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Questions and Answers

What is a characteristic feature of Cryptococcus neoformans?

  • Spindle-shaped yeast cells with thin walls
  • Rod-shaped bacteria with a smooth surface
  • Budding yeast cells with a refractile gelatinous capsule (correct)
  • Oval yeast cells with no visible capsule

Which condition may lead to Balanitis and vaginitis due to lowered pH?

  • Increased exercise
  • Excessive hydration
  • High protein diet
  • Antibiotic therapy (correct)

What is a typical discharge associated with vaginal infections caused by yeast?

  • Brownish bloody discharge
  • Clear and watery discharge
  • Curdlike yellow-white liquid discharge (correct)
  • Thick green pus-like discharge

Which microscopic feature helps identify Geotrichum candidum?

<p>Arthroconidia resembling a 'hockey stick' (B)</p> Signup and view all the answers

What pH is typically maintained in a healthy vagina, partially due to Doderlein's bacilli?

<p>Acidic pH of about 4.5 (C)</p> Signup and view all the answers

What is the primary mode of transmission for Sporotrichosis?

<p>Trauma (A)</p> Signup and view all the answers

Which type of lesions develop at the site of implantation in Fixed Cutaneous Sporotrichosis?

<p>Primary lesions (D)</p> Signup and view all the answers

What is a common characteristic of the lesions in Lymphocutaneous Sporotrichosis?

<p>They ulcerate and drain (C)</p> Signup and view all the answers

Which of the following is NOT a type of infection mentioned?

<p>Dermatophytosis (C)</p> Signup and view all the answers

What can happen if the lesions from Sporotrichosis become infected?

<p>Secondary bacterial infection (C)</p> Signup and view all the answers

Where are primary lesions most commonly found in Fixed Cutaneous Sporotrichosis?

<p>Limbs, hands, and fingers (A)</p> Signup and view all the answers

Which fungus is responsible for causing Sporotrichosis?

<p>Sporothrix schenckii (A)</p> Signup and view all the answers

Which of the following statements about subcutaneous fungi is true?

<p>Most are saprobes found in decaying vegetation. (D)</p> Signup and view all the answers

Which organism is associated with the disease Chromoblastomycosis?

<p>Phialophora verrucosa (B), Fonsecaea pedrosoi (C), Cladosporium carionii (D)</p> Signup and view all the answers

What type of conidiation is characterized by a tree-like appearance with chains branching from a conidium?

<p>Cladosporium (D)</p> Signup and view all the answers

Which of the following fungi is specifically identified as causing mycetoma with light-colored granules?

<p>Pseudallescheria boydii (C)</p> Signup and view all the answers

Which organism has a 'vase base phialide' as part of its morphology?

<p>Phialophora (B)</p> Signup and view all the answers

What is the characteristic morphology of Exophiala jeanselmei?

<p>Hyaline septate and loosely arranged hyphae (C)</p> Signup and view all the answers

Sporothrix schenckii is known for causing what type of infection?

<p>Sporotrichosis (A)</p> Signup and view all the answers

Which of the following fungi may have a secondary infection associated with its disease manifestation?

<p>Fonsecaea pedrosoi (A)</p> Signup and view all the answers

Which type of conidia are arranged sympodially on short denticles and resemble a body builder?

<p>Rhinocladiella (B)</p> Signup and view all the answers

What is a common feature of the hyphae of Phialophora verrucosa?

<p>Dark septate with a swollen center (A)</p> Signup and view all the answers

Which of the following statements about Madura foot is true?

<p>It can involve multiple fungal agents. (C)</p> Signup and view all the answers

What is one of the primary mechanisms by which certain viruses cause mRNA degradation?

<p>Activation of an RNA endonuclease (B)</p> Signup and view all the answers

What is a characteristic of the adenoviruses mentioned?

<p>Stable in the environment and resistant to disinfection (D)</p> Signup and view all the answers

Which of the following responses are not protective against Hepatitis?

<p>Cell-mediated responses (C)</p> Signup and view all the answers

What is the main way the adenovirus enters hepatocytes?

<p>Through the bloodstream (A)</p> Signup and view all the answers

What is a possible outcome of chronic hepatitis?

<p>Development of cirrhosis (A)</p> Signup and view all the answers

Which type of immune response specifically targets virally-infected cells?

<p>Cytotoxic T-lymphocyte response (D)</p> Signup and view all the answers

What is a common symptom of hepatitis?

<p>Jaundice (C)</p> Signup and view all the answers

Which type of virus is classified under the Herpes Viridae family?

<p>Herpes Simplex Virus (B)</p> Signup and view all the answers

How are adenoviruses primarily characterized in their structure?

<p>Linear double-stranded DNA (A)</p> Signup and view all the answers

What is a critical action in controlling virally spread infections like Hepatitis?

<p>Blood screening (A)</p> Signup and view all the answers

What characteristic differentiates Phaeohyphomycosis from Hyalohyphomycosis?

<p>It is a chronic infectious condition. (B), It involves skin and subcutaneous tissue. (D)</p> Signup and view all the answers

What is a key identifying cellular feature of Pneumocystis carinii?

<p>Cyst: reddish-blue against a blue background (C)</p> Signup and view all the answers

Which of the following best describes Saccharomyces cerevisiae?

<p>It is involved in the production of fermented beverages. (C)</p> Signup and view all the answers

What type of fungal infection is often associated with HIV-infected individuals?

<p>Pneumonia caused by Pneumocystis carinii (B)</p> Signup and view all the answers

What feature characterizes 'phialide' in fungi?

<p>It stops elongating once the first conidium appears. (A)</p> Signup and view all the answers

Which term best describes the cells where conidia arise?

<p>Conidiogenous cells (B)</p> Signup and view all the answers

What are chlamydospores known for?

<p>They are thick-walled structures. (D)</p> Signup and view all the answers

Which organism is strictly haploid and primarily grows in yeast form?

<p>Candida glabrata (D)</p> Signup and view all the answers

Which of the following correctly describes annellides in fungal reproduction?

<p>They continue growing while producing conidia. (A)</p> Signup and view all the answers

What type of factors commonly increase the risk of Pneumocystis carinii infections?

<p>HIV-infection (D)</p> Signup and view all the answers

Which types of viruses exhibit latency in nerve cells?

<p>Herpes Simplex Virus (HSV) and Varicella-Zoster Virus (VZV) (A)</p> Signup and view all the answers

What is a common cause of Pharyngeal-conjunctival Fever?

<p>Contaminated water in swimming pools (A)</p> Signup and view all the answers

What is one of the common infections in military recruits?

<p>Pneumonia (C)</p> Signup and view all the answers

Which type of immune response is predominantly involved in early infection control?

<p>Cytotoxic T-cell action (C)</p> Signup and view all the answers

What is the primary method for diagnosing these viral infections?

<p>Characteristic lesions and intranuclear inclusions on smear (D)</p> Signup and view all the answers

Which viruses are known to cause latency in lymphocytes?

<p>Epstein-Barr Virus (EBV) and Cytomegalovirus (CMV) (B)</p> Signup and view all the answers

What kind of cells are usually infected by neurotropic viruses?

<p>Nerve cells (B)</p> Signup and view all the answers

What is a common characteristic of cold climate epidemiology concerning viral infections?

<p>More prevalent in children under 6 (C)</p> Signup and view all the answers

Flashcards

Subcutaneous Fungi

Fungi that live in decaying vegetation and wood.

Sporotrichosis

A fungal infection caused by Sporothrix schenckii.

Sporotrichosis Transmission

Usually occurs from trauma-related injuries from contact with infected vegetation/wood.

Sporotrichosis Lesions

Characterized by nodules, suppuration, ulceration, and draining sores, possibly spreading to lymph nodes.

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Fixed Cutaneous Sporotrichosis

Primary lesions develop at the site of inoculation, often on limbs, hands or fingers.

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Lymphocutaneous Sporotrichosis

Primary lesions develop at the site of inoculation; secondary lesions may appear along lymphatic vessels.

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Phaeohyphomycosis

A type of subcutaneous fungal infection.

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Mycetoma

Another type of subcutaneous fungal infection characterized by nodules.

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Blastoconidia

Yeast cells that reproduce by budding, producing asexual spores.

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Pseudohyphae

Chains of yeast cells that look like hyphae but do not have true walls between cells.

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Chlamydospores

Thick-walled, resting spores formed by some yeasts for survival.

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Pneumocystis carinii

A fungus that can cause pneumonia, especially in individuals with weakened immune systems.

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Phialide

Specialized fungal structure where conidia arise in a determinate manner (stops growing after each conidium)

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Annellides

Specialized fungal structure where conidia arise in indeterminate manner (continues growing after producing the first conidium).

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Opportunistic Fungi

Fungi that cause disease mainly in immunocompromised individuals.

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Saccharomyces cerevisiae

Single-celled fungus used in fermentation processes, like beer and bread production.

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Candida albicans microscopic appearance

Yeast cells, sometimes single or multiple budding, and thick-walled, 2-15µm in diameter.

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Geotrichum candidum microscopic appearance

Arthroconidia resembling a "hockey stick"

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Candida Infections (Balanitis, Vaginitis)

Caused by lowered vaginal pH due to factors like contraceptives, diabetes, or pregnancy.

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Geotrichum candidum isolation sources

Frequently found in dairy products, vegetables, and fruits.

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Geotrichosis

Disease caused by Geotrichum candidum.

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Chromoblastomycosis

A chronic skin infection caused by specific fungi.

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Cladosporium carionii

A fungus causing a type of skin infection (chromoblastomycosis).

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Phialophora verrucosa

A fungus that causes a type of skin infection (chromoblastomycosis).

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Fonsecaea pedrosoi

A fungus, significant causative agent of Mycetoma and/or Chromoblastomycosis.

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Conidia

Spores of a fungus, often responsible for spreading the infection (like a seed).

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Phialophora

A type of fungus with a unique conidium structure (vase-like base).

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Pseudallescheria boydii

A fungus causing Eumycotic Mycetoma, fast grower, has two forms.

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Sporothrix schenckii

A fungus causing sporotrichosis, commonly found in gardens.

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Acute Febrile Pharyngitis

A common infection in children that causes a sore throat, fever, and inflammation of the back of the throat. It can be difficult to differentiate from a common cold or flu.

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Pharyngeal-conjunctival Fever

An infection caused by adenoviruses, often spread through contaminated water or surfaces. Symptoms include fever, sore throat, and pink eye.

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Acute Respiratory Disease

A respiratory infection that can affect military recruits. It's often accompanied by a rash.

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Neurotropic Viruses

Viruses that infect and can remain dormant in nerve cells. Examples include Herpes Simplex Virus 1 and 2 (HSV), and Varicella Zoster Virus (VZV).

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Lymphotropic Viruses

Viruses that infect and can remain dormant in lymphocytes. Some are associated with cancers. Examples include Epstein-Barr Virus (EBV) and Cytomegalovirus (CMV).

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Host Defenses Against Viral Infections

The immune system uses various strategies to fight viral infections. Cytotoxic T-cells directly kill infected cells, preventing further spread. Antibodies can also neutralize viruses, but they are not always produced quickly enough to be effective.

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Intranuclear Inclusions

Clusters of viral particles inside the nucleus of infected cells. They are characteristic of certain viral infections and aid in diagnosis.

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Multinucleated Giant Cells

Large cells formed when multiple cells fuse together after being infected with certain viruses. They are another diagnostic feature.

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Adenovirus Structure

Non-enveloped, 70-90 nm, icosahedral with 252 capsomeres, containing a linear ds DNA genome.

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Adenovirus Properties

Stable in the environment, resistant to disinfection, stable in the GI tract.

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Adenovirus Infection Sites

Infects mucoepithelial cells of the respiratory, GI, and GU tracts, leading to viremia.

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Adenovirus Pathogenesis

Causes cytopathic changes in infected cells, leading to disease symptoms.

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Hepatitis

Inflammation of the liver, potentially asymptomatic, with carrier state possibilities and risk of chronic progression to cirrhosis.

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Hepatitis B Virus Entry

Enters hepatocytes (liver cells) via the bloodstream.

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HBcAg and HBeAg

Viral antigens expressed on hepatocyte cell surfaces, recognized by the immune response (cytotoxic T cells), contributing to the clinical syndrome.

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Herpes Viridae

Enveloped virus that replicates in the host's nucleus, potentially causing recurrent infections.

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Antiviral Antibody Defense

Prevents viral adsorption to target cells, and cytotoxic T lymphocytes recognize and destroy infected cells, reducing viral production.

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Host Defenses Against Viruses

Antiviral antibodies and cytotoxic T lymphocytes work together to prevent viral adsorption, destroy infected cells, and reduce viral production.

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Study Notes

Subcutaneous Fungi

  • Most are saprobes found in decaying vegetation and wood
  • Transmission is often via trauma
  • Can form nodules that ulcerate
  • Secondary bacterial infections are possible

Kinds of Infection

  • Phaeohyphomycosis: Caused by fungi such as Exophiala, Phialophora, and Wangiella. Characterized by various symptoms
  • Mycetoma: Chronic granulomatous infection of the skin, subcutaneous tissue, and sometimes bone. Sinuses discharge organisms. Also known as "Madura foot" or "watering can foot"
  • Sporotrichosis: Caused by Sporothrix schenckii. Characterized by nodular lesions that suppurate, ulcerate, and drain. Often affects the upper and lower limbs
  • Chromoblastomycosis: Verrucoid crusted nodules of the skin. Painless if without secondary infection
  • The infection is often spread along lymphatic channels

Types of Sporotrichosis

  • Fixed cutaneous: Primary lesions develop at the site of implantation. Common locations are limbs, hands, and fingers
  • Lymphocutaneous: Primary and secondary lesions develop at the site of implantation and along lymphatic channels. No systemic symptoms
  • Pulmonary: Hematogenous dissemination, common symptoms are cough, sputum production, fever and weight loss
  • Osteoarticular: Lesions typically confined to long bones near affected joints, resulting in joint stiffness and pain.

Mycetoma

  • Chronic granulomatous or actinomycotic infection of the skin, subcutaneous tissue, and occasionally bone.
  • Sinuses discharge different types of fungi and bacteria
  • Commonly called"Madura foot" or "watering can foot"

Chromoblastomycosis

  • Verrucoid crusted nodules of the skin develop
  • Often painless if without secondary infections
  • Dematiaceous (dark pigmented/copper coloured) fungi develop in the tissue
  • Trauma can introduce the fungal elements in the skin

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