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Statins and Cholesterol Synthesis Quiz
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Statins and Cholesterol Synthesis Quiz

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Questions and Answers

What is the primary target of statins in cholesterol synthesis?

  • Plasma LDL
  • SREBP2
  • LDL receptor
  • HMG-CoA reductase (correct)

    • What is the consequence of inhibiting HMG-CoA reductase?

  • Decrease in LDL receptor expression
  • Increase in cellular cholesterol concentration
  • Transient, modest decrease in cellular cholesterol concentration (correct)
  • Activation of SREBP2

    • What is the role of SREBP2 in response to decreased cholesterol concentration?

  • Activates HMG-CoA reductase
  • Increases plasma LDL-cholesterol concentration
  • Down-regulates expression of the gene encoding the LDL receptor
  • Up-regulates expression of the gene encoding the LDL receptor (correct)

    • Where are approximately 70% of LDL receptors expressed?

    <p>Hepatocytes</p> Signup and view all the answers

    What is the clinical significance of statins in reducing mortality after a myocardial infarction?

    <p>Secondary prevention</p> Signup and view all the answers

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