Statics: Equilibrium and Reactions

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Questions and Answers

Which of the following antacids carries an increased risk of fluid retention as an adverse effect?

  • Calcium carbonate
  • Sodium bicarbonate (correct)
  • Magnesium hydroxide
  • Aluminum hydroxide

Cimetidine, an H-2 receptor antagonist, has which notable side effect that necessitates cautious prescribing, especially in the elderly?

  • Reduced bone density
  • Increased appetite
  • Confusion (correct)
  • Exacerbation of GERD symptoms

Proton pump inhibitors (PPIs) are associated with which of the following adverse effects that requires monitoring for long-term use?

  • Decreased appetite
  • Increased saliva production
  • Gastric hyperacidity
  • Bone loss and fractures (correct)

Which of these medications used to control acid production is contraindicated during pregnancy?

<p>Misoprostol (D)</p> Signup and view all the answers

Which of the following best describes the most important instruction to provide patients taking antacids for PUD, gastritis, gastric hypersecretory, or heartburn?

<p>Take it at least 1-2 hours after other medications. (A)</p> Signup and view all the answers

Which of the following statements regarding the use of scopolamine as an antiemetic is most accurate?

<p>It has additive drying effects when used with antihistamines and antidepressants. (D)</p> Signup and view all the answers

In a patient prescribed diphenhydramine as an antiemetic, what potential interaction should be given special consideration?

<p>Increased CNS depressant effects with opioids, hypnotics, and alcohol (C)</p> Signup and view all the answers

When administering prochlorperazine, an antidopaminergic antiemetic, which adverse effect should prompt immediate intervention?

<p>Neuroleptic malignant syndrome (B)</p> Signup and view all the answers

Metoclopramide is prescribed as a prokinetic agent, what condition would be a contraindication for this medication?

<p>Seizures (C)</p> Signup and view all the answers

Which of the following is the most important consideration when prescribing antiemetic medications to manage nausea and vomiting?

<p>The underlying cause of the nausea and vomiting (C)</p> Signup and view all the answers

Which of the following is the correct antidote to reverse the adverse effects associated with bethanechol overdose?

<p>Atropine (B)</p> Signup and view all the answers

Anticholinergics like oxybutynin are prescribed to treat urinary frequency, urgency, and urge incontinence, but which of the following conditions would be a contraindication for this medication?

<p>Glaucoma (D)</p> Signup and view all the answers

A patient taking phenazopyridine should receive comprehensive education, including which of the following considerations?

<p>Do not break, crush or chew the tablet (B)</p> Signup and view all the answers

C. difficile or infectious diarrhea is a contraindication of which of the following medications?

<p>Diphenoxylate with atropine (D)</p> Signup and view all the answers

Which of the following instructions regarding bulk-forming laxatives is most important for the safe use of this medication?

<p>Take the medication with 8oz of water to facilitate proper absorption and prevent obstruction. (B)</p> Signup and view all the answers

What rationale supports the monitoring of blood pressure when initiating alpha-1 adrenergic blockers, such as tamsulosin, in male patients?

<p>To monitor orthostatic hypotension (D)</p> Signup and view all the answers

Why are women of childbearing age advised not to handle finasteride tablets used for BPH?

<p>The drug can result in birth defects in male babies. (A)</p> Signup and view all the answers

Why is the concurrent use of nitrates contraindicated when prescribing phosphodiesterase type 5 (PDE5) inhibitors for erectile dysfunction, such as sildenafil?

<p>Increased risk of severe hypotension (B)</p> Signup and view all the answers

What guidance should clinicians provide to patients starting therapy with testosterone regarding potential adverse effects?

<p>The medication can lead to fluid retention and weight gain. (B)</p> Signup and view all the answers

In addition to assessing liver function, what monitoring regimen is important for patients taking testosterone therapy?

<p>Weight and edema (C)</p> Signup and view all the answers

Flashcards

Antacids

Medications that neutralize stomach acid.

Aluminum Hydroxide

Aluminum Hydroxide is an antacid but can cause constipation.

Calcium Carbonate

Calcium Carbonate is an antacid.

Magnesium Hydroxide

Magnesium Hydroxide is an antacid.

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Sodium Bicarbonate

Sodium Bicarbonate contains tums and neutralizes stomach acid.

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H-2 Receptor Antagonists

Drugs that block histamine H2 receptors in the stomach to reduce acid production.

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Cimetidine

Cimetidine is an H-2 receptor antagonist.

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Ranitidine

Ranitidine is an H-2 receptor antagonist.

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Famotidine

Famotidine is an H-2 receptor antagonist.

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Nizatidine

Nizatidine is an H-2 receptor antagonist.

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Proton Pump Inhibitors (PPIs)

Drugs that inhibit the proton pump in the stomach, reducing acid secretion.

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Esomeprazole

Esomeprazole is a PPI.

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Lansoprazole

Lansoprazole is a PPI.

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Omeprazole

Omeprazole is a PPI.

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Pantoprazole

Pantoprazole is a PPI.

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Cholinergic Agonist

Drugs that increase muscle tone in GI to treat urinary retention, muscle tone in GI and heartburn.

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Bethanechol

Direct-acting cholinergic agent used to treat urinary retention, muscle tone in GI and heartburn.

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Urinary Tract Analgesic

Medication to treat urinary tract pain, frequency and urgency

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Phenazopyridine

Medication used as a urinary analgesic.

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Antidiarrheals

Medications that relieve diarrhea.

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Study Notes

Statics - Chapter 3: Equilibrium

  • Equilibrium occurs when the sum of forces and moments is zero: $\sum \overrightarrow{F} = 0$ and $\sum \overrightarrow{M_0} = 0$.

Reactions at Supports and Connections for a 2-D Structure

  • Cable connections result in tension with a known line of action.
  • Roller connections result in a force with a known line of action.
  • Smooth surface connections result in a force perpendicular to the surface.
  • Hinge connections result in a force with unknown direction.
  • Fixed support connections result in a force and couple with unknown direction and magnitude.

Two- and Three- Force Members

  • A Two-Force Member in equilibrium has two forces with the same magnitude, acting along the same line, and opposing sense.
  • A Three-Force Member in equilibrium must have three forces that are either concurrent or parallel.

Sample Problem 3.1: Concrete Block Suspended by Cables

  • Find the tension in each cable supporting a 200-kg concrete block.
  • Equilibrium equations are:
    • $\sum F_x = 0$: $-T_{AC}\cos 60^\circ + T_{AB} = 0$
    • $\sum F_y = 0$: $T_{AC}\sin 60^\circ - 1962 N = 0$.
  • Solving these yields $T_{AC} = 2266 N$ and $T_{AB} = 1133 N$.

Sample Problem 3.2: Crane Lifting a Machine

  • Determine the force in each cable and the reaction at point C for a crane lifting a 2400-lb machine.
  • Relevant equilibrium equations include:
    • $\sum M_c = 0$: $A_B (36 ft) - 2400 lb (5 ft + 14ft) = 0$
    • $\sum F_x = 0$: $C_x - A_B \cos 30^\circ = 0$
    • $\sum F_y = 0$: $C_y + A_B \sin 30^\circ - 2400 lb = 0$.
  • Solving these equations yields $A_B = 1267 lb$, $C_x = 1097 lb$, and $C_y = 1767 lb$.

Sample Problem 3.3: Frame Supporting a Load

  • A frame with members $AD$, $CFE$ and $DB$ supports a 500-N load at A; find the reactions at $B$ and $E$.
  • Analyze member $AD$, using $\sum M_D = 0$, $500N (0.2m) - A_B (0.15m) = 0$, to find $A_B = 666.7 N$.
  • Also for AD: $\sum F_x = 0$, $D_x - 500 N = 0$ resulting in $D_x = 500 N$, and $\sum F_y = 0$, $D_y - A_B = 0$ resulting in $D_y = 666.7 N$.
  • Analyze member $CFE$, with $\sum M_E = 0$, $-C_x (0.4m) - D_x (0.2m) + D_y (0.2m) = 0$, to find $C_x = 83.35 N$.
  • Also for CFE: $\sum F_x = 0$, $E_x + C_x - D_x = 0$ resulting in $E_x = 416.65 N$, and $\sum F_y = 0$, $E_y - D_y = 0$ resulting in $E_y = 666.7 N$.
  • The reactions at B and E are then $B_x = -A_B = -666.7 N$ and $B_y = -83.35 N$.

Understanding Deep Learning - Backpropagation - Chapter 4

  • The backpropagation algorithm is a cornerstone of deep learning.

The Forward Pass

  • Input vector: $\mathbf{x} \in \mathbb{R}^{D}$
  • Weights: $\mathbf{W}^{(l)} \in \mathbb{R}^{M \times N}$
  • Bias: $\mathbf{b}^{(l)} \in \mathbb{R}^{M}$
  • Activation function: $\sigma$
  • Forward propagation equations: $\mathbf{a}^{(l)} = \mathbf{W}^{(l)} \mathbf{h}^{(l-1)} + \mathbf{b}^{(l)}$ and $\mathbf{h}^{(l)} = \sigma(\mathbf{a}^{(l)})$, where $\mathbf{h}^{(0)} = \mathbf{x}$ and $\mathbf{y} = \mathbf{h}^{(L)}$.

Computing the Gradients

  • Loss function: $J(\mathbf{\theta})$, where $\mathbf{\theta}$ are the parameters.
  • Gradient descent update rule: $\mathbf{\theta} \leftarrow \mathbf{\theta} - \alpha \nabla_{\mathbf{\theta}} J(\mathbf{\theta})$, with learning rate $\alpha$.

Backpropagating the Error

  • $\mathbf{\delta}^{(l)} = \frac{\partial J}{\partial \mathbf{a}^{(l)}}$
  • Backpropagation equations:
    • $\mathbf{\delta}^{(L)} = \nabla_{\mathbf{y}} J \odot \sigma'(\mathbf{a}^{(L)})$
    • $\mathbf{\delta}^{(l)} = ((\mathbf{W}^{(l+1)})^T \mathbf{\delta}^{(l+1)}) \odot \sigma'(\mathbf{a}^{(l)})$

Computing the Parameter Gradients

  • $\frac{\partial J}{\partial \mathbf{W}^{(l)}} = \mathbf{\delta}^{(l)} (\mathbf{h}^{(l-1)})^T$
  • $\frac{\partial J}{\partial \mathbf{b}^{(l)}} = \mathbf{\delta}^{(l)}$.

Backpropagation Algorithm

  • Perform forward pass to get activations for all layers
  • Compute error term $\mathbf{\delta}^{(L)}$ for output layer.
  • For $l = L-1, L-2,..., 1$, compute $\mathbf{\delta}^{(l)} = ((\mathbf{W}^{(l+1)})^T \mathbf{\delta}^{(l+1)}) \odot \sigma'(\mathbf{a}^{(l)})$.
  • Compute gradients $\frac{\partial J}{\partial \mathbf{W}^{(l)}} = \mathbf{\delta}^{(l)} (\mathbf{h}^{(l-1)})^T$ and $\frac{\partial J}{\partial \mathbf{b}^{(l)}} = \mathbf{\delta}^{(l)}$.

Algorithmic Complexity

  • Complexity represents the resources required by an algorithm.
  • Time complexity refers to execution time.
  • Space complexity refers to memory space.
  • Both time and space complexity are expressed as functions of the size of the input.

How to Measure Complexity

  • Experimental analysis involves implementing and running the algorithm with varying-sized inputs.
  • Theoretical analysis characterizes running time as a function of the input size $n$.

Experimental Analysis Limitations

  • It requires implementing the algorithm.
  • Results rely on hardware and software.
  • Experiments use a limited set of inputs.

Theoretical Analysis

  • Is based on a pseudo-code description.
  • Evaluates time as a function of input size.

Primitive Operations

  • These are basic computations.
  • They are identifiable in pseudocode.
  • They have constent time cost.
  • Examples include assigning values, comparing numbers, indexing into arrays, etc.

Counting Primitive Operations

  • Determine the maximum number of primitive operations as a function of input size.
  • Example: in Algorithm arrayMax(A, n) $7n - 2$ primitive operations are executed in the worst case arrayMax.

Growth Rate of Running Time

  • Changing the hardware/software environment affects running time by a constant factor.
  • The number of primitive operations is related to actual running time by a constant factor.

Focus on Growth Rate

  • The growth rate of running time is most important for algorithm efficiency for LARGE input sizes.

Asymptotic Notation

  • Includes Big-Oh, Big-Omega, and Big-Theta notation.

Big-Oh Notation

  • Given functions $f(n)$ and $g(n)$, $f(n)$ is $O(g(n))$ if there are positive constants $c$ and $n_0$ such that $f(n) \leq cg(n)$ for $n \geq n_0$.
  • Describes the asymptotic upper bound.

Big-Omega Notation

  • Given functions $f(n)$ and $g(n)$, $f(n)$ is $\Omega(g(n))$ if there is a positive constant $c$ such that $f(n) \geq cg(n)$ for infinitely many values of $n$.
  • Describes the asymptotic lower bound.

Big-Theta Notation

  • Given functions $f(n)$ and $g(n)$, $f(n)$ is $\Theta(g(n))$ if $f(n)$ is $O(g(n))$ and $f(n)$ is $\Omega(g(n))$.
  • Used to describe the asymptotic tight bound.

Properties of Asymptotic Notation

  • Constant Factors: $O(cf(n)) = O(f(n))$, $\Omega(cf(n)) = \Omega(f(n))$, and $\Theta(cf(n)) = \Theta(f(n))$.
  • Summation: $O(f(n)) + O(g(n)) = O(max(f(n), g(n)))$, etc.
  • Product: $O(f(n)) * O(g(n)) = O(f(n) * g(n))$, etc.

Big-Oh Rules

  • If $f(n)$ is a polynomial of degree $d$, then $f(n)$ is $O(n^d)$.
  • Use the smallest possible class of functions.
  • Use the simplest expression of the class.

Examples

  • Examples of determining asymptotic complexity
    • $f(n) = 2n^3 + 4n^2 + 10n$ is $O(n^3)$.
    • $f(n) = 2^n + n^2$ is $O(2^n)$.
    • $f(n) = n \log n + n$ is $O(n \log n)$.
    • $f(n) = \log_2 n + \log_{10}n$ is $O(\log n)$.

Comparing Growth Rates

  • This is based on $lim_{n \to \infty} \frac{f(n)}{g(n)}$.
  • A limit of 0 indicates $f(n)$ grows slower than $g(n)$.
  • A limit of $c > 0$ indicates $f(n)$ and $g(n)$ grow at the same rate.
  • A limit of $\infty$ indicates $f(n)$ grows faster than $g(n)$.

Common Functions (Growth Rates)

  • From smallest to largest: Constant $O(1)$, Logarithmic $O(\log n)$, Log-Linear $O(n \log n)$, Linear $O(n)$, Quadratic $O(n^2)$, Cubic $O(n^3)$, Exponential $O(2^n)$.

Prefix Averages Example (pseudo-code)

  • Prefix averages algorithm 1 is $O(n^2)$.
  • Prefix averages algorithm 2 is $O(n)$.

Algorithmes gloutons (Greedy Algorithms)

  • These algorithms solve optimization problems.
  • At each step, make the locally best choice.
  • Intention is to find the globally optimal solution.
  • In other words: make a sequence of locally optimal choices, without ever going back on a choice.

Exemple introductif (Introductory example)

  • The problem is to make change for an amount c with the fewest coins given a coin system.
  • An example coin system is euro coins {1, 2, 5, 10, 20, 50, 100, 200}, in centimes.
  • A greedy algorithm might be: choose the largest coin <= amount, add it to the solution, then decrease the amount left to make change for.
  • To make change for 37 centimes: choose 20, leaving 17; choose 10, leaving 7; choose 5, leaving 2; choose 2, leaving 0.
  • The solution is therefore: 1 piece of 20, 1 piece of 10, 1 piece of 5 and 1 piece of 2.

Optimalité? (Optimality)

  • Is the greedy algorithm always optimal? Does it always lead to the fewest coins in the solution?
  • In euros, yes.
  • But not for all coin systems.
  • For example: coins of {1, 3, 4} making change for 6. Greedy chooses 4, 1, 1 for 3 coins; but optimal is 3, 3 for 2 coins.

Schéma général (General Scheme)

fonction glouton(données)
    solution = solution_vide
    tant que solution pas complète
        choix = choisir(données)  # optimal local choice
        si choix valide
            ajouter choix à solution
            données = mettre_à_jour(données, choix)
        sinon
            retourner "pas de solution"
    retourner solution

Quand utiliser un algorithme glouton? (When to use a greedy algorithm?)

  • Greedy algorithms are simple to implement and often efficient, but they do not always guarantee optimality of the solution.
  • Necessary conditions include: the problem admits an optimal solution that is built step by step by locally optimal choices, and choices never compromise possible later choices.
  • Satisfying these conditions does not guarantee optimality, which requires proof.

Exemples d’applications (Examples of applications)

  • Making change (in euros).
  • Fractional knapsack (sac à dos fractionnaire) problem.
  • Minimum spanning tree (arbre couvrant de poids minimum).
  • Shortest paths (plus courts chemins).
  • Task scheduling (ordonnancement de tâches).
  • Data compression (compression de données).

Descriptive Statistics

  • These are definitions of basic concepts in statistics.

Population

  • The entire set of individuals or objects of interest.

Sample

  • A subset of the population.

Variable

  • An attribute subject to variations from one individual to another.

Data

  • Observed or measured values of a variable.

Types de variables (Types of variables)

  • Qualitative and quantitative variables.

Variables qualitatives (Qualitative Variables)

  • Qualitative variables are non-numeric, either nominal or ordinal.
  • Nominal variables cannot be ordered (e.g. eye color, gender).
  • Ordinal variables can be ordered (e.g satisfaction level, level of education).

Variables quantitatives (Quantitative Variables)

  • Quantitative variables can be measured numerically, and are either discrete or continuous.
  • Discrete variables take a limited count (e.g. number of children, number of cars in parking).
  • Continuous variables have any value in a range (e.g. height, weight).

Mesures de tendance centrale (Measures of Central Tendency)

  • Three measures of central tendency: mean, median, mode.

Moyenne (Mean)

  • Population $\qquad \mu = \frac{\sum_{i=1}^{N} x_i}{N}$.
  • Sample $\qquad \bar{x} = \frac{\sum_{i=1}^{n} x_i}{n}$.

Médiane (Median)

  • The value separating a data set into two equal parts.

Mode

  • The value that appears the most often in a data set.

Mesures de dispersion (Measures of Dispersion)

  • Range, variance, standard deviation, coefficient of variation.

Étendue (Range)

  • The difference between the largest and smallest values.

Variance

  • Population $\qquad \sigma^2 = \frac{\sum_{i=1}^{N} (x_i - \mu)^2}{N}$.
  • Sample $\qquad s^2 = \frac{\sum_{i=1}^{n} (x_i - \bar{x})^2}{n-1}$.

Écart-type (Standard Deviation)

  • Population $\qquad \sigma = \sqrt{\sigma^2}$.
  • Sample $\qquad s = \sqrt{s^2}$.

Coefficient de variation (Coefficient of Variation)

  • Population $\qquad CV = \frac{\sigma}{\mu}$.
  • Sample $\qquad CV = \frac{s}{\bar{x}}$.

Fonction Exponentielle (The Exponential Function)

  • The exponential function, exp(x) or $e^x$, is the unique function that satisfies the differential equation $f'(x) = f(x)$ with $f(0) = 1$.

Propriétés (Properties)

  • $e^0 = 1$
  • $e^1 = e \approx 2.718$
  • $e^{a+b} = e^a \cdot e^b$
  • $e^{a-b} = \frac{e^a}{e^b}$
  • $(e^a)^b = e^{ab}$
  • $e^x > 0$ for all $x \in \mathbb{R}$
  • $\lim_{x \to +\infty} e^x = +\infty$
  • $\lim_{x \to -\infty} e^x = 0$

Dérivée (Derivative)

  • The derivative of the exponential function is itself, $\frac{d}{dx} e^x = e^x$.
  • If $u(x)$ is a differentiable function of $x$, then $\frac{d}{dx} e^{u(x)} = u'(x) e^{u(x)}$.

Représentation Graphique (Graphical Representation)

  • Passes through (0, 1).
  • Always positive.
  • Always increasing.
  • X-axis is horizontal asymptote as $x \to -\infty$.

Tableau de variation (Variation Table)

Shows function behavior as limited by $\pm \infty$.

Applications

  • Has uses in: mathematics, physics, engineering, finance, and in modeling exponential growth and decay.

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