SSRIs Pharmacology Quiz
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Questions and Answers

What is the primary neurotransmitter affected by citalopram?

  • Dopamine
  • Acetylcholine
  • Norepinephrine
  • Serotonin (correct)
  • What is the maximum recommended daily dose of escitalopram for adults?

  • 40 mg
  • 30 mg
  • 10 mg
  • 20 mg (correct)
  • Which SSRI is FDA-approved for the treatment of premenstrual dysphoric disorder?

  • Paroxetine
  • Citalopram
  • Sertraline
  • Fluoxetine (correct)
  • What is the recommended starting dose of duloxetine for the treatment of depression?

    <p>60 mg/day</p> Signup and view all the answers

    Which neurotransmitters are affected by bupropion?

    <p>Dopamine and norepinephrine</p> Signup and view all the answers

    What is the maximum recommended single dose of bupropion?

    <p>120 mg</p> Signup and view all the answers

    Which SSRI is FDA-approved for the treatment of obsessive-compulsive disorder (OCD)?

    <p>Fluvoxamine</p> Signup and view all the answers

    What is the primary neurotransmitter affected by desvenlafaxine?

    <p>Serotonin and norepinephrine</p> Signup and view all the answers

    What is the recommended starting dose of fluoxetine for the treatment of depression in adolescents and adults?

    <p>20 mg/day</p> Signup and view all the answers

    What is the maximum recommended daily dose of duloxetine for the treatment of depression?

    <p>60 mg</p> Signup and view all the answers

    What is the most significant adverse effect associated with selective serotonin reuptake inhibitors (SSRIs)?

    <p>Serotonin syndrome</p> Signup and view all the answers

    Which of the following is a potential symptom of serotonin syndrome?

    <p>Hyperthermia</p> Signup and view all the answers

    Which SSRI does not require gradual tapering when discontinuing due to its long half-life and active metabolites?

    <p>Fluoxetine</p> Signup and view all the answers

    What is a safe guideline when switching from one serotonergic drug to another?

    <p>Allow five half-lives per dose decrease</p> Signup and view all the answers

    Which of the following is a potential drug interaction with SSRIs?

    <p>All of the above</p> Signup and view all the answers

    Which of the following substances may contribute to serotonin syndrome when taken with SSRIs?

    <p>Both A and B</p> Signup and view all the answers

    Which enzyme metabolizes vortioxetine primarily?

    <p>CYP2D6</p> Signup and view all the answers

    What is the half-life of fluoxetine's first metabolite, norfluoxetine?

    <p>4-16 days</p> Signup and view all the answers

    Which SSRI has a half-life that ranges from 24 to 26 hours?

    <p>Sertraline</p> Signup and view all the answers

    In which phase of pregnancy should SSRIs be avoided?

    <p>First trimester</p> Signup and view all the answers

    Which SSRIs are Pregnancy Category C?

    <p>Fluvoxamine and vortioxetine</p> Signup and view all the answers

    Which antidepressant is not approved for use in children due to lack of effectiveness?

    <p>Paroxetine</p> Signup and view all the answers

    'SSRIs should be used cautiously in patients with severe ______ impairment.' Fill in the blank.

    <p>Renal</p> Signup and view all the answers

    'Neonates exposed to SSRIs in the late ____ trimester have demonstrated complications soon after birth.' Fill in the blank.

    <p>Third</p> Signup and view all the answers

    Which of the following statements about SSRIs is correct?

    <p>They were first introduced with the approval of fluoxetine (Prozac) in 1985.</p> Signup and view all the answers

    Which of the following statements about the pharmacodynamics of SSRIs is correct?

    <p>They block the serotonin transporter from returning serotonin to the presynaptic cell, increasing serotonin availability.</p> Signup and view all the answers

    Which of the following SSRIs is considered the closest to a true selective serotonin reuptake inhibitor?

    <p>Citalopram (Celexa) and escitalopram (Lexapro)</p> Signup and view all the answers

    Which of the following statements about the pharmacokinetics of SSRIs is correct?

    <p>Their peak plasma levels are reached within 1 to 8 hours after oral administration.</p> Signup and view all the answers

    Which of the following statements about the SSRIs is incorrect?

    <p>They are not as effective as tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs).</p> Signup and view all the answers

    Which of the following statements about the SSRIs is correct?

    <p>They have a biodistribution volume ranging from 12 to 40 L/kg.</p> Signup and view all the answers

    Which medication is primarily used for treating obsessive-compulsive disorder (OCD) and social anxiety disorder?

    <p>Fluvoxamine (Luvox)</p> Signup and view all the answers

    Which medication is specifically approved for the treatment of fibromyalgia?

    <p>Milnacipran (Savella)</p> Signup and view all the answers

    Which medication is primarily used for the treatment of depression and has a secondary effect on histamine, serotonin, and norepinephrine?

    <p>Mirtazapine (Remeron)</p> Signup and view all the answers

    Which medication is specifically formulated as a delayed-release capsule?

    <p>Nefazodone</p> Signup and view all the answers

    Which medication is primarily used for the treatment of major depressive disorder and has a titration schedule?

    <p>Levomilnacipran (Fetzima)</p> Signup and view all the answers

    Which medication is available in both tablet and disintegrating tablet (Soltab) formulations?

    <p>Mirtazapine (Remeron)</p> Signup and view all the answers

    Which medication is specifically indicated for the treatment of premenstrual dysphoric disorder (PMDD)?

    <p>Paroxetine (Paxil CR)</p> Signup and view all the answers

    Which medication is available in both tablet and oral suspension formulations?

    <p>Paroxetine (Paxil)</p> Signup and view all the answers

    Which medication is specifically indicated for the treatment of vortioxetine (Brintellix) major depressive disorder?

    <p>Vortioxetine (Brintellix)</p> Signup and view all the answers

    Which medication is primarily used for the treatment of depression and has a secondary effect on serotonin and adrenergic receptors?

    <p>Trazodone (Desyrel)</p> Signup and view all the answers

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