Soft Tissue Tumors Classification

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Which type of sarcoma is typically associated with a simple karyotype and a monomorphic microscopic appearance?

Undifferentiated pleomorphic sarcoma

Liposarcoma

Ewing sarcoma (correct)

Leiomyosarcoma

What is the approximate percentage of sarcomas that have a complex karyotype with multiple chromosomal gains and losses?

15-20%

80-85% (correct)

90-95%

50-60%

Which of the following is NOT a feature of sarcomas with a complex karyotype?

Microscopically pleomorphic

Demonstrate multiple chromosomal gains and losses

More common in children (correct)

Aneuploid or polyploid

Which of the following is a potential molecular target for diagnosis and therapy of sarcomas?

Tumor-specific fusion proteins Signup and view all the answers

What is the main prognostic factor for sarcomas, according to the information provided?

Tumor grade Signup and view all the answers

Which parameter is used to grade tumors based on differentiation, mitoses, and necrosis?

Degree of necrosis Signup and view all the answers

What is the most common subtype of benign tumors of fat in adults?

Lipomas Signup and view all the answers

What is a common presentation of lipomas?

Mobile, slowly enlarging, painless masses Signup and view all the answers

Where do liposarcomas typically occur?

In the retroperitoneum Signup and view all the answers

Which parameter is used to stage tumors according to their size?

Tumor dimension Signup and view all the answers

Which of the following is NOT a tumor of adipose tissue?

Fibrosarcoma Signup and view all the answers

Which type of sarcoma is commonly seen in children?

Rhabdomyosarcoma Signup and view all the answers

Which of the following tumors is associated with human herpesvirus 8 (HHV8) infection?

Kaposi sarcoma Signup and view all the answers

Which of the following genetic syndromes is associated with neurofibroma and malignant schwannoma?

Neurofibromatosis type 1 Signup and view all the answers

Which of the following is the most characteristic feature of well-differentiated liposarcoma/atypical lipomatous tumor?

Presence of lipoblasts with cytoplasmic lipid vacuoles that scallop the nucleus Signup and view all the answers

Which of the following statements about soft tissue tumors is correct?

They are classified based on lines of differentiation, such as fat, fibrous tissue, and neural or vascular tissues. Signup and view all the answers

Which of the following is the most characteristic genetic alteration seen in myxoid liposarcoma?

t(12;16) FUS-DDIT3 fusion Signup and view all the answers

Which of the following liposarcoma subtypes has the worst prognosis?

Pleomorphic liposarcoma Signup and view all the answers

What is the typical location of well-differentiated liposarcoma and dedifferentiated liposarcoma?

Deep soft tissues of extremities or in the retroperitoneum Signup and view all the answers

What is the most characteristic feature of nodular fasciitis?

Self-limited fibroblastic proliferation Signup and view all the answers

Which type of fibromatosis is typically found in the abdomen, abdominal wall, and muscles of the trunk and extremities?

Deep fibromatosis (desmoid tumors) Signup and view all the answers

What is the typical histological appearance of fibromatoses?

Plump spindle cells arranged in broad sweeping fascicles that penetrate the adjacent tissue Signup and view all the answers

Which type of fibromatosis is associated with Dupuytren contracture and Peyronie disease?

Superficial fibromatosis Signup and view all the answers

What is the typical clinical presentation of fibromatoses?

Rapidly growing, solitary masses on the volar aspect of the forearm, chest, or back Signup and view all the answers

Which genetic mutations are often found in deep fibromatoses (desmoid tumors)?

Mutations in the APC or β-catenin genes Signup and view all the answers