Sterilization and Sealing of Ampoules

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Questions and Answers

What is essential for handling sterile products?

  • A pharmacist or technician with experience in a hospital setting
  • A pharmacist or technician with a graduate degree
  • A pharmacist or technician with basic training
  • A pharmacist or technician with proper training in aseptic technique (correct)

What is the primary requirement for a pharmacist or technician working with sterile products?

  • Having experience in a retail pharmacy setting
  • Having a master's degree in pharmacy
  • Having proper training in aseptic technique and sterile product information (correct)
  • Having a certification in pharmacology

What is the main goal of proper training in aseptic technique and sterile product information?

  • To improve customer satisfaction
  • To increase efficiency in the pharmacy
  • To ensure the quality and safety of sterile products (correct)
  • To reduce costs associated with product waste

Who is responsible for ensuring the quality and safety of sterile products?

<p>The pharmacist or technician (C)</p> Signup and view all the answers

What is the consequence of improper training in aseptic technique and sterile product information?

<p>Contamination of sterile products (A)</p> Signup and view all the answers

What is the purpose of testing sealed ampoules by fusion?

<p>To verify the hermetic seal was obtained (A)</p> Signup and view all the answers

What is the first step in testing sealed ampoules by fusion?

<p>Ampoules are immersed in a dye solution with their necks down in a vacuum desiccator (C)</p> Signup and view all the answers

Why are the ampoules placed with their necks down in a vacuum desiccator?

<p>To ensure the dye solution reaches the seal (C)</p> Signup and view all the answers

What is one of the factors that influence the amount of adsorption?

<p>Concentration (D)</p> Signup and view all the answers

What is the purpose of the dye solution in testing sealed ampoules?

<p>To detect any leaks or imperfections in the seal (D)</p> Signup and view all the answers

What is another factor that affects the amount of adsorption?

<p>Surface area of the tubing (B)</p> Signup and view all the answers

Which of the following is not a factor that affects the amount of adsorption?

<p>Gravity (C)</p> Signup and view all the answers

What is the environment in which the ampoules are tested?

<p>A vacuum desiccator (C)</p> Signup and view all the answers

What can be increased to increase the amount of adsorption?

<p>Surface area of the tubing (B)</p> Signup and view all the answers

What is the most significant factor that affects the amount of adsorption?

<p>Concentration (B)</p> Signup and view all the answers

What is the layer of the eye that lies between the sclera and the retina?

<p>Choroids (D)</p> Signup and view all the answers

What is the main function of the blood vessels in the choroids?

<p>To provide nourishment to the outer layers of the retina (B)</p> Signup and view all the answers

Which of the following layers is in contact with the choroids?

<p>Sclera (D)</p> Signup and view all the answers

What is the purpose of the choroids in the eye?

<p>To supply oxygen and nutrients to the retina (C)</p> Signup and view all the answers

Which of the following is NOT a function of the choroids?

<p>Regulating the amount of light entering the eye (D)</p> Signup and view all the answers

What can affect the pH of a product?

<p>Product degradation, diffusion of gases, and container effects (A)</p> Signup and view all the answers

What type of compounds are commonly used in pharmaceutical products?

<p>Weak base and salt of a weak base or weak acid and salt of a weak acid (D)</p> Signup and view all the answers

Why is it important to consider the effect of gases on a product's pH?

<p>Gases can react with the product, altering its pH (B)</p> Signup and view all the answers

What is a potential consequence of container and stopper effects on a product's pH?

<p>Altered product pH (D)</p> Signup and view all the answers

What is the main concern related to the diffusion of gases through the closure?

<p>Changes in the product's pH (C)</p> Signup and view all the answers

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Study Notes

Sterile Product Preparation

  • A carefully trained pharmacist or technician with proper training in aseptic technique and sterile product information is necessary.

Factors Affecting Adsorption

  • The amount of adsorption depends on several factors, including:
    • Concentration
    • Surface area of the tubing

Sealed Ampoules Testing

  • Sealed ampoules by fusion should be tested to ensure that a hermetic seal was obtained.
  • The testing process involves:
    • Immersing ampoules in a dye solution with their necks down in a vacuum desiccator.

Anatomy of the Eye

  • The choroid is the second layer of the eye, located between the sclera and the retina.
  • The choroid contains the blood vessels that provide nourishment to the outer layers of the retina.

Factors Influencing pH

  • pH is influenced by several factors, including:
    • Product degradation
    • Diffusion of gases through the closure
    • Effect of gases in the product
    • Container and stopper effects

pH Buffering Agents

  • Weak base and salt of a weak base or weak acid and salt of a weak acid are normally used as pH buffering agents, such as:
    • Acetates
    • Citrates
    • Phosphates

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