25 Questions
Which type of sarcoma is typically associated with a simple karyotype and a monomorphic microscopic appearance?
Ewing sarcoma
What is the approximate percentage of sarcomas that have a complex karyotype with multiple chromosomal gains and losses?
80-85%
Which of the following is NOT a feature of sarcomas with a complex karyotype?
More common in children
Which of the following is a potential molecular target for diagnosis and therapy of sarcomas?
Tumor-specific fusion proteins
What is the main prognostic factor for sarcomas, according to the information provided?
Tumor grade
Which parameter is used to grade tumors based on differentiation, mitoses, and necrosis?
Degree of necrosis
What is the most common subtype of benign tumors of fat in adults?
Lipomas
What is a common presentation of lipomas?
Mobile, slowly enlarging, painless masses
Where do liposarcomas typically occur?
In the retroperitoneum
Which parameter is used to stage tumors according to their size?
Tumor dimension
Which of the following is NOT a tumor of adipose tissue?
Fibrosarcoma
Which type of sarcoma is commonly seen in children?
Rhabdomyosarcoma
Which of the following tumors is associated with human herpesvirus 8 (HHV8) infection?
Kaposi sarcoma
Which of the following genetic syndromes is associated with neurofibroma and malignant schwannoma?
Neurofibromatosis type 1
Which of the following is the most characteristic feature of well-differentiated liposarcoma/atypical lipomatous tumor?
Presence of lipoblasts with cytoplasmic lipid vacuoles that scallop the nucleus
Which of the following statements about soft tissue tumors is correct?
They are classified based on lines of differentiation, such as fat, fibrous tissue, and neural or vascular tissues.
Which of the following is the most characteristic genetic alteration seen in myxoid liposarcoma?
t(12;16) FUS-DDIT3 fusion
Which of the following liposarcoma subtypes has the worst prognosis?
Pleomorphic liposarcoma
What is the typical location of well-differentiated liposarcoma and dedifferentiated liposarcoma?
Deep soft tissues of extremities or in the retroperitoneum
What is the most characteristic feature of nodular fasciitis?
Self-limited fibroblastic proliferation
Which type of fibromatosis is typically found in the abdomen, abdominal wall, and muscles of the trunk and extremities?
Deep fibromatosis (desmoid tumors)
What is the typical histological appearance of fibromatoses?
Plump spindle cells arranged in broad sweeping fascicles that penetrate the adjacent tissue
Which type of fibromatosis is associated with Dupuytren contracture and Peyronie disease?
Superficial fibromatosis
What is the typical clinical presentation of fibromatoses?
Rapidly growing, solitary masses on the volar aspect of the forearm, chest, or back
Which genetic mutations are often found in deep fibromatoses (desmoid tumors)?
Mutations in the APC or β-catenin genes
Learn about the classification of soft tissue tumors based on lines of differentiation such as fat, fibrous tissue, neural, or vascular origin. This quiz covers the classification of tumors arising from non-epithelial tissues like bone, cartilage, central nervous system, hematopoietic, and lymphoid tissues.
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