Sustained Angiogenesis in Solid Tumors
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Questions and Answers

Which of the following is true about the growth of solid tumors?

  • Solid tumors can only grow up to 5 mm in diameter without angiogenesis.
  • Solid tumors can grow to any size without angiogenesis.
  • Solid tumors can only grow up to 10 mm in diameter without angiogenesis.
  • Solid tumors can only grow up to 1-2 mm in diameter without angiogenesis. (correct)

    • Which of the following is a role of neovascularization in tumor growth?

  • Neovascularization supplies waste products to tumors.
  • Neovascularization inhibits tumor growth.
  • Neovascularization provides needed nutrients and oxygen to tumors. (correct)
  • Neovascularization prevents the formation of endothelial cells.

    • Which of the following growth factors are secreted by newly formed endothelial cells during neovascularization?

  • Vascular Endothelial Growth Factor (VEGF) and Transforming Growth Factor (TGF) (correct)
  • Insulin-Like Growth Factors (IGF) and Platelet-Derived Growth Factors (PDGF)
  • Epidermal Growth Factor (EGF) and Fibroblast Growth Factor (FGF)
  • Tumor Necrosis Factor (TNF) and Interleukin-6 (IL-6)

    • Why do solid tumors require angiogenesis for growth?

    <p>To promote the delivery of oxygen and nutrients to the tumor.</p> Signup and view all the answers

    What is the maximal distance across which oxygen, nutrients, and waste can diffuse from existing blood vessels?

    <p>1-2 mm</p> Signup and view all the answers

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