Stability Considerations in Dosage Form Design
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Questions and Answers

What is stability in the context of dosage form design?

  • The ability of a product to withstand extreme temperatures
  • The ability of a product to maintain its color and appearance over time
  • The resistance of a product to external forces like pressure and impact
  • The extent to which a product retains its properties throughout its period of storage and use (correct)

    • Which of the following is not a factor contributing to the decomposition of drug substances?

  • Alkaline pH (correct)
  • Heat
  • Oxygen
  • Moisture

    • How can drugs be classified based on their sensitivity to breakdown?

  • Based on their taste
  • Based on their color
  • Based on their stability in different conditions (correct)
  • Based on their route of administration

    • What is checked during the design of formulations to ensure drug safety?

    <p>Interactions between drugs and added excipients</p> Signup and view all the answers

    Which thermal analysis technique is particularly useful for identifying possible drug-additive and drug-drug interactions?

    <p>Micro calorimetry</p> Signup and view all the answers

    What has thermal analysis revealed about magnesium stearate and aspirin?

    <p>Magnesium stearate interacts with aspirin and should be avoided in formulations containing this drug</p> Signup and view all the answers

    Which type of stability concern is related to the retention of antimicrobial agents' effectiveness within specified limits?

    <p>Microbiologic</p> Signup and view all the answers

    What is the most frequently encountered destructive process chemically?

    <p>Hydrolysis</p> Signup and view all the answers

    Which chemical group is most susceptible to the hydrolytic process?

    <p>Esters</p> Signup and view all the answers

    What type of stability ensures that the original physical properties of a drug are retained?

    <p>Physical</p> Signup and view all the answers

    Which type of stability concerns the retention of the therapeutic effect of a drug?

    <p>Therapeutic</p> Signup and view all the answers

    What is the example given for ester hydrolysis in the text?

    <p>Formation of salicylic acid and acetic acid</p> Signup and view all the answers

    What catalyzes the hydrolysis of amides?

    <p>Acids or bases</p> Signup and view all the answers

    Which type of drug is too unstable to be formulated as solutions?

    <p>Penicillins and cephalosporins</p> Signup and view all the answers

    What enhances the stability of drug products through the reduction or elimination of water from the pharmaceutical system?

    <p>Aqueous solution</p> Signup and view all the answers

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