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Questions and Answers
What is the precursor molecule for the synthesis of noradrenaline?
What is the precursor molecule for the synthesis of noradrenaline?
- Tyrosine (correct)
- Dopamine
- L-DOPA
- Metirosine
Which enzyme is involved in the conversion of L-tyrosine to DOPA in the synthesis of noradrenaline?
Which enzyme is involved in the conversion of L-tyrosine to DOPA in the synthesis of noradrenaline?
- Methyldopa
- DOPA decarboxylase
- Tyrosine hydroxylase (correct)
- Carbidopa
What is the final product of the multi-enzyme synthetic pathway for noradrenaline synthesis?
What is the final product of the multi-enzyme synthetic pathway for noradrenaline synthesis?
- L-DOPA
- Methyl-NA
- Noradrenaline (correct)
- Dopamine
In what form is noradrenaline stored and released at sympathetic nerve endings?
In what form is noradrenaline stored and released at sympathetic nerve endings?
Which drug inhibits the enzyme DOPA decarboxylase in the synthesis of dopamine?
Which drug inhibits the enzyme DOPA decarboxylase in the synthesis of dopamine?
What clinical condition might require stabilization with Metirosine before surgical intervention?
What clinical condition might require stabilization with Metirosine before surgical intervention?
Which neurotransmitter precursor cannot cross the Blood-Brain Barrier (BBB)?
Which neurotransmitter precursor cannot cross the Blood-Brain Barrier (BBB)?
What is the primary use of Methyldopa in clinical practice?
What is the primary use of Methyldopa in clinical practice?
Which enzyme is inhibited by a-methyl-p-tyrosine (Metirosine) in the synthesis of noradrenaline?
Which enzyme is inhibited by a-methyl-p-tyrosine (Metirosine) in the synthesis of noradrenaline?
Which neurotransmitter is synthesized at most postsynaptic sympathetic fibers?
Which neurotransmitter is synthesized at most postsynaptic sympathetic fibers?
Which drug is used as a substrate for the NET transporter?
Which drug is used as a substrate for the NET transporter?
What is the overall effect of drugs depleting NA such as Reserpine?
What is the overall effect of drugs depleting NA such as Reserpine?
How does Reserpine affect the VMAT transporter?
How does Reserpine affect the VMAT transporter?
What happens to vesicles in the presence of Guanethidine?
What happens to vesicles in the presence of Guanethidine?
How do drugs inhibiting the release of NA like Guanethidine work?
How do drugs inhibiting the release of NA like Guanethidine work?
What is the historical use of Reserpine as an antihypertensive?
What is the historical use of Reserpine as an antihypertensive?
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