15 Questions
What is stability in the context of dosage form design?
The extent to which a product retains its properties throughout its period of storage and use
Which of the following is not a factor contributing to the decomposition of drug substances?
Alkaline pH
How can drugs be classified based on their sensitivity to breakdown?
Based on their stability in different conditions
What is checked during the design of formulations to ensure drug safety?
Interactions between drugs and added excipients
Which thermal analysis technique is particularly useful for identifying possible drug-additive and drug-drug interactions?
Micro calorimetry
What has thermal analysis revealed about magnesium stearate and aspirin?
Magnesium stearate interacts with aspirin and should be avoided in formulations containing this drug
Which type of stability concern is related to the retention of antimicrobial agents' effectiveness within specified limits?
Microbiologic
What is the most frequently encountered destructive process chemically?
Hydrolysis
Which chemical group is most susceptible to the hydrolytic process?
Esters
What type of stability ensures that the original physical properties of a drug are retained?
Physical
Which type of stability concerns the retention of the therapeutic effect of a drug?
Therapeutic
What is the example given for ester hydrolysis in the text?
Formation of salicylic acid and acetic acid
What catalyzes the hydrolysis of amides?
Acids or bases
Which type of drug is too unstable to be formulated as solutions?
Penicillins and cephalosporins
What enhances the stability of drug products through the reduction or elimination of water from the pharmaceutical system?
Aqueous solution
Test your knowledge on stability considerations in dosage form design, including the extent to which a product retains its properties and characteristics over time, and factors that can cause drug substances to decompose.
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