Student Feedback and Final Exam Prep
48 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What type of muscle is predominantly found in the gastrointestinal (GI) organs?

  • Skeletal muscle
  • Smooth muscle (correct)
  • Cardiac muscle
  • Striated muscle
  • Which of the following statements about the action potentials in GI smooth muscle is true?

  • They are brief and have significant overshoot.
  • They are prolonged and have little or no overshoot. (correct)
  • They are triggered by neural input only.
  • They are faster than those in skeletal muscle.
  • What is the duration of a tonic contraction in smooth muscle?

  • Minutes to hours (correct)
  • Milliseconds
  • Hours to days
  • Seconds
  • What role do Interstitial Cells of Cajal (ICC) play in the GI tract?

    <p>They act as pacemakers and initiate slow waves. (A)</p> Signup and view all the answers

    Which region of the GI tract has the highest frequency of ICC pacemaker activity?

    <p>Duodenum (B)</p> Signup and view all the answers

    Which type of contraction provided by smooth muscles is characterized by being fast and strong?

    <p>Phasic contraction (C)</p> Signup and view all the answers

    What distinguishes slow waves initiated by ICC from action potentials?

    <p>Slow waves have no overshoot. (D)</p> Signup and view all the answers

    Which of the following movements is NOT a main pattern of mobility in the gut?

    <p>Cyclic movement (B)</p> Signup and view all the answers

    What is the primary purpose of performing a colonoscopy?

    <p>To observe the GI walls and take biopsies (C)</p> Signup and view all the answers

    At what age should average-risk individuals begin colorectal cancer screening through a colonoscopy?

    <p>50 years (C)</p> Signup and view all the answers

    Which procedure is noted as the most effective non-invasive tool for visualizing the small intestine?

    <p>Video capsule endoscopy (D)</p> Signup and view all the answers

    What advantage does video capsule endoscopy have over traditional endoscopy?

    <p>It avoids the need for sedation. (A)</p> Signup and view all the answers

    What is a significant benefit of using video capsule endoscopy for detecting gastrointestinal bleeding?

    <p>It captures images continuously as it passes through the bowel. (D)</p> Signup and view all the answers

    Which part of the small intestine is typically hardest to reach using traditional endoscopy?

    <p>Jejunum (C)</p> Signup and view all the answers

    What is the role of a biopsy in the context of endoscopic procedures?

    <p>To examine tissue samples in a lab (C)</p> Signup and view all the answers

    What innovative technology is mentioned as a method for gastrointestinal bleeding detection?

    <p>Ingestible bacterial-electronic system (C)</p> Signup and view all the answers

    What is the main function of downstream receptors in the regulation of gastric emptying?

    <p>To sense nutrient composition and adjust pyloric opening (B)</p> Signup and view all the answers

    What are prokinetic drugs primarily used for?

    <p>To stimulate motor activity in the gastrointestinal tract (D)</p> Signup and view all the answers

    Which mechanism is thought to be involved in the Enterra device's action?

    <p>Indirect stimulation of the enteric nervous system (A)</p> Signup and view all the answers

    What does electrogastrography (EGG) measure?

    <p>The electrical activity resulting from gastric slow waves (C)</p> Signup and view all the answers

    In which area of the nervous system do prokinetic drugs exert their effects?

    <p>Both central and peripheral nervous systems (A)</p> Signup and view all the answers

    What is one of the key functions of the vagus nerve in gastric function?

    <p>To stimulate the vomiting center in the brain (B)</p> Signup and view all the answers

    Which of the following statements about gastric electrical stimulation (GES) is true?

    <p>It involves stimulation of the enteric nervous system (C)</p> Signup and view all the answers

    What type of musculature is primarily found in the small intestine?

    <p>Smooth muscle (D)</p> Signup and view all the answers

    What is a distinguishing feature of magnetogastrography compared to electrogastrography?

    <p>It records magnetic fields of the stomach (D)</p> Signup and view all the answers

    What is the primary purpose of the migrating motor complex in the gastrointestinal tract?

    <p>Regular electrical activity during fasting (A)</p> Signup and view all the answers

    What is the diameter of the large intestine compared to the small intestine?

    <p>Roughly double the diameter (B)</p> Signup and view all the answers

    What is a key function of segmental propulsion in the large intestine?

    <p>Shuttling content back and forth for fluid re-absorption (B)</p> Signup and view all the answers

    Which of the following accurately describes the mass movement in the large intestine?

    <p>It serves as a clearing mechanism similar to the MMC (C)</p> Signup and view all the answers

    What is the length of the large intestine in living humans?

    <p>1.5 meters (C)</p> Signup and view all the answers

    What type of musculature is found in the outer anal sphincter?

    <p>Skeletal muscle (D)</p> Signup and view all the answers

    What does esophageal manometry primarily assess?

    <p>The motility of the esophagus (A)</p> Signup and view all the answers

    Why is the appendix considered clinically relevant, despite not being part of the large intestine?

    <p>It can become infected (A)</p> Signup and view all the answers

    What occurs when the lower esophageal sphincter relaxes in response to swallowing?

    <p>Normal swallowing function (D)</p> Signup and view all the answers

    What percentage of the general population is estimated to be affected by gastro-esophageal reflux disease (GERD)?

    <p>18-27% (A)</p> Signup and view all the answers

    Which of the following is NOT listed as a treatment option for GERD?

    <p>Immunotherapy (D)</p> Signup and view all the answers

    What is the primary purpose of using barium sulfate solution in gastric motility assessments?

    <p>To enhance visibility during x-ray imaging (C)</p> Signup and view all the answers

    What is the efficacy reported for the Linx device used in GERD treatment?

    <p>80% (A)</p> Signup and view all the answers

    Which procedure involves taking x-ray images over time to assess gastric motility?

    <p>X-ray fluoroscopy (D)</p> Signup and view all the answers

    Which type of drugs used in GERD treatment focuses on increasing contractility within the stomach?

    <p>Prokinetic agents (D)</p> Signup and view all the answers

    What is the purpose of γ-scintigraphy in the context of gastric motility?

    <p>To visualize the proportion of a radiolabeled meal in the stomach over time (A)</p> Signup and view all the answers

    What type of meal is suitable for γ-scintigraphy?

    <p>Solid, liquid, or capsule forms of meals are suitable (D)</p> Signup and view all the answers

    In the Siegel model, which parameter corresponds to the type of food affecting gastric motility?

    <p>β (B)</p> Signup and view all the answers

    What is tlag in the context of the assessment of gastric emptying for solids?

    <p>The time taken to reach maximum emptying rate (B)</p> Signup and view all the answers

    What role do gamma cameras play in γ-scintigraphy?

    <p>They detect emitted gamma radiation to form images (A)</p> Signup and view all the answers

    Which of the following statements about γ-scintigraphy is FALSE?

    <p>It provides three-dimensional images of gastric motility (D)</p> Signup and view all the answers

    What is indicated by a β value greater than 1 in the Siegel model?

    <p>The food is a solid (D)</p> Signup and view all the answers

    If a patient has slow gastric motility, how would this affect the parameters k and β in the Siegel model?

    <p>k would increase; β would decrease (D)</p> Signup and view all the answers

    Flashcards

    Smooth Muscle Contractions

    GI organs contain smooth muscles, which contract involuntarily slower than skeletal muscles, with prolonged action potentials.

    Phasic Contractions

    A type of smooth muscle contraction, characterized by fast and strong contractions, lasting seconds.

    Tonic Contractions

    A type of smooth muscle contraction, characterized by slow, sustained contractions lasting minutes or hours.

    Skeletal Muscle Input

    Skeletal muscles' contractions are triggered by neural signals.

    Signup and view all the flashcards

    Interstitial Cells of Cajal (ICC)

    Pacemakers of the gut, initiating slow waves. Do not initiate action potentials.

    Signup and view all the flashcards

    Slow Waves

    Spontaneous rhythmic electrical signals in the GI tract, essential for movement (mixing, propulsion, pendular)

    Signup and view all the flashcards

    GI Tract Regions

    Different regions of the GI tract have varying ICC pacemaker frequencies (stomach3/minute, duodenum11-12/minute, etc.)

    Signup and view all the flashcards

    GI Mobility Patterns

    Mixing (segmentation), propulsion (peristalsis), and pendular movement are the main ways food moves through the GI tract.

    Signup and view all the flashcards

    Small Intestine Motility

    The movement of material through the small intestine, including the migrating motor complex (MMC).

    Signup and view all the flashcards

    Migrating Motor Complex (MMC)

    A regular cycle of electrical activity in the GI tract during fasting.

    Signup and view all the flashcards

    Small Intestine Motility Patterns

    Includes stretch and contract, and pendular movements to mix and move digested food.

    Signup and view all the flashcards

    Large Intestine Diameter

    Approximately 6 cm (about twice the small intestine).

    Signup and view all the flashcards

    Large Intestine Length

    About 1.5 meters in humans

    Signup and view all the flashcards

    Large Intestine Muscle Types

    Smooth muscle cells, with some voluntary striated muscle in the anal sphincter

    Signup and view all the flashcards

    Segmental Propulsion (Large Intestine)

    Content shuttled back and forth in the large intestine, reabsorbing fluids.

    Signup and view all the flashcards

    Mass Movement (Large Intestine)

    A clearing mechanism similar to the MMC (Migrating Motor Complex), moving contents aborally.

    Signup and view all the flashcards

    Esophageal Manometry

    A medical procedure assessing the function and movement of the esophagus, often using a pressure-sensitive catheter.

    Signup and view all the flashcards

    Clouse Plot

    A graphical representation of esophageal pressure changes over time, used to analyze esophageal motility and lower esophageal sphincter (LES) function.

    Signup and view all the flashcards

    What does the arrow indicate on a Clouse Plot?

    The arrow points to a relaxation of the lower esophageal sphincter (LES) in response to a swallow, indicating normal LES function.

    Signup and view all the flashcards

    GERD

    Gastroesophageal reflux disease, occurring when the lower esophageal sphincter (LES) weakens, allowing stomach acid to back up into the esophagus.

    Signup and view all the flashcards

    GERD Treatment Options

    Lifestyle changes, medications (to reduce stomach acid or enhance gut movement), and surgery (like the Linx device) are the main GERD treatment approaches.

    Signup and view all the flashcards

    Linx Device

    A medical device implanted around the lower esophageal sphincter (LES) to tighten it, limiting reflux and GERD.

    Signup and view all the flashcards

    Barium Sulfate

    A contrast agent used in x-ray fluoroscopy to visualize the digestive tract, making the organs visible on x-rays.

    Signup and view all the flashcards

    X-ray Fluoroscopy

    A medical imaging technique using x-rays over time to observe the movement and function of the digestive organs.

    Signup and view all the flashcards

    Gastric Emptying: Speed vs. Liquid Type

    Different liquids empty from the stomach at different rates. Glucose solutions leave faster than protein solutions, while solids leave the slowest.

    Signup and view all the flashcards

    Gastric Emptying Regulation

    The stomach's emptying rate is controlled by downstream receptors that sense the chemical composition of its contents and send signals back to regulate the opening and closing of the pylorus.

    Signup and view all the flashcards

    Gastroparesis: What Is It?

    Gastroparesis is a condition where the stomach empties food too slowly. This can cause symptoms like nausea, vomiting, and feeling full.

    Signup and view all the flashcards

    Prokinetic Drug Action (1)

    Prokinetic drugs stimulate enteric neurons to release more acetylcholine, which promotes smooth muscle contractions and faster stomach emptying.

    Signup and view all the flashcards

    Prokinetic Drug Action (2)

    Prokinetic drugs also stimulate receptors in the chemoreceptor trigger zone in the CNS, which can help reduce nausea and vomiting.

    Signup and view all the flashcards

    Enterra Device: Mechanism

    While the exact mechanism is unclear, the Enterra device may work by stimulating the ENS and vagus nerve, indirectly influencing the stomach's emptying rate.

    Signup and view all the flashcards

    Electrogastrography (EGG)

    EGG is a non-invasive diagnostic tool that records stomach electrical activity through skin electrodes. It helps identify the dominant frequency of slow waves in the stomach.

    Signup and view all the flashcards

    Other Stomach Diagnostics: Magnetogastroscopy

    Magnetogastrography measures the magnetic field generated by the stomach's electrical activity. It's not yet used clinically.

    Signup and view all the flashcards

    Colonoscopy

    A procedure that examines the large intestine using a flexible camera to view the lining and take biopsies. Used for cancer screening and detecting abnormalities.

    Signup and view all the flashcards

    Upper GI Endoscopy

    A procedure to examine the upper digestive tract (esophagus, stomach, and duodenum) using a flexible camera to visualize the lining and take biopsies.

    Signup and view all the flashcards

    Small Intestine Endoscopy

    A procedure to examine the small intestine, often difficult to reach, using techniques like double-balloon endoscopy or video capsule endoscopy.

    Signup and view all the flashcards

    Video Capsule Endoscopy (VCE)

    A non-invasive way to visualize the small intestine by swallowing a tiny camera pill that captures images as it travels through the digestive tract.

    Signup and view all the flashcards

    VCE Advantages

    VCE allows access to the full length of the small intestine, is less invasive, and helps detect intermittent bleeding by capturing continuous images.

    Signup and view all the flashcards

    Gastrointestinal Bleeding Detection

    Techniques like ingestible capsules and genetically encoded bacteria sensing inflammation are used to detect bleeding in the digestive tract.

    Signup and view all the flashcards

    Genetically Encoded Bacteria

    Bacteria engineered to respond to specific signals like inflammation, allowing for targeted detection and diagnosis of digestive issues.

    Signup and view all the flashcards

    Inda-Webb et al.

    Researchers who contributed to advancements in gastrointestinal bleeding detection using genetically encoded bacteria.

    Signup and view all the flashcards

    Gamma Scintigraphy

    A diagnostic imaging technique that uses radioisotopes attached to a meal to visualize the stomach's emptying rate.

    Signup and view all the flashcards

    Siegel Model Equation

    A mathematical equation used to quantify gastric emptying by describing the fraction of a meal remaining in the stomach over time.

    Signup and view all the flashcards

    What does 'β' represent in the Siegel model?

    'β' represents a parameter that depends on the type of food and the patient's gastric motility. It influences the shape of the gastric emptying curve.

    Signup and view all the flashcards

    What is 'tlag' in the Siegel Model?

    'tlag' represents the time taken to reach maximum emptying rate for solids. It shows the delay before the stomach starts emptying effectively.

    Signup and view all the flashcards

    Why is gastric emptying quantified?

    Quantifying gastric emptying helps understand how efficiently the stomach processes food and identify potential problems with motility.

    Signup and view all the flashcards

    How does liquid emptying differ from solid emptying?

    Liquids empty from the stomach faster than solids, as indicated by the Siegel Model parameter 'β', which is less than 1 for liquids and greater than 1 for solids.

    Signup and view all the flashcards

    What is the 'pylorus'?

    The pylorus is the muscular valve that controls the flow of food from the stomach into the small intestine.

    Signup and view all the flashcards

    What factors influence gastric emptying?

    Factors such as food type, gastric motility, and the presence of downstream receptors that sense the chemical composition of the stomach contents can all influence emptying rates.

    Signup and view all the flashcards

    Study Notes

    Student Feedback Exercise

    • Students' feedback is important for improving learning experiences and modules.
    • Constructive comments are valuable to increase the value of feedback.
    • Feedback should be specific and describe how teachers or module organization have helped (or not helped) learning.
    • Inappropriate language or personal comments undermine feedback and are not acceptable.
    • Abusive comments will be discarded.
    • Feedback is confidential; professors will only see an aggregate report after exam results are released.
    • Feedback can be completed on-campus, at home, or on the go using a mobile-friendly platform.

    Final Exam Information

    • The final exam is scheduled for Saturday, November 30, 2024.
    • The exam venue is MPSH2-A, starting at 1 pm.
    • The exam format includes multiple-choice questions (MCQs) and open-ended questions.
    • The exam covers material from weeks 8 to 13.
    • Section 1: Respiratory Physiology (14 MCQs and 1 open-ended question; 20 points).
    • Section 2: Neural Physiology (24 MCQs and 2 open-ended questions; 44 points).
    • Section 3: Gastrointestinal Physiology (22 MCQs and 2 open-ended questions; 36 points).
    • The overall exam consists of 60 MCQs and 5 open-ended questions (100 points total).
    • Students can use one A4 size sheet of paper (double-sided) for notes.
    • Electronic calculators are permitted.

    Recap: Neural Stimulation Threshold Current

    • IthresholdI_{threshold}Ithreshold​ = IrheobaseI_{rheobase}Irheobase​ (1 + tchronaxietpulse\frac{t_{chronaxie}}{t_{pulse}}tpulse​tchronaxie​​)

    Recap: Divergence in a Neural Circuit

    • The question asks to identify an example of divergence in a neural circuit
    • The provided options include stretch reflex scenarios and neuron responses to stimuli
    • In a stretch reflex, a single sensory neuron might connect to multiple motor neurons, a type of divergence
    • other provided answers are not example of divergence

    A True Story: Competitive Eating Effects on GI System

    • A video showing effects of competitive eating

    BN2201: Gastrointestinal Physiology I

    • This is a course name

    Part I: General GI Introduction and Motility

    • Topics include the general introduction to the GI tract, motility of esophagus, stomach, small intestine, and large intestine.

    GI Tract - Hollow Tube Components

    • Structures within the GI tract include mouth, salivary glands, esophagus, stomach, pancreas, liver, gallbladder, small intestine, and large intestine.

    GI Terminology

    • Oral/Orad direction: Towards the mouth
    • Aboral/Anal/Caudal direction: Away from the mouth/towards the anus
    • Gut: General term for the stomach and intestine
    • Bowel/Enteric: Related to the intestine
    • Hepatic: Associated with the liver
    • Visceral: Related to internal organs of the body

    The Alimentary Canal: Anatomy

    • Structures and locations within the digestive tract (Mouth, esophagus, Stomach, Small Intestine, Large Intestine)

    GI Compartmentalization: Sphincters

    • Muscular structures controlled by nervous and hormonal systems.
    • Contraction prevents food movement.
    • Lower esophageal sphincter (LES) prevents acid reflux.

    Tissue Organization in the GI Wall

    • Mucosa, submucosa layers include different tissues- epithelium, lamina propria, muscularis mucosae, glands in submucosa, duct of gland (outside tract), lymphatic tissue & lumen
    • Muscularis, Serosa layers include different tissues, blood vessels- Myenteric plexus, arteries, veins.

    Regulation Mechanism in GI Tract

    • Endocrine: Hormones released into blood, enterochromaffin-like cells (ECL)
    • Neurocrine: Extrinsic nervous system (e.g., vagus nerve; parasympathetic and sympathetic); Intrinsic nervous system (enteric nervous system): Myenteric plexus and submucosal plexus
    • Paracrine: Local signaling molecules (eg serotonin), smooth muscle function, absorption

    Integrated Response to a Meal

    • GI activities during ingestion, propulsion, mechanical digestion, secretion, absorption of nutrients, and defecation.

    Involuntary Muscle

    • Smooth muscle and cardiac muscle are involuntary muscles responsible for body functions.

    Types of Muscles

    • GI organs are mostly composed of smooth muscles.
    • Smooth muscles exhibit slower, involuntary contractions compared to skeletal muscles.
    • Action potentials in GI smooth muscle are longer than those in skeletal muscle and lack overshoots.

    Types of Contractions (Smooth, Cardiac, Skeletal)

    • Smooth muscles perform two main types of contractions: phasic (fast and strong) and tonic (slow and sustained).
    • These contractions are involved in motility patterns like mixing, propulsion, and pendular movement.

    Skeletal vs Smooth Muscles

    • Skeletal muscles require neural input for contraction, whereas smooth muscles in the gut can contract spontaneously.
    • "Slow waves", a type of spontaneous fluctuation in membrane potential, are common in smooth muscle tissue (except the esophagus).

    Electrophysiology of the GI Tract

    • Interstitial cells of Cajal (ICCs) initiate slow waves but are not involved in action potentials.
    • ICC pacemaker activity differs across the GI tract; specifically in the stomach, duodenum, ileum, and colon.

    ICC, ENS, and Smooth Muscles

    • ICCs—the pacemakers—electrically couple to smooth muscle cells through gap junctions.
    • Slow waves in ICCs cause smooth muscle contractions through calcium channel opening, calcium accumulation, and activation of Myosin Light Chain Kinase (MLCK).

    Contraction in the Gut

    • Slow waves (from ICCs) and appropriate ENS input cause contraction.
    • Slow waves reaching threshold amplitude trigger contraction and release of neurotransmitters from enteric neurons.
    • Nonzero resting tension/tone in smooth muscle.

    Motility of the Esophagus: Propulsive and Protective Functions

    • The esophagus transfers food from the pharynx to the stomach.
    • It has upper and lower esophageal sphincters (UES, LES) that prevent reflux and protect the airway
    • The esophagus is 18-25 cm long and contains skeletal and smooth muscles.
    • Motility is controlled by somatic and autonomic nerves.

    Relaxation of LES

    • Swallowing causes neural reflex relaxation of the LES and the proximal stomach.

    Motility of the Stomach

    • 15-25 cm long in adults
    • empty stomach ~50 ml and fully distended ~4 liters
    • Types include mixing, grinding, emptying

    Motility of the Stomach: Fed State

    • Mixing, grinding, and emptying occur after eating.
    • Jetlike retropulsion moves solids through the stomach outlet.

    Motility of the Stomach: Fed State

    • Small openings allow liquids to pass through the pylorus quickly, but larger particles to proceed more slowly.

    Motility of the Stomach: Fasting State

    • Migrating Motor Complex (MMC) clears the stomach, approximately every 100 minutes, unless food arrives, with 5-10 minutes of luminal occlusive contractions.
    • Strong phasic contractions occur throughout the stomach.

    Motility of the Small Intestine

    • The small intestine (2.5–4 cm diameter, ~25 cm duodenum, 2.5 meters jejunum, 3.6 meters ileum)
    • It takes approximately two hours for food to pass through the small intestine, clearing up the entire structure through various contractions (primarily smooth muscle contractions).

    Motility of the Small Intestine: Migrating Motor Complex

    • Electrical activity patterns occur in the regular cycle of fasting.

    Motility of the Small Intestine: Patterns

    • Segmentation (mixing), peristalsis, pendular movement are important for mixing and propulsion

    Motility of the Large Intestine

    • 6 cm diameter and ~1.5 meters long.
    • The large intestine is involved in reabsorbing water and some electrolytes.
    • Its musculature involves smooth muscle and some striated voluntary muscle cells, primarily present in the outer anal sphincter

    Motility of the Large Intestine: Patterns

    • Segmental propulsion – content moves back and forth between haustra.
    • Mass movement – a clearing mechanism similar to MMC.

    Part I Summary

    • This is a summary of the parts of the GI intro and motility

    Part II Summary

    • This section summarizes the stats on GI disorders, esophagus and Dr Clouse, accessibility of the stomach, and methods to look from the inside.

    GI Disorders

    • Functional gastrointestinal disorders (FGIDs) are defined as a combination of motility disturbance, visceral hypersensitivity, Altered Central Nervous System processing and immune function, gut microbiota and altered central nervous system processing.
    • They occur in about 40% of the population.

    GI Disorders – Why is BME Needed?

    • Numerous underlying diseases can cause gastrointestinal disorders, including diabetic gastroparesis, idiopathic gastroparesis, cyclic vomiting syndrome, intestinal pseudo-obstruction (a functional disorder), functional dyspepsia, achalasia, and gastroesophageal reflux disease (GERD).

    Esophageal Manometry

    • Assessing esophageal function and motility via esophageal manometry

    Clouse Plots

    • Analysis of esophageal function and pressures during swallowing.

    GERD: An Extremely Prevalent Disease

    • Gastroesophageal reflux disease (GERD) happens when the lower esophageal sphincter (LES) malfunctions.
    • Stomach acid, then enters the esophagus, causing symptoms in about 18-27% of the population.

    GERD: Treatment Options

    • Treatment options for GERD include lifestyle modifications, drug therapies, surgical interventions (e.g., the Linx device).
    • The Linx device is a surgical approach with roughly 80% effectiveness in treating chronic GERD despite medical therapy in some cases.

    Assessing Gastric Motility

    • X-ray fluoroscopy (Barium sulfate) is used to observe the proportion of the meal in the stomach over time and the walls of the nearby adjacent GI organs.
    • Y-scintigraphy: A method used for detecting the time it takes for the meal to clear the stomach by using a radiolabeled meal.

    Assessing Gastric Motility- y-scintigraphy and liquid/capsule y-scintigraphy

    • A radiolabeled meal (either solid, liquid, or capsule form) is given.
    • The amount of meal in the stomach over time is tracked (gastric emptying) via external detection of emitted radiation.
    • Liquid or capsule-type forms are commonly used.

    Quantifying Gastric Emptying: The Siegel Model

    • Mathematical model (y= 1-(1-e-kt)β) describes how much food remains in the stomach over time.
    • Parameters (β and k) are dependent on food type and patient's gastric motility.

    Visualizing Gastric Emptying

    • X-rays can visualize the different parts of the stomach, including the duodenum, pylorus, the gastric body, and more.

    Regulation of Gastric Emptying

    • The chemical signals from the food (liquids like glucose and protein solutions) dictate how and when the pylorus regulates the opening/closing/flow.
    • Downstream receptors detect this composition and send signals back to the stomach.

    Gastroparesis

    • This is a disease in which the stomach has difficulty emptying.
    • This causes an endless search for answers when trying to determine the cause.
    • This includes different diagnostic methods and investigations such as CT, MRI, endoscopies, and ultrasound scans, as well as gastric emptying scans.

    Therapeutic Options (1): Drugs

    • Prokinetic drugs are used to stimulate enteric neurons, increasing neurotransmitter release and stimulating receptors in the chemoreceptor trigger zone (CNS)

    Therapeutic Options (2): Enterra Device

    • Enterra device is a surgical device that stimulates the enteric nervous system for treating certain gastrointestinal conditions.
    • The actions and mechanism are not entirely known.
    • This device induces neural neuromodulation of parasympathetic nerves or ganglia which regulate gastric motility.

    Other Stomach Diagnostics: Electrogastrography (EGG)

    • Recording of slow wave activity in the stomach from the detection of the electrical output of the stomach via skin electrodes.

    Looking from Inside: Colonoscopy

    • Colonoscopy is a procedure that allows visualization of the colon and rectum.
    • Biopsies can be taken during colonoscopy.
    • It is used for colorectal cancer screening for average-risk individuals over 50 years old.

    Looking from Inside: Upper GI Endoscopy

    • Visualization of the upper GI tract (including esophagus, stomach, duodenum)
    • Can aid in tissue biopsy, aiding in the diagnosis of abnormalities.

    Looking from Inside: Small Intestine Endoscopy

    • Small intestine is difficult to visualize anatomically.
    • Different techniques include double balloon and capsule endoscopy
    • Various types of imaging (i.e. Pillcam and more) are available to visualize the structure of the small intestine,

    Video Capsule Endoscopy vs Traditional Endoscopy

    • Advantages of video capsule endoscopy (VCE) over traditional techniques include non-invasiveness and the ability to detect certain types of bleeding.

    Beyond Camera - Ingestible Bacterial-Electronic System

    • Genetically encoded bacteria detect inflammation-associated molecules.
    • Wireless capsule records GI bleeding

    Your Gut - the Second Brain?

    • Shows the connection between the gut and mental wellbeing.
    • The gut may affect appetite, anxiety, and Parkinson's disease

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Description

    This quiz covers important guidelines for student feedback and details regarding the upcoming final exam scheduled for November 30, 2024. It emphasizes the importance of constructive feedback and provides insights into the exam format and content. Prepare effectively with this comprehensive overview.

    More Like This

    Student Feedback on School Programs
    16 questions
    Student Feedback Review
    10 questions
    Student Feedback Form
    12 questions

    Student Feedback Form

    ExemplaryClover3209 avatar
    ExemplaryClover3209
    Student Feedback Techniques
    40 questions

    Student Feedback Techniques

    ProtectiveLapisLazuli5490 avatar
    ProtectiveLapisLazuli5490
    Use Quizgecko on...
    Browser
    Browser