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Questions and Answers
What is the primary function of the spleen in relation to blood?
What is the primary function of the spleen in relation to blood?
- To filter blood (correct)
- To produce red blood cells
- To store platelets
- To produce antibodies
What is the spleen's role in the immune system?
What is the spleen's role in the immune system?
- To produce cytokines
- To activate T-cells
- To recognize and respond to antigens
- To produce antibodies and release them into circulation (correct)
What is the impact of not having a spleen on a person's health?
What is the impact of not having a spleen on a person's health?
- They are more susceptible to parasitic infections
- They are more susceptible to bacterial infections (correct)
- They are more susceptible to viral infections
- They are more susceptible to fungal infections
What is the spleen's role in the removal of red blood cells?
What is the spleen's role in the removal of red blood cells?
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What type of cells bring antigens to the spleen via the bloodstream?
What type of cells bring antigens to the spleen via the bloodstream?
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Study Notes
Spleen Location and Structure
- Located in the left upper quadrant of the abdomen
- Weighs approximately 150 grams
- Has a dense fibrous capsule with muscular trabeculae that subdivide the spleen into lobules
Spleen Functions
- Filters blood
- Synthesizes and releases antibodies into circulation
- Captures foreign antigens from the blood that passes through the spleen
- Receives antigens brought by migratory macrophages and dendritic cells via the bloodstream
Importance of the Spleen
- Persons lacking a spleen (e.g., after splenectomy) are highly susceptible to infections with capsulated bacteria (e.g., pneumococci and meningococci)
Spleen's Role in Phagocytosis and RBC Destruction
- Major site for phagocytosis of antibody-coated bacteria
- Responsible for the destruction of aged red blood cells (RBCs)
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