Podcast
Questions and Answers
Which type of receptor is activated by one of the catecholamine transmitters?
Which type of receptor is activated by one of the catecholamine transmitters?
Which drug classification is based on the chemical structure and potency in activating adrenergic receptors?
Which drug classification is based on the chemical structure and potency in activating adrenergic receptors?
Which enzyme inactivates catecholamines like epinephrine and norepinephrine?
Which enzyme inactivates catecholamines like epinephrine and norepinephrine?
Why do catecholamines have a brief period of action if given parenterally?
Why do catecholamines have a brief period of action if given parenterally?
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What is a characteristic of non-catecholamines compared to catecholamines?
What is a characteristic of non-catecholamines compared to catecholamines?
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Which type of adrenergic receptor blocker is responsible for venular vasodilation and pooling of blood?
Which type of adrenergic receptor blocker is responsible for venular vasodilation and pooling of blood?
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Which drug classification includes drugs that deplete the storage of norepinephrine?
Which drug classification includes drugs that deplete the storage of norepinephrine?
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Which class of α-blockers is further classified as reversible competitive (Short acting)?
Which class of α-blockers is further classified as reversible competitive (Short acting)?
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What is the pharmacological effect of α-blockers on arterioles?
What is the pharmacological effect of α-blockers on arterioles?
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Which drug is an example of a centrally acting α2 agonist?
Which drug is an example of a centrally acting α2 agonist?
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Study Notes
Adrenergic Receptors
- Adrenergic receptors are activated by catecholamine transmitters.
- Drug classification is based on the chemical structure and potency in activating adrenergic receptors.
Catecholamine Inactivation
- Catecholamines like epinephrine and norepinephrine are inactivated by the enzyme catechol-O-methyltransferase (COMT).
Catecholamine Action
- Catecholamines have a brief period of action if given parenterally due to rapid inactivation by COMT.
Catecholamines vs. Non-Catecholamines
- A characteristic of non-catecholamines compared to catecholamines is that they are not inactivated by COMT.
Adrenergic Receptor Blockers
- Alpha-2 adrenergic receptor blockers are responsible for venular vasodilation and pooling of blood.
Drug Classification
- The drug classification that includes drugs that deplete the storage of norepinephrine is known as Vesicular Monoamine Transporter 2 (VMAT2) inhibitors.
Alpha-Blockers
- The class of α-blockers that is further classified as reversible competitive is the short-acting type.
Pharmacological Effect of Alpha-Blockers
- The pharmacological effect of α-blockers on arterioles is vasodilation.
Centrally Acting Alpha-2 Agonists
- Clonidine is an example of a centrally acting α2 agonist.
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Description
Test your knowledge of sympathomimetic drugs and their effects on the sympathetic nervous system. Learn about adrenoceptors, alpha and beta receptors, and their response to catecholamine transmitters.
