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Questions and Answers
What is the main effect of MOA (various) on stored triglycerides in adipose tissue?
What is the main effect of MOA (various) on stored triglycerides in adipose tissue?
- Convert lipids into glucose
- No effect on lipolysis
- Increase lipolysis
- Decrease lipolysis (correct)
What is the major side effect of Niacin?
What is the major side effect of Niacin?
- Flushing and GI distress (correct)
- Nausea
- Headache
- Dizziness
What is the impact of R1 in Fibric Acids derivatives on oral absorption?
What is the impact of R1 in Fibric Acids derivatives on oral absorption?
- It helps in metabolism of drugs
- It has no effect on oral absorption
- It increases oral absorption (correct)
- It decreases oral absorption
What is the chemical name of the active anionic form that gives Fibric Acids their name?
What is the chemical name of the active anionic form that gives Fibric Acids their name?
What is the enzyme targeted by statins to decrease cholesterol?
What is the enzyme targeted by statins to decrease cholesterol?
What is the primary mechanism of action of fibrates like propyl group?
What is the primary mechanism of action of fibrates like propyl group?
What is the consequence of R2 being highly protein bound and displacing anticoagulants and sulfonylureas?
What is the consequence of R2 being highly protein bound and displacing anticoagulants and sulfonylureas?
What is the coenzyme required by HMGR for the conversion of HMG-CoA to Mevalonic acid?
What is the coenzyme required by HMGR for the conversion of HMG-CoA to Mevalonic acid?
Which enzyme metabolizes fluvastatin?
Which enzyme metabolizes fluvastatin?
What inhibits CYP3A4, a key enzyme for metabolizing several statins?
What inhibits CYP3A4, a key enzyme for metabolizing several statins?
Which statin is resistant to CYP3A4 and is oxidized in the gut/liver?
Which statin is resistant to CYP3A4 and is oxidized in the gut/liver?
Why are lipophilic groups important for the transport of drug molecules into the liver?
Why are lipophilic groups important for the transport of drug molecules into the liver?
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