Sterile Compounding Flashcards

Sterile Compounding and Aseptic Technique

• Ante-room: An ISO Class 8 or cleaner area with fixed walls and doors, essential for preparation and transition in sterile compounding.

• Compounding Conditions for Hazardous Medications: Hazardous medications must be compounded in a negative pressure environment, not a positive pressure room.

• Laminar Airflow Workbench (LAFW): Work should be conducted within 6 inches of the edge to ensure proper airflow and contamination control.

• Airflow in Compounding Areas: LAFWs provide horizontal or vertical unidirectional HEPA-filtered airflow, critical for maintaining aseptic conditions.

• Syringe Filling Guidelines: When drawing up solutions, the volume should not exceed 80% of the total syringe capacity to prevent contamination and ensure accuracy.

• Vial Withdrawal Technique: Before withdrawing a solution, inject air equal to the volume that will be extracted to avoid creating a vacuum in the vial.

• Class II Biological Safety Cabinet (BSC): A ventilated cabinet designed for hazardous compounding with open front and inward and downward unidirectional HEPA-filtered airflow.

• Ampule Handling: Must filter solutions withdrawn from ampules prior to injection to remove potential glass particles and ensure safety.

• Needle Insertion Angle: When inserting a needle into a vial, maintain a bevel up position at a 45-degree angle to facilitate smooth penetration and reduce contamination risk.

• Buffer Room: An area classified as ISO Class 7 or cleaner with fixed walls and doors, used for preparing sterile products and compounding hazardous materials.