Questions and Answers
What is the brand name of Solifenacin?
What is the generic name for the medication Vesicare?
Solifenacin
What are the indications for Solifenacin?
Treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.
What is the recommended starting dose of Solifenacin?
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The strength(s) of Solifenacin available in tablets are ______.
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What class of medication does Solifenacin belong to?
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What is the mechanism of action of Solifenacin?
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Which of the following are strong CYP3A4 inhibitors that may interact with Solifenacin? (Select all that apply)
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Which of the following are side effects of Solifenacin? (Select all that apply)
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Who should avoid using Solifenacin? (Select all that apply)
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What are some important patient counseling points for Solifenacin?
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Study Notes
Solifenacin Overview
- Brand name: Vesicare
- Generic name: Solifenacin
Indications
- Treats overactive bladder
- Addresses symptoms: urge urinary incontinence, urgency, urinary frequency
Dosing Recommendations
- Starting dose: 5 mg once daily
- If tolerated, can increase to: 10 mg once daily
Available Strengths
- Dosage forms: Tablets
- Strengths: 5 mg and 10 mg
Medication Class
- Classified as a Urinary Bladder Modifier
Pharmacology
- Mechanism: Competitive muscarinic receptor antagonist
- Functions by inhibiting muscarinic receptors linked to bladder contraction and salivary stimulation
Drug Interactions
- Risk D with potent CYP3A4 inhibitors
- Includes: ketoconazole, itraconazole, ritonavir, nelfinavir, clarithromycin, nefazodone
- May decrease hepatic metabolism of solifenacin
Side Effects
- Common effects: dry mouth, constipation, blurred vision
- Other possible effects: UTI, dyspepsia, nausea, abdominal pain, dizziness, fatigue, dry eyes, drowsiness
Contraindications
- Not for patients with:
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Bladder outflow obstruction
- Gastrointestinal obstructive disorders
- Decreased GI motility
- Ulcerative colitis
- Myasthenia gravis
- Controlled narrow-angle glaucoma
- Hepatic or renal impairment
- If pregnant or nursing (risk category C)
- Patients with QT prolongation or on QT-prolonging medications
- Rare reports of angioedema
Patient Counseling
- Avoid prolonged exposure to heat
- Be cautious with activities requiring alertness due to potential dizziness or drowsiness
- Can be taken with or without food
- Swallow tablets whole; do not chew, split, or crush
- Possible effects include dry mouth or blurred vision
- Store medication in a cool, dry place away from children
- Contact a physician for persistent or severe side effects
- If a dose is missed, skip it and return to normal schedule
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Description
Test your knowledge on Solifenacin, including its brand name, indications, and dosing information. These flashcards will help reinforce your understanding of this medication used for treating overactive bladder. Perfect for pharmacy students and healthcare professionals.
