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Questions and Answers
What is the point of intersection of the straight line with the curve?
What is the point of intersection of the straight line with the curve?
- The zero time-point (correct)
- The maximum concentration point
- The half-life point
- The point of maximum absorption
What is the slope of the straight line equivalent to?
What is the slope of the straight line equivalent to?
- The rate of elimination
- The rate of absorption
- The maximum concentration
- V0 (correct)
Why is the linear part of the curve used to obtain V0?
Why is the linear part of the curve used to obtain V0?
- Because it is the simplest part of the curve to analyze
- Because it is the most accurate part of the curve
- Because it is the longest part of the curve
- Because it represents the initial rate of absorption (correct)
What is the purpose of drawing a straight line through the linear part of the curve?
What is the purpose of drawing a straight line through the linear part of the curve?
What is the relationship between the slope of the straight line and V0?
What is the relationship between the slope of the straight line and V0?
What is the standard concentration of substrates and products of a reaction?
What is the standard concentration of substrates and products of a reaction?
Why is it convenient to refer to ΔG under a standard set of conditions?
Why is it convenient to refer to ΔG under a standard set of conditions?
What is the primary purpose of defining ΔG under standard conditions?
What is the primary purpose of defining ΔG under standard conditions?
Under what conditions is ΔG typically defined?
Under what conditions is ΔG typically defined?
What happens to the equilibrium in the absence of bound substrate?
What happens to the equilibrium in the absence of bound substrate?
What is the significance of the standard concentration of 1.0 M?
What is the significance of the standard concentration of 1.0 M?
What is the effect of substrate binding to every active site in the T-state?
What is the effect of substrate binding to every active site in the T-state?
What is the relationship between the T-state and the R-state in the absence of bound substrate?
What is the relationship between the T-state and the R-state in the absence of bound substrate?
What is the role of substrate binding in the shift of the equilibrium?
What is the role of substrate binding in the shift of the equilibrium?
What is the result of substrate binding to every active site in the T-state?
What is the result of substrate binding to every active site in the T-state?
What happens to the velocity of an enzyme-catalyzed reaction at high substrate concentrations?
What happens to the velocity of an enzyme-catalyzed reaction at high substrate concentrations?
What is the significance of the maximum value of velocity at high substrate concentrations?
What is the significance of the maximum value of velocity at high substrate concentrations?
What is the relationship between velocity and substrate concentration at high [S]?
What is the relationship between velocity and substrate concentration at high [S]?
What is the purpose of Fig. 4a in the context of enzyme-catalyzed reactions?
What is the purpose of Fig. 4a in the context of enzyme-catalyzed reactions?
What is the trend of velocity as substrate concentration increases?
What is the trend of velocity as substrate concentration increases?
What is the main limitation of both models in describing allosteric binding?
What is the main limitation of both models in describing allosteric binding?
What can be said about the two models in terms of describing the mechanism of action of allosteric enzymes?
What can be said about the two models in terms of describing the mechanism of action of allosteric enzymes?
What is the difference between the two models in describing the cooperative nature of allosteric binding?
What is the difference between the two models in describing the cooperative nature of allosteric binding?
What is the implication of both models being interchangeable in describing the mechanism of action of allosteric enzymes?
What is the implication of both models being interchangeable in describing the mechanism of action of allosteric enzymes?
What is the common limitation of both models in describing allosteric enzymes?
What is the common limitation of both models in describing allosteric enzymes?
Study Notes
Standard Conditions for ΔG
- ΔG is often referred to under a standard set of conditions, where substrates and products of a reaction are present at concentrations of 1.0 M.
Determining V0
- V0 is obtained by drawing a straight line through the linear part of the curve, starting at the zero time-point.
- The slope of this straight line is equal to V0.
Velocity at High Substrate Concentrations
- At high substrate concentrations, the velocity tends towards a maximum value.
- The rate becomes independent of substrate concentration [S].
Allosteric Binding
- In the absence of bound substrate, the equilibrium favors the T-state.
- As substrate binds to every active site in the T-state, the equilibrium shifts towards the R-state.
Limitations of Models
- Neither model can satisfactorily describe the cooperative nature of allosteric binding of substrate to enzymes.
- Both models can be used interchangeably to properly describe the mechanism of action of any particular allosteric enzyme.
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Description
This quiz covers the standard conditions of ΔG, where substrates and products of a reaction are present at concentrations of 1.0 M. Understand the concept and its applications in chemistry.
