Somatostatin (SST) Function and Disorders

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Questions and Answers

Which of the following is a primary function of somatostatin (SST) in the context of glucose metabolism?

Inhibiting both insulin and glucagon release to lower postprandial glucose levels. (correct)
Accelerating gastric emptying and intestinal motility to facilitate glucose absorption.
Enhancing insulin release to increase glucose uptake by cells.
Stimulating glucagon secretion to elevate blood glucose levels.

Somatostatin (SST) interneurons primarily exert their influence by directly exciting pyramidal neurons in the cortex.

False (B)

Name two neurological or psychiatric disorders in which somatostatin (SST) interneuron dysfunction has been implicated.

Epilepsy, Schizophrenia, Alzheimer's disease

Somatostatin (SST) binds to a family of receptors known as G protein-coupled receptors, abbreviated as __________.

SSTR1-5 Signup and view all the answers

Match the synthetic analogs of Somatostatin (SST) with their clinical applications:

Octreotide = Treatment of hormone hypersecretion conditions Lanreotide = Treatment of acromegaly and neuroendocrine tumors Signup and view all the answers

Which neurotransmitter is primarily released by inhibitory neurons that are modulated by Somatostatin (SST)?

GABA (A) Signup and view all the answers

The term 'Sst, All' describes a condition where somatostatin influences only a limited and specific subset of neurons, excluding the vast majority.

False (B) Signup and view all the answers

Name three techniques used to study Somatostatin (SST) function in neurons.

Electrophysiology, Optogenetics, Chemogenetics, Imaging Techniques Signup and view all the answers

The ability of neuronal circuits to modify their structure and function over time in response to experience is known as __________.

plasticity Signup and view all the answers

Which of the following best describes the role of Somatostatin (SST) in synaptic transmission?

SST modulates synaptic transmission by affecting the release of other neurotransmitters and receptor activity. (D) Signup and view all the answers

Flashcards

What is Somatostatin (SST)?

A cyclic peptide hormone that often acts as an inhibitory substance and regulates physiological functions.

What are SST interneurons?

Major class of inhibitory neurons in the cortex that regulate the activity of pyramidal neurons by releasing GABA.

What are SST Analogs?

Synthetic compounds that mimic SST, used to treat conditions involving hormone hypersecretion with more selective receptor binding profiles.

What are Neurons?

Fundamental units of the nervous system, consisting of a soma, dendrites, and an axon, which conduct signals to other cells.