Podcast
Questions and Answers
What is the role of rexed laminae in the transmission of nociception?
What is the role of rexed laminae in the transmission of nociception?
Which stage of nociception begins at the synapse between first and second order neurons at the dorsal horn of the spinal cord?
Which stage of nociception begins at the synapse between first and second order neurons at the dorsal horn of the spinal cord?
What is the function of interneurons in the transmission of nociception?
What is the function of interneurons in the transmission of nociception?
Which pathway carries information on pain, temperature, and crude touch to terminal synapses in the brain, such as the thalamus?
Which pathway carries information on pain, temperature, and crude touch to terminal synapses in the brain, such as the thalamus?
Signup and view all the answers
What structures are classified by Rexed Laminae?
What structures are classified by Rexed Laminae?
Signup and view all the answers
Where do the small contributions of archi and paleo tracts terminate?
Where do the small contributions of archi and paleo tracts terminate?
Signup and view all the answers
Which type of pain is associated with slow and non-specific distribution?
Which type of pain is associated with slow and non-specific distribution?
Signup and view all the answers
Which receptors are responsible for acutely reducing the magnitude of nociceptive action potential before reaching the brain?
Which receptors are responsible for acutely reducing the magnitude of nociceptive action potential before reaching the brain?
Signup and view all the answers
What type of fibers are mainly associated with the spinothalamic tract?
What type of fibers are mainly associated with the spinothalamic tract?
Signup and view all the answers
Which neural sources are responsible for mediating the descending inhibition system and nociception at PAG?
Which neural sources are responsible for mediating the descending inhibition system and nociception at PAG?
Signup and view all the answers
What is the main function of the periaqueductal gray matter?
What is the main function of the periaqueductal gray matter?
Signup and view all the answers
Which neurotransmitters are released at the dorsal horn to inhibit primary and second order neurons?
Which neurotransmitters are released at the dorsal horn to inhibit primary and second order neurons?
Signup and view all the answers
What is the difference between central sensitization and peripheral sensitization?
What is the difference between central sensitization and peripheral sensitization?
Signup and view all the answers
What process is associated with an increase in action potential output from dorsal horn neurons and activation of nociceptive neurons in C fibers?
What process is associated with an increase in action potential output from dorsal horn neurons and activation of nociceptive neurons in C fibers?
Signup and view all the answers
Which structure is responsible for mediating nociception through descending neurons and interacting with 1st order and 2nd order neurons associated with C-fibers?
Which structure is responsible for mediating nociception through descending neurons and interacting with 1st order and 2nd order neurons associated with C-fibers?
Signup and view all the answers
Where do lamina 1 and 2 neurons primarily receive presynaptic terminals from?
Where do lamina 1 and 2 neurons primarily receive presynaptic terminals from?
Signup and view all the answers
Which neuropeptide is primarily released by first-order C fibers at the synaptic junction?
Which neuropeptide is primarily released by first-order C fibers at the synaptic junction?
Signup and view all the answers
Which ascending pathway carries both noxious and non-noxious information from A beta, A delta, and C fibers from the periphery to the thalamus?
Which ascending pathway carries both noxious and non-noxious information from A beta, A delta, and C fibers from the periphery to the thalamus?
Signup and view all the answers
Which tract is responsible for providing immediate experience of pain and carries quicker fibers with heavier myelination?
Which tract is responsible for providing immediate experience of pain and carries quicker fibers with heavier myelination?
Signup and view all the answers
Which structure is responsible for altering sensory input before it’s experienced and mediating sympathetic responses to sensation?
Which structure is responsible for altering sensory input before it’s experienced and mediating sympathetic responses to sensation?
Signup and view all the answers
What is the primary function of the Reticular Formation RN and Raphe Nuclei PVG & PAG in the context of noxious stimulus?
What is the primary function of the Reticular Formation RN and Raphe Nuclei PVG & PAG in the context of noxious stimulus?
Signup and view all the answers
What is the role of the Periaqueductal Gray (PAG) in the processing of noxious input?
What is the role of the Periaqueductal Gray (PAG) in the processing of noxious input?
Signup and view all the answers
What is the primary function of the Dorsal Horn interneurons in modulating sensory input?
What is the primary function of the Dorsal Horn interneurons in modulating sensory input?
Signup and view all the answers
Which brain structures are primarily associated with visceral, emotional, and autonomic modulation in the context of nociception?
Which brain structures are primarily associated with visceral, emotional, and autonomic modulation in the context of nociception?
Signup and view all the answers
What differentiates descending inhibition from gate control theory in pain modulation?
What differentiates descending inhibition from gate control theory in pain modulation?
Signup and view all the answers
