Podcast
Questions and Answers
What is the location of ATP synthase?
What is the location of ATP synthase?
Which part of ATP synthase contains the catalytic subunits?
Which part of ATP synthase contains the catalytic subunits?
What drives the rotation of the c-ring in ATP synthase?
What drives the rotation of the c-ring in ATP synthase?
What is the role of the gamma spindle in ATP synthase?
What is the role of the gamma spindle in ATP synthase?
Signup and view all the answers
In which conformational state do ATP and Pi bind to the beta subunit of ATP synthase?
In which conformational state do ATP and Pi bind to the beta subunit of ATP synthase?
Signup and view all the answers
What causes the confirmational change in the alpha beta hexamer of ATP synthase?
What causes the confirmational change in the alpha beta hexamer of ATP synthase?
Signup and view all the answers
Which structure remains embedded in the mitochondrial membrane in ATP synthase?
Which structure remains embedded in the mitochondrial membrane in ATP synthase?
Signup and view all the answers
How does H+ cause the c-ring in ATP synthase to rotate?
How does H+ cause the c-ring in ATP synthase to rotate?
Signup and view all the answers
What is the role of the gamma subunit in ATP synthesis?
What is the role of the gamma subunit in ATP synthesis?
Signup and view all the answers
How does the ATP synthesis cycle progress from the tight stage?
How does the ATP synthesis cycle progress from the tight stage?
Signup and view all the answers
How many protons are required for each confirmational change in the ATP synthase complex?
How many protons are required for each confirmational change in the ATP synthase complex?
Signup and view all the answers
From which stage of the ATP synthesis cycle does the gamma spindle turn via energy from the proton gradient?
From which stage of the ATP synthesis cycle does the gamma spindle turn via energy from the proton gradient?
Signup and view all the answers
How many ATP molecules are produced in total from aerobic glucose utilization involving glycolysis and the TCA cycle?
How many ATP molecules are produced in total from aerobic glucose utilization involving glycolysis and the TCA cycle?
Signup and view all the answers
Where does the adenine nucleotide translocase swap ADP and ATP from one side of the membrane to another?
Where does the adenine nucleotide translocase swap ADP and ATP from one side of the membrane to another?
Signup and view all the answers
What happens if the proton motive force has not built up in the mitochondria during oxidative phosphorylation?
What happens if the proton motive force has not built up in the mitochondria during oxidative phosphorylation?
Signup and view all the answers
Which enzyme is an important site of control in oxidative phosphorylation?
Which enzyme is an important site of control in oxidative phosphorylation?
Signup and view all the answers
What is the total number of ATP molecules produced from aerobic glucose utilization involving glycolysis and the TCA cycle?
What is the total number of ATP molecules produced from aerobic glucose utilization involving glycolysis and the TCA cycle?
Signup and view all the answers
How many protons are required for each confirmational change in the ATP synthase complex?
How many protons are required for each confirmational change in the ATP synthase complex?
Signup and view all the answers
What is the role of the gamma subunit in ATP synthesis?
What is the role of the gamma subunit in ATP synthesis?
Signup and view all the answers
What happens if the proton motive force has not built up in the mitochondria during oxidative phosphorylation?
What happens if the proton motive force has not built up in the mitochondria during oxidative phosphorylation?
Signup and view all the answers
Which enzyme is an important site of control in oxidative phosphorylation?
Which enzyme is an important site of control in oxidative phosphorylation?
Signup and view all the answers
Explain the molecular structure of the F1F0-ATPase and its location within the mitochondria.
Explain the molecular structure of the F1F0-ATPase and its location within the mitochondria.
Signup and view all the answers
Describe the process by which H+ passage through F0 drives the rotation of the c-ring in the mitochondrial membrane.
Describe the process by which H+ passage through F0 drives the rotation of the c-ring in the mitochondrial membrane.
Signup and view all the answers
Explain the significance of the three conformational states of the beta subunit in the ATP synthase complex.
Explain the significance of the three conformational states of the beta subunit in the ATP synthase complex.
Signup and view all the answers
Discuss the role of the gamma spindle in connecting F0 to F1 and its importance in ATP synthesis.
Discuss the role of the gamma spindle in connecting F0 to F1 and its importance in ATP synthesis.
Signup and view all the answers
Explain how the alpha beta hexamer in ATP synthase facilitates the conversion of ADP and Pi to ATP.
Explain how the alpha beta hexamer in ATP synthase facilitates the conversion of ADP and Pi to ATP.
Signup and view all the answers
The gamma subunit in ATP synthase converts ADP and Pi into ATP by binding to them tightly.
The gamma subunit in ATP synthase converts ADP and Pi into ATP by binding to them tightly.
Signup and view all the answers
The alpha/beta hexamer turns but the gamma spindle remains stationary during the ATP synthesis cycle.
The alpha/beta hexamer turns but the gamma spindle remains stationary during the ATP synthesis cycle.
Signup and view all the answers
Each confirmational change in the ATP synthase complex requires 2 protons.
Each confirmational change in the ATP synthase complex requires 2 protons.
Signup and view all the answers
More ATP is produced from glycolysis than from oxidative phosphorylation.
More ATP is produced from glycolysis than from oxidative phosphorylation.
Signup and view all the answers
ATP synthesis is tightly controlled and linked to the production of NADH from electron transport chain.
ATP synthesis is tightly controlled and linked to the production of NADH from electron transport chain.
Signup and view all the answers
ATP synthase is also known as F1F0-ATPase.
ATP synthase is also known as F1F0-ATPase.
Signup and view all the answers
The F1 portion of ATP synthase contains the proton channel.
The F1 portion of ATP synthase contains the proton channel.
Signup and view all the answers
The c-ring in ATP synthase rotates clockwise when H+ enters from the a-half channel.
The c-ring in ATP synthase rotates clockwise when H+ enters from the a-half channel.
Signup and view all the answers
The gamma spindle connects the F0 portion to the F1 portion in ATP synthase.
The gamma spindle connects the F0 portion to the F1 portion in ATP synthase.
Signup and view all the answers
There are 4 confirmational states of the beta subunits in ATP synthase during the conversion of ADP to ATP.
There are 4 confirmational states of the beta subunits in ATP synthase during the conversion of ADP to ATP.
Signup and view all the answers
