Sympathomimetic Drugs Quiz
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Sympathomimetic Drugs Quiz

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@SaneUvarovite

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Questions and Answers

Which type of receptor is activated by one of the catecholamine transmitters?

  • Ligand-gated ion channels
  • G protein-coupled receptors (correct)
  • Intracellular receptors
  • Receptor tyrosine kinases

    • Which drug classification is based on the chemical structure and potency in activating adrenergic receptors?

  • Catecholamine vs. Non-Catecholamine (correct)
  • Alpha vs. Beta receptors
  • Direct-acting vs. Indirect-acting agonists
  • Sympathomimetic agonist vs. Sympatholytic antagonist

    • Which enzyme inactivates catecholamines like epinephrine and norepinephrine?

  • Acetylcholinesterase
  • Catechol-O-methyltransferase (COMT) (correct)
  • Aldose reductase
  • Monoamine oxidase (MAO)

    • Why do catecholamines have a brief period of action if given parenterally?

    <p>Rapid inactivation by COMT &amp; MAO</p> Signup and view all the answers

    What is a characteristic of non-catecholamines compared to catecholamines?

    <p>$Non-Catecholamines$ are not inactivated by COMT</p> Signup and view all the answers

    Which type of adrenergic receptor blocker is responsible for venular vasodilation and pooling of blood?

    <p>α-blockers</p> Signup and view all the answers

    Which drug classification includes drugs that deplete the storage of norepinephrine?

    <p>Adrenergic neurons blockers</p> Signup and view all the answers

    Which class of α-blockers is further classified as reversible competitive (Short acting)?

    <p>Phentolamine</p> Signup and view all the answers

    What is the pharmacological effect of α-blockers on arterioles?

    <p>Arteriolar vasodilation and decreased total peripheral resistance (TPR)</p> Signup and view all the answers

    Which drug is an example of a centrally acting α2 agonist?

    <p>Clonidine</p> Signup and view all the answers

    Study Notes

    Adrenergic Receptors

    • Adrenergic receptors are activated by catecholamine transmitters.
    • Drug classification is based on the chemical structure and potency in activating adrenergic receptors.

    Catecholamine Inactivation

    • Catecholamines like epinephrine and norepinephrine are inactivated by the enzyme catechol-O-methyltransferase (COMT).

    Catecholamine Action

    • Catecholamines have a brief period of action if given parenterally due to rapid inactivation by COMT.

    Catecholamines vs. Non-Catecholamines

    • A characteristic of non-catecholamines compared to catecholamines is that they are not inactivated by COMT.

    Adrenergic Receptor Blockers

    • Alpha-2 adrenergic receptor blockers are responsible for venular vasodilation and pooling of blood.

    Drug Classification

    • The drug classification that includes drugs that deplete the storage of norepinephrine is known as Vesicular Monoamine Transporter 2 (VMAT2) inhibitors.

    Alpha-Blockers

    • The class of α-blockers that is further classified as reversible competitive is the short-acting type.

    Pharmacological Effect of Alpha-Blockers

    • The pharmacological effect of α-blockers on arterioles is vasodilation.

    Centrally Acting Alpha-2 Agonists

    • Clonidine is an example of a centrally acting α2 agonist.

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    Description

    Test your knowledge of sympathomimetic drugs and their effects on the sympathetic nervous system. Learn about adrenoceptors, alpha and beta receptors, and their response to catecholamine transmitters.

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