Small Intestine and Digestion

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Questions and Answers

What is the primary role of enterokinase in the small intestine?

  • Emulsifying fats for easier digestion.
  • Activating trypsinogen into trypsin for protein digestion. (correct)
  • Neutralizing acidic chyme from the stomach.
  • Absorbing monosaccharides across the intestinal wall.

Where does the digestion of fats primarily occur, aided by bile produced by the liver and stored in the gallbladder?

  • Ileum
  • Stomach
  • Duodenum (correct)
  • Esophagus

How do villi contribute to nutrient absorption in the small intestine?

  • Increasing the surface area to maximize nutrient absorption. (correct)
  • Promoting the release of bicarbonate to neutralize acids.
  • Increasing the rate of enzyme secretion.
  • Decreasing the surface area for absorption.

Which secretion is released into the small intestine to neutralize the acidic chyme coming from the stomach?

<p>Bicarbonate (B)</p> Signup and view all the answers

What is the primary function of bile salts in fat digestion?

<p>Emulsifying fats into smaller droplets. (D)</p> Signup and view all the answers

How are triglycerides and other lipids reassembled into for transport after being absorbed by intestinal cells?

<p>Chylomicrons (B)</p> Signup and view all the answers

How are glucose and galactose absorbed across the intestinal epithelium?

<p>Active transport (C)</p> Signup and view all the answers

What is the primary role of the pancreas in the small intestine's digestive process?

<p>Producing digestive enzymes to break down macromolecules. (A)</p> Signup and view all the answers

What is the function of the gallbladder regarding digestion?

<p>Storing and concentrating bile for fat digestion. (D)</p> Signup and view all the answers

Which of the following carbohydrates is broken down into glucose and galactose?

<p>Lactose (C)</p> Signup and view all the answers

How are di- and tripeptides transported across the intestinal epithelium?

<p>Active transport coupled with hydrogen ions. (D)</p> Signup and view all the answers

Through what route do chylomicrons primarily enter the bloodstream after absorption in the small intestine?

<p>Through the lymphatic system. (C)</p> Signup and view all the answers

What is the main function of the colon in the large intestine?

<p>Absorption of water and electrolytes. (D)</p> Signup and view all the answers

What role do resident microbes play in the large intestine?

<p>Synthesizing certain vitamins and fermenting undigested material. (C)</p> Signup and view all the answers

What is the primary trigger for 'homeostatic hunger'?

<p>Depletion of energy stores. (A)</p> Signup and view all the answers

Which of the following is the correct classification of bile salts?

<p>Amphipathic (C)</p> Signup and view all the answers

What is the potential consequence if intact proteins are absorbed into the bloodstream?

<p>Immune reaction or food allergy. (A)</p> Signup and view all the answers

Which transport mechanism is used to absorb fructose in the intestines?

<p>Facilitated transport. (A)</p> Signup and view all the answers

What process is affected when a person has a deficiency in lactase?

<p>Lactose digestion. (D)</p> Signup and view all the answers

What is 'hedonic hunger' primarily motivated by?

<p>The drive to eat for pleasure in the absence of an energy deficit. (A)</p> Signup and view all the answers

Flashcards

Pancreas Role

Main contributor of digestive enzymes.

Gallbladder function

Stores bile, which is produced by the liver, and aids in fat digestion.

Amphipathic Bile Salts

Bile salts are both hydrophilic and lipophilic, allowing them to emulsify fats.

Villi Function

The small intestinal mucosa increases surface area for nutrient absorption.

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Small Intestine Secretions

Secretions released into the lumen of the small intestine upon the opening of the pyloric sphincter.

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Digestive Enzymes Location

Anchored on the luminal surface of small intestine epithelial cells, aiding in digestion.

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Carbohydrate Absorption

Monosaccharides absorbed into the blood.

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Active Transport

Glucose and galactose are absorbed by this mechanism.

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Facilitated Transport

Fructose is absorbed via this mechanism.

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Food Allergy Cause

Occurs if intact proteins are absorbed into the hepatic portal vein causing Immune Reaction.

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Fat Digestion Products

Breaking down fat by Lipase results in these products.

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Chylomicrons

Type of lipoprotein that transports dietary triglycerides and other lipids from the small intestine.

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Energy Depletion

Homeostatic hunger driven by

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Pleasure

Hedonic hunger driven by

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Illeum Contents

Ileal chyme, unabsorbed nutrients, hormones, and microbes

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Colonic Epithelium

Absorbs water and small ions.

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Digestion byproduct

Resident microbes produce gases.

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Study Notes

Small Intestine & Accessory Organs

  • The pancreas is the primary contributor to digestive enzymes.
  • Enzymes are released from the pancreas in an inactive form
    • Ex: Trypsinogen.
  • Enterokinase in the small intestine activates enzymes to form trypsin in the duodenum for protein digestion.
  • The gallbladder stores bile, which is produced by the liver.
  • Bile is crucial for fat digestion.

Absorption in the Small Intestine

  • Villi in the small intestinal mucosa increase the surface area to promote nutrient absorption.

Carbohydrate Absorption & Transport

  • Maltose is composed of 2 glucose molecules
  • Sucrose is composed of fructose and glucose.
  • Lactose is composed of galactose and glucose.
  • Starch is a polymer of glucose molecules.

Lactose Intolerance

  • Lactase deficiency causes lactose intolerance.
  • Glucose and galactose are absorbed via active transport.
  • Fructose is absorbed via facilitated transport.

Peptide & Amino Acid Transport

  • Intact proteins are not typically absorbed into the hepatic portal vein.
  • Intestinal damage or "leakiness" can lead to the absorption of intact proteins.
  • Absorption of intact proteins may result in an immune reaction or food allergy.

Emulsifying Fat

  • Emulsifying fat happens by fats becoming soluble with bile.
  • Bile salts are amphipathic, being both hydrophilic and lipophilic, similar to soaps or detergents.

Breakdown of Fat by Lipase

  • Lipase breaks down fat droplets into monoglycerides and fatty acids.

Lipid Absorption & Transport

  • Fatty acids and monoglycerides are absorbed.
  • Triglycerides are reassembled and packaged into chylomicrons, a type of lipoprotein.
  • Chylomicrons are too large to cross the capillary wall, so they are absorbed into the lymphatic system.
  • Lipids re-enter circulation via the thoracic duct near the heart.

Large Intestinal Phase of Digestion & Absorption

  • Ileal chyme, a chemical and particle-rich liquid, enters from the ileum.
  • Unabsorbed nutrients, hormones, chemical messengers, soluble fiber (prebiotic), insoluble fiber (bulking agent), microbes (probiotics), cellular debris and liver excretion products are found in the large intestine.

Large Intestine (Cecum & Colon) Function

  • Colonic epithelium absorbs water and simple ions like sodium, potassium, magnesium, and calcium.
  • Resident microbes digest and absorb chemicals that they can via fermentation.
    • This produces short-chain fatty acids.
  • Resident microbes produce vitamins (K, some B vitamins) as a byproduct of their metabolism.
  • Resident microbes produce gases (carbon dioxide, methane, hydrogen sulfide) during digestion.
  • Newly arriving live microbes seek to colonize the microbial ecosystem.

Motivation to Eat

  • Hedonic hunger/eating involves eating to obtain pleasure in the absence of an energy deficit.
  • Homeostatic hunger/eating involves an increased motivation to eat after depletion of energy stores.

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