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Statins and Cholesterol Synthesis Quiz

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Questions and Answers

What is the primary target of statins in cholesterol synthesis?

Plasma LDL

SREBP2

LDL receptor

HMG-CoA reductase (correct)

What is the consequence of inhibiting HMG-CoA reductase?

Decrease in LDL receptor expression

Increase in cellular cholesterol concentration

Transient, modest decrease in cellular cholesterol concentration (correct)

Activation of SREBP2

What is the role of SREBP2 in response to decreased cholesterol concentration?

Activates HMG-CoA reductase

Increases plasma LDL-cholesterol concentration

Down-regulates expression of the gene encoding the LDL receptor

Up-regulates expression of the gene encoding the LDL receptor (correct)

Where are approximately 70% of LDL receptors expressed?

<p>Hepatocytes</p> Signup and view all the answers

What is the clinical significance of statins in reducing mortality after a myocardial infarction?

<p>Secondary prevention</p> Signup and view all the answers

Statins and Cholesterol Synthesis Quiz

Choose a study mode

Podcast

Questions and Answers

What is the primary target of statins in cholesterol synthesis?

What is the consequence of inhibiting HMG-CoA reductase?

What is the role of SREBP2 in response to decreased cholesterol concentration?

Where are approximately 70% of LDL receptors expressed?

What is the clinical significance of statins in reducing mortality after a myocardial infarction?

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