of Intervention
Acceptability of Intervention
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Clear and Precise Recommendation Goal
Clear and Precise Recommendation Goal
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Feasibility of Intervention
Feasibility of Intervention
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Systematic Review Purpose
Systematic Review Purpose
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NOT a PICO Component
NOT a PICO Component
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Bias Assessment Goal
Bias Assessment Goal
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ROBINS-I
ROBINS-I
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Meta-Analysis Purpose
Meta-Analysis Purpose
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Network Meta-Analysis
Network Meta-Analysis
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GRADE Approach
GRADE Approach
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Visual Inspection Purpose
Visual Inspection Purpose
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Study Design Type
Study Design Type
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Appraising the Evidence
Appraising the Evidence
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Most Suitable Study Type
Most Suitable Study Type
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Systematic Review Purpose
Systematic Review Purpose
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Search Strategy Advantage
Search Strategy Advantage
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Relying on Consultant's Opinion
Relying on Consultant's Opinion
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Risk of Bias Tool Purpose
Risk of Bias Tool Purpose
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Advantage of AI system
Advantage of AI system
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Relying on Textbook
Relying on Textbook
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Advantage of Systematic View
Advantage of Systematic View
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Assessing Study Quality Purpose
Assessing Study Quality Purpose
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Systematic Search Advantage
Systematic Search Advantage
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Study Notes
Systematic Review
- A systematic review is a summary of evidence on a specific topic
- It involves a systematic search, collection, and synthesis of evidence, as well as appraisal of evidence
- May include meta-analysis, network meta-analysis, time-to-event meta-analysis, and IPD meta-analysis
PICO
- PICO stands for Patient (population), Intervention (exposure), Comparator (control), and Outcome(s)
- Used to formulate a specific research question
Evidence Appraisal
- Risk of bias: assessing the methodological quality of individual studies
- Inconsistency: assessing the variability in results across studies
- Indirectness: assessing the extent to which the results of the studies can be generalized to the population of interest
- Imprecision: assessing the degree of uncertainty in the results of the studies
- Publication bias: assessing the potential for selective reporting of results
GRADE
- A system for grading the quality of evidence and strength of recommendations
- Quality of evidence: very low, low, moderate, or high
- Strength of recommendations: strong or weak
Case Scenario
- A 32-year-old pregnant woman in the 9th week of pregnancy presents with pain and tenderness in the right lower abdominal fossa
- The patient has acute uncomplicated appendicitis and the attending suggests watchful waiting
- The doctor is unsure of the right course of action and needs to search for evidence
Searching for Evidence
- Use a specific search strategy, such as (pregnan* AND appendicit*) AND (treatment OR management)
- Search for systematic reviews, a type of study that provides a summary of evidence on a specific topic
Evidence to Decision
- A framework for making decisions based on evidence
- Consider the benefits and risks (or burden) of an intervention
- Consider the overall certainty of the evidence
- Consider the patients' values and preferences
- Consider the acceptability, feasibility, and resources required for the intervention
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