Structure of Renal Corpuscle and Glomerulus

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Questions and Answers

What is the primary function of the principal cells in the collecting duct?

  • To regulate water permeability through ADH-regulated water channels (correct)
  • To secrete hydrogen ions
  • To produce mucus to prevent cell damage from urine
  • To facilitate the exchange of sodium and potassium ions

What is the histological characteristic of the cells lining the collecting ducts as they descend from the cortex to the medulla?

  • They change from columnar to cuboidal to squamous
  • They change from squamous to cuboidal to columnar (correct)
  • They change from squamous to columnar to cuboidal
  • They remain cuboidal throughout

What is the primary function of the intercalated cells in the collecting duct?

  • To secrete hydrogen ions or bicarbonate ions (correct)
  • To regulate water permeability through ADH-regulated water channels
  • To facilitate the exchange of sodium and potassium ions
  • To produce mucus to prevent cell damage from urine

What is the function of the collecting ducts in the kidney?

<p>To drain urine from the nephron to the renal pelvis (C)</p> Signup and view all the answers

What is the characteristic of the epithelium lining the collecting tubules and ducts?

<p>Simple cuboidal/columnar epithelium (C)</p> Signup and view all the answers

What is the location of the collecting ducts in the kidney?

<p>In the medullary ray within the cortex (C)</p> Signup and view all the answers

What is the function of aldosterone in the collecting duct?

<p>To stimulate the reabsorption of sodium ions (C)</p> Signup and view all the answers

What is the primary function of the glomerular filtration barrier?

<p>To prevent some large molecules from entering the capsular space (B)</p> Signup and view all the answers

What type of epithelium forms the outer or parietal layer of Bowman's capsule?

<p>Simple squamous epithelium (A)</p> Signup and view all the answers

What is the function of the mesangial cells in the glomerulus?

<p>To give structural support to podocytes and vessels (B)</p> Signup and view all the answers

What is the name of the network of blood capillaries surrounded by Bowman's capsule?

<p>Glomerulus (A)</p> Signup and view all the answers

What is the name of the thin membrane that spans the filtration slits?

<p>Filtration slit membrane (D)</p> Signup and view all the answers

What is the name of the cells that form the inner layer of Bowman's capsule?

<p>Podocytes (C)</p> Signup and view all the answers

What is the name of the space between the outer and inner epithelial layers of Bowman's capsule?

<p>Capsular space (D)</p> Signup and view all the answers

What is the primary function of the proximal convoluted tubule in the nephron?

<p>Transport of majority of recovered water, ions, and glucose from the filtrate (B)</p> Signup and view all the answers

What is the effect of antidiuretic hormone (ADH) on the collecting ducts?

<p>Makes collecting ducts more permeable to water and increases the rate of water reabsorption (C)</p> Signup and view all the answers

What is the histological characteristic of the epithelial cells lining the proximal convoluted tubule?

<p>Simple cuboidal with microvilli (C)</p> Signup and view all the answers

Which segment of the nephron is responsible for ion exchange and regulation of Na+ and K+ concentration?

<p>Distal convoluted tubule (D)</p> Signup and view all the answers

What is the function of the juxtaglomerular apparatus?

<p>Regulation of blood pressure (C)</p> Signup and view all the answers

What is the histological characteristic of the epithelial cells lining the descending limb of the loop of Henle?

<p>Simple squamous (C)</p> Signup and view all the answers

What is the primary function of the ascending limb of the loop of Henle?

<p>Concentration of the filtrate through osmotic gradient (D)</p> Signup and view all the answers

What is the main function of the filtration membrane in the renal corpuscle?

<p>To filter waste and excess substances from the blood (B)</p> Signup and view all the answers

Which structure is responsible for influencing the resorption of sodium ions in the nephron?

<p>Macula densa (A)</p> Signup and view all the answers

What is the primary function of the juxtaglomerular apparatus in the nephron?

<p>To regulate blood pressure (B)</p> Signup and view all the answers

What is the term for the specialized smooth muscle cells in the afferent arteriole that contain renin in secretory granules?

<p>Juxtaglomerular cells (D)</p> Signup and view all the answers

What is the function of the podocyte filtration slits in the glomerulus?

<p>To filter waste and excess substances from the blood (A)</p> Signup and view all the answers

Which structure is responsible for producing renin in response to falling blood pressure?

<p>Juxtaglomerular cells (D)</p> Signup and view all the answers

What is the term for the portion of the terminal distal straight tubule adjacent to the renal corpuscle?

<p>Macula densa (C)</p> Signup and view all the answers

What is the primary component of the filtration barrier in the glomerulus?

<p>All of the above (D)</p> Signup and view all the answers

What is the function of the mesangial cells in the glomerulus?

<p>To phagocytose and remove waste from the glomerular capillaries (A)</p> Signup and view all the answers

Flashcards

Collecting System

Continuation of distal convoluted tubules, descends through medulla.

Ducts

Coalesce and increase in size, changing from squamous to cuboidal to columnar.

Papillary Ducts

Terminate at the tip of the renal pyramid.

Collecting Ducts

Resorb Na+, H2O, transfer K+, regulated by aldosterone and ADH.

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Light Cells

Principal cells of collecting duct, pale staining with primary cilium.

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ADH Channels

Water channels AQP-2 regulated by ADH in light cells.

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Dark Cells

Intercalated cells, denser cytoplasm, secrete H+ or HCO3-.

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Renal Papilla

Area where collecting ducts terminate.

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Renal Calyx

Funnel-shaped structure collecting urine from renal papilla.

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Ureter Layers

Three layers: tunica mucosa, muscular layer, adventitia.

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Proximal Convoluted Tubule

Simple cuboidal with microvilli, reabsorbs water, ions, glucose.

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Loop of Henle

Regulates sodium and potassium concentration.

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Distal Convoluted Tubule

Regulates sodium and potassium concentration in response to aldosterone.

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Renal Corpuscle

Comprises glomerulus and Bowman's capsule, initial filtration area.

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Glomerulus

Network of blood capillaries surrounded by Bowman's capsule.

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Bowman's Capsule

Capsule surrounding the glomerulus.

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Podocytes

Complex cells with foot-like processes forming a fenestrated epithelium.

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Blood-Urine Barrier

Filtration membrane composed of glomerular structures.

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Fenestrated Endothelium

Endothelium type in glomerulus that allows filtration.

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Glomerular Basement Membrane (GBM)

Supports filtration in the blood-urine barrier.

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Filtration Slits

Gaps formed by podocytes for filtration.

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Simple Cuboidal Epithelium

Type of tissue in proximal convoluted tubule.

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Transitional Epithelium

Type of epithelium found in the ureter, allows stretch.

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Aldosterone

Hormone regulating sodium and potassium levels.

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ADH (Antidiuretic Hormone)

Hormone that regulates water balance.

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Mitochondria in Dark Cells

Numerous in intercalated cells, support metabolic needs.

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Secretion of H+ or HCO3-

Function of dark cells for acid-base balance.

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Microvilli

Tiny projections that increase surface area in nephron segments.

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Principal and Intercalated Cells

Two types of cells in collecting ducts.

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Capillaries in Ureter

Attached to tunica mucosa for support.

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Function of Proximal Convoluted Tubule

Transports majority of recovered water, ions, glucose from filtrate.

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Study Notes

Collecting System

  • The collecting system starts in the cortex as a continuation of the distal convoluted tubules and descends through the medulla
  • The ducts coalesce and increase in size, with cells changing from squamous to cuboidal to columnar and becoming increasingly stratified
  • The ducts terminate at the tip of the renal pyramid as the papillary ducts

Collecting Ducts

  • Function: resorb Na+, H2O, transfer K+, regulated by aldosterone and ADH
  • Simple cuboidal/columnar epithelium
  • Two types of cells: Light cells (Principal cells) and Dark cells (Intercalated cells)

Light Cells

  • Also known as Collecting Duct or CD cells
  • Principal cells of the system
  • Pale staining cells
  • Basal infoldings present
  • Single primary cilium
  • Few short microvilli
  • Small, spherical mitochondria
  • Possess abundance of ADH-regulated water channels AQP-2, responsible for water permeability of collecting duct

Dark Cells

  • Also known as Intercalated cells or IC cells
  • Less in number
  • Cytoplasm is denser
  • Many mitochondria
  • No basal infoldings
  • Basally located interdigitations with neighboring cells
  • Numerous vesicles present in apical cytoplasm
  • Secrete Hydrogen (H+) or Bicarbonate (HCO3-) ions

Renal Papilla and Renal Calyx

  • Renal papilla: area where collecting ducts terminate
  • Renal calyx: funnel-shaped structure that collects urine from the renal papilla

Ureter

  • 3 layers in wall:
    1. Tunica mucosa: transitional epithelium and lamina propria
    2. Also attached to capillaries
    3. Supports contraction, phagocytosis, and secretion

Histology of Renal Tubule and Collecting Duct

  • Proximal convoluted tubule: simple cuboidal with brush border of microvilli
  • Descending limb of Loop of Henle: simple squamous
  • Ascending limb of Loop of Henle: simple cuboidal to low columnar
  • Distal convoluted tubule and collecting ducts: simple cuboidal composed of principal and intercalated cells with microvilli

Functions of Renal Tubule Segments

  • Proximal convoluted tubule: transports majority of recovered water, ions, and glucose from filtrate back to blood
  • Loop of Henle: regulates sodium and potassium concentration in response to aldosterone secretion
  • Distal convoluted tubule: regulates sodium and potassium concentration in response to aldosterone secretion

Renal Corpuscle

  • Glomerulus: network of blood capillaries surrounded by Bowman's capsule
  • Bowman's capsule: capsule that surrounds the glomerulus
  • Podocytes: complex cells with small foot-like processes (pedicles) that form a fenestrated epithelium around the fenestrated capillaries of the glomerulus

Blood-Urine Barrier

  • Filtration membrane composed of:
    1. Fenestrated endothelium of the glomerulus
    2. Glomerular basement membrane (GBM)
    3. Filtration slits of the podocyte

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