SSRIs Pharmacology Quiz
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Questions and Answers

What is the primary neurotransmitter affected by citalopram?

  • Dopamine
  • Acetylcholine
  • Norepinephrine
  • Serotonin (correct)

What is the maximum recommended daily dose of escitalopram for adults?

  • 40 mg
  • 30 mg
  • 10 mg
  • 20 mg (correct)

Which SSRI is FDA-approved for the treatment of premenstrual dysphoric disorder?

  • Paroxetine
  • Citalopram
  • Sertraline
  • Fluoxetine (correct)

What is the recommended starting dose of duloxetine for the treatment of depression?

<p>60 mg/day (C)</p> Signup and view all the answers

Which neurotransmitters are affected by bupropion?

<p>Dopamine and norepinephrine (B)</p> Signup and view all the answers

What is the maximum recommended single dose of bupropion?

<p>120 mg (B)</p> Signup and view all the answers

Which SSRI is FDA-approved for the treatment of obsessive-compulsive disorder (OCD)?

<p>Fluvoxamine (C)</p> Signup and view all the answers

What is the primary neurotransmitter affected by desvenlafaxine?

<p>Serotonin and norepinephrine (B)</p> Signup and view all the answers

What is the recommended starting dose of fluoxetine for the treatment of depression in adolescents and adults?

<p>20 mg/day (C)</p> Signup and view all the answers

What is the maximum recommended daily dose of duloxetine for the treatment of depression?

<p>60 mg (C)</p> Signup and view all the answers

What is the most significant adverse effect associated with selective serotonin reuptake inhibitors (SSRIs)?

<p>Serotonin syndrome (D)</p> Signup and view all the answers

Which of the following is a potential symptom of serotonin syndrome?

<p>Hyperthermia (A)</p> Signup and view all the answers

Which SSRI does not require gradual tapering when discontinuing due to its long half-life and active metabolites?

<p>Fluoxetine (B)</p> Signup and view all the answers

What is a safe guideline when switching from one serotonergic drug to another?

<p>Allow five half-lives per dose decrease (C)</p> Signup and view all the answers

Which of the following is a potential drug interaction with SSRIs?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following substances may contribute to serotonin syndrome when taken with SSRIs?

<p>Both A and B (B)</p> Signup and view all the answers

Which enzyme metabolizes vortioxetine primarily?

<p>CYP2D6 (C)</p> Signup and view all the answers

What is the half-life of fluoxetine's first metabolite, norfluoxetine?

<p>4-16 days (D)</p> Signup and view all the answers

Which SSRI has a half-life that ranges from 24 to 26 hours?

<p>Sertraline (D)</p> Signup and view all the answers

In which phase of pregnancy should SSRIs be avoided?

<p>First trimester (D)</p> Signup and view all the answers

Which SSRIs are Pregnancy Category C?

<p>Fluvoxamine and vortioxetine (D)</p> Signup and view all the answers

Which antidepressant is not approved for use in children due to lack of effectiveness?

<p>Paroxetine (B)</p> Signup and view all the answers

'SSRIs should be used cautiously in patients with severe ______ impairment.' Fill in the blank.

<p>Renal (C)</p> Signup and view all the answers

'Neonates exposed to SSRIs in the late ____ trimester have demonstrated complications soon after birth.' Fill in the blank.

<p>Third (A)</p> Signup and view all the answers

Which of the following statements about SSRIs is correct?

<p>They were first introduced with the approval of fluoxetine (Prozac) in 1985. (A)</p> Signup and view all the answers

Which of the following statements about the pharmacodynamics of SSRIs is correct?

<p>They block the serotonin transporter from returning serotonin to the presynaptic cell, increasing serotonin availability. (C)</p> Signup and view all the answers

Which of the following SSRIs is considered the closest to a true selective serotonin reuptake inhibitor?

<p>Citalopram (Celexa) and escitalopram (Lexapro) (B)</p> Signup and view all the answers

Which of the following statements about the pharmacokinetics of SSRIs is correct?

<p>Their peak plasma levels are reached within 1 to 8 hours after oral administration. (A)</p> Signup and view all the answers

Which of the following statements about the SSRIs is incorrect?

<p>They are not as effective as tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs). (C)</p> Signup and view all the answers

Which of the following statements about the SSRIs is correct?

<p>They have a biodistribution volume ranging from 12 to 40 L/kg. (D)</p> Signup and view all the answers

Which medication is primarily used for treating obsessive-compulsive disorder (OCD) and social anxiety disorder?

<p>Fluvoxamine (Luvox) (A)</p> Signup and view all the answers

Which medication is specifically approved for the treatment of fibromyalgia?

<p>Milnacipran (Savella) (C)</p> Signup and view all the answers

Which medication is primarily used for the treatment of depression and has a secondary effect on histamine, serotonin, and norepinephrine?

<p>Mirtazapine (Remeron) (B)</p> Signup and view all the answers

Which medication is specifically formulated as a delayed-release capsule?

<p>Nefazodone (C)</p> Signup and view all the answers

Which medication is primarily used for the treatment of major depressive disorder and has a titration schedule?

<p>Levomilnacipran (Fetzima) (C)</p> Signup and view all the answers

Which medication is available in both tablet and disintegrating tablet (Soltab) formulations?

<p>Mirtazapine (Remeron) (C)</p> Signup and view all the answers

Which medication is specifically indicated for the treatment of premenstrual dysphoric disorder (PMDD)?

<p>Paroxetine (Paxil CR) (D)</p> Signup and view all the answers

Which medication is available in both tablet and oral suspension formulations?

<p>Paroxetine (Paxil) (C)</p> Signup and view all the answers

Which medication is specifically indicated for the treatment of vortioxetine (Brintellix) major depressive disorder?

<p>Vortioxetine (Brintellix) (D)</p> Signup and view all the answers

Which medication is primarily used for the treatment of depression and has a secondary effect on serotonin and adrenergic receptors?

<p>Trazodone (Desyrel) (B)</p> Signup and view all the answers

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