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Questions and Answers
What is the first stage in drug discovery?
What is the first stage in drug discovery?
- Isolating and purifying the lead compound
- Choosing a disease (correct)
- Improving target interactions
- Identifying a bioassay
During which stage is the lead compound determined?
During which stage is the lead compound determined?
- Drug design
- Carrying out preclinical trials
- Drug development
- Drug discovery (correct)
What is the main focus of drug design?
What is the main focus of drug design?
- Identifying the pharmacophore (correct)
- Designing a manufacturing process
- Registering and marketing the drug
- Choosing a disease
What is a key aspect of drug development according to the text?
What is a key aspect of drug development according to the text?
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What is a significant cost associated with the process of discovering, designing, and developing a new drug?
What is a significant cost associated with the process of discovering, designing, and developing a new drug?
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Study Notes
Drug Discovery
- The process begins with finding a lead compound, which is an active naturally sourced or synthetic compound.
- The steps to find a lead compound include:
- Choosing a disease and a drug target
- Identifying a bioassay
- Finding a lead compound
- Isolating and purifying the lead compound
- Determining the structure of the lead compound
Drug Design
- The goal of drug design is to identify structure-activity relationships (SARs) and the pharmacophore.
- This involves improving target interactions (pharmacodynamics) and pharmacokinetic properties.
Drug Development
- The process involves several stages, including:
- Patenting the drug
- Conducting preclinical trials, which include:
- Drug metabolism studies
- Toxicology studies
- Formulation and stability tests
- Pharmacology studies
- Designing a manufacturing process (chemical and process development)
- Conducting clinical trials
- Registering and marketing the drug
Key Facts
- The entire process of drug discovery, design, and development can take over 15 years.
- It can involve the synthesis of over 10,000 compounds.
- The total cost can be around $2.5 million USD.
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Description
Learn about the key stages involved in drug discovery, design, and development process. Understand the process of finding a lead compound, drug design involving structure-activity relationships and pharmacophore identification, and improving target interactions and pharmacokinetic properties.
