31 Questions
What is the primary function of myoglobin?
Muscle stores oxygen
Which type of proteins have a compact, globular structure and are water soluble?
Globular proteins
What is the primary function of hemoglobin?
Transport oxygen from the lung to the tissues
What is the role of the heme group in myoglobin and hemoglobin?
Binds oxygen and protects iron from oxidation
What is the main function of hemoglobin?
Transport gases through the blood
What is the quaternary structure of hemoglobin?
Oligomeric protein with 4 polypeptide chains and 4 heme prosthetic groups
What triggers the change in conformation of hemoglobin from T state to R state?
Binding of oxygen to a Hb subunit in the T state
What effect do protons and CO2 have on hemoglobin's affinity for oxygen?
Reduce the affinity of Hb for oxygen
What is the primary function of collagen?
Provide strength in connective tissues
What is the secondary structure of collagen helix?
Left-handed helix with three amino acid residues per turn
What disease is caused by a genetic disorder resulting in fragile bones that break easily?
Osteogenesis imperfecta
What is required for the formation of hydroxyproline in collagen?
Vitamin C
What are the subunits present in myosin?
2 heavy chains and 2 light chains
What type of filament does actin polymerize to form?
F-actin (filamentous actin)
Which type of proteins have a compact, globular structure and are water soluble?
Globular proteins
What is the primary function of myoglobin?
Stores oxygen in muscle
What is the quaternary structure of hemoglobin?
Consists of four subunits
What is the role of the heme group in myoglobin and hemoglobin?
To protect iron from oxidation
What triggers the change in conformation of hemoglobin from T state to R state?
$O_2$ concentration
What is the main function of hemoglobin?
Transport oxygen from the lung to the tissues
What is the quaternary structure of hemoglobin?
Oligomeric protein with 4 polypeptide chains and 4 heme prosthetic groups
What is the main function of collagen?
Resistance to tension in skin, bone, tendon, and teeth
What triggers the change in conformation of hemoglobin from T state to R state?
The binding of O2 to a Hb subunit in the T state
What is required to form hydroxyproline in collagen?
$Vitamin C$
What is the secondary structure of collagen helix?
$left-handed helix$
What effect do protons and $CO_2$ have on hemoglobin's affinity for oxygen?
$Reduce the affinity of Hb for oxygen, leading to release of $O_2$ to the tissues$
What disease is caused by a genetic disorder resulting in fragile bones that break easily?
Osteogenesis imperfecta
What are the subunits present in myosin?
Two heavy chains and two light chains
What type of filament does actin polymerize to form?
Thin filament (F-actin)
What is the primary function of myoglobin?
Transport gases through the blood
Which one of these describes the quaternary structure of hemoglobin?
An oligomeric protein with 4 polypeptide chains and 4 heme prosthetic groups
Study Notes
Protein Structure and Function
- Globular proteins have a compact, globular structure and are water soluble.
- Myoglobin and hemoglobin are examples of globular proteins.
Myoglobin
- The primary function of myoglobin is to store oxygen in muscles.
- The heme group in myoglobin plays a crucial role in binding oxygen.
Hemoglobin
- The primary function of hemoglobin is to transport oxygen from lungs to tissues.
- The quaternary structure of hemoglobin is a tetramer, consisting of two alpha and two beta subunits.
- The heme group in hemoglobin plays a crucial role in binding oxygen.
- The change in conformation of hemoglobin from T state to R state is triggered by the binding of oxygen.
- The main function of hemoglobin is to transport oxygen from lungs to tissues.
- Protons and CO2 decrease hemoglobin's affinity for oxygen.
Collagen
- The primary function of collagen is to provide structure and strength to connective tissue.
- The secondary structure of collagen helix is a triple helix.
- Hydroxyproline is required for the formation of collagen, and vitamin C is necessary for its formation.
- Osteogenesis imperfecta is a disease caused by a genetic disorder resulting in fragile bones that break easily.
Muscle Proteins
- Myosin has two subunits: heavy chain and light chain.
- Actin polymerizes to form microfilaments.
Explore the structure-function relationship in specific proteins with this quiz, focusing on globular proteins like hemoglobin and myoglobin, and fibrous proteins such as collagen, myosin, and actin fibers.
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