L33. Neuroscience: Somatosensory Pathways Touch & Pain
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Questions and Answers

At which spinal level(s) does the fasciculus cuneatus begin?

  • C2
  • C8
  • S5
  • T6 (correct)
  • Which of the following is NOT a characteristic of the fasciculus gracilis?

  • It carries DC-ML axons to the nucleus gracilis.
  • It is slender in shape.
  • It carries axons from T6 to C2 dermatomes. (correct)
  • It is found throughout the length of the spinal cord.
  • What is the significance of the posterior intermediate septum and sulcus?

  • It regulates motor function of the limbs.
  • It separates the dorsal columns into the fasciculus gracilis and fasciculus cuneatus. (correct)
  • It is involved in the processing of pain signals.
  • It carries sensory information from the limbs.
  • Which of the following is a correct statement about the spinothalamic tract in the cervical spinal cord section?

    <p>It is located medial to the fasciculus cuneatus. (A)</p> Signup and view all the answers

    What happens to the dorsal columns as they ascend in the spinal cord?

    <p>They become larger as they carry more information. (C)</p> Signup and view all the answers

    Where is the spinothalamic tract located in the spinal cord?

    <p>In the lateral funiculus (B)</p> Signup and view all the answers

    What is the reason why the spinothalamic tract is more elongated in the cervical spinal cord section compared to the thoracic section?

    <p>The cervical section includes information from a wider range of dermatomes. (D)</p> Signup and view all the answers

    What is the main reason why the dorsal columns are larger in the thoracic spinal cord compared to the cervical spinal cord?

    <p>The thoracic spinal cord carries information from more dermatomes. (A)</p> Signup and view all the answers

    What is the primary function of the DC-ML pathway?

    <p>To transmit touch and pressure signals. (C)</p> Signup and view all the answers

    What is the primary function of the inferior olivary nucleus?

    <p>It separates the medial lemniscus (ML) from the spinothalamic tract (ALS) laterally. (D)</p> Signup and view all the answers

    What is the significance of the somatotopic organization of the medial lemniscus (ML) in the medulla?

    <p>It allows for the precise localization of sensory stimuli on the body. (B)</p> Signup and view all the answers

    What is the clinical implication of a lesion affecting half of the medulla at the level described in the text?

    <p>The patient would experience loss of fine discriminative touch and conscious proprioception from the contralateral side of the body, and pain and temperature sensation from the contralateral side of the body. (D)</p> Signup and view all the answers

    What is the key anatomical change that occurs to the medial lemniscus (ML) as it ascends through the pons?

    <p>It shifts from a ventral-to-dorsal orientation to a medial-to-lateral orientation. (B)</p> Signup and view all the answers

    Why is the somatotopic organization of the medial lemniscus (ML) in the pons important?

    <p>It allows for the precise localization of sensory stimuli on the body by matching the somatotopic organization of the spinothalamic tract (ALS). (D)</p> Signup and view all the answers

    What is the anatomical landmark that displaces the medial lemniscus (ML) dorsolaterally within the midbrain?

    <p>The Red Nucleus (D)</p> Signup and view all the answers

    What is the primary function of the spinothalamic tract (ALS)?

    <p>To transmit pain and temperature signals from the body to the thalamus. (D)</p> Signup and view all the answers

    If a patient had a penetrating injury that destroyed ½ of the spinal cord at C1, what would be the clinical presentation?

    <p>Loss of fine discriminatory touch and conscious proprioception from the ipsilateral body and pain and temperature sensation from the contralateral body. (C)</p> Signup and view all the answers

    What is the significance of the fact that both the medial lemniscus (ML) and the spinothalamic tract (ALS) are positioned laterally in the midbrain?

    <p>It facilitates communication between the sensory cortex and the motor cortex. (D)</p> Signup and view all the answers

    What is the major difference in the somatotopic organization of the medial lemniscus (ML) in the medulla and the pons?

    <p>In the medulla, the ML is organized in a ventral-to-dorsal orientation, while in the pons, it is organized in a medial-to-lateral orientation. (A)</p> Signup and view all the answers

    What happens to the somatosensory fibers as they ascend the spinal cord?

    <p>They are located in the dorsal columns, with specific tracts being formed based on the origin of the fibers. (A)</p> Signup and view all the answers

    Where do the Fasciculus Gracilis (FG) fibers synapse?

    <p>Nucleus Gracilis (NG) (A)</p> Signup and view all the answers

    What is the clinical consequence of a lesion affecting the medial lemniscus (ML) in the midbrain?

    <p>The patient would experience loss of fine discriminative touch and conscious proprioception from the contralateral side of the body. (C)</p> Signup and view all the answers

    What is the medial lemniscus?

    <p>A tract of fibers that carry fine discriminatory touch and conscious proprioception. (A)</p> Signup and view all the answers

    What is the somatotopic organization of the spinothalamic tract?

    <p>Sacral lateral and cervical medial. (A)</p> Signup and view all the answers

    What is the role of the dorsal root ganglia (DRGs) in the somatosensory pathways?

    <p>They serve as the site of origin for first-order neurons in the dorsal columns. (B)</p> Signup and view all the answers

    What is the difference between the DC-ML and the spinothalamic pathways?

    <p>The DC-ML pathway carries fine discriminatory touch and conscious proprioception, while the spinothalamic pathway carries pain and temperature information. (B)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the second order somatosensory neurons in the DC-ML pathway?

    <p>They originate in the dorsal horn of the spinal cord. (C)</p> Signup and view all the answers

    Why is the somatotopic organization of the spinothalamic tract significant?

    <p>It allows for the brain to process sensory information from different body regions separately. (B)</p> Signup and view all the answers

    What does the term "cross the midline" refer to in the context of the somatosensory pathways?

    <p>The fibers cross from one side of the spinal cord to the other side of the spinal cord. (C)</p> Signup and view all the answers

    Which of the following sensory modalities is NOT transmitted by the Dorsal Column-Medial Lemniscus (DC-ML) pathway?

    <p>Pain (D)</p> Signup and view all the answers

    A patient presents with impaired ability to differentiate between different tactile sensations on their left hand. What is the most likely location of the lesion?

    <p>Left VPL thalamus. (A)</p> Signup and view all the answers

    What is the term for the ability to recognize objects by touch, which is a component of fine discriminatory touch?

    <p>Stereognosis (B)</p> Signup and view all the answers

    A patient reports losing the ability to feel vibration on their right hand, but can still feel pain and temperature on the same hand. Where is the lesion most likely located?

    <p>Right dorsal column. (D)</p> Signup and view all the answers

    Where do the first-order neurons of the DC-ML pathway synapse?

    <p>Nucleus Gracilis and Nucleus Cuneatus (B)</p> Signup and view all the answers

    A physician is examining a patient who has lost the ability to sense their left leg position with their eyes closed. The patient can still distinguish fine textures on the left leg. Which of the following is the most likely location of the lesion?

    <p>Right dorsal column nuclei. (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of unconscious proprioception?

    <p>Consciously perceived (D)</p> Signup and view all the answers

    What is the name of the structure where the second-order neurons of the DC-ML pathway cross the midline?

    <p>Medial Lemniscus (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the somatosensory homunculus?

    <p>It depicts the functional organization of the motor cortex. (B)</p> Signup and view all the answers

    A patient presents with a complete loss of fine touch sensation on their right side of the body, including their right arm and leg. Which of the following is the most likely explanation?

    <p>Lesion of the right dorsal column nuclei. (A)</p> Signup and view all the answers

    Which of the following statements about the DC-ML pathway is TRUE?

    <p>It is a two-neuron pathway (C)</p> Signup and view all the answers

    What is the function of the thalamus in the DC-ML pathway?

    <p>It relays sensory information to the cerebral cortex (A)</p> Signup and view all the answers

    Flashcards

    Conscious Proprioception

    Sensations that allow perception of limb position and movement, relayed via thalamus to the cortex.

    Unconscious Proprioception

    Information about muscle stretch and tension, processed by the cerebellum without conscious awareness.

    Pain Sensation

    Perception of damaging stimuli like mechanical stress, temperature extremes, and chemicals.

    Dorsal Column-Medial Lemniscus Pathway

    Pathway that transmits fine touch, vibration, and conscious proprioception information to the brain.

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    1st Order Neuron

    Sensory neurons that carry signals from the body to the spinal cord, originating from the dorsal root ganglion.

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    Nucleus Gracilis

    Synapse point for first order neurons that receive information from lower spinal levels in the DC-ML pathway.

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    2nd Order Neuron

    Neurons originating from Nucleus Gracilis and Nucleus Cuneatus that cross midline to form the Medial Lemniscus.

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    Spinothalamic Tract

    A sensory pathway that transmits pain and temperature sensations to the brain.

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    Dorsal Columns

    Part of the spinal cord carrying fine touch and proprioception information.

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    Fasciculus Gracilis

    A bundle of axons carrying 1st order DC-ML axons from S5 to T7 dermatomes.

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    Fasciculus Cuneatus

    A bundle of axons for 1st order DC-ML signals from T6 to C2 dermatomes.

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    Posterior Intermediate Sulcus

    A groove that separates the fasciculus gracilis and cuneatus in the spinal cord.

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    Nucleus Cuneatus

    A collection of 2nd order neurons in the medulla that receive input from the fasciculus cuneatus.

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    Cervical Enlargement

    A region of the spinal cord that is larger due to more neurons for upper limb control.

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    Sacral to Cervical Mapping

    The arrangement of spinothalamic tract levels from sacral to cervical in the spinal cord.

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    Sensory Homunculus

    A somatotopic map in the cortex representing body areas based on receptor density.

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    Brodmann Areas 5,7

    Regions in the superior parietal lobule involved in higher integrative processing of sensory information.

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    Ipsilateral Symptoms

    Symptoms affecting the same side of the body as the lesion before the pathway crosses midline.

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    Contralateral Deficits

    Symptoms affecting the opposite side of the body from the lesion after the pathway crosses midline.

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    Stereognosis

    Ability to recognize objects by touch without visual aid, tested clinically.

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    Dorsal Root Ganglion (DRG)

    Cluster of sensory neuron cell bodies located near the spinal cord.

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    Contralateral Spinal Horn

    Location of second order neurons for pain and temperature pathways in the spinal cord.

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    Internal Arcuate Fibers

    Fibers that carry second order neurons from Nucleus Gracilis and Cuneatus to the medial lemniscus after crossing midline.

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    Medial Lemniscus (ML)

    Pathway formed by second order DC-ML axons that carries touch and proprioceptive information to the thalamus.

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    Somatosensory Pathways

    Neural pathways that transmit sensory information from the body to the brain.

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    Fasciculus Gracilis (FG)

    Dorsal column fibers that carry sensory information from lower body regions to Nucleus Gracilis.

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    Fine Discriminatory Touch

    Ability to perceive and differentiate between different types of touch stimuli.

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    Sacral Lateral Organization

    Refers to how sacral fibers are arranged laterally in the spinothalamic tract.

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    Somatotopic Organization

    The spatial arrangement of sensory pathways corresponding to body regions.

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    Inferior Olivary Nucleus

    A structure in the medulla that separates the ML from the spinothalamic tract.

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    Contralateral Sensation

    Sensation perceived on the opposite side of the body from the stimulus.

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    Spinothalamic Tract (ALS)

    Pathway responsible for transmitting pain and temperature sensations.

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    Caudal Medulla

    The area where the DC-ML fibers cross to the opposite side.

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    Mid-Pons

    Region where the orientation of the ML changes from ventral-dorsal to medial-lateral.

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    Red Nucleus

    A large nucleus in the midbrain functioning as a motor landmark.

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    Dorsolateral Positioning

    The location of the ML in the midbrain, displaced laterally by the red nucleus.

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    Midbrain

    The part of the brain located above the pons, housing the red nucleus.

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    Study Notes

    Somatosensory Pathways Touch & Pain

    • Students should be able to accurately summarize the functional anatomy of the somatosensory pathways for touch and pain by the end of the session.
    • Students should also be able to describe clinical deficits and tests for somatosensory pathway lesions by the end of the session
    • Somatosensation is the detection of stimuli from the body surface, like touch, pain, temperature, and the sensing of limb position and movement (proprioception).
    • Somatosensation is crucial for diagnosing neurological issues and localizing the affected part of the nervous system.
    • Fine discriminatory touch allows for the discrimination of surface characteristics (rough, smooth, sharp, dull etc).
    • Fine touch also includes sensing pressure, vibration, and the differentiated location of touch.
    • Stereognosis is the ability to recognize an object through touch, often with manipulation
    • Limb position and movement is detected by the brain at two levels: conscious and unconscious
    • Conscious proprioception involves sensing limb position and movement, relayed to the cerebral cortex via the thalamus.
    • Unconscious proprioception provides information on muscle stretch and tension to the cerebellum, which is not consciously perceived.
    • Pain, temperature, itch, and crude touch sensations are perceived through various types of stimuli.
    • The Dorsal Column-Medial Lemniscus (DC-ML) pathway transmits information about fine discriminatory touch, vibration, pressure, and proprioception, with the 1st-order neurons in the dorsal root ganglia.
    • DC-ML pathways have first-order axons that ascend in the dorsal column and synapse in the medulla on the nucleus cuneatus and nucleus gracilis, from which the second-order axons decussate to form the medial lemniscus.
    • Third-order neurons originate in the thalamus and project directly to the ipsilateral somatosensory cortex.
    • The spinothalamic pathway (ALS) transmits innocuous stimuli (temperature, itch, crude touch), as well as damaging stimuli (mechanical, thermal, and chemical- pain, nociception).
    • Somatosensation relies on first, second, and third-order neurons with varying myelination, fiber diameters etc.
    • Different pain sensations (sharp versus dull, or fast versus slow) are transmitted via separate pathways using Aδ and C fibers.
    • Aδ fibers transmit sharp, fast pain, C fibers transmit dull, slow pain) and itch.
    • The 1st order neuron cell bodies are located in the dorsal root ganglion (DRG).
    • Central processes of DRGs enter the spinal cord via the dorsal root.
    • ALS pathway neurons cross the midline via the anterior white commissure. Its target nuclei include the ventral posterolateral (VPL) thalamic nucleus.
    • The spinothalamic pathway axons project to the VPL thalamus which then projects to the primary somatosensory cortex.
    • Both pathways project to the thalamus and ultimately to the primary somatosensory cortex for conscious sensation.
    • The primary somatosensory cortex (SI) receives input from particular skin areas.
    • The sensory homunculus represents the specific body areas overrepresented in the SI cortex, with higher densities of receptors corresponding to larger areas.
    • The primary somatosensory cortex processes input further.
    • Clinical tests help evaluate whether somatosensory pathways are injured. These tests include fine touch, texture discrimination, conscious proprioception, two-point discrimination, vibration sense, and stereognosis.

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    Description

    This quiz focuses on the functional anatomy of the somatosensory pathways related to touch and pain. Students will learn to summarize crucial aspects of somatosensation, recognize clinical deficits, and perform relevant tests for somatosensory pathway lesions. Understanding these concepts is essential for diagnosing neurological issues effectively.

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