Podcast
Questions and Answers
Staphylococcal Scalded Skin Syndrome (SSSS) is primarily mediated by what bacterial virulence factor?
Staphylococcal Scalded Skin Syndrome (SSSS) is primarily mediated by what bacterial virulence factor?
- The formation of bacterial biofilms on the skin surface
- Exfoliative toxins produced by _Staphylococcus aureus_ (correct)
- An IgE-mediated hypersensitivity reaction to _Staphylococcus aureus_
- Direct bacterial invasion and destruction of tissue
A neonate presents with a widespread, painful rash and superficial blisters. Gentle pressure on the skin causes the epidermis to separate from the underlying dermis. What is the most likely diagnosis?
A neonate presents with a widespread, painful rash and superficial blisters. Gentle pressure on the skin causes the epidermis to separate from the underlying dermis. What is the most likely diagnosis?
- Tinea corporis
- Impetigo
- Contact dermatitis
- Staphylococcal Scalded Skin Syndrome (SSSS) (correct)
Why are bacterial cultures of blister fluid from a patient with Staphylococcal Scalded Skin Syndrome typically negative?
Why are bacterial cultures of blister fluid from a patient with Staphylococcal Scalded Skin Syndrome typically negative?
- Antibiotics in the bloodstream rapidly kill any bacteria present in the blisters
- The causative bacteria are intracellular and cannot be cultured
- The blisters are caused by toxins, not by the bacteria themselves (correct)
- The blisters are sterile and only contain host immune cells
What is a key clinical feature differentiating Staphylococcal Scalded Skin Syndrome from bullous impetigo?
What is a key clinical feature differentiating Staphylococcal Scalded Skin Syndrome from bullous impetigo?
Which patient population is most likely to experience a high mortality rate from Staphylococcal Scalded Skin Syndrome (SSSS)?
Which patient population is most likely to experience a high mortality rate from Staphylococcal Scalded Skin Syndrome (SSSS)?
A child is diagnosed with Staphylococcal Scalded Skin Syndrome (SSSS). What pathogenic mechanism is primarily responsible for the skin sloughing observed in this condition?
A child is diagnosed with Staphylococcal Scalded Skin Syndrome (SSSS). What pathogenic mechanism is primarily responsible for the skin sloughing observed in this condition?
A patient has a suspected case of SSSS. What physical exam finding would help confirm your suspicion?
A patient has a suspected case of SSSS. What physical exam finding would help confirm your suspicion?
After diagnosis of SSSS, a 3 year old is expected to make a full recovery in 1 week and be discharged. However, the patient is still showing signs of the disease after 2 weeks. Which factor could be responsible?
After diagnosis of SSSS, a 3 year old is expected to make a full recovery in 1 week and be discharged. However, the patient is still showing signs of the disease after 2 weeks. Which factor could be responsible?
A patient is suspected of having SSSS, what common symptom can you observe to help confirm the diagnosis?
A patient is suspected of having SSSS, what common symptom can you observe to help confirm the diagnosis?
What immunological process leads to the resolution of Staphylococcal Scalded Skin Syndrome (SSSS)?
What immunological process leads to the resolution of Staphylococcal Scalded Skin Syndrome (SSSS)?
Flashcards
Staphylococcal Scalded Skin Syndrome (SSSS)
Staphylococcal Scalded Skin Syndrome (SSSS)
A skin condition caused by Staphylococcus aureus strains that produce exfoliative toxins, primarily affecting neonates and children.
Perioral Erythema in SSSS
Perioral Erythema in SSSS
Redness of the skin around the mouth that spreads across the body within 2 days.
Blister Formation and Desquamation in SSSS
Blister Formation and Desquamation in SSSS
The formation of cutaneous blisters followed by the shedding of the epithelium.
Positive Nikolsky Sign
Positive Nikolsky Sign
Signup and view all the flashcards
Bacteria in SSSS blisters
Bacteria in SSSS blisters
Signup and view all the flashcards
SSSS Healing Time
SSSS Healing Time
Signup and view all the flashcards
Study Notes
- Staphylococcal Scalded Skin Syndrome (SSSS), also known as Ritter Disease, arises from Staphylococcus aureus strains producing exfoliative toxins.
- Primarily affects neonates and children.
- Initial symptom is perioral erythema, which spreads across the body within 2 days.
- Cutaneous blisters then develop, leading to epithelial desquamation.
- Blisters are free of bacteria.
- Positive Nikolsky sign is observed.
- Recovery occurs in 7-10 days with the emergence of antitoxin antibodies.
- Mortality rate is low in neonates and young children, remaining below 5%.
- Immunocompromised adults face a higher mortality rate of 60%.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
