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Questions and Answers
What is the mechanism of action of β-lactam antibiotics?
What is the mechanism of action of β-lactam antibiotics?
- Inhibition of protein synthesis
- Inhibition of nucleic acid metabolism
- Inhibition of cell wall synthesis (correct)
- Inhibition of intermediary metabolism of folic acid
What is the name of the enzyme that β-lactam antibiotics inactivate?
What is the name of the enzyme that β-lactam antibiotics inactivate?
- Peptidase
- Transpeptidase (correct)
- Penicilloic enzyme
- Transaminase
What is the name of the complex formed when penicillin inactivates the enzyme?
What is the name of the complex formed when penicillin inactivates the enzyme?
- Transpeptidase complex
- β-lactam complex
- Penicilloic-enzyme complex (correct)
- Peptidoglycan complex
What is the name of the subclass of β-lactams that are broad-spectrum and used for treating severe infections of resistant bacteria?
What is the name of the subclass of β-lactams that are broad-spectrum and used for treating severe infections of resistant bacteria?
What is the name of the β-lactamase inhibitor that protects β-lactams from hydrolytic activity?
What is the name of the β-lactamase inhibitor that protects β-lactams from hydrolytic activity?
What is the mechanism of action of glycopeptides?
What is the mechanism of action of glycopeptides?
What is the name of the enzyme that is responsible for the assembly, maintenance, and regulation of peptidoglycan structures?
What is the name of the enzyme that is responsible for the assembly, maintenance, and regulation of peptidoglycan structures?
What is the name of the type of antibiotic that is effective against both gram-positive and gram-negative organisms?
What is the name of the type of antibiotic that is effective against both gram-positive and gram-negative organisms?
What is the name of the type of antibiotic that is effective against mycobacteria?
What is the name of the type of antibiotic that is effective against mycobacteria?
What is the name of the type of antibiotic that is effective against gram-positive and gram-negative organisms, and is also used in combination with β-lactamase inhibitors?
What is the name of the type of antibiotic that is effective against gram-positive and gram-negative organisms, and is also used in combination with β-lactamase inhibitors?
What is the mechanism of action of macrolides?
What is the mechanism of action of macrolides?
What is the primary mechanism of resistance to macrolides?
What is the primary mechanism of resistance to macrolides?
What is the unique characteristic of azithromycin compared to other macrolides?
What is the unique characteristic of azithromycin compared to other macrolides?
What is the primary effect of clindamycin on toxin production by GAS and S.aureus?
What is the primary effect of clindamycin on toxin production by GAS and S.aureus?
What is the primary route of excretion for clarithromycin?
What is the primary route of excretion for clarithromycin?
What is the characteristic of clindamycin's activity against staphylococci, streptococci, anaerobes, and H.pylori?
What is the characteristic of clindamycin's activity against staphylococci, streptococci, anaerobes, and H.pylori?
What is the primary mechanism of action of aminoglycosides?
What is the primary mechanism of action of aminoglycosides?
What is a common adverse effect of aminoglycosides?
What is a common adverse effect of aminoglycosides?
Which class of antibiotics is bactericidal against pneumococci, GAS, and anaerobes?
Which class of antibiotics is bactericidal against pneumococci, GAS, and anaerobes?
What is the mechanism of action of fluoroquinolones?
What is the mechanism of action of fluoroquinolones?
What is the mechanism of action of metronidazole?
What is the mechanism of action of metronidazole?
What is the mechanism of action of sulfonamides?
What is the mechanism of action of sulfonamides?
What is the primary mechanism of resistance to aminoglycosides?
What is the primary mechanism of resistance to aminoglycosides?
Which antibiotic is bacteriostatic against most organisms but has some bactericidal activity against streptococci?
Which antibiotic is bacteriostatic against most organisms but has some bactericidal activity against streptococci?
What is the primary mechanism of action of tetracyclines?
What is the primary mechanism of action of tetracyclines?
Which antibiotic is used for protozoal infections, such as Entamoeba histolytica and Trichomonas vaginalis?
Which antibiotic is used for protozoal infections, such as Entamoeba histolytica and Trichomonas vaginalis?
What is the ideal approach to antibiotic treatment?
What is the ideal approach to antibiotic treatment?
What is the term for an area of the body that is poorly penetrated by pharmacological agents?
What is the term for an area of the body that is poorly penetrated by pharmacological agents?
What category of antibiotic has a remote possibility of fetal harm?
What category of antibiotic has a remote possibility of fetal harm?
What is the purpose of determining the MIC of an antibiotic?
What is the purpose of determining the MIC of an antibiotic?
What type of antibiotic killing is optimized when the concentration of antibiotic is above the MIC for as long of a time period as possible?
What type of antibiotic killing is optimized when the concentration of antibiotic is above the MIC for as long of a time period as possible?
What is the term for the ratio of the antibiotic area under the curve to the time above MIC needed to inhibit microorganisms?
What is the term for the ratio of the antibiotic area under the curve to the time above MIC needed to inhibit microorganisms?
What is the purpose of pulsed dosing in antibiotic treatment?
What is the purpose of pulsed dosing in antibiotic treatment?
Which of the following antibiotics has a narrow spectrum of activity?
Which of the following antibiotics has a narrow spectrum of activity?
What is the term for the maximum serum concentration of an antibiotic needed to inhibit microorganisms?
What is the term for the maximum serum concentration of an antibiotic needed to inhibit microorganisms?
Which of the following factors can affect the efficacy of antibiotic treatment?
Which of the following factors can affect the efficacy of antibiotic treatment?
