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Questions and Answers
What is the primary target of statins in cholesterol synthesis?
What is the primary target of statins in cholesterol synthesis?
- Plasma LDL
- SREBP2
- LDL receptor
- HMG-CoA reductase (correct)
What is the consequence of inhibiting HMG-CoA reductase?
What is the consequence of inhibiting HMG-CoA reductase?
- Decrease in LDL receptor expression
- Increase in cellular cholesterol concentration
- Transient, modest decrease in cellular cholesterol concentration (correct)
- Activation of SREBP2
What is the role of SREBP2 in response to decreased cholesterol concentration?
What is the role of SREBP2 in response to decreased cholesterol concentration?
- Activates HMG-CoA reductase
- Increases plasma LDL-cholesterol concentration
- Down-regulates expression of the gene encoding the LDL receptor
- Up-regulates expression of the gene encoding the LDL receptor (correct)
Where are approximately 70% of LDL receptors expressed?
Where are approximately 70% of LDL receptors expressed?
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What is the clinical significance of statins in reducing mortality after a myocardial infarction?
What is the clinical significance of statins in reducing mortality after a myocardial infarction?
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