Podcast
Questions and Answers
What is the first stage in drug discovery?
What is the first stage in drug discovery?
During which stage is the lead compound determined?
During which stage is the lead compound determined?
What is the main focus of drug design?
What is the main focus of drug design?
What is a key aspect of drug development according to the text?
What is a key aspect of drug development according to the text?
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What is a significant cost associated with the process of discovering, designing, and developing a new drug?
What is a significant cost associated with the process of discovering, designing, and developing a new drug?
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Study Notes
Drug Discovery
- The process begins with finding a lead compound, which is an active naturally sourced or synthetic compound.
- The steps to find a lead compound include:
- Choosing a disease and a drug target
- Identifying a bioassay
- Finding a lead compound
- Isolating and purifying the lead compound
- Determining the structure of the lead compound
Drug Design
- The goal of drug design is to identify structure-activity relationships (SARs) and the pharmacophore.
- This involves improving target interactions (pharmacodynamics) and pharmacokinetic properties.
Drug Development
- The process involves several stages, including:
- Patenting the drug
- Conducting preclinical trials, which include:
- Drug metabolism studies
- Toxicology studies
- Formulation and stability tests
- Pharmacology studies
- Designing a manufacturing process (chemical and process development)
- Conducting clinical trials
- Registering and marketing the drug
Key Facts
- The entire process of drug discovery, design, and development can take over 15 years.
- It can involve the synthesis of over 10,000 compounds.
- The total cost can be around $2.5 million USD.
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Description
Learn about the key stages involved in drug discovery, design, and development process. Understand the process of finding a lead compound, drug design involving structure-activity relationships and pharmacophore identification, and improving target interactions and pharmacokinetic properties.
