Sympathetic Nervous System: Neurotransmitter Synthesis and Release
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Questions and Answers

What is the precursor molecule for the synthesis of noradrenaline?

  • Tyrosine (correct)
  • Dopamine
  • L-DOPA
  • Metirosine
  • Which enzyme is involved in the conversion of L-tyrosine to DOPA in the synthesis of noradrenaline?

  • Methyldopa
  • DOPA decarboxylase
  • Tyrosine hydroxylase (correct)
  • Carbidopa
  • What is the final product of the multi-enzyme synthetic pathway for noradrenaline synthesis?

  • L-DOPA
  • Methyl-NA
  • Noradrenaline (correct)
  • Dopamine
  • In what form is noradrenaline stored and released at sympathetic nerve endings?

    <p>In vesicles at varicosities</p> Signup and view all the answers

    Which drug inhibits the enzyme DOPA decarboxylase in the synthesis of dopamine?

    <p>Carbidopa</p> Signup and view all the answers

    What clinical condition might require stabilization with Metirosine before surgical intervention?

    <p>Pheochromocytoma</p> Signup and view all the answers

    Which neurotransmitter precursor cannot cross the Blood-Brain Barrier (BBB)?

    <p>Dopamine</p> Signup and view all the answers

    What is the primary use of Methyldopa in clinical practice?

    <p>Hypertension during pregnancy</p> Signup and view all the answers

    Which enzyme is inhibited by a-methyl-p-tyrosine (Metirosine) in the synthesis of noradrenaline?

    <p>Tyrosine hydroxylase</p> Signup and view all the answers

    Which neurotransmitter is synthesized at most postsynaptic sympathetic fibers?

    <p>Noradrenaline</p> Signup and view all the answers

    Which drug is used as a substrate for the NET transporter?

    <p>Guanethidine</p> Signup and view all the answers

    What is the overall effect of drugs depleting NA such as Reserpine?

    <p>Block of adrenergic neurons</p> Signup and view all the answers

    How does Reserpine affect the VMAT transporter?

    <p>Inhibits VMAT</p> Signup and view all the answers

    What happens to vesicles in the presence of Guanethidine?

    <p>Vesicles fuse but do not contain NA</p> Signup and view all the answers

    How do drugs inhibiting the release of NA like Guanethidine work?

    <p>By blocking adrenergic neurons</p> Signup and view all the answers

    What is the historical use of Reserpine as an antihypertensive?

    <p>Experimental tool only</p> Signup and view all the answers

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