Spleen Pathology Overview
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Questions and Answers

What are the ligaments that stabilize the spleen?

  • Lienorenal ligament, Gastrosplenic ligament, Phrenicocolic ligament (correct)
  • Splenorenal ligament, Gastrosplenic ligament, Phrenicocolic ligament
  • Splenorenal ligament, Gastrosplenic ligament, Phrenicohepatic ligament
  • Lienorenal ligament, Splenic ligament, Phrenicocolic ligament
  • At what length is the spleen considered grossly enlarged?

    Greater than 13 cm

    What is the primary function of red pulp in the spleen?

    Filter old/damaged RBCs

    What is the normal echogenicity of the spleen?

    <p>Isoechoic or slightly hyperechoic compared to the liver</p> Signup and view all the answers

    What is the most common cause of splenomegaly?

    <p>Portal hypertension</p> Signup and view all the answers

    What accounts for 80% of splenic cysts?

    <p>Pseudocysts, usually from trauma or infarction</p> Signup and view all the answers

    What is the most common cause of splenic calcifications?

    <p>Granulomatous infection</p> Signup and view all the answers

    What are the four major causes of splenomegaly?

    <p>Masses, Infections, Hematologic diseases, Congestive diseases (A)</p> Signup and view all the answers

    What is the most common cause of congestive splenomegaly?

    <p>Portal hypertension</p> Signup and view all the answers

    What is the sonographic appearance of granulomatous disease in the spleen?

    <p>Bright echogenic lesions w/ shadowing</p> Signup and view all the answers

    How does a splenic abscess appear sonographically?

    <p>Hypoechoic lesion with hyperechoic foci w/ debris</p> Signup and view all the answers

    What is the sonographic appearance of a splenic infarct?

    <p>Hypoechoic, wedge-shaped</p> Signup and view all the answers

    What are common trauma findings in the spleen?

    <p>Hematoma or free fluid</p> Signup and view all the answers

    What are the symptoms of splenic trauma?

    <p>LUQ pain, left shoulder pain, dizziness, hypotension, decreased hemoglobin</p> Signup and view all the answers

    What is the most common benign splenic tumor?

    <p>Cavernous hemangioma</p> Signup and view all the answers

    What is the sonographic appearance of a cavernous hemangioma?

    <p>Heterogeneous echogenic mass with small hypoechoic areas</p> Signup and view all the answers

    Hamartoma is a rare vascular tumor (splenoma), associated with

    <p>Wiskott-Aldrich syndrome.</p> Signup and view all the answers

    What is the sonographic appearance of splenic lymphoma?

    <p>Hypoechoic bulky nodules</p> Signup and view all the answers

    What cancer most commonly metastasizes to the spleen?

    <p>Melanoma</p> Signup and view all the answers

    Portal hypertension forces blood backward, leading to

    <p>spleenomegaly</p> Signup and view all the answers

    What is a key sonographic finding of sickle cell anemia in early-stage crisis?

    <p>Enlarged spleen</p> Signup and view all the answers

    Which storage disease involves the deposition of amyloid proteins?

    <p>Amyloidosis</p> Signup and view all the answers

    Which is the most common cause of focal splenic infarction?

    <p>Occlusion of a splenic artery branch</p> Signup and view all the answers

    A subcapsular splenic hematoma is characterized by:

    <p>Intact splenic capsule</p> Signup and view all the answers

    Which is a major risk factor for developing splenic abscesses?

    <p>Bacterial endocarditis</p> Signup and view all the answers

    Which infection is most associated with multiple small, hypoechoic splenic lesions?

    <p>HIV/AIDS</p> Signup and view all the answers

    What is the most common primary malignancy affecting the spleen?

    <p>Lymphoma</p> Signup and view all the answers

    Which splenic malignancy is highly aggressive and has a poor prognosis?

    <p>Angiosarcoma</p> Signup and view all the answers

    What is the typical ultrasound appearance of metastatic lesions in the spleen?

    <p>&quot;Bull's-eye&quot; hypoechoic lesions</p> Signup and view all the answers

    Autosplenectomy is when the spleen

    <p>shrinks and slowly dies</p> Signup and view all the answers

    A 58-year-old man with cirrhosis due to alcohol use presents with fatigue, jaundice, and abdominal distension. Exam shows splenomegaly and ascites. This is most consistent with ______.

    <p>Congestive splenomegaly</p> Signup and view all the answers

    What is the sonographic sign of portal hypertension?

    <p>Dilated splenic vein</p> Signup and view all the answers

    What is the most common cause of portal hypertension?

    <p>Cirrhosis</p> Signup and view all the answers

    What is the sonographic appearance of granulomatous disease?

    <p>Bright echogenic foci and shadowing</p> Signup and view all the answers

    A 50-year-old man with cirrhosis presents with fatigue and abdominal distension. Ultrasound shows splenomegaly and dilated splenic and portal veins with varices. This is most consistent with ______.

    <p>Portal Hypertension</p> Signup and view all the answers

    A 10-year-old boy fell off his bike and now has severe LUQ pain and hypotension. Ultrasound shows free fluid in the peritoneum and a hypoechoic mass in the spleen. This is most consistent with ______.

    <p>Splenic Rupture</p> Signup and view all the answers

    A 25-year-old male with sickle cell disease presents with sudden LUQ pain. Ultrasound shows a wedge-shaped hypoechoic lesion in the spleen. This is most consistent with ______.

    <p>Splenic Infarct</p> Signup and view all the answers

    What infection is linked to bird/bat droppings?

    <p>Histoplasmosis</p> Signup and view all the answers

    Fatty deposits in spleen causing enlargement

    <p>Gaucher’s Disease is</p> Signup and view all the answers

    Lipid metabolism disorder, hyperechoic, enlargement

    <p>Gaucher's Disease</p> Signup and view all the answers

    Gaucher's Disease sonographically appears with

    <p>multiple hypoechoic lesions</p> Signup and view all the answers

    Angiosarcoma

    <p>Rare, aggressive vascular malignancy that affects older males</p> Signup and view all the answers

    Histoplamosis and tuberculosis have _______ lesions with or without shadowing.

    <p>hyperechoic</p> Signup and view all the answers

    Histoplamosis

    <p>Histoplasmosis is an infection linked to bird/bat droppings, producing hyperechoic lesions, with or without shadowing.</p> Signup and view all the answers

    Spleen infarct

    <p>A spleen infarct is a wedge-shaped hypoechoic lesion, often occurring in people with sickle cell anemia.</p> Signup and view all the answers

    Hematoma

    <p>A hematoma is a collection of blood within the spleen, often seen after trauma, and appears as a hypoechoic mass.</p> Signup and view all the answers

    Ruptured spleen

    <p>A ruptured spleen involves a tear in the splenic capsule, and can result in hemorrhage and abdominal pain.</p> Signup and view all the answers

    Cavernous hemangioma

    <p>A cavernous hemangioma is the most common benign tumor of the spleen, appearing as a heterogeneous echogenic mass with small hypoechoic areas on ultrasound.</p> Signup and view all the answers

    Spleen abssess

    <p>A spleen abscess is an infection, often caused by bacterial endocarditis, appearing as a hypoechoic lesion with hyperechoic foci.</p> Signup and view all the answers

    Stores urine

    <p>The function of the bladder is to store urine.</p> Signup and view all the answers

    What is the normal bladder capacity?

    <p>500 mL</p> Signup and view all the answers

    What is the normal bladder wall thickness when full?

    <p>3 mm</p> Signup and view all the answers

    What are the layers of the bladder wall (outer to inner)?

    <p>Serosa → Detrusor muscle → Submucosa → Mucosa (transitional epithelium)</p> Signup and view all the answers

    What is the purpose of transitional epithelium in the bladder?

    <p>Allows for expansion</p> Signup and view all the answers

    What is the trigone of the bladder?

    <p>Triangular area formed by 3 openings, 2 ureters + urethra</p> Signup and view all the answers

    What holds the bladder in place?

    <p>Pelvic muscle &amp; medial umbilical ligament</p> Signup and view all the answers

    A 58-year-old man with cirrhosis due to alcohol use presents with fatigue, jaundice, and abdominal distension. Exam shows splenomegaly and ascites. What is the most likely cause of his enlarged spleen?

    <p>Congestive splenomegaly</p> Signup and view all the answers

    A 50-year-old man with cirrhosis presents with fatigue and abdominal distension. Ultrasound shows splenomegaly and dilated splenic and portal veins with varices. This is most consistent with

    <p>Portal Hypertension</p> Signup and view all the answers

    A 10-year-old boy fell off his bike and now has severe LUQ pain and hypotension. Ultrasound shows free fluid in the peritoneum and a hypoechoic mass in the spleen. What is the most likely diagnosis?

    <p>Splenic Rupture</p> Signup and view all the answers

    A 25-year-old male with sickle cell disease presents with sudden LUQ pain. Ultrasound shows a wedge-shaped hypoechoic lesion in the spleen. What is the most likely diagnosis?

    <p>Splenic Infarct</p> Signup and view all the answers

    Gaucher's Disease is

    <p>Fatty deposits in spleen causing enlargement</p> Signup and view all the answers

    Rare, aggressive vascular malignancy that affects older males

    <p>Angiosarcoma</p> Signup and view all the answers

    What is the function of the bladder?

    <p>Stores urine</p> Signup and view all the answers

    What is the function of the ureterovesical junction?

    <p>Prevents urine reflux into the ureters</p> Signup and view all the answers

    What is the normal post-void residual volume?

    <p>Less than 10% of pre-void volume</p> Signup and view all the answers

    What is the sonographic appearance of a normal bladder?

    <p>Anechoic with thin echogenic walls</p> Signup and view all the answers

    What is bladder duplication?

    <p>Complete or partial duplication of the bladder (rare).</p> Signup and view all the answers

    What is bladder exstrophy?

    <p>Bladder is exposed outside the body due to failure of anterior abdominal wall closure.</p> Signup and view all the answers

    What is a patent urachus?

    <p>Failure of the fetal urachus to close, causing urine leakage from the umbilicus.</p> Signup and view all the answers

    Flashcards

    Lienorenal ligament

    Ligament stabilizing the spleen.

    Grossly enlarged spleen

    Spleen considered enlarged at greater than 13 cm.

    Red pulp function

    Primary function is to filter old/damaged RBCs.

    Normal spleen echogenicity

    Normal spleen appears isoechoic or slightly hyperechoic compared to liver.

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    Splenomegaly cause

    Most common cause is portal hypertension.

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    Splenic cysts

    Pseudocysts, usually resulting from trauma or infarction, account for 80% of cases.

    Signup and view all the flashcards

    Causes of splenic calcifications

    Granulomatous infection is the most common cause.

    Signup and view all the flashcards

    Major causes of splenomegaly

    Include masses, infections, hematologic diseases, and congestive diseases.

    Signup and view all the flashcards

    Congestive splenomegaly cause

    Portal hypertension is the most common cause.

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    Granulomatous disease appearance

    Sonographically appears as bright echogenic lesions with shadowing.

    Signup and view all the flashcards

    Splenic abscess appearance

    Hypoechoic lesion with hyperechoic foci and debris on ultrasound.

    Signup and view all the flashcards

    Sonographic appearance of splenic infarct

    Appears hypoechoic and wedge-shaped on ultrasound.

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    Common trauma findings in spleen

    Hematoma or free fluid are common after trauma.

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    Symptoms of splenic trauma

    Include LUQ pain, left shoulder pain, dizziness, hypotension, and decreased hemoglobin.

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    Benign splenic tumor

    Cavernous hemangioma is the most common benign tumor of the spleen.

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    Cavernous hemangioma appearance

    Appears as a heterogeneous echogenic mass with small hypoechoic areas on ultrasound.

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    Wiskott-Aldrich syndrome association

    Hamartoma, a rare vascular tumor, is associated with this syndrome.

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    Sonographic appearance of splenic lymphoma

    Hypoechoic bulky nodules appear on ultrasound.

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    Most common metastasizing cancer to spleen

    Melanoma is the cancer that most commonly metastasizes to the spleen.

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    Portal hypertension effects

    Causes spleen enlargement, known as splenomegaly.

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    Key finding in sickle cell anemia

    Enlarged spleen is a key sonographic finding in early-stage crisis.

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    Amyloidosis involvement

    Involves deposition of amyloid proteins, affecting the spleen's function.

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    Focal splenic infarction cause

    Most commonly caused by occlusion of a splenic artery branch.

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    Subcapsular splenic hematoma characteristic

    Characterized by an intact splenic capsule.

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    Risk factor for splenic abscess

    Bacterial endocarditis is a major risk factor.

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    HIV/AIDS association with spleen

    Most associated with multiple small, hypoechoic splenic lesions.

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    Most common primary malignancy of spleen

    Lymphoma is the most common primary malignancy affecting the spleen.

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    Highly aggressive splenic malignancy

    Angiosarcoma is highly aggressive and has a poor prognosis.

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    Typical ultrasound appearance of metastatic lesions

    Tend to present as 'Bull's-eye' hypoechoic lesions in the spleen.

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    Autosplenectomy process

    Occurs when the spleen shrinks and slowly dies.

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    Bladder function

    The bladder's primary function is to store urine.

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    Bladder capacity

    Normal bladder capacity is 500 mL.

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    Bladder wall thickness

    Normal bladder wall thickness when full is 3 mm.

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    Layers of bladder wall

    Layers include serosa, detrusor muscle, submucosa, and mucosa.

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    Transitional epithelium purpose

    Allows for expansion of the bladder.

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    Trigone of the bladder

    Triangular area formed by 3 openings: 2 ureters and urethra.

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    Support structures of bladder

    Supported by pelvic muscle and medial umbilical ligament.

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    Ureterovesical junction function

    Prevents urine reflux into the ureters.

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    Post-void residual volume

    Normal is less than 10% of pre-void volume.

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    Normal bladder echogenicity

    A normal bladder appears anechoic with thin echogenic walls.

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    Bladder duplication

    Rare condition of complete or partial duplication of the bladder.

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    Bladder exstrophy

    Bladder exposed outside the body due to wall closure failure.

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    Patent urachus

    Failure of the fetal urachus to close causes urine leakage from the umbilicus.

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    Urachal cyst

    Cystic structure superior to the bladder.

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    Ureterocele appearance

    Round, thin-walled cystic structure on posterior bladder wall.

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    Posterior urethral valve syndrome

    Urethral obstruction in male infants due to a tissue flap.

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    Keyhole sign

    Sonographic appearance indicating posterior urethral valve syndrome.

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    Cystitis definition

    Inflammation of the bladder wall, usually due to infection.

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    Cystitis symptoms

    Symptoms include polyuria, pain, pelvic tenderness, dysuria.

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    Cystitis sonographic findings

    Findings include thickened bladder wall with echogenic debris.

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    Emphysematous cystitis

    Bladder infection by gas-producing bacteria.

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    Hemorrhagic cystitis

    Bladder infection with blood in urine and echogenic debris.

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    Purulent cystitis

    Bladder infection with pus mixed in urine.

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    Conditions leading to urinary stasis

    Include bladder outlet obstruction, neoplasm, stones, pregnancy, catheterization.

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    Neurogenic bladder definition

    Bladder pathology associated with spinal cord injury.

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    Neurogenic bladder sonographic findings

    Findings include trabeculated and enlarged bladder with urine retention.

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    Bladder diverticulum

    External herniation of the bladder wall, leading to urine stasis.

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    Bladder outlet obstruction cause

    Posterior urethral valves are the most common cause in newborn males.

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    Right ureteral obstruction indicator

    Absence of right ureteral jet on Doppler.

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    Urinoma definition

    Fluid collection caused by bladder trauma.

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    Study Notes

    Spleen Pathology

    • Splenomegaly Causes: Portal hypertension, infections, hematologic diseases, congestive diseases are the four major causes
    • Splenomegaly Size: Spleen is considered grossly enlarged when greater than 13 cm
    • Splenic Ligaments: Lienorenal, gastrosplenic, and phrenicocolic ligaments stabilize the spleen
    • Normal Spleen Echogenicity: Typically isoechoic or slightly hyperechoic compared to the liver
    • Splenic Cysts (80%): Pseudocysts, commonly from trauma or infarction, account for the majority
    • Splenic Calcifications: Granulomatous infection is the most prevalent cause
    • Splenic Trauma Findings: Hematoma, free fluid, are common findings in splenic trauma
    • Splenic Trauma Symptoms: LUQ pain, left shoulder pain, dizziness, hypotension, decreased hemoglobin
    • Benign Splenic Tumor: Cavernous hemangioma is the most frequent benign tumor
    • Splenic Hemangioma Appearance: Heterogeneous echogenic mass with small hypoechoic areas
    • Splenic Hamartoma: A rare vascular tumor related to Wiskott-Aldrich syndrome;
    • Splenic Lymphoma Appearance: Hypoechoic bulky nodules
    • Metastatic Cancer to Spleen: Melanoma is the most common type of metastasizing cancer to the spleen; metastatic lesions often appear as "bull's-eye" hypoechoic lesions
    • Splenic Infarct: Wedge-shaped hypoechoic lesion. Common cause is occlusion of a splenic artery branch
    • Splenic Abscess Appearance: Hypoechoic lesion with hyperechoic foci and debris;
    • Congestive Splenomegaly Origin: Portal hypertension is the most common cause
    • Granulomatous Disease Ultrasound: Bright echogenic lesions with shadowing
    • Sickle Cell Anemia (Early-Stage Crisis): Enlarged spleen is a key finding
    • Splenic Function: Filter old/damaged red blood cells (RBCs).
    • Autosplenectomy: Spleen shrinks and slowly dies
    • Cirrhosis: A major cause of portal hypertension and the leading cause of congestive splenomegaly
    • **Dilated Splenic/Portal Veins:**Sonographic sign of portal hypertension
    • Amyloidosis: Storage disease involving amyloid protein deposition
    • Bacterial Endocarditis: Major risk factor for splenic abscesses.
    • HIV/AIDS: Associated with multiple small, hypoechoic splenic lesions.
    • Lymphoma: Most common primary malignancy.
    • Angiosarcoma: Highly aggressive, poor prognosis vascular splenic malignancy
    • Gaucher's disease: Lipid metabolism disorder causing fatty deposits & splenomegaly. Sonographically presents with multiple hypoechoic lesions. The spleen is often enlarged and hyperechoic.
    • Histoplasmosis: Infection linked to bird and bat droppings; hyperechoic lesions, sometimes with shadowing.
    • Subcapsular Hematoma: Intact splenic capsule characterizes this condition

    Kidney Pathology

    • Normal Bladder Capacity: Typically around 500 mL
    • Normal Bladder Wall Thickness (Full): Approximately 3 mm
    • Bladder Wall Layers (Outer to Inner): Serosa, detrusor muscle, submucosa, mucosa (transitional epithelium)
    • Transitional Epithelium Function: Allows for bladder expansion
    • Trigone: A triangular region formed by the two ureteral openings and the urethra
    • Bladder Support Structures: Pelvic muscles and medial umbilical ligament
    • Ureterovesical Junction Function: Prevents urine reflux into the ureters
    • Normal Post-Void Residual Volume: Less than 10% of pre-void volume
    • Normal Bladder Ultrasound Appearance: Anechoic with thin echogenic walls

    Bladder Pathology

    • Bladder Duplication: Complete or partial duplication of the bladder (rare)
    • Bladder Exstrophy: The bladder is exposed outside the body due to anterior abdominal wall closure failure.
    • Patent Urachus: Failure of the fetal urachus to close, causing urine leakage from the umbilicus
    • Urachal Cyst: A cystic structure that is superior to the bladder.
    • Ureterocele: A round, thin-walled cystic structure on the posterior bladder wall
    • Posterior Urethral Valve Syndrome: Urethral obstruction in male infants due to a tissue flap causing bilateral hydronephrosis
    • Posterior Urethral Valve Ultrasound: "Keyhole" sign (dilated urethra)
    • Cystitis: Bladder wall inflammation, often from infection
    • Cystitis Symptoms: Polyuria, pain, pressure, pelvic tenderness, dysuria
    • Cystitis Sonographic Findings: Thickened bladder wall; may contain echogenic debris.
    • Emphysematous Cystitis: Bladder infection with gas-producing bacteria; CT may show air within the bladder wall.
    • Hemorrhagic Cystitis: Bladder infection with blood in the urine (echogenic debris in bladder).
    • Purulent Cystitis: Bladder infection with pus in the urine
    • Urinary Stasis Conditions: Bladder outlet obstruction, neoplasms, stones, pregnancy, catheterization
    • Neurogenic Bladder Signs: Trabeculated, enlarged bladder with urine retention.
    • Bladder Diverticulum: External herniation of the bladder wall leading to urine stasis and infection risk
    • Most Common Newborn Male Bladder Outlet Obstruction: Posterior urethral valves
    • Right Ureteral Obstruction Indication: Absence of a right ureteral jet on Doppler
    • Urinoma: Fluid collection caused by bladder trauma
    • Vesicoureteral Reflux (VUR): Backflow of urine into the ureters due to an incompetent ureterovesical junction
    • Most Common Bladder Cancer: Transitional cell carcinoma (TCC)
    • Primary Bladder Cancer Risk Factor: Smoking
    • Bladder Cancer Symptoms: Painless hematuria, dysuria, increased urinary frequency
    • Squamous Cell Carcinoma of Bladder: Rare, aggressive bladder cancer associated with chronic infection.
    • Bladder Papilloma: A benign bladder tumor that could become cancerous
    • Bladder Cancer Ultrasound Appearance: Irregular, solid mass
    • Neurogenic Bladder Causes: Spinal cord injury, diabetes
    • Urinary Tract Infection(UTI) Imaging: Can be associated with conditions like cystitis and pyelonephritis
    • Uterovesical Space: Space between the uterus and bladder
    • Rectovesical Pouch (Males): Space between the bladder and rectum
    • Space of Retzius (Prevesical Space): Space between the bladder and pubic symphysis

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    Description

    Explore key concepts related to spleen pathology, including splenomegaly causes, normal echogenicity, and trauma findings. This quiz covers essential aspects like splenic ligaments, cysts, and benign tumors. Test your knowledge on this vital organ's pathology!

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