WK 4: Stem Cells
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Questions and Answers

What is the main goal of targeting cancer stem cells according to the cancer stem cell hypothesis?

  • To induce quiescence in proliferating stem cells
  • To prevent cancer recurrence (correct)
  • To increase the frequency of cancer stem cells
  • To stimulate tissue homeostasis

    • Which of the following is NOT an application of stem cell research?

  • Improving tissue engineering
  • Understanding human tissue development
  • Creating genetically modified organisms (correct)
  • Developing new drugs

    • What type of stem cells are responsible for maintaining tissue homeostasis?

  • Tissue-specific stem cells (correct)
  • Proliferating stem cells
  • Quiescent stem cells
  • Progenitor cells

    • What is the main advantage of using pluripotent stem cells in drug discovery?

    <p>They can differentiate into any cell type</p> Signup and view all the answers

    What is the main concern with unproven stem cell procedures?

    <p>They are not evidence-based</p> Signup and view all the answers

    What is the main goal of regenerative medicine using stem cells?

    <p>To stimulate cells and tissues to re-grow or repair</p> Signup and view all the answers

    What is the primary characteristic of pluripotent stem cells that distinguishes them from tissue-specific stem cells?

    <p>Ability to differentiate into multiple cell types</p> Signup and view all the answers

    What is the role of tissue-specific stem cells in tissue homeostasis?

    <p>To maintain tissue health and function</p> Signup and view all the answers

    What is a concern regarding the clinical application of emerging stem cell therapies?

    <p>They have not been proven to be safe and effective</p> Signup and view all the answers

    What is a characteristic of symmetric self-renewal cell division in stem cells?

    <p>Producing two identical daughter cells</p> Signup and view all the answers

    What is a key difference between pluripotent stem cells and tissue-specific stem cells?

    <p>Ability to differentiate into multiple cell types</p> Signup and view all the answers

    What is the main issue with unproven stem cell procedures?

    <p>They have not been tested for safety and efficacy</p> Signup and view all the answers

    What percentage of completed trials had published results?

    <p>46%</p> Signup and view all the answers

    What percentage of trials reported positive outcomes?

    <p>63.7%</p> Signup and view all the answers

    What is a characteristic of pluripotent stem cells?

    <p>They can generate any cell type of the body.</p> Signup and view all the answers

    Why is it important for patients to be educated about stem cell tourism?

    <p>So they can make informed decisions about unproven treatments.</p> Signup and view all the answers

    What is the purpose of the International Society for Stem Cell Research?

    <p>To provide information to help patients evaluate stem cell treatment claims.</p> Signup and view all the answers

    What is a concern about stem cell tourism clinics?

    <p>None of them have reported results.</p> Signup and view all the answers

    What is the primary limitation of using tissue-restricted stem cells for treatment?

    <p>They can only make one or a few specialized cell types</p> Signup and view all the answers

    What is the timeframe for generating and purifying differentiated cell types of interest?

    <p>1 to 3 months</p> Signup and view all the answers

    What is a characteristic of pluripotent stem cells?

    <p>They can make all the cells in the body</p> Signup and view all the answers

    What characteristic do tissue-specific stem cells typically exhibit?

    <p>Extensive proliferative potential</p> Signup and view all the answers

    What is a concern with commercial provision of unproven stem cell therapies?

    <p>Lack of regulation</p> Signup and view all the answers

    What is the primary role of the stem cell niche in tissue homeostasis?

    <p>To regulate the stem cell behavior</p> Signup and view all the answers

    Why are induced pluripotent stem cells considered a promising treatment option for acute injuries?

    <p>They are not suitable for acute injuries, such as spinal injury</p> Signup and view all the answers

    What is a key feature distinguishing pluripotent stem cells from tissue-specific stem cells?

    <p>Ability to generate cells of multiple tissues</p> Signup and view all the answers

    What is the approximate frequency of hematopoietic stem cells in bone marrow cells?

    <p>1 in 100,000</p> Signup and view all the answers

    What is a potential application of stem cell research in ocular therapies?

    <p>Treatment of both adult and childhood cataracts</p> Signup and view all the answers

    What is a principle guiding the clinical application of human pluripotent stem cells?

    <p>The 3R principle</p> Signup and view all the answers

    What is the primary role of tissue-specific stem cells in maintaining tissue homeostasis?

    <p>To maintain tissue homeostasis</p> Signup and view all the answers

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