32 Questions
What is the main function of the spleen as a secondary lymphoid organ?
Immune function
Which process does the spleen undergo as a blood filter?
Destruction of blood cells
What is the structure that surrounds the spleen?
Stroma
In what state does the spleen act as a blood store?
Normal state
Which cells mainly make up the white splenic pulp?
T cells
What forms the framework of the spleen, enveloped by reticular cells?
Collagen fibers
Which zone of the spleen is formed by reticular fibers and cells, occupied by specialized B cells and macrophages?
Marginal zone
What is the main function of the macrophages in the splenic cords?
Hemocatheretic function
Which type of circulation theory involves capillaries opening in the splenic cords?
Open circulation
What do the venous sinuses flow into?
Pulp veins
Where are the lymphoid follicles mainly made up of B cells located?
White splenic pulp
What is the characteristic of the venous sinuses' basement membrane?
Discontinuous basement membrane
Which cells form the periarterial lymphoid sheaths and lymphoid follicles of the white splenic pulp?
B cells
What cells are found in the transition zone between white and red splenic pulp?
Specialized B cells and macrophages
Which structures form the hilum of the spleen, where arteries, veins, lymphatics, and nerves enter?
Splenic capsule
What do central and follicular arteries supply in the spleen?
Lymphoid structures
Which of the following is NOT a major function of the spleen as a secondary lymphoid organ?
Synthetic function
What is the name of the parenchyma of the spleen that presents a pulpy appearance when cut?
Pulp
In what state does the spleen act as a blood filter?
Normal state
What is the name of the capsule that surrounds the spleen?
Fibrous capsule
What type of cells mainly make up the splenic cords?
Macrophages
Which theory of splenic circulation involves a combination of both closed and open circulation?
Modified open circulation
What type of cells form the framework of the spleen, enveloped by reticular cells?
Fibroblasts
What is the characteristic of the venous sinuses' basement membrane?
Discontinuous basement membrane
Where are the lymphoid follicles mainly made up of B cells located?
White splenic pulp
Which structures form the hilum of the spleen, where arteries, veins, lymphatics, and nerves enter?
Spleen capsule
In what state does the spleen act as a blood store?
Contracted state
What do central and follicular arteries supply in the spleen?
Lymphoid structures
What is the main function of the spleen as a secondary lymphoid organ?
Immune response activation
What process does the spleen undergo as a blood filter?
Phagocytosis
Which type of circulation theory involves capillaries opening in the splenic cords?
Open circulation
What cells are found in the transition zone between white and red splenic pulp?
Specialized B cells and macrophages
Study Notes
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Spleen capsule lined by mesothelium thickened in hilum, where arteries, veins, lymphatics, and nerves enter
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Trabeculae made up of fibroblasts, collagen fibers, elastic fibers, and smooth muscle fibers
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Collagen fibers of trabeculae continued with reticular fibers, forming the framework of the spleen, enveloped by reticular cells
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White splenic pulp: periarterial lymphoid sheaths and lymphoid follicles (Malpighian corpuscles), made up mainly of T cells
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Lymphoid follicles, made up of B cells, follicular dendritic cells, and macrophages, can proliferate and displace central artery, becoming eccentric or follicular artery
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Central and follicular arteries emit collaterals and supply lymphoid structures
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Capillaries, both simple and sheathed, flow into venous sinuses, made up of rounded endothelial cells, discontinuous basement membrane, and reticular cells
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Venous sinuses flow into pulp veins, which drain into trabecular veins and form splenic vein
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Splenic cords surround venous sinuses and are mainly made up of macrophages, which carry out haemocatheretic function in red splenic pulp
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Marginal zone: a transition zone between white and red splenic pulp, formed by reticular fibers and cells, occupied by specialized B cells and macrophages
-
Three theories on splenic circulation: closed circulation (all capillaries flow into venous sinuses), open circulation (capillaries open in splenic cords), and modified open circulation (a combination of both)
-
The text includes several figures to illustrate the described structures and processes.
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Spleen capsule lined by mesothelium thickened in hilum, where arteries, veins, lymphatics, and nerves enter
-
Trabeculae made up of fibroblasts, collagen fibers, elastic fibers, and smooth muscle fibers
-
Collagen fibers of trabeculae continued with reticular fibers, forming the framework of the spleen, enveloped by reticular cells
-
White splenic pulp: periarterial lymphoid sheaths and lymphoid follicles (Malpighian corpuscles), made up mainly of T cells
-
Lymphoid follicles, made up of B cells, follicular dendritic cells, and macrophages, can proliferate and displace central artery, becoming eccentric or follicular artery
-
Central and follicular arteries emit collaterals and supply lymphoid structures
-
Capillaries, both simple and sheathed, flow into venous sinuses, made up of rounded endothelial cells, discontinuous basement membrane, and reticular cells
-
Venous sinuses flow into pulp veins, which drain into trabecular veins and form splenic vein
-
Splenic cords surround venous sinuses and are mainly made up of macrophages, which carry out haemocatheretic function in red splenic pulp
-
Marginal zone: a transition zone between white and red splenic pulp, formed by reticular fibers and cells, occupied by specialized B cells and macrophages
-
Three theories on splenic circulation: closed circulation (all capillaries flow into venous sinuses), open circulation (capillaries open in splenic cords), and modified open circulation (a combination of both)
-
The text includes several figures to illustrate the described structures and processes.
Learn about the functions of the spleen as a secondary lymphoid organ, including its roles in hematopoiesis, hemocatheresis, immune response, and blood filtration.
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