10 Questions
Which type of receptor is activated by one of the catecholamine transmitters?
G protein-coupled receptors
Which drug classification is based on the chemical structure and potency in activating adrenergic receptors?
Catecholamine vs. Non-Catecholamine
Which enzyme inactivates catecholamines like epinephrine and norepinephrine?
Catechol-O-methyltransferase (COMT)
Why do catecholamines have a brief period of action if given parenterally?
Rapid inactivation by COMT & MAO
What is a characteristic of non-catecholamines compared to catecholamines?
$Non-Catecholamines$ are not inactivated by COMT
Which type of adrenergic receptor blocker is responsible for venular vasodilation and pooling of blood?
α-blockers
Which drug classification includes drugs that deplete the storage of norepinephrine?
Adrenergic neurons blockers
Which class of α-blockers is further classified as reversible competitive (Short acting)?
Phentolamine
What is the pharmacological effect of α-blockers on arterioles?
Arteriolar vasodilation and decreased total peripheral resistance (TPR)
Which drug is an example of a centrally acting α2 agonist?
Clonidine
Study Notes
Adrenergic Receptors
- Adrenergic receptors are activated by catecholamine transmitters.
- Drug classification is based on the chemical structure and potency in activating adrenergic receptors.
Catecholamine Inactivation
- Catecholamines like epinephrine and norepinephrine are inactivated by the enzyme catechol-O-methyltransferase (COMT).
Catecholamine Action
- Catecholamines have a brief period of action if given parenterally due to rapid inactivation by COMT.
Catecholamines vs. Non-Catecholamines
- A characteristic of non-catecholamines compared to catecholamines is that they are not inactivated by COMT.
Adrenergic Receptor Blockers
- Alpha-2 adrenergic receptor blockers are responsible for venular vasodilation and pooling of blood.
Drug Classification
- The drug classification that includes drugs that deplete the storage of norepinephrine is known as Vesicular Monoamine Transporter 2 (VMAT2) inhibitors.
Alpha-Blockers
- The class of α-blockers that is further classified as reversible competitive is the short-acting type.
Pharmacological Effect of Alpha-Blockers
- The pharmacological effect of α-blockers on arterioles is vasodilation.
Centrally Acting Alpha-2 Agonists
- Clonidine is an example of a centrally acting α2 agonist.
Test your knowledge of sympathomimetic drugs and their effects on the sympathetic nervous system. Learn about adrenoceptors, alpha and beta receptors, and their response to catecholamine transmitters.
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