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Questions and Answers
What is the significance of the regulation of de novo synthesis of purine nucleotides?
What is the significance of the regulation of de novo synthesis of purine nucleotides?
- [GTP]=[ATP]
- Fulfill the need of the body, without wasting (correct)
- Save the fuel
- Synthesize nucleotides by salvage pathway
Which enzyme is responsible for the conversion of AMP and GMP?
Which enzyme is responsible for the conversion of AMP and GMP?
- GMP synthetase (correct)
- Adenylate kinase
- Adenosine deaminase
- Ribonucleotide reductase
What is the course of the salvage pathway for nucleotide synthesis?
What is the course of the salvage pathway for nucleotide synthesis?
- Guanine + PRPP -> GMP -> ADP
- Hypoxanthine + PRPP -> IMP -> AMP (correct)
- Adenine + PRPP -> GMP -> ATP
- Adenine + PRPP -> AMP -> ATP
What happens in the absence of activity of HGPRT?
What happens in the absence of activity of HGPRT?
Which molecule is a structural analog of purine nucleotides?
Which molecule is a structural analog of purine nucleotides?
What is the significance of the salvage pathway for nucleotide synthesis?
What is the significance of the salvage pathway for nucleotide synthesis?
Which enzyme is involved in the formation of deoxyribonucleotide at the nucleoside diphosphate level?
Which enzyme is involved in the formation of deoxyribonucleotide at the nucleoside diphosphate level?
What is the first line reaction to form deoxyribonucleotides?
What is the first line reaction to form deoxyribonucleotides?
What are the two pathways leading to nucleotide synthesis?
What are the two pathways leading to nucleotide synthesis?
Which statement is correct regarding the formation of deoxyribonucleotide at the nucleoside diphosphate level?
Which statement is correct regarding the formation of deoxyribonucleotide at the nucleoside diphosphate level?
Which metabolic precursors are involved in the de novo synthesis of nucleotides?
Which metabolic precursors are involved in the de novo synthesis of nucleotides?
What is the product of the 9 steps involved in de novo purine synthesis?
What is the product of the 9 steps involved in de novo purine synthesis?
Which enzyme catalyzes the conversion of 5-phosphoribosylamine to inosine 5-monophosphate (IMP)?
Which enzyme catalyzes the conversion of 5-phosphoribosylamine to inosine 5-monophosphate (IMP)?
What is the role of PRPP kinase in de novo purine synthesis?
What is the role of PRPP kinase in de novo purine synthesis?
Which molecule provides the one-carbon unit necessary for purine synthesis?
Which molecule provides the one-carbon unit necessary for purine synthesis?
What is the function of GAR transformylase in de novo purine synthesis?
What is the function of GAR transformylase in de novo purine synthesis?
Which molecule is formed from the conversion of AICAR by AICAR transformylase?
Which molecule is formed from the conversion of AICAR by AICAR transformylase?
Which enzyme catalyzes the conversion of FAICAR to 5-formaminoimidazole-4-carboxamide ribonucleotide (FAICAR) in purine synthesis?
Which enzyme catalyzes the conversion of FAICAR to 5-formaminoimidazole-4-carboxamide ribonucleotide (FAICAR) in purine synthesis?
What is the final product formed from the conversion of SAICAR by SAICAR lyase in de novo purine synthesis?
What is the final product formed from the conversion of SAICAR by SAICAR lyase in de novo purine synthesis?
What is the significance of the regulation of de novo synthesis of purine nucleotides?
What is the significance of the regulation of de novo synthesis of purine nucleotides?
Which enzyme is involved in the formation of deoxyribonucleotides at the nucleoside diphosphate level?
Which enzyme is involved in the formation of deoxyribonucleotides at the nucleoside diphosphate level?
What happens in the absence of activity of HGPRT?
What happens in the absence of activity of HGPRT?
Which molecule provides the one-carbon unit necessary for purine synthesis?
Which molecule provides the one-carbon unit necessary for purine synthesis?
What is the product of the 9 steps involved in de novo purine synthesis?
What is the product of the 9 steps involved in de novo purine synthesis?
Which statement is correct regarding the formation of deoxyribonucleotide at the nucleoside diphosphate level?
Which statement is correct regarding the formation of deoxyribonucleotide at the nucleoside diphosphate level?
What is the function of GAR transformylase in de novo purine synthesis?
What is the function of GAR transformylase in de novo purine synthesis?
Which metabolic precursors are involved in the de novo synthesis of nucleotides?
Which metabolic precursors are involved in the de novo synthesis of nucleotides?
Which enzyme catalyzes the conversion of FAICAR to 5-formaminoimidazole-4-carboxamide ribonucleotide (FAICAR) in purine synthesis?
Which enzyme catalyzes the conversion of FAICAR to 5-formaminoimidazole-4-carboxamide ribonucleotide (FAICAR) in purine synthesis?
Which molecule is formed from the conversion of AICAR by AICAR transformylase?
Which molecule is formed from the conversion of AICAR by AICAR transformylase?
Which enzyme is involved in the conversion of 5-phosphoribosylamine to inosine 5-monophosphate (IMP) in de novo purine synthesis?
Which enzyme is involved in the conversion of 5-phosphoribosylamine to inosine 5-monophosphate (IMP) in de novo purine synthesis?
Which molecule is a structural analog of purine nucleotides?
Which molecule is a structural analog of purine nucleotides?
What is the final product formed from the conversion of SAICAR by SAICAR lyase in de novo purine synthesis?
What is the final product formed from the conversion of SAICAR by SAICAR lyase in de novo purine synthesis?
Which molecule provides the one-carbon unit necessary for purine synthesis?
Which molecule provides the one-carbon unit necessary for purine synthesis?
What happens in the absence of activity of HGPRT?
What happens in the absence of activity of HGPRT?
What is the function of GAR transformylase in de novo purine synthesis?
What is the function of GAR transformylase in de novo purine synthesis?
Which metabolic precursors are involved in the de novo synthesis of nucleotides?
Which metabolic precursors are involved in the de novo synthesis of nucleotides?
What is the significance of the salvage pathway for nucleotide synthesis?
What is the significance of the salvage pathway for nucleotide synthesis?
What is the role of PRPP kinase in de novo purine synthesis?
What is the role of PRPP kinase in de novo purine synthesis?
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