Structure-Function Relationship in Specific Proteins

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Questions and Answers

What is the primary function of myoglobin?

  • Act as an enzyme
  • Transport CO2 from tissues to lungs
  • Transport oxygen from the lung to the tissues
  • Muscle stores oxygen (correct)

Which type of proteins have a compact, globular structure and are water soluble?

  • Fibrous proteins
  • Globular proteins (correct)
  • Collagen
  • Myosin

What is the primary function of hemoglobin?

  • Transport oxygen from the lung to the tissues (correct)
  • Muscle stores oxygen
  • Transport CO2 from tissues to lungs
  • Act as a motor protein

What is the role of the heme group in myoglobin and hemoglobin?

<p>Binds oxygen and protects iron from oxidation (C)</p> Signup and view all the answers

What is the main function of hemoglobin?

<p>Transport gases through the blood (C)</p> Signup and view all the answers

What is the quaternary structure of hemoglobin?

<p>Oligomeric protein with 4 polypeptide chains and 4 heme prosthetic groups (C)</p> Signup and view all the answers

What triggers the change in conformation of hemoglobin from T state to R state?

<p>Binding of oxygen to a Hb subunit in the T state (D)</p> Signup and view all the answers

What effect do protons and CO2 have on hemoglobin's affinity for oxygen?

<p>Reduce the affinity of Hb for oxygen (A)</p> Signup and view all the answers

What is the primary function of collagen?

<p>Provide strength in connective tissues (A)</p> Signup and view all the answers

What is the secondary structure of collagen helix?

<p>Left-handed helix with three amino acid residues per turn (C)</p> Signup and view all the answers

What disease is caused by a genetic disorder resulting in fragile bones that break easily?

<p>Osteogenesis imperfecta (C)</p> Signup and view all the answers

What is required for the formation of hydroxyproline in collagen?

<p>Vitamin C (B)</p> Signup and view all the answers

What are the subunits present in myosin?

<p>2 heavy chains and 2 light chains (B)</p> Signup and view all the answers

What type of filament does actin polymerize to form?

<p>F-actin (filamentous actin) (D)</p> Signup and view all the answers

Which type of proteins have a compact, globular structure and are water soluble?

<p>Globular proteins (A)</p> Signup and view all the answers

What is the primary function of myoglobin?

<p>Stores oxygen in muscle (D)</p> Signup and view all the answers

What is the quaternary structure of hemoglobin?

<p>Consists of four subunits (B)</p> Signup and view all the answers

What is the role of the heme group in myoglobin and hemoglobin?

<p>To protect iron from oxidation (D)</p> Signup and view all the answers

What triggers the change in conformation of hemoglobin from T state to R state?

<p>$O_2$ concentration (A)</p> Signup and view all the answers

What is the main function of hemoglobin?

<p>Transport oxygen from the lung to the tissues (B)</p> Signup and view all the answers

What is the quaternary structure of hemoglobin?

<p>Oligomeric protein with 4 polypeptide chains and 4 heme prosthetic groups (A)</p> Signup and view all the answers

What is the main function of collagen?

<p>Resistance to tension in skin, bone, tendon, and teeth (B)</p> Signup and view all the answers

What triggers the change in conformation of hemoglobin from T state to R state?

<p>The binding of O2 to a Hb subunit in the T state (A)</p> Signup and view all the answers

What is required to form hydroxyproline in collagen?

<p>$Vitamin C$ (D)</p> Signup and view all the answers

What is the secondary structure of collagen helix?

<p>$left-handed helix$ (C)</p> Signup and view all the answers

What effect do protons and $CO_2$ have on hemoglobin's affinity for oxygen?

<p>$Reduce the affinity of Hb for oxygen, leading to release of $O_2$ to the tissues$ (B)</p> Signup and view all the answers

What disease is caused by a genetic disorder resulting in fragile bones that break easily?

<p>Osteogenesis imperfecta (D)</p> Signup and view all the answers

What are the subunits present in myosin?

<p>Two heavy chains and two light chains (C)</p> Signup and view all the answers

What type of filament does actin polymerize to form?

<p>Thin filament (F-actin) (B)</p> Signup and view all the answers

What is the primary function of myoglobin?

<p>Transport gases through the blood (A)</p> Signup and view all the answers

Which one of these describes the quaternary structure of hemoglobin?

<p>An oligomeric protein with 4 polypeptide chains and 4 heme prosthetic groups (C)</p> Signup and view all the answers

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Study Notes

Protein Structure and Function

  • Globular proteins have a compact, globular structure and are water soluble.
  • Myoglobin and hemoglobin are examples of globular proteins.

Myoglobin

  • The primary function of myoglobin is to store oxygen in muscles.
  • The heme group in myoglobin plays a crucial role in binding oxygen.

Hemoglobin

  • The primary function of hemoglobin is to transport oxygen from lungs to tissues.
  • The quaternary structure of hemoglobin is a tetramer, consisting of two alpha and two beta subunits.
  • The heme group in hemoglobin plays a crucial role in binding oxygen.
  • The change in conformation of hemoglobin from T state to R state is triggered by the binding of oxygen.
  • The main function of hemoglobin is to transport oxygen from lungs to tissues.
  • Protons and CO2 decrease hemoglobin's affinity for oxygen.

Collagen

  • The primary function of collagen is to provide structure and strength to connective tissue.
  • The secondary structure of collagen helix is a triple helix.
  • Hydroxyproline is required for the formation of collagen, and vitamin C is necessary for its formation.
  • Osteogenesis imperfecta is a disease caused by a genetic disorder resulting in fragile bones that break easily.

Muscle Proteins

  • Myosin has two subunits: heavy chain and light chain.
  • Actin polymerizes to form microfilaments.

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