Stem Cell Differentiation

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Questions and Answers

What term was used in ancient China to describe anything essential for existence?

  • Essentiality
  • Lifeblood (correct)
  • Vitality
  • Necessity

What did ancient Western civilizations believe circulated in the blood as per the text?

  • Healing energy
  • Evil spirits (correct)
  • Physical strength
  • Life force

What was the approach of ancient Chinese physicians towards bleeding patients to cure disease?

  • Highly effective treatment
  • Mandatory treatment
  • Commonly practiced treatment
  • Not a standard form of treatment (correct)

Who described the circulation of blood through the heart and blood vessels long before William Harvey?

<p>Ancient Chinese physicians (A)</p> Signup and view all the answers

What is the primary reason Johann Muehlegg was expelled and stripped of his gold medal at the 2002 Salt Lake City Winter Olympics?

<p>He tested positive for a performance-enhancing chemical that increased the oxygen-carrying capacity of his blood (A)</p> Signup and view all the answers

Which blood component is responsible for transporting oxygen from the lungs to the tissues?

<p>Red blood cells (C)</p> Signup and view all the answers

What is the function of platelets in the blood?

<p>Coagulation to prevent blood loss in damaged vessels (A)</p> Signup and view all the answers

Which type of white blood cell is responsible for specific immune responses directed against invaders?

<p>Lymphocytes (C)</p> Signup and view all the answers

What is the primary function of plasma proteins in the blood?

<p>Maintaining colloid osmotic pressure and carrying various substances (D)</p> Signup and view all the answers

Which cellular element in the blood plays a key role in defending the body against foreign invaders such as parasites, bacteria, and viruses?

<p>White blood cells (C)</p> Signup and view all the answers

What is the main function of neutrophils, monocytes, and macrophages in the body?

<p>Engulfing and ingesting foreign particles such as bacteria (D)</p> Signup and view all the answers

What is the term used for cell fragments that have split off a relatively large parent cell known as a megakaryocyte?

<p>Thrombocytes (D)</p> Signup and view all the answers

Which types of white blood cells contain cytoplasmic inclusions that give them a granular appearance?

<p>Basophils, eosinophils, and neutrophils (C)</p> Signup and view all the answers

What are tissue basophils called?

<p>Mast cells (A)</p> Signup and view all the answers

What is the primary role of monocytes after they leave the circulation and enter the tissues?

<p>Developing into macrophages (C)</p> Signup and view all the answers

What was Muehlegg's sport at the 2002 Salt Lake City Winter Olympics?

<p>Cross-country skiing (C)</p> Signup and view all the answers

What did Galen of Pergamum advocate as a treatment for many disorders?

<p>Bloodletting (C)</p> Signup and view all the answers

What was the percentage of total body weight that constituted the total blood volume in a 70-kg man?

<p>4% (A)</p> Signup and view all the answers

In the plasma, what accounts for about 92% of its weight?

<p>Water (A)</p> Signup and view all the answers

Which protein makes up about 60% of the total proteins in the plasma?

<p>Albumins (C)</p> Signup and view all the answers

What makes the osmotic pressure of the blood higher than that of the interstitial fluid?

<p>Plasma proteins (C)</p> Signup and view all the answers

What is responsible for carrying material from one part of the body to another?

<p>Plasma (C)</p> Signup and view all the answers

Who synthesizes and secretes some globulins, known as immunoglobulins or antibodies?

<p>Specialized blood cells (D)</p> Signup and view all the answers

What component of blood accounts for about 2 liters in a 5-liter blood volume?

<p>Red blood cells (D)</p> Signup and view all the answers

What component of blood participates in defense against foreign invaders?

<p>Plasma (C)</p> Signup and view all the answers

What practice did leeches reportedly help ancient Indians distinguish between healthy and infected blood?

<p>Bloodletting (D)</p> Signup and view all the answers

What are cytokines?

<p>Peptides or proteins released from one cell that affect the growth and development of blood cells (A)</p> Signup and view all the answers

What does the name 'interleukin' signify?

<p>Cytokines released by white blood cells to act on other white blood cells (A)</p> Signup and view all the answers

Which cytokine regulates the growth and maturation of megakaryocytes?

<p>Thrombopoietin (C)</p> Signup and view all the answers

What stimulates the production of erythropoietin (EPO)?

<p>Low oxygen levels in the tissues (B)</p> Signup and view all the answers

What is the role of thrombopoietin (TPO) in the body?

<p>Stimulate platelet production (D)</p> Signup and view all the answers

How did scientists identify erythropoietin (EPO)?

<p>By isolating and cloning the gene for it after identifying its amino acid sequence (D)</p> Signup and view all the answers

What is the primary source of thrombopoietin (TPO) in the body?

<p>Liver (C)</p> Signup and view all the answers

What is responsible for stimulating EPO synthesis and release?

<p>Hypoxia (B)</p> Signup and view all the answers

What are colony-stimulating factors?

<p>Molecules that affect the growth and development of neutrophils (C)</p> Signup and view all the answers

What are interleukins?

<p>Cytokines released by white blood cells to act on other white blood cells (D)</p> Signup and view all the answers

What is a characteristic of EPO that caused a delay in its isolation?

<p>It is made on demand and not stored like classic peptide hormones (A)</p> Signup and view all the answers

Where are uncommitted hematopoietic stem cells primarily found?

<p>Bone marrow (B)</p> Signup and view all the answers

At birth, which organ and/or tissue no longer produce blood cells?

<p>Liver and spleen (C)</p> Signup and view all the answers

What makes active bone marrow appear red in color?

<p>Abundance of red blood cells (A)</p> Signup and view all the answers

Where does hematopoiesis occur in adults?

<p>Pelvis and spine (A)</p> Signup and view all the answers

What is the primary source of hematopoietic stem cells for transplants in patients with hematological diseases?

<p>Bone marrow (C)</p> Signup and view all the answers

What type of cells differentiate into red blood cells, lymphocytes, other white blood cells, and megakaryocytes?

<p>Progenitor cells (A)</p> Signup and view all the answers

Which part of the body can resume blood cell production in times of need?

<p>Inactive marrow (D)</p> Signup and view all the answers

Why is umbilical cord blood considered a rich source of hematopoietic stem cells?

<p>Presence of uncommitted stem cells (B)</p> Signup and view all the answers

What characterizes the life span of white blood cells in comparison to red blood cells?

<p>Shorter life span (C)</p> Signup and view all the answers

Where does blood synthesis primarily spread to as the embryo develops?

<p>Bone marrow (D)</p> Signup and view all the answers

What is the estimated proportion of uncommitted stem cells in the bone marrow?

<p>1 out of every 100,000 cells (A)</p> Signup and view all the answers

What drives scientists to isolate and grow uncommitted hematopoietic stem cells?

<p>To use as replacements in patients with damaged stem cells (C)</p> Signup and view all the answers

What is the primary function of erythropoietin (EPO)?

<p>Controlling red blood cell synthesis (A)</p> Signup and view all the answers

Which cells primarily produce erythropoietin (EPO)?

<p>Kidney cells (B)</p> Signup and view all the answers

What is the main role of colony-stimulating factors (CSFs) in leukopoiesis?

<p>Promoting leukocyte production and development (A)</p> Signup and view all the answers

What is the fascinating aspect of leukopoiesis mentioned in the text?

<p>The regulation of leukocyte development by existing white blood cells (A)</p> Signup and view all the answers

What is the purpose of differential white cell count in clinical diagnosis?

<p>To assess the relative proportions of different types of leukocytes in the circulation (D)</p> Signup and view all the answers

What is the primary influence of thrombopoietin (TPO) on blood cell production?

<p>Controlling platelet production and development (D)</p> Signup and view all the answers

What do cytokines released by active leukocytes fighting bacterial infections stimulate?

<p>Production of additional neutrophils and monocytes (C)</p> Signup and view all the answers

What is one of the key roles of cytokines linked to hematopoiesis?

<p>Mobilizing hematopoietic stem cells (D)</p> Signup and view all the answers

What is the distinguishing feature of erythropoietin (EPO) compared to peptide hormones?

<p>It is primarily made on demand rather than stored in vesicles like peptide hormones (D)</p> Signup and view all the answers

What is the primary source of thrombopoietin (TPO) in the body?

<p>Liver (D)</p> Signup and view all the answers

What happens once a leukocyte matures?

<p>It loses its ability to undergo mitosis (D)</p> Signup and view all the answers

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