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Questions and Answers
Which statement best describes the basic strategy in dosage form design?
Which statement best describes the basic strategy in dosage form design?
Which factor is a determining factor in drug efficacy according to the text?
Which factor is a determining factor in drug efficacy according to the text?
According to Fick's law of Diffusion, what does it predict the rate of drug release based on?
According to Fick's law of Diffusion, what does it predict the rate of drug release based on?
Which type of dosage forms follows Fick's law of Diffusion?
Which type of dosage forms follows Fick's law of Diffusion?
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What effect do sublingual dosage forms have on drug absorption?
What effect do sublingual dosage forms have on drug absorption?
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What is the primary function of pharmaceutical excipients in dosage form design?
What is the primary function of pharmaceutical excipients in dosage form design?
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Which type of dosage form design is a key consideration for achieving the desired drug absorption pattern and controlled release of the drug?
Which type of dosage form design is a key consideration for achieving the desired drug absorption pattern and controlled release of the drug?
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What is the purpose of achieving the desired drug absorption pattern and controlled release of the drug in dosage form design?
What is the purpose of achieving the desired drug absorption pattern and controlled release of the drug in dosage form design?
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Which property of a solution is influenced by the mole fraction of components?
Which property of a solution is influenced by the mole fraction of components?
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What does the addition of a solute to a solvent result in, in terms of boiling point?
What does the addition of a solute to a solvent result in, in terms of boiling point?
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What does the addition of a solute to a solvent result in, in terms of freezing point?
What does the addition of a solute to a solvent result in, in terms of freezing point?
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What does the van’t Hoff factor (i) account for in the freezing point depression equation?
What does the van’t Hoff factor (i) account for in the freezing point depression equation?
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What does the osmotic pressure of a solution depend on?
What does the osmotic pressure of a solution depend on?
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What does the van’t Hoff factor (i) represent in the context of electrolyte solutions?
What does the van’t Hoff factor (i) represent in the context of electrolyte solutions?
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What does it mean for a solution to be isotonic with biological fluids?
What does it mean for a solution to be isotonic with biological fluids?
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What is the most common agent used to adjust the tonicity of liquid drug delivery systems?
What is the most common agent used to adjust the tonicity of liquid drug delivery systems?
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What is the Sodium Chloride Equivalent (E) defined as?
What is the Sodium Chloride Equivalent (E) defined as?
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What does the D1% Method help determine in the context of isotonic solutions?
What does the D1% Method help determine in the context of isotonic solutions?
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What does the Liso represent in the context of isotonic solutions?
What does the Liso represent in the context of isotonic solutions?
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Study Notes
Dosage Form Design
- The basic strategy in dosage form design is to optimize the drug's therapeutic effectiveness by tailoring the release and absorption of the drug to the specific needs of the patient.
Factors Affecting Drug Efficacy
- The determining factor in drug efficacy is the bioavailability of the drug, which depends on the dosage form's ability to release the drug in a controlled manner.
Fick's Law of Diffusion
- Fick's law predicts the rate of drug release based on the concentration gradient of the drug, the diffusion coefficient of the drug, and the thickness of the barrier.
Dosage Forms Following Fick's Law
- Matrix-type dosage forms, such as transdermal patches, follow Fick's law of diffusion.
Sublingual Dosage Forms
- Sublingual dosage forms allow for rapid drug absorption into the bloodstream through the mucous membranes of the mouth.
Pharmaceutical Excipients
- The primary function of pharmaceutical excipients in dosage form design is to enhance the stability, appearance, and performance of the dosage form.
Controlled Release of Drugs
- The type of dosage form design that is a key consideration for achieving the desired drug absorption pattern and controlled release of the drug is modified-release dosage forms.
Purpose of Controlled Release
- The purpose of achieving the desired drug absorption pattern and controlled release of the drug in dosage form design is to optimize the drug's therapeutic effectiveness and minimize adverse effects.
Properties of Solutions
- The mole fraction of components influences the vapor pressure of a solution.
Effect of Solutes on Boiling Point and Freezing Point
- The addition of a solute to a solvent results in an increase in boiling point and a decrease in freezing point.
van't Hoff Factor
- The van't Hoff factor (i) accounts for the degree of ionization of the solute in the freezing point depression equation.
Osmotic Pressure
- The osmotic pressure of a solution depends on the concentration of the solute and the temperature of the solution.
van't Hoff Factor in Electrolyte Solutions
- The van't Hoff factor (i) represents the number of ions formed by a solute in an electrolyte solution.
Isotonic Solutions
- A solution is isotonic with biological fluids if it has the same osmotic pressure as the biological fluids.
Adjusting Tonicity
- The most common agent used to adjust the tonicity of liquid drug delivery systems is sodium chloride.
Sodium Chloride Equivalent (E)
- The Sodium Chloride Equivalent (E) is defined as the concentration of sodium chloride that would produce the same osmotic pressure as a solution of a given solute.
D1% Method
- The D1% Method helps determine the isotonicity of a solution by measuring the concentration of sodium chloride required to produce the same osmotic pressure as a 1% solution of the solute.
Liso
- Liso represents the concentration of sodium chloride that is isotonic with a 1% solution of the solute.
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Description
Test your knowledge of colligative properties and dosage form (DF) design with this quiz. Explore key concepts such as the most common DFs, pharmaceutical agents, and their forms, and how they contribute to achieving a desired drug delivery and improving therapeutic effects.
