Podcast
Questions and Answers
What are the characteristic symptoms for Atrophic Rhinitis in swine?
What are the characteristic symptoms for Atrophic Rhinitis in swine?
What is the etiology of Atrophic Rhinitis in swine?
What is the etiology of Atrophic Rhinitis in swine?
What type of pneumonia pattern is more likely to be caused by viruses?
What type of pneumonia pattern is more likely to be caused by viruses?
Which of the following is NOT a potential cause of pneumonia in swine?
Which of the following is NOT a potential cause of pneumonia in swine?
Signup and view all the answers
What is the potential role of endotoxin in Atrophic Rhinitis?
What is the potential role of endotoxin in Atrophic Rhinitis?
Signup and view all the answers
What is the primary method of transmission for Mycoplasma hyopneumoniae in pigs?
What is the primary method of transmission for Mycoplasma hyopneumoniae in pigs?
Signup and view all the answers
Which of the following is NOT a characteristic of Mycoplasma hyopneumoniae?
Which of the following is NOT a characteristic of Mycoplasma hyopneumoniae?
Signup and view all the answers
What is a key feature of Mycoplasma hyopneumoniae infection in pigs?
What is a key feature of Mycoplasma hyopneumoniae infection in pigs?
Signup and view all the answers
What is the most common source of Mycoplasma hyopneumoniae infection in pigs?
What is the most common source of Mycoplasma hyopneumoniae infection in pigs?
Signup and view all the answers
Which of these is a common symptom of Atrophic Rhinitis in pigs?
Which of these is a common symptom of Atrophic Rhinitis in pigs?
Signup and view all the answers
Which of the following contribute to the development of Atrophic Rhinitis in pigs?
Which of the following contribute to the development of Atrophic Rhinitis in pigs?
Signup and view all the answers
What is the most common method of controlling Atrophic Rhinitis in pig herds?
What is the most common method of controlling Atrophic Rhinitis in pig herds?
Signup and view all the answers
What is a key diagnostic feature for confirming a diagnosis of Actinobacillus pleuropneumoniae?
What is a key diagnostic feature for confirming a diagnosis of Actinobacillus pleuropneumoniae?
Signup and view all the answers
What type of cells does the PRRS virus specifically target and infect?
What type of cells does the PRRS virus specifically target and infect?
Signup and view all the answers
How long can the PRRS virus persist in carrier pigs after infection?
How long can the PRRS virus persist in carrier pigs after infection?
Signup and view all the answers
What is the potential consequence of a sow being infected with PRRS virus during pregnancy?
What is the potential consequence of a sow being infected with PRRS virus during pregnancy?
Signup and view all the answers
Which of these factors can influence the severity of PRRS clinical signs in a herd?
Which of these factors can influence the severity of PRRS clinical signs in a herd?
Signup and view all the answers
Which of these is a common clinical sign of PRRS in pigs?
Which of these is a common clinical sign of PRRS in pigs?
Signup and view all the answers
How is PRRS virus commonly spread among pigs?
How is PRRS virus commonly spread among pigs?
Signup and view all the answers
What is the most significant control point for preventing the spread of PRRS virus through semen?
What is the most significant control point for preventing the spread of PRRS virus through semen?
Signup and view all the answers
What happens to antibody titers in pigs after PRRS infection?
What happens to antibody titers in pigs after PRRS infection?
Signup and view all the answers
Which of the following is NOT a common clinical sign of Actinobacillus pleuropneumoniae infection in pigs?
Which of the following is NOT a common clinical sign of Actinobacillus pleuropneumoniae infection in pigs?
Signup and view all the answers
How are Actinobacillus pleuropneumoniae infections typically spread?
How are Actinobacillus pleuropneumoniae infections typically spread?
Signup and view all the answers
What is the significance of the exotoxins produced by Actinobacillus pleuropneumoniae in the disease process?
What is the significance of the exotoxins produced by Actinobacillus pleuropneumoniae in the disease process?
Signup and view all the answers
What is the primary factor determining the success of early weaning or medicated early weaning in minimizing losses due to Actinobacillus pleuropneumoniae?
What is the primary factor determining the success of early weaning or medicated early weaning in minimizing losses due to Actinobacillus pleuropneumoniae?
Signup and view all the answers
What is the most effective measure for controlling Actinobacillus pleuropneumoniae infections in a pig herd?
What is the most effective measure for controlling Actinobacillus pleuropneumoniae infections in a pig herd?
Signup and view all the answers
Which of the following is a significant factor in the pathogenesis of Actinobacillus pleuropneumoniae infections?
Which of the following is a significant factor in the pathogenesis of Actinobacillus pleuropneumoniae infections?
Signup and view all the answers
What is the significance of the observation that Actinobacillus pleuropneumoniae does not persist in the environment?
What is the significance of the observation that Actinobacillus pleuropneumoniae does not persist in the environment?
Signup and view all the answers
Which of the following factors contribute to the potential for high morbidity and mortality in Actinobacillus pleuropneumoniae outbreaks?
Which of the following factors contribute to the potential for high morbidity and mortality in Actinobacillus pleuropneumoniae outbreaks?
Signup and view all the answers
What is the most likely reason for the presence of sequestered or encapsulated nodules of necrosis in the lungs of pigs that have recovered from Actinobacillus pleuropneumoniae infection?
What is the most likely reason for the presence of sequestered or encapsulated nodules of necrosis in the lungs of pigs that have recovered from Actinobacillus pleuropneumoniae infection?
Signup and view all the answers
What is the primary reason for depopulating sow farms that are positive for Actinobacillus pleuropneumoniae?
What is the primary reason for depopulating sow farms that are positive for Actinobacillus pleuropneumoniae?
Signup and view all the answers
In growing pigs infected with PRRS, what is the typical age range for peak disease?
In growing pigs infected with PRRS, what is the typical age range for peak disease?
Signup and view all the answers
Which of the following is NOT a common clinical sign of PRRS in breeding age pigs?
Which of the following is NOT a common clinical sign of PRRS in breeding age pigs?
Signup and view all the answers
What is the most accurate diagnostic method to differentiate between PRRS strains?
What is the most accurate diagnostic method to differentiate between PRRS strains?
Signup and view all the answers
Which of the following is a potential outcome of introducing naïve animals to a PRRS-infected herd?
Which of the following is a potential outcome of introducing naïve animals to a PRRS-infected herd?
Signup and view all the answers
Which of the following is NOT a recommended measure to control PRRS?
Which of the following is NOT a recommended measure to control PRRS?
Signup and view all the answers
Which type of PRRS infection is most likely to result in a significant increase in post-weaning mortality?
Which type of PRRS infection is most likely to result in a significant increase in post-weaning mortality?
Signup and view all the answers
What is a common microscopic lesion observed in PRRS-affected pigs?
What is a common microscopic lesion observed in PRRS-affected pigs?
Signup and view all the answers
What does the term 'heterologous strains' refer to in the context of PRRS?
What does the term 'heterologous strains' refer to in the context of PRRS?
Signup and view all the answers
Which of the following PRRS diagnostic tests is most useful for determining the age of infection?
Which of the following PRRS diagnostic tests is most useful for determining the age of infection?
Signup and view all the answers
What is the role of vaccination in the control of PRRS?
What is the role of vaccination in the control of PRRS?
Signup and view all the answers
Flashcards
Interstitial Pneumonia
Interstitial Pneumonia
A pneumonia pattern associated with viral causes.
Bronchopneumonia
Bronchopneumonia
A pneumonia pattern typically linked to bacterial infections.
Atrophic Rhinitis
Atrophic Rhinitis
A respiratory disease in pigs marked by nasal atrophy and distortion.
Bordetella bronchiseptica
Bordetella bronchiseptica
Signup and view all the flashcards
Pasteurella multocida Type D
Pasteurella multocida Type D
Signup and view all the flashcards
Symptoms of Atrophic Rhinitis
Symptoms of Atrophic Rhinitis
Signup and view all the flashcards
Control Measures for Atrophic Rhinitis
Control Measures for Atrophic Rhinitis
Signup and view all the flashcards
Mycoplasma hyopneumoniae
Mycoplasma hyopneumoniae
Signup and view all the flashcards
Transmission of Mycoplasma
Transmission of Mycoplasma
Signup and view all the flashcards
Necropsy Findings in Mycoplasma Infection
Necropsy Findings in Mycoplasma Infection
Signup and view all the flashcards
Control of Mycoplasma Infection
Control of Mycoplasma Infection
Signup and view all the flashcards
Actinobacillus pleuropneumoniae
Actinobacillus pleuropneumoniae
Signup and view all the flashcards
Exotoxins
Exotoxins
Signup and view all the flashcards
Transmission of APP
Transmission of APP
Signup and view all the flashcards
Clinical signs of APP
Clinical signs of APP
Signup and view all the flashcards
Pathogenesis of APP
Pathogenesis of APP
Signup and view all the flashcards
Diagnosis of APP
Diagnosis of APP
Signup and view all the flashcards
Lesions in APP
Lesions in APP
Signup and view all the flashcards
Control measures for APP
Control measures for APP
Signup and view all the flashcards
Carriers of APP
Carriers of APP
Signup and view all the flashcards
PRRS overview
PRRS overview
Signup and view all the flashcards
Genetic variability in isolates
Genetic variability in isolates
Signup and view all the flashcards
Viral persistence in carrier pigs
Viral persistence in carrier pigs
Signup and view all the flashcards
Inactivation by disinfectants
Inactivation by disinfectants
Signup and view all the flashcards
Replicating in immune cells
Replicating in immune cells
Signup and view all the flashcards
Highly infectious but not contagious
Highly infectious but not contagious
Signup and view all the flashcards
Clinical signs of PRRS
Clinical signs of PRRS
Signup and view all the flashcards
Transmission through semen
Transmission through semen
Signup and view all the flashcards
Viremia and compromised lungs
Viremia and compromised lungs
Signup and view all the flashcards
Mild Cyanosis
Mild Cyanosis
Signup and view all the flashcards
PRRS Clinical Signs
PRRS Clinical Signs
Signup and view all the flashcards
Pre-weaning Mortality
Pre-weaning Mortality
Signup and view all the flashcards
Dyspnea in Nursing Pigs
Dyspnea in Nursing Pigs
Signup and view all the flashcards
PRRS Lesions
PRRS Lesions
Signup and view all the flashcards
Common Diagnostics for PRRS
Common Diagnostics for PRRS
Signup and view all the flashcards
Interventional Strategies for PRRS
Interventional Strategies for PRRS
Signup and view all the flashcards
Mummified Fetuses
Mummified Fetuses
Signup and view all the flashcards
Co-infection Effects
Co-infection Effects
Signup and view all the flashcards
Severity of Disease in Age
Severity of Disease in Age
Signup and view all the flashcards
Study Notes
Swine Respiratory Diseases
- Swine respiratory diseases are a significant concern in the swine industry
- Various pathogens contribute to respiratory issues in pigs
- Understanding disease patterns (e.g., interstitial vs. bronchopneumonia) is crucial for diagnosis
- Some diseases are highly contagious while others persist in carrier animals
Swine Respiratory System
- The respiratory system in swine includes the nasal section, trachea, and lungs
Pneumonia
- Interstitial pneumonia suggests viral infection
- Bronchopneumonia suggests bacterial etiology Normal lung histology is characterized by distinct alveoli structure
Atrophic Rhinitis
- Characterized by snuffling, sneezing, and nasal bleeding
- Nasal turbinate atrophy and distortion common
- Toxigenic strains of Bordetella bronchiseptica and Pasteurella multocida Type D are frequently associated
- Management and husbandry play a role, including dust reduction and ventilation
- Symptoms can appear as early as 1 week of age
- Diagnostics include history, lesions, clinical signs, and culturing of affected portions
Mycoplasma hyopneumoniae
- Enzootic disease, often associated with the Porcine Respiratory Disease Complex (PRDC)
- Carrier swine are a major source of infection
- Chronic persistent, non-productive cough; suppressed growth despite normal appetite are symptoms
- Morbidities are high but mortality is generally low
- Bacteria survives in pigs for months.
- Difficult to transmit to other animals
Epidemiology of Mycoplasma hyopneumoniae
- Survives poorly in environment but lasts for months in pigs
- Spread is via direct contact or aerosol transmission
- Pathogenesis involves lung consolidation, bronchitis, bronchiolitis, and airway obstruction
- Diagnosis through immunohistochemistry, PCR, and serology
- Treatment with parenteral antibiotics available
Actinobacillus pleuropneumoniae (APP)
- Actinobacillus pleuropneumoniae is host-specific to swine
- Hemolytic, Gram-capsulated coccobacillus
- 15 serotypes exist, with 1 and 5 being more virulent
- Does not persist in the environment, but can colonize and stay infectious for a long duration
- Four exotoxins (RTX toxins) are produced
- Antibodies to exotoxins are crucial for immunity
Epidemiology of APP
- Survivors can remain carriers
- Transmission via direct contact with nasal secretions or aerosols, but fomites don't remain infectious for long
- Pathogenesis involves hemolysin and toxins targeting endothelial cells, vasculitis in the lungs, thrombosis inflammation and infarction.
- Sudden death can occur from shock
- Immunity can occur gradually through colostrum
- In naïve pigs, fulminating disease is common
Clinical Signs of APP
- Acute outbreaks often lead to sudden death
- Common symptoms include prostration, high temperatures, apathy, anorexia, stiffness, vomiting and diarrhea
- As disease progresses, dyspnea with oral breathing may be accompanied by foamy bloody discharge
- Peripheral and generalized cyanosis of extremities can follow
Lesions of APP
- Lesions most often affect the respiratory tract, causing necro-hemorrhaging, fibrinous pleuritis and fluid build in thoracic cavities
- Necrosis and hemorrhage frequently observed in dorsal diaphragmatic lobes
- Bloody frothy buildup in large airways, which then may develop into inflammation and infarction
- Serofibrinous pericarditis, pharyngitis, and occasional polyarthritis may occur
- Lungs may have necrotic nodules or may be fibrous causing rib cage adhesion
Diagnosis of APP
- Sudden onset of acute widespread disease
- Isolation and identification of organism via tissue culture and PCR
- Complement fixation and ELISA also used
- Management strategies include restricting introduction of new animals, quarantines, vaccination with subunit vaccines or older types, cleaning/disinfection of facilities.
- Also depopulation/repopulation methods to control spread
Porcine Reproductive and Respiratory Syndrome (PRRS)
- Enveloped RNA arterivirus with significant heterogeneity
- Moderate resistance to environmental degradation.
- Inactivated by phenol, formaldehyde, and some disinfectants
- Replicates in macrophages, particularly pulmonary intravascular and alveolar macrophages (PIMS and PAMs) in vitro
- Variation in virulence among strains
- Interactions with other diseases, particularly Mycoplasma hyopneumoniae
Epidemiology of PRRS
- Persisting long-term carrier status in pigs (> +200 days), but most stop shedding by 60 days post-infection
- Highly contagious virus (10 virions can cause disease)
- Found in respiratory secretions, urine, semen, mammary secretions, and feces
- Boars can shed the virus up to 92 days in semen
- Aerosol spread possible
- Viral transmission occurs through direct contact and aerosol
Pathogenesis of PRRS
- Transmission via tonsils and upper respiratory system replication in lymphoid tissues persistent viremia
- Infects and compromises PIMS and PAMs function → interstitial pneumonia
- Increased host lung vulnerability to secondary pathogens
Clinical signs PRRS
- Reproductive problems in breeding animals: abortions, mummified fetuses, stillbirths, conception failure, boar sterility
- Respiratory problems in growing animals
Swine Influenza
- Type A orthomyxoviridae virus with glycoprotein spikes serving as major antigens
- Hemagglutinin (H) has 16 varieties, Neuraminidase (N) has 9 varieties
- Classical subtype in swine is H1N1, including variants like H3N2 and H1N2
- Virus persists a short period outside hosts (<2 weeks) and is easy-to-inactivate
Pathogenesis of Swine Influenza
- Attacks nasopharynx, causes inflammation, and necrosis in respiratory epithelium
- Can affect bronchial/bronchiolar structures, interlobular septa, and turbinate epithelium
- Type 2 pneumocytes affected in lungs causing lower surfactant production and impaired phagocytosis of secondary micro-organisms
Clinical Signs of Swine Influenza
- Sudden onset in infected groups.
- Fever, oculonasal discharge, prostration, weakness, anorexia, coughing
- Uncomplicated cases rarely cause death, but significant weight loss, body condition score changes and costs of medication may appear.
Diagnostic tests for Swine influenza
- Sudden onset of disease across herd
- Fluorescent antibody test on fresh lung sections
- Virus isolation from lung tissue and nasal swabs in embryonated eggs
- PCR tests on nasal swabs and/or lung tissue
- Paired serologic titers tests to monitor virus increases
- Comorbidities like Mycoplasmal pneumonia may also be present
Porcine Respiratory Coronavirus
- Not zoonotic
- May have a mild seasonal impact in some herds.
- Asymptomatic herds can be identified via serology
Porcine Circovirus
- Novel strain (PCV2) identified 1990s as distinct from non-pathogenic PCV1
- Further strain PCV3 identified in 2015 associated with high morbidity, mortality, PMWS, PDNS, reproductive failure
- PCV2 is ubiquitous in swine populations making it hard to distinguish from inapparent infections
- Will increase severity of other diseases like Mycoplasma hyopneumoniae, IAV, and PRRS
- PCV2 is consistently seen in pigs with PMWS
Epidemiology of PCV
- Nearly all US swine herds seropositive (positive antibody response) for PCV2
- Seroconversion (antibody development) by 2-4 months of age, though clinical symptoms often absent
- PMWS pigs tend to grow for a period and then decline
- Morbidity can range from 2-30% and case fatality often is high (80%)
- PCV2 Infection
- Infects macrophages and monocytes persisting in lymphoid tissues and lungs
- Chronic lymphohistiocytic/granulomatous inflammation, pneumonia, interstitial pneumonia, erosive bronchiolitis fibrosis occur in various tissues and organs
- May result in blotchy purple skin lesions/nephropathy (likely an immune response, PDNS )
PCV Clinical signs
- Pallor
- Lymph node and spleen enlargement
- Interstitial pneumonia
- Depletion of lymphoid tissues (germinal centers)
- Immune-mediated vasculitis
- Skin discoloration, kidney swelling, hemorrhage, mulitfocal nephritis
PCV Diagnosis
- PCR testing
- Immunohistochemistry
- Clinical signs and lesions observation
- Demonstration of PCV2 in tissue lesions
- Treatment with antibiotics to manage secondary infections
Porcine Dermatitis and Nephropathy Syndrome
- Other viremias to consider (ASF, CSF, and Eryisepelas Salmonella)
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
Test your knowledge on Atrophic Rhinitis and pneumonia in swine. This quiz covers symptoms, etiology, and diagnosis of various swine respiratory diseases, focusing on Mycoplasma infections and their characteristics. Perfect for veterinary students and professionals in animal health.