16 Questions
What is the precursor molecule for the synthesis of noradrenaline?
Tyrosine
Which enzyme is involved in the conversion of L-tyrosine to DOPA in the synthesis of noradrenaline?
Tyrosine hydroxylase
What is the final product of the multi-enzyme synthetic pathway for noradrenaline synthesis?
Noradrenaline
In what form is noradrenaline stored and released at sympathetic nerve endings?
In vesicles at varicosities
Which drug inhibits the enzyme DOPA decarboxylase in the synthesis of dopamine?
Carbidopa
What clinical condition might require stabilization with Metirosine before surgical intervention?
Pheochromocytoma
Which neurotransmitter precursor cannot cross the Blood-Brain Barrier (BBB)?
Dopamine
What is the primary use of Methyldopa in clinical practice?
Hypertension during pregnancy
Which enzyme is inhibited by a-methyl-p-tyrosine (Metirosine) in the synthesis of noradrenaline?
Tyrosine hydroxylase
Which neurotransmitter is synthesized at most postsynaptic sympathetic fibers?
Noradrenaline
Which drug is used as a substrate for the NET transporter?
Guanethidine
What is the overall effect of drugs depleting NA such as Reserpine?
Block of adrenergic neurons
How does Reserpine affect the VMAT transporter?
Inhibits VMAT
What happens to vesicles in the presence of Guanethidine?
Vesicles fuse but do not contain NA
How do drugs inhibiting the release of NA like Guanethidine work?
By blocking adrenergic neurons
What is the historical use of Reserpine as an antihypertensive?
Experimental tool only
Learn about the synthesis, storage, regulation of release, and termination of the signal of neurotransmitter NA in the sympathetic nervous system. Explore the receptors for NA, the transmitters at target organs, and exceptions in neurotransmitter release. Dive into the multi-enzyme synthetic pathway for NA synthesis.
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