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Questions and Answers
What is the primary function of the principal cells in the collecting duct?
What is the primary function of the principal cells in the collecting duct?
- To regulate water permeability through ADH-regulated water channels (correct)
- To secrete hydrogen ions
- To produce mucus to prevent cell damage from urine
- To facilitate the exchange of sodium and potassium ions
What is the histological characteristic of the cells lining the collecting ducts as they descend from the cortex to the medulla?
What is the histological characteristic of the cells lining the collecting ducts as they descend from the cortex to the medulla?
- They change from columnar to cuboidal to squamous
- They change from squamous to cuboidal to columnar (correct)
- They change from squamous to columnar to cuboidal
- They remain cuboidal throughout
What is the primary function of the intercalated cells in the collecting duct?
What is the primary function of the intercalated cells in the collecting duct?
- To secrete hydrogen ions or bicarbonate ions (correct)
- To regulate water permeability through ADH-regulated water channels
- To facilitate the exchange of sodium and potassium ions
- To produce mucus to prevent cell damage from urine
What is the function of the collecting ducts in the kidney?
What is the function of the collecting ducts in the kidney?
What is the characteristic of the epithelium lining the collecting tubules and ducts?
What is the characteristic of the epithelium lining the collecting tubules and ducts?
What is the location of the collecting ducts in the kidney?
What is the location of the collecting ducts in the kidney?
What is the function of aldosterone in the collecting duct?
What is the function of aldosterone in the collecting duct?
What is the primary function of the glomerular filtration barrier?
What is the primary function of the glomerular filtration barrier?
What type of epithelium forms the outer or parietal layer of Bowman's capsule?
What type of epithelium forms the outer or parietal layer of Bowman's capsule?
What is the function of the mesangial cells in the glomerulus?
What is the function of the mesangial cells in the glomerulus?
What is the name of the network of blood capillaries surrounded by Bowman's capsule?
What is the name of the network of blood capillaries surrounded by Bowman's capsule?
What is the name of the thin membrane that spans the filtration slits?
What is the name of the thin membrane that spans the filtration slits?
What is the name of the cells that form the inner layer of Bowman's capsule?
What is the name of the cells that form the inner layer of Bowman's capsule?
What is the name of the space between the outer and inner epithelial layers of Bowman's capsule?
What is the name of the space between the outer and inner epithelial layers of Bowman's capsule?
What is the primary function of the proximal convoluted tubule in the nephron?
What is the primary function of the proximal convoluted tubule in the nephron?
What is the effect of antidiuretic hormone (ADH) on the collecting ducts?
What is the effect of antidiuretic hormone (ADH) on the collecting ducts?
What is the histological characteristic of the epithelial cells lining the proximal convoluted tubule?
What is the histological characteristic of the epithelial cells lining the proximal convoluted tubule?
Which segment of the nephron is responsible for ion exchange and regulation of Na+ and K+ concentration?
Which segment of the nephron is responsible for ion exchange and regulation of Na+ and K+ concentration?
What is the function of the juxtaglomerular apparatus?
What is the function of the juxtaglomerular apparatus?
What is the histological characteristic of the epithelial cells lining the descending limb of the loop of Henle?
What is the histological characteristic of the epithelial cells lining the descending limb of the loop of Henle?
What is the primary function of the ascending limb of the loop of Henle?
What is the primary function of the ascending limb of the loop of Henle?
What is the main function of the filtration membrane in the renal corpuscle?
What is the main function of the filtration membrane in the renal corpuscle?
Which structure is responsible for influencing the resorption of sodium ions in the nephron?
Which structure is responsible for influencing the resorption of sodium ions in the nephron?
What is the primary function of the juxtaglomerular apparatus in the nephron?
What is the primary function of the juxtaglomerular apparatus in the nephron?
What is the term for the specialized smooth muscle cells in the afferent arteriole that contain renin in secretory granules?
What is the term for the specialized smooth muscle cells in the afferent arteriole that contain renin in secretory granules?
What is the function of the podocyte filtration slits in the glomerulus?
What is the function of the podocyte filtration slits in the glomerulus?
Which structure is responsible for producing renin in response to falling blood pressure?
Which structure is responsible for producing renin in response to falling blood pressure?
What is the term for the portion of the terminal distal straight tubule adjacent to the renal corpuscle?
What is the term for the portion of the terminal distal straight tubule adjacent to the renal corpuscle?
What is the primary component of the filtration barrier in the glomerulus?
What is the primary component of the filtration barrier in the glomerulus?
What is the function of the mesangial cells in the glomerulus?
What is the function of the mesangial cells in the glomerulus?
Flashcards
Collecting System
Collecting System
Continuation of distal convoluted tubules, descends through medulla.
Ducts
Ducts
Coalesce and increase in size, changing from squamous to cuboidal to columnar.
Papillary Ducts
Papillary Ducts
Terminate at the tip of the renal pyramid.
Collecting Ducts
Collecting Ducts
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Light Cells
Light Cells
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ADH Channels
ADH Channels
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Dark Cells
Dark Cells
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Renal Papilla
Renal Papilla
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Renal Calyx
Renal Calyx
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Ureter Layers
Ureter Layers
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Proximal Convoluted Tubule
Proximal Convoluted Tubule
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Loop of Henle
Loop of Henle
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Distal Convoluted Tubule
Distal Convoluted Tubule
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Renal Corpuscle
Renal Corpuscle
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Glomerulus
Glomerulus
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Bowman's Capsule
Bowman's Capsule
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Podocytes
Podocytes
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Blood-Urine Barrier
Blood-Urine Barrier
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Fenestrated Endothelium
Fenestrated Endothelium
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Glomerular Basement Membrane (GBM)
Glomerular Basement Membrane (GBM)
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Filtration Slits
Filtration Slits
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Simple Cuboidal Epithelium
Simple Cuboidal Epithelium
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Transitional Epithelium
Transitional Epithelium
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Aldosterone
Aldosterone
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ADH (Antidiuretic Hormone)
ADH (Antidiuretic Hormone)
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Mitochondria in Dark Cells
Mitochondria in Dark Cells
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Secretion of H+ or HCO3-
Secretion of H+ or HCO3-
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Microvilli
Microvilli
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Principal and Intercalated Cells
Principal and Intercalated Cells
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Capillaries in Ureter
Capillaries in Ureter
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Function of Proximal Convoluted Tubule
Function of Proximal Convoluted Tubule
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Study Notes
Collecting System
- The collecting system starts in the cortex as a continuation of the distal convoluted tubules and descends through the medulla
- The ducts coalesce and increase in size, with cells changing from squamous to cuboidal to columnar and becoming increasingly stratified
- The ducts terminate at the tip of the renal pyramid as the papillary ducts
Collecting Ducts
- Function: resorb Na+, H2O, transfer K+, regulated by aldosterone and ADH
- Simple cuboidal/columnar epithelium
- Two types of cells: Light cells (Principal cells) and Dark cells (Intercalated cells)
Light Cells
- Also known as Collecting Duct or CD cells
- Principal cells of the system
- Pale staining cells
- Basal infoldings present
- Single primary cilium
- Few short microvilli
- Small, spherical mitochondria
- Possess abundance of ADH-regulated water channels AQP-2, responsible for water permeability of collecting duct
Dark Cells
- Also known as Intercalated cells or IC cells
- Less in number
- Cytoplasm is denser
- Many mitochondria
- No basal infoldings
- Basally located interdigitations with neighboring cells
- Numerous vesicles present in apical cytoplasm
- Secrete Hydrogen (H+) or Bicarbonate (HCO3-) ions
Renal Papilla and Renal Calyx
- Renal papilla: area where collecting ducts terminate
- Renal calyx: funnel-shaped structure that collects urine from the renal papilla
Ureter
- 3 layers in wall:
- Tunica mucosa: transitional epithelium and lamina propria
- Also attached to capillaries
- Supports contraction, phagocytosis, and secretion
Histology of Renal Tubule and Collecting Duct
- Proximal convoluted tubule: simple cuboidal with brush border of microvilli
- Descending limb of Loop of Henle: simple squamous
- Ascending limb of Loop of Henle: simple cuboidal to low columnar
- Distal convoluted tubule and collecting ducts: simple cuboidal composed of principal and intercalated cells with microvilli
Functions of Renal Tubule Segments
- Proximal convoluted tubule: transports majority of recovered water, ions, and glucose from filtrate back to blood
- Loop of Henle: regulates sodium and potassium concentration in response to aldosterone secretion
- Distal convoluted tubule: regulates sodium and potassium concentration in response to aldosterone secretion
Renal Corpuscle
- Glomerulus: network of blood capillaries surrounded by Bowman's capsule
- Bowman's capsule: capsule that surrounds the glomerulus
- Podocytes: complex cells with small foot-like processes (pedicles) that form a fenestrated epithelium around the fenestrated capillaries of the glomerulus
Blood-Urine Barrier
- Filtration membrane composed of:
- Fenestrated endothelium of the glomerulus
- Glomerular basement membrane (GBM)
- Filtration slits of the podocyte
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