Synthesis of Purine Nucleotides in Molecular Biology

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What is the significance of the regulation of de novo synthesis of purine nucleotides?

[GTP]=[ATP]

Fulfill the need of the body, without wasting (correct)

Save the fuel

Synthesize nucleotides by salvage pathway

Which enzyme is responsible for the conversion of AMP and GMP?

GMP synthetase (correct)

Adenylate kinase

Adenosine deaminase

Ribonucleotide reductase

What is the course of the salvage pathway for nucleotide synthesis?

Guanine + PRPP -> GMP -> ADP

Hypoxanthine + PRPP -> IMP -> AMP (correct)

Adenine + PRPP -> GMP -> ATP

Adenine + PRPP -> AMP -> ATP

What happens in the absence of activity of HGPRT?

Lesch-Nyhan syndrome Signup and view all the answers

Which molecule is a structural analog of purine nucleotides?

Antimetabolites Signup and view all the answers

What is the significance of the salvage pathway for nucleotide synthesis?

Save the fuel Signup and view all the answers

Which enzyme is involved in the formation of deoxyribonucleotide at the nucleoside diphosphate level?

Ribonucleotide reductase Signup and view all the answers

What is the first line reaction to form deoxyribonucleotides?

Mg2+OH- + ribonucleoside diphosphate + thioredoxin reductase -> NDP + SH-thioredoxin + S-S-thioredoxin + H2O + NADP + FAD Signup and view all the answers

What are the two pathways leading to nucleotide synthesis?

De novo synthesis and salvage pathways Signup and view all the answers

Which statement is correct regarding the formation of deoxyribonucleotide at the nucleoside diphosphate level?

Thioredoxin reduces ribonucleotides and forms NDPs. Signup and view all the answers

Which metabolic precursors are involved in the de novo synthesis of nucleotides?

Amino acids, ribose-5-phosphate, CO2, and one-carbon units Signup and view all the answers

What is the product of the 9 steps involved in de novo purine synthesis?

Inosine 5-monophosphate (IMP) Signup and view all the answers

Which enzyme catalyzes the conversion of 5-phosphoribosylamine to inosine 5-monophosphate (IMP)?

Glu amidotransferase Signup and view all the answers

What is the role of PRPP kinase in de novo purine synthesis?

Conversion of PRPP to R-5-P Signup and view all the answers

Which molecule provides the one-carbon unit necessary for purine synthesis?

N10-formyltetrahydrofolate (N10-CHO FH4) Signup and view all the answers

What is the function of GAR transformylase in de novo purine synthesis?

Conversion of FGAR to FGAM Signup and view all the answers

Which molecule is formed from the conversion of AICAR by AICAR transformylase?

(N-formylcarboxamide) ribonucleotide (FAICAR) Signup and view all the answers

Which enzyme catalyzes the conversion of FAICAR to 5-formaminoimidazole-4-carboxamide ribonucleotide (FAICAR) in purine synthesis?

(N-formylcarboxamide) ribonucleotide transformylase Signup and view all the answers

What is the final product formed from the conversion of SAICAR by SAICAR lyase in de novo purine synthesis?

Inosine 5-monophosphate (IMP) Signup and view all the answers

What is the significance of the regulation of de novo synthesis of purine nucleotides?

Fulfillment of the body's need without waste Signup and view all the answers

Which enzyme is involved in the formation of deoxyribonucleotides at the nucleoside diphosphate level?

Ribonucleotide reductase Signup and view all the answers

What happens in the absence of activity of HGPRT?

Lesch-Nyhan syndrome Signup and view all the answers

Which molecule provides the one-carbon unit necessary for purine synthesis?

NADPH + H+ Signup and view all the answers

What is the product of the 9 steps involved in de novo purine synthesis?

IMP Signup and view all the answers

Which statement is correct regarding the formation of deoxyribonucleotide at the nucleoside diphosphate level?

Formation involves the reduction of the sugar moiety Signup and view all the answers

What is the function of GAR transformylase in de novo purine synthesis?

Conversion of GAR to FGAR Signup and view all the answers

Which metabolic precursors are involved in the de novo synthesis of nucleotides?

$PRPP$ and $amino acids$ Signup and view all the answers

Which enzyme catalyzes the conversion of FAICAR to 5-formaminoimidazole-4-carboxamide ribonucleotide (FAICAR) in purine synthesis?

$AICAR$ transformylase Signup and view all the answers

Which molecule is formed from the conversion of AICAR by AICAR transformylase?

FAICAR Signup and view all the answers

Which enzyme is involved in the conversion of 5-phosphoribosylamine to inosine 5-monophosphate (IMP) in de novo purine synthesis?

Gln amidotransferase Signup and view all the answers

Which molecule is a structural analog of purine nucleotides?

FAICAR Signup and view all the answers

What is the final product formed from the conversion of SAICAR by SAICAR lyase in de novo purine synthesis?

AICAR Signup and view all the answers

Which molecule provides the one-carbon unit necessary for purine synthesis?

CO2 Signup and view all the answers

What happens in the absence of activity of HGPRT?

Increased production of SAICAR Signup and view all the answers

What is the function of GAR transformylase in de novo purine synthesis?

Converts GAR to FGAR Signup and view all the answers

Which metabolic precursors are involved in the de novo synthesis of nucleotides?

Amino acids, ribose-5-phosphate, CO2, and one-carbon units Signup and view all the answers

What is the significance of the salvage pathway for nucleotide synthesis?

It recycles free bases or nucleosides released from nucleic acid breakdown Signup and view all the answers

What is the role of PRPP kinase in de novo purine synthesis?

It catalyzes the conversion of R-5-P to PRPP Signup and view all the answers

Synthesis of Purine Nucleotides in Molecular Biology

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Questions and Answers

What is the significance of the regulation of de novo synthesis of purine nucleotides?

Which enzyme is responsible for the conversion of AMP and GMP?

What is the course of the salvage pathway for nucleotide synthesis?

What happens in the absence of activity of HGPRT?

Which molecule is a structural analog of purine nucleotides?

What is the significance of the salvage pathway for nucleotide synthesis?

Which enzyme is involved in the formation of deoxyribonucleotide at the nucleoside diphosphate level?

What is the first line reaction to form deoxyribonucleotides?

What are the two pathways leading to nucleotide synthesis?

Which statement is correct regarding the formation of deoxyribonucleotide at the nucleoside diphosphate level?

Which metabolic precursors are involved in the de novo synthesis of nucleotides?

What is the product of the 9 steps involved in de novo purine synthesis?

Which enzyme catalyzes the conversion of 5-phosphoribosylamine to inosine 5-monophosphate (IMP)?

What is the role of PRPP kinase in de novo purine synthesis?

Which molecule provides the one-carbon unit necessary for purine synthesis?

What is the function of GAR transformylase in de novo purine synthesis?

Which molecule is formed from the conversion of AICAR by AICAR transformylase?

Which enzyme catalyzes the conversion of FAICAR to 5-formaminoimidazole-4-carboxamide ribonucleotide (FAICAR) in purine synthesis?

What is the final product formed from the conversion of SAICAR by SAICAR lyase in de novo purine synthesis?

What is the significance of the regulation of de novo synthesis of purine nucleotides?

Which enzyme is involved in the formation of deoxyribonucleotides at the nucleoside diphosphate level?

What happens in the absence of activity of HGPRT?

Which molecule provides the one-carbon unit necessary for purine synthesis?

What is the product of the 9 steps involved in de novo purine synthesis?

Which statement is correct regarding the formation of deoxyribonucleotide at the nucleoside diphosphate level?

What is the function of GAR transformylase in de novo purine synthesis?

Which metabolic precursors are involved in the de novo synthesis of nucleotides?

Which enzyme catalyzes the conversion of FAICAR to 5-formaminoimidazole-4-carboxamide ribonucleotide (FAICAR) in purine synthesis?

Which molecule is formed from the conversion of AICAR by AICAR transformylase?

Which enzyme is involved in the conversion of 5-phosphoribosylamine to inosine 5-monophosphate (IMP) in de novo purine synthesis?

Which molecule is a structural analog of purine nucleotides?

What is the final product formed from the conversion of SAICAR by SAICAR lyase in de novo purine synthesis?

Which molecule provides the one-carbon unit necessary for purine synthesis?

What happens in the absence of activity of HGPRT?

What is the function of GAR transformylase in de novo purine synthesis?

Which metabolic precursors are involved in the de novo synthesis of nucleotides?

What is the significance of the salvage pathway for nucleotide synthesis?

What is the role of PRPP kinase in de novo purine synthesis?

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