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Questions and Answers
What is the role of cytokines in terminating the immune response during inflammation?
What is the role of cytokines in terminating the immune response during inflammation?
Cytokines provide anti-inflammatory signals that terminate the immune response.
Which of the following statements about fever is true?
Which of the following statements about fever is true?
During the Coagulation Phase of haemostasis, _______ is converted to thrombin, which then converts fibrinogen to fibrin.
During the Coagulation Phase of haemostasis, _______ is converted to thrombin, which then converts fibrinogen to fibrin.
prothrombin
The Coroners Court is responsible for determining the cause of death only in cases of natural causes.
The Coroners Court is responsible for determining the cause of death only in cases of natural causes.
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What are venous thrombi primarily composed of?
What are venous thrombi primarily composed of?
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What conditions can be commonly caused by low-flow, low-pressure venous circulation? Select all that apply.
What conditions can be commonly caused by low-flow, low-pressure venous circulation? Select all that apply.
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Heparin enhances the activity of antithrombin III, which inhibits thrombin and factor Xa, preventing the formation of _________ clots.
Heparin enhances the activity of antithrombin III, which inhibits thrombin and factor Xa, preventing the formation of _________ clots.
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Aspirin inhibits the platelet enzyme COX-1, reducing platelet aggregation.
Aspirin inhibits the platelet enzyme COX-1, reducing platelet aggregation.
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Match the drug with its function:
Match the drug with its function:
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Define surgical nursing?
Define surgical nursing?
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How many phases is the perioperative journey divided into?
How many phases is the perioperative journey divided into?
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What are some items documented on a preoperative checklist?
What are some items documented on a preoperative checklist?
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The nurse's responsibility is to ensure that the patient has legal consent before surgery.
The nurse's responsibility is to ensure that the patient has legal consent before surgery.
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Match the following roles in perioperative nursing with their responsibilities:
Match the following roles in perioperative nursing with their responsibilities:
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What is the study of how drugs interact with biological systems known as?
What is the study of how drugs interact with biological systems known as?
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What does pharmacodynamics study?
What does pharmacodynamics study?
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Higher affinity between a drug and its target receptor leads to a weaker binding.
Higher affinity between a drug and its target receptor leads to a weaker binding.
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What is the difference between Antagonist and Agonist drugs?
What is the difference between Antagonist and Agonist drugs?
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What is the role of Depolarizing Anaesthetic Agents?
What is the role of Depolarizing Anaesthetic Agents?
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What is the purpose of Analgesics in healthcare?
What is the purpose of Analgesics in healthcare?
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Define antiemetics?
Define antiemetics?
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Vomiting can be triggered by sensory impulses like taste and smell.
Vomiting can be triggered by sensory impulses like taste and smell.
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Study Notes
Surgical Nursing
- Definition: Surgery is an invasive medical procedure performed to diagnose or treat illness, injury, or deformity.
Perioperative Journey
-
Consists of 3 phases:
Preoperative
- Discussion between healthcare team and patient about benefits, risks, and alternatives to surgery
- Instructions on how to prepare for surgery
- Physical, mental, and social assessments conducted prior to surgery
Intraoperative
- Patient transported to operating room
- Surgical team prepares for operation
- Anesthesia used to sedate or control unconsciousness
- Surgical procedure performed
- Nurses' role: monitoring patient's vital signs throughout the operation
Postoperative
- Patient moved to Post Anesthesia Recovery Unit (PACU) room until stable
- Transferred to regular nursing unit for recovery
- Nursing care: managing pain, monitoring vital signs, and preventing infections and complications
Preparing a Patient for Surgery
- Preoperative checklist:
- Patient identification
- Consent
- Allergies
- Fasting time
- Diagnostic test results
- History and physical exam
- Vital signs
- Patient preparation:
- Hospital gown
- Dentures and glasses removed
- Jewelry locked
Legal Considerations/Rights for Care
- Ensuring patient has been legally prepared and consent is gained and documented
- Patient and family members clearly understand what is happening
- Complete medical records
- Advance care or goals discussed
Roles of Perioperative Nursing
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Aesthetic Nurse:
- Greets patient and ensures preparation
- Verifies patient ID and consent
- Checks allergies and fasting status
- Monitors vital signs
- Assists anaesthetist during induction, maintenance, and reversal of anesthesia
-
Scout (Circulating Nurse):
- Manages Operating Room (OR) and monitors activities of the surgical team
- Maintains OR environment and documentation
- Ensures sterile environment maintained
-
Scrub (Instrument Nurse):
- Sets up sterile tables and equipment
- Prepares instruments and sutures
- Assists surgeon by passing instruments and setting up drains
- Accounts for all items during surgery
-
Recovery/PACU Nurse:
- Monitors patients' ABCs
- Conducts assessments relevant to patient (neurological, neurovascular, etc.)
- Provides care postoperative care until patient recovers from anesthesia
Pharmacology
-
Definition: Study of how drugs interact with biological systems
-
Pharmacodynamics: Study of how drugs interact with and exert their effects on the body
Affinity
- Refers to the strength of the binding between a drug and its target receptor
- Higher affinity indicates a stronger and more specific binding leading to a greater pharmacological effect
Antagonist vs Agonist Drugs
- Antagonist: Drug binds to receptor without eliciting a response or blocks the activation of the receptor
- Agonist: Drug binds to a receptor and causes a response
Anaesthetics
Depolarising vs Non-Depolarizing Anaesthetic Agents
- Depolarizing: Anaesthetic agents, like succinylcholine, briefly stimulate muscle contraction by mimicking acetylcholine at neuromuscular junctions
- Non-Depolarizing: Anaesthetic agents, like rocuronium, block acetylcholine from binding to neuromuscular receptors, leading to muscle paralysis
Antipyretics and Analgesics
- Analgesics: Medications used to relieve pain by acting on the CNS or peripheral pain pathways
- 3 types:
- Non-Opioids: Paracetamol, aspirin, ibuprofen
- Opioids: Morphine, oxycodone
- Adjuvant analgesics: Medication used to enhance the effects of analgesics
Antiemetics
- Definition: Medications used to prevent or alleviate nausea and vomiting
- Work by targeting various pathways in the body involved in the sensation of nausea and the reflexes that lead to vomiting
- Examples: Ondansetron, promethazine, metoclopramide, and dimenhydrinate
Body System Responses
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Immune Response:
- Innate/Non-Specific Immune Response:
- First line of defence: surface barriers (skin, mucous, tears, gastric acid)
- Second line of defence: nonspecific natural killer cells (phagocytes, dendritic cells, NK cells, macrophages)
- Adaptive Immune Response:
- Humoral Immunity: involves the production of antibodies by B cells
- Cellular Immunity: involves the direct action of immune cells to recognize and destroy infected or abnormal cells
- Innate/Non-Specific Immune Response:
-
Inflammation:
- Definition: Nonspecific defence mechanism, involving a complex series of events to eliminate the cause of cell injury, clear out damaged cells and tissues, and initiate tissue repair
- Acute inflammation: Rapid and short-term response to injury or infection
- Chronic inflammation: Prolonged and persistent state that can lead to tissue damage
-
Fever:
- Definition: Temporary increase in body temperature, usually in response to an infection or illness
- Helps to inhibit pathogen growth, enhance immune response, mobilize immune response, and increase metabolic rate
Principles of Fluids and Electrolyte
-
Compartments:
- Intracellular Fluid (ICF): 80% of fluid in the body, inside cells
- Extracellular Fluid (ECF): 1/3 of fluid weight in the body, outside cells
- Plasma
- Lymph
- Transcellular fluid (e.g., cerebrospinal fluid, GIT secretion, synovial fluid)
-
Transport mechanisms:
- Active Transport: net movement from low concentration gradient to high concentration gradient, requires energy
- Passive Transport: net movement of molecules from high concentration gradient to low concentration gradient, no energy required
- Osmosis: movement of water solvent
- Diffusion: movement of molecules down concentration gradient
- Facilitated Diffusion: uses protein carrier, glucose transport
- Filtration: movement of water and solutes through a membrane
Nutrition and Metabolism
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Definition:
- Macronutrients: carbohydrates, fats, proteins
- Micronutrients: vitamins, minerals
- Water: essential for bodily functions
-
Assessing for Malnutrition:
- Insufficient energy intake
- Weight and muscle mass loss
- Loss of subcutaneous fat### Sudden or Unexplained Deaths
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Deaths that occur suddenly or unexpectedly, with unclear or unknown causes, may require investigation by the coroner.
-
Examples include:
- Violent or suspicious deaths (e.g., homicide, suicide, accidents)
- Deaths in custody (e.g., prison, police cell, detention facility)
- Industrial or occupational deaths (e.g., workplace accidents)
- Deaths resulting from medical procedures (e.g., medical malpractice, negligence)
- Deaths due to notifiable diseases (e.g., infectious diseases)
- Deaths due to environmental factors (e.g., exposure to extreme temperatures, chemicals)
- Deaths of unknown identity
Phases of Haemostasis
- Haemostasis is the process of stopping blood loss from damaged vessels.
- The four phases of haemostasis are:
- Vascular phase: vasoconstriction of blood vessels to reduce blood flow
- Platelet phase: platelets stick to the injured blood vessel wall, aggregating and plugging the hole
- Coagulation phase: chemical reactions lead to the production of a thrombus (blood clot)
- Fibrinolysis phase: the breakdown of the thrombus by plasmin
Blood Transfusion
- Blood must be matched with the patient before administration.
- Main blood groups are:
- ABO (A, B, AB, O)
- Rhesus (Rh-positive, Rh-negative)
- Important blood types:
- O negative: universal donor
- AB negative: universal recipient
Transfusion Reactions
- Types of transfusion reactions include:
- Febrile reactions: fever, chills, and malaise in response to a rise in temperature
- Allergic reactions: immune response to a substance, leading to symptoms such as rash, itching, or difficulty breathing
- Haemolytic reactions: life-threatening destruction of red blood cells, often due to incompatible blood transfusions or autoimmune conditions
Venous Thrombosis Embolism (VTE)
- Arterial thrombi: composed of rich platelets and fibrin, forming rapidly in high-flow, high-pressure arterial circulation, often leading to ischemic events like heart attacks or strokes
- Venous thrombi: composed primarily of fibrin and red blood cells, forming more slowly in low-flow, low-pressure venous circulation, commonly causing conditions such as deep vein thrombosis or pulmonary embolism
- Virchow's Triad: indicates the development of DVT, with factors including:
- Stasis (blood stasis)
- Hypercoagulability (excessive blood clotting)
- Endothelial damage (damage to blood vessel walls)
Anticoagulants and Fibrinolytic Drugs
- Antiplatelet drugs: used to treat white thrombi (arterial thrombi), examples include:
- Aspirin: inhibits platelet enzyme COX-1, reducing platelet aggregation
- Risks: bleeding, Ryes syndrome, chronic overdose, acute salicylate poisoning, and interaction with warfarin
- Anticoagulants: used to treat red thrombi (deep vein thrombi), examples include:
- Heparin: enhances antithrombin III activity, inhibiting thrombin and factor Xa, preventing blood clot formation
- Warfarin: inhibits vitamin K epoxide reductase, reducing synthesis of vitamin K-dependent clotting factors
- Enoxaparin: inhibits factor Xa and, to a lesser extent, factor IIa, preventing clot formation
Integumentary System
- Functions of the integumentary system include:
- Protection: forming a barrier against physical, chemical, and microbial damage
- Temperature regulation: controlling heat loss through sweating and heat retention through vasoconstriction or vasodilation
- Sensation: perceiving tactile sensations, temperature changes, and pain
- Excretion: eliminating waste products through sweat secretion
- Immune function: detecting and responding to pathogens, allergens, and other foreign substances
- Synthesis of vitamin D: essential for calcium absorption and bone health
- Water regulation: maintaining proper hydration levels
- Blood reservoir: serving as a reservoir for circulating blood volume
Wound Healing
- The four stages of wound healing are:
- Haemostasis: blood vessels constrict, and clotting begins to stop bleeding
- Inflammation: white blood cells move to the wound to fight infection and clear debris
- Proliferation: new tissue forms as cells multiply, filling the wound and creating new blood vessels and collagen
- Maturation/Remodelling: the wound contracts and strengthens as collagen is remodelled, and new tissue gains strength and flexibility
Types of Wound Healing
- Primary intention: wound edges are brought together (e.g., with sutures, staples), healing occurs quickly with minimal scarring
- Secondary intention: wound is left open and heals naturally from the bottom up, resulting in more scar tissue and a longer healing process
- Tertiary intention: wound is initially left open to allow for debridement or infection control, then closed surgically, combining features of both primary and secondary healing
Antibiotics and Infections
- Antibiotics target specific sites in bacterial cells, including:
- Cell wall
- Inhibiting bacterial enzymes
- Disrupting bacterial protein synthesis
- Inhibiting bacterial DNA or RNA synthesis
- Types of antibiotics include:
- Penicillins: inhibit bacterial cell wall formation
- Cephalosporins: work similarly to penicillins, inhibiting bacterial cell wall synthesis
- Macrolides: inhibit bacterial protein synthesis
- Tetracyclines: interfere with bacterial protein synthesis
- Fluoroquinolones: inhibit bacterial DNA replication
- Antibiotic resistance occurs when bacteria change in response to the use of antibiotics, rendering the drugs ineffective against them.
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Description
Test your knowledge on surgical nursing, including the definition and perioperative journey. Learn about the surgical process from decision to postoperative recovery.