Skin Microbiome and Bacteria Quiz
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Questions and Answers

What role does Cutibacterium acnes play in the hair follicle environment?

  • It competes with Staphylococcus epidermidis through the production of antimicrobial peptides. (correct)
  • It promotes the overgrowth of Malassezia fungi.
  • It enhances biofilm formation of Staphylococcus epidermidis.
  • It is responsible for the degradation of lipids.
  • Which of the following statements accurately describes Malassezia fungi?

  • They are often found in areas rich in sebaceous glands. (correct)
  • They can cause systemic infections in healthy individuals.
  • They do not require lipids for growth.
  • They are primarily Basidiomycetous fungi found in the gastrointestinal tract.
  • What mechanism does Staphylococcus epidermidis use to inhibit the growth of Cutibacterium acnes?

  • Forming a protective biofilm on the skin surface.
  • Exchanging resistance genes with related species.
  • Utilizing lipases to break down oils.
  • Producing antimicrobial peptides and fermenting glycerol. (correct)
  • What condition is associated with the overgrowth of Cutibacterium acnes?

    <p>Acne vulgaris. (B)</p> Signup and view all the answers

    Which of the following are characteristics associated with antibiotic-resistant strains of Staphylococcus species?

    <p>Acquired resistance genes from other species. (C)</p> Signup and view all the answers

    What is one primary function of the skin microbiome?

    <p>Providing an antibacterial shield (D)</p> Signup and view all the answers

    How can the skin microbiome affect pathogen growth?

    <p>It can promote or limit pathogen growth based on commensal interactions. (D)</p> Signup and view all the answers

    Which microbial taxon is primarily found on the skin?

    <p>Malassezia spp. (B)</p> Signup and view all the answers

    What drives the diversity of the skin microbiome?

    <p>Sampling methods and environmental factors (B)</p> Signup and view all the answers

    Which skin layer is primarily composed of keratinocytes?

    <p>Epidermis (C)</p> Signup and view all the answers

    What is the significance of consistent skin microbiota sampling techniques?

    <p>To ensure accurate assessment of species diversity (A)</p> Signup and view all the answers

    In which layers of skin can sampling methods capture microorganisms?

    <p>Both surface and deeper skin layers (A)</p> Signup and view all the answers

    Which feature of skin provides a barrier to pathogens?

    <p>Sebum secretion (C)</p> Signup and view all the answers

    Which bacteria are known to produce short-chain fatty acids like proprionate and butyrate important for skin health?

    <p>Propionibacterium spp. (D)</p> Signup and view all the answers

    What role do vitamins K and B12 play in skin health?

    <p>Barrier integrity (D)</p> Signup and view all the answers

    Which statement about the skin microbiome is TRUE?

    <p>Skin microbiome varies significantly based on moisture and sebum levels. (D)</p> Signup and view all the answers

    How does diet affect the skin microbiome?

    <p>It can influence microbial population dynamics. (B)</p> Signup and view all the answers

    Which skin-associated fungi is specifically mentioned in the content?

    <p>Malassezia spp. (C)</p> Signup and view all the answers

    What can UV exposure influence regarding skin health?

    <p>Vitamin D production (B)</p> Signup and view all the answers

    What is one downside of the skin microbiome mentioned in relation to wounds?

    <p>Formation of biofilms (B)</p> Signup and view all the answers

    Which method of delivery affects the initial colonization of skin microbiota in newborns?

    <p>Cesarean section (C)</p> Signup and view all the answers

    What is the primary role of sweat glands in relation to the skin?

    <p>They contribute to thermoregulation and acidify the skin. (B)</p> Signup and view all the answers

    Which area of the body is most likely to be moist due to sweat glands?

    <p>Groin (B)</p> Signup and view all the answers

    Which factor contributes to the variation in microenvironments on the skin?

    <p>Sebum content (B)</p> Signup and view all the answers

    What is the significance of capturing microorganisms in skin studies?

    <p>To identify spatial distribution and variation in skin microbiome. (B)</p> Signup and view all the answers

    How does the skin microbiome help in training the immune system?

    <p>By creating a barrier against external pathogens. (D)</p> Signup and view all the answers

    What is a common method that may not capture microorganisms at deeper skin layers?

    <p>Swab (D)</p> Signup and view all the answers

    What does the presence of free fatty acids in sweat contribute to?

    <p>Lubricating and providing an antibacterial shield (D)</p> Signup and view all the answers

    What contributes to the high turnover of the skin microbiome?

    <p>The skin’s consistent exposure to environmental factors (C)</p> Signup and view all the answers

    What role does the skin microbiome play in relation to Staphylococcus aureus colonization?

    <p>It limits S.aureus colonization in some cases. (D)</p> Signup and view all the answers

    Which of the following is NOT a way that Staphylococcus epidermidis inhibits S.aureus?

    <p>Forming biofilms. (D)</p> Signup and view all the answers

    What is a significant concern regarding methicillin-resistant Staphylococcus aureus (MRSA)?

    <p>It poses a serious risk in hospital infections. (B)</p> Signup and view all the answers

    What unique characteristic differentiates Propionibacterium acnes in its relationship with S.aureus?

    <p>It produces coproporphyrin that promotes S.aureus aggregation. (C)</p> Signup and view all the answers

    Which of the following Staphylococcus species predominantly colonizes moist skin sites?

    <p>Staphylococcus epidermidis. (C)</p> Signup and view all the answers

    What are biofilms primarily used for by bacteria on human skin?

    <p>To protect against host defenses and antibiotics. (D)</p> Signup and view all the answers

    Which statement about Staphylococcus epidermidis is correct?

    <p>It dominates in skin niches at varying densities. (B)</p> Signup and view all the answers

    How does the skin microbiome affect biofilm formation in S.aureus?

    <p>It impacts both negatively and positively. (B)</p> Signup and view all the answers

    Which bacterial species is commonly found in dry skin environments?

    <p>Propionibacterium acnes (D)</p> Signup and view all the answers

    Which of the following is considered an accidental pathogen found on the skin?

    <p>Staphylococcus epidermidis (D)</p> Signup and view all the answers

    Which eukaryotic species is prevalent on moist skin regions?

    <p>Malassezia globosa (A)</p> Signup and view all the answers

    What type of bacteria is Staphylococcus epidermidis?

    <p>Gram-positive and cocci (A)</p> Signup and view all the answers

    In which type of skin environment is Corynebacterium tuberculostearicum predominantly found?

    <p>Moist skin (C)</p> Signup and view all the answers

    What role does the skin microbiome serve as a barrier?

    <p>Blocks harmful pathogens (D)</p> Signup and view all the answers

    Which organism is associated with both dry and sebaceous skin regions?

    <p>Propionibacterium acnes (C)</p> Signup and view all the answers

    Which microbial species thrives in sebaceous skin environments?

    <p>Malassezia restricta (A)</p> Signup and view all the answers

    How does skin injury affect the balance of the skin microbiome?

    <p>It disrupts the existing balance. (A)</p> Signup and view all the answers

    Which bacterial species is NOT typically found in foot skin environments?

    <p>Streptococcus mitis (B)</p> Signup and view all the answers

    What is a primary characteristic of the skin microbiome that enables it to limit pathogen growth?

    <p>Secretion of antimicrobial peptides (A)</p> Signup and view all the answers

    Which of the following best describes the impact of the skin microbiome fungi on human health?

    <p>They can have both beneficial and detrimental effects depending on their balance. (D)</p> Signup and view all the answers

    How does the diversity of the skin microbiome primarily develop?

    <p>By interaction with environmental factors and individual health (D)</p> Signup and view all the answers

    Which skin layer is primarily involved in forming a keratin barrier?

    <p>Epidermis (C)</p> Signup and view all the answers

    What sampling method is often used to study the skin microbiota?

    <p>Swabbing the skin surface (A)</p> Signup and view all the answers

    What is one role of sweat glands beyond thermoregulation?

    <p>They provide an antibacterial shield. (A)</p> Signup and view all the answers

    Which factor is critical for understanding the spatial distribution of microorganisms in the skin?

    <p>The sampling method used. (A)</p> Signup and view all the answers

    What distinguishes moist skin regions from dry skin regions in terms of microbial colonization?

    <p>Moist regions are predominantly colonized by different bacterial taxa. (A)</p> Signup and view all the answers

    How do variations in environmental conditions on the skin contribute to microbial diversity?

    <p>They allow for a variety of microorganisms to adapt and thrive. (B)</p> Signup and view all the answers

    Which area of the body typically exhibits high sebum content due to sebaceous glands?

    <p>The face and back. (D)</p> Signup and view all the answers

    Which bacterial species is most frequently found in dry skin environments?

    <p>Propionibacterium acnes (B)</p> Signup and view all the answers

    Which eukaryotic species is primarily identified in sebaceous skin regions?

    <p>Malassezia restricta (B)</p> Signup and view all the answers

    What characteristic best describes Staphylococcus epidermidis?

    <p>Gram-positive cocci that form clusters (B)</p> Signup and view all the answers

    Which bacterial species is associated with moist skin environments?

    <p>Staphylococcus epidermidis (C)</p> Signup and view all the answers

    What functional role can Staphylococcus epidermidis play in the skin microbiome?

    <p>Acting as an accidental pathogen (C)</p> Signup and view all the answers

    Which of these bacteria is commonly associated with the foot skin environment?

    <p>Staphylococcus warneri (D)</p> Signup and view all the answers

    Which eukaryotic organism is noted for its presence on both dry and moist skin?

    <p>Malassezia globosa (D)</p> Signup and view all the answers

    Which of the following fungi is specifically indicated as a component of the skin microbiome?

    <p>Malassezia spp. (D)</p> Signup and view all the answers

    What is one of the primary metabolites produced by certain bacteria that is important for maintaining keratinocyte barrier integrity?

    <p>Butyrate (B)</p> Signup and view all the answers

    How does diet influence the skin microbiome?

    <p>By modifying microbial diversity and composition (D)</p> Signup and view all the answers

    Which bacterial species is primarily associated with producing adherens that enhance attachment to the skin?

    <p>Corynebacterium spp. (B)</p> Signup and view all the answers

    What factor significantly influences the initial colonization of the skin in newborn babies?

    <p>Mode of delivery (B)</p> Signup and view all the answers

    Which type of microbe is primarily associated with wound healing in the skin?

    <p>Commensal bacteria (B)</p> Signup and view all the answers

    What negative aspect is associated with the skin microbiome in relation to wounds?

    <p>Promotion of biofilms (C)</p> Signup and view all the answers

    Which microorganisms are known for producing short-chain fatty acids like proprionate?

    <p>Propionibacterium and Staphylococcus (B)</p> Signup and view all the answers

    Flashcards

    Skin microbiome diversity

    The variety of microorganisms living on the skin.

    Skin microbiome functions

    The roles of microorganisms on the skin, including protecting against pathogens.

    Skin microbiome development

    Changes in the skin microbiome throughout a person's life.

    Skin microbiome-pathogen interaction

    How skin microbes sometimes prevent or encourage pathogen growth.

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    Skin microbiome fungi

    The fungal part of the skin microbiome, like Malassezia.

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    Skin microbiome-other microbiome links

    Connections between the skin microbiome and the oral, gut, and lung microbiomes.

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    Commensal microbes in the lung

    Beneficial microbes living in the lungs, contributing to health.

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    Skin layers and microbes

    Microbes can be found at different depths in the skin and the sampling method affects what is found.

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    Skin Microbiome Variation

    The skin microbiome is not uniform; different microenvironments (e.g., oily vs. dry areas) have varying microbial populations.

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    Skin Microbiome Sampling

    Methods to sample the skin microbiome (like swabs or biopsies) affect which microbes are identified.

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    Stratum Corneum

    The outermost layer of the skin, where many microbes in the skin microbiome are found.

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    Skin Microenvironment

    Different parts of the skin have varying conditions (e.g. moisture, oil, temperature).

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    Sebaceous/Oily Areas

    Areas of the skin where oil production is higher.

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    Moist Areas

    Areas of the skin where moisture is higher. The face isn't the only example.

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    Dry Areas

    Areas of the skin with low moisture levels.

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    Skin Microbiome Composition

    The skin is colonized by diverse bacteria, fungi, and viruses.

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    Key Skin Microbes

    Bacteria like Propionibacterium, Staphylococcus, and Corynebacterium; fungi like Malassezia are prevalent on skin.

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    Skin Microbiome & Wound Healing

    Appropriate microflora can enhance wound healing by interacting with the immune system.

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    Skin Microbiome & Sebum/Moisture

    Skin microbiome diversity depends on moisture and sebum levels.

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    Skin Microbiome Influence

    Diet, UV exposure, and delivery mode influence the skin's initial microbiome.

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    Negative Skin Microbiome Effects

    Biofilms and harmful bacteria like MRSA can negatively impact wound healing.

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    Initial Skin Colonization

    Newborn babies' initial skin colonization depends on delivery mode (vaginal vs. C-section).

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    S. epidermidis

    A common bacterium found on human skin, often residing in the upper layers of the epidermis. It can be a source of infections, particularly in individuals with compromised immune systems.

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    Antibiotic Resistance in S. epidermidis

    S. epidermidis can acquire resistance to antibiotics through mechanisms such as genetic exchange with other bacteria, plasmids, and phages.

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    Cutibacterium acnes

    A type of bacteria primarily residing in hair follicles, playing a role in acne development. It produces an antimicrobial peptide (AMP) called cutimycin to compete with other bacteria.

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    Cutimycin

    An antimicrobial peptide (AMP) produced by Cutibacterium acnes. It inhibits the growth of other bacteria, like Staphylococcus epidermidis, by disrupting their cell membranes.

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    Malassezia

    A genus of fungi commonly found on the skin of humans and animals, known for its association with dandruff, eczema, and other skin conditions. It requires lipids for growth, making those areas with sebaceous glands a preferred habitat.

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    What's the role of P. acnes in S. aureus colonization?

    Propionibacterium acnes (P. acnes) produces a molecule called coproporphyrin III, which promotes the aggregation of Staphylococcus aureus (S. aureus) cells.

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    What does S. epidermidis secrete to fight S. aureus?

    Staphylococcus epidermidis (S. epidermidis) produces a protease called Esp that inhibits the formation of biofilms by Staphylococcus aureus (S. aureus).

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    What are lantibiotics?

    Lantibiotics are antimicrobial peptides produced by some bacteria, including Staphylococcus lugdunensis and Staphylococcus hominis. They specifically target Staphylococcus aureus (S. aureus).

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    How do biofilms protect bacteria?

    Biofilms are a protective layer formed by bacteria, shielding them from antibiotics, host immune responses, and other environmental stresses.

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    What's MRSA?

    MRSA stands for Methicillin-Resistant Staphylococcus aureus. It's a strain of S. aureus resistant to many common antibiotics, leading to serious infections.

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    S. aureus in the environment

    Staphylococcus aureus (S. aureus) is generally harmless in normal environments like skin and mucous membranes. However, it can cause infections when it enters wounds.

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    Skin microbiome's impact

    The skin microbiome plays a crucial role in regulating S. aureus colonization and biofilm formation. Some bacteria inhibit S. aureus growth, while others promote it.

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    S. epidermidis's role in the skin

    Staphylococcus epidermidis (S. epidermidis) is a dominant colonizer of moist skin sites. It occupies various niches, including the epidermis and hair follicle.

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    Skin Microbiome: Frontline Defense

    The skin's microbiome acts as the first line of defense against external threats like pathogens.

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    Staphylococcus epidermidis: Accidental Pathogen

    While typically harmless, Staphylococcus epidermidis can cause infections if the skin's barrier is compromised.

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    What are the top 10 most abundant bacterial species on dry skin?

    The top 10 most abundant bacterial species on dry skin are: Propionibacterium acnes, Corynebacterium tuberculostearicum, Streptococcus mitis, Streptococcus oralis, Streptococcus pseudopneumoniae, Streptococcus sanguinis, Micrococcus luteus, Staphylococcus epidermidis, Staphylococcus capitis, and Veillonella parvula.

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    What are the top 10 most abundant bacterial species on moist skin?

    The top 10 most abundant bacterial species on moist skin are: Corynebacterium tuberculostearicum, Staphylococcus hominis, Propionibacterium acnes, Staphylococcus epidermidis, Staphylococcus capitis, Corynebacterium fastidiosum, Micrococcus luteus, Enhydrobacter aerosaccus, Corynebacterium simulans, and Corynebacterium afermentans.

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    What are the top 10 most abundant bacterial species on sebaceous skin?

    The top 10 most abundant bacterial species on sebaceous skin are: Propionibacterium acnes, Staphylococcus epidermidis, Corynebacterium tuberculostearicum, Staphylococcus capitis, Corynebacterium simulans, Streptococcus mitis, Staphylococcus hominis, Corynebacterium aurimucosum, Corynebacterium kroppenstedtii, and Corynebacterium amycolatum.

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    What are the top 10 most abundant bacterial species on foot skin?

    The top 10 most abundant bacterial species on foot skin are: Corynebacterium tuberculostearicum, Staphylococcus hominis, Staphylococcus warneri, Staphylococcus epidermidis, Staphylococcus capitis, Staphylococcus haemolyticus, Micrococcus luteus, Corynebacterium afermentans, Corynebacterium simulans, and Corynebacterium resistens.

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    What are some eukaryotic species abundant on the skin?

    Malassezia restricta, Malassezia globosa, Aspergillus tubingensis, Candida parapsilosis, Zymoseptoria tritici, Tilletia walkeri, Pyramimonas parkeae and Trichophyton rubrum are some of the eukaryotic species that are abundant on the skin.

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    What are some viral species abundant on the skin?

    Aureoumbra lagunensis, Pycnococcus provasolii, Parachlorella kessleri, Nephroselmis olivacea, Gracilaria tenuistipitata, Epidermophyton floccosum, Nannizzia nana and Trichophyton mentagrophytes are some viral species that are abundant on the skin.

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    How do wounds disrupt the skin microbiome?

    Wounds or cuts disrupt the skin's barrier, allowing pathogens to enter and potentially cause infection.

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    What kind of bacteria is Staphylococcus epidermidis?

    Staphylococcus epidermidis is a gram-positive coccus bacteria that forms clusters and is a facultative anaerobe.

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    What is Cutibacterium acnes?

    A type of bacteria mostly found in hair follicles, known for producing an antimicrobial peptide.

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    Skin Microenvironment Variation

    Different areas of the skin have unique conditions like moisture, oil levels, and temperature, influencing which microbes thrive.

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    Sebaceous vs. Moist vs. Dry Skin

    Skin can be classified as sebaceous (oily), moist, or dry based on its moisture and oil content. These types provide different environments for microbes.

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    Skin Microbiome's Role in Immunity

    The skin microbiome helps train the immune system by constantly interacting with it, leading to a stronger defense against pathogens.

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    How Does Skin Microbiome Vary?

    The composition of the skin microbiome varies depending on factors like location on the body, age, genetics, and even hygiene.

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    What are the main functions of the skin microbiome?

    The skin microbiome plays a crucial role in protecting against pathogens, contributing to immune system development, and helping with wound healing.

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    Skin Microbiome's Role

    The skin microbiome plays a vital role in protecting us from harmful microbes and helps maintain skin health.

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    Bacteria on the Skin

    The most common bacteria on the skin belong to the genera Propionibacterium, Staphylococcus, and Corynebacterium.

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    Fungal Resident

    The most common fungus on the skin is Malassezia. It consumes sebum, making oily areas its favorite habitat.

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    Skin Microbiome: Birth & Delivery

    The way a baby is born (vaginally or via C-section) greatly influences the initial skin microbiome composition.

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    UV Exposure & Skin Microbiome

    UV exposure can influence vitamin D production and the composition of the skin microbiome.

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    Wound Healing & the Microbiome

    A healthy skin microbiome can enhance wound healing by interacting with the immune system.

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    Biofilms and MRSA

    Biofilms are protective layers formed by bacteria that can make wounds more susceptible to infections, especially from MRSA (Methicillin-Resistant Staphylococcus aureus) bacteria.

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    Wounds and Skin Microbiome

    Wounds or cuts disrupt the skin's barrier, allowing pathogens to enter and potentially cause infection. This disrupts the balance of the skin microbiome.

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    Staphylococcus epidermidis: Gram+ Coccus

    Staphylococcus epidermidis is a gram-positive coccus bacteria that forms clusters. It's a facultative anaerobe, meaning it can survive with or without oxygen.

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    Top 10 Abundant Bacteria: Dry Skin

    The 10 most common bacteria on dry skin are: Propionibacterium acnes, Corynebacterium tuberculostearicum, Streptococcus mitis, Streptococcus oralis, Streptococcus pseudopneumoniae, Streptococcus sanguinis, Micrococcus luteus, Staphylococcus epidermidis, Staphylococcus capitis, and Veillonella parvula.

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    Top 10 Abundant Bacteria: Moist Skin

    The 10 most common bacteria on moist skin are: Corynebacterium tuberculostearicum, Staphylococcus hominis, Propionibacterium acnes, Staphylococcus epidermidis, Staphylococcus capitis, Corynebacterium fastidiosum, Micrococcus luteus, Enhydrobacter aerosaccus, Corynebacterium simulans, and Corynebacterium afermentans.

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    Top 10 Abundant Bacteria: Sebaceous Skin

    The 10 most common bacteria on sebaceous skin are: Propionibacterium acnes, Staphylococcus epidermidis, Corynebacterium tuberculostearicum, Staphylococcus capitis, Corynebacterium simulans, Streptococcus mitis, Staphylococcus hominis, Corynebacterium aurimucosum, Corynebacterium kroppenstedtii, and Corynebacterium amycolatum.

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    Study Notes

    Skin and Respiratory Microbiomes

    • Skin microbiome diversity is influenced by factors like sebum levels, moisture, and location (e.g., oily areas vs. dry areas).
    • Skin, oral, gut, and lung microbiomes can be linked, influencing health and disease.
    • Commensal microbes in the lung play key roles in health and disease.
    • Skin microbial diversity varies during development.
    • Interactions between commensal skin microbes can impact pathogen growth.
    • Skin microbiome fungi, like Malassezia, have functions related to health and disease, including causing dandruff, eczema, and dermatitis
    • The skin's two main layers are the epidermis and dermis.
    • Epidermis keratinocytes create a barrier linked to forming a resistant keratin layer.
    • Dermis has sebum which forms a layer over hair follicles.
    • Microenvironments within the skin vary in oxygen, UV light, pH, temperature, and moisture.
    • Moisture levels vary across the skin (e.g., dry palm vs. moist skin folds).
    • Sweat glands help regulate body temperature, and also have antimicrobial properties (e.g., free fatty acids).
    • Skin microbiome trains the immune system.
    • Dysbiosis/imbalance in skin microbiome is linked to various skin disorders.
    • Skin microbiome can produce short-chain fatty acids (SCFAs) like propionate and butyrate, as well as vitamins like K and B12, and influences Vitamin D production.
    • Skin microbiome enhances wound healing, but can also lead to biofilms or MRSA-associated issues.
    • Propionibacterium acnes, Staphylococcus epidermidis, Corynebacterium and Malassezia are common skin microbes.
    • Skin microbiome bacteria and fungi vary based on moisture and sebum. Staphylococcus aureus is also present and can become pathogenic, causing wound infections.

    General Functions of the Skin Microbiome

    • Skin microbiome functions include training and strengthening the immune system.
    • Skin microbiome is vital for barrier function and also for integrity of keratinocytes.
    • Skin microbiome has positive and negative interactions that impact S. aureus colonization and biofilm formation.
    • Certain microbes produce lantibiotics to inhibit S. aureus, including S. lugunensis and S. hominus.
    • S. epidermis produces proteases that inhibit S. aureus biofilm, contrasting with P. acnes producing copropophyrin which promotes S. aureus aggregation.
    • Skin microbiome contributes to wound healing processes.
    • Skin microbiome interacts with the immune system (innate immune system).

    Microbial Diversity and Development

    • Microbial diversity in the skin increases with age.
    • Firmicutes, Actinobacteria, Proteobacteria, Bacteroidetes, and other phyla are found on human skin.
    • Microbial diversity is site-specific, varying on areas like forehead, arm, foot. Location of skin (e.g., oily or dry areas) affects which bacteria or fungi thrive.

    Skin as a Barrier

    • Skin acts as a physical barrier in the body.
    • Damage to the skin, such as wounds, disrupts the balance by introducing pathogenic microorganisms like S.aureus.

    Nasal and Lung Microbiome

    • Nasal and lung microbiomes include Propionibacterium, Moraxella catarrhalis, Corynebacterium, and Staphylococcus.
    • The lung microbiome includes Prevotella, Streptococcus, Haemophilus, and Veillonella.
    • Interactions between nasal and lung microbiomes can affect upper and lower airways, influencing diseases like asthma and other respiratory illnesses.

    Drivers of Lung Microbiome Dysbiosis

    • Microbiological immigration and elimination affect lung microbiome balance.
    • Factors such as microaspiration, cough, and mucociliary clearance impact microbiome.
    • Regional conditions, like pH, temperature, oxygen, and nutrient availability, affect microbial growth and interactions, affecting microbial immigration and elimination.
    • Dysbiosis of the lung microbiome is linked to different diseases, like asthma, cystic fibrosis, and other respiratory conditions.

    Microbiome Activity

    • Microbiome "theatre of activity" involves interactions between microbial structural elements, metabolic products, and environmental conditions.
    • Microbial elements include proteins, peptides, nucleic acids, lipids, and polysaccharides.

    Microbe-Host Interactions

    • Microbe-host interactions occur across different scales, including intra-microbial, inter-microbial, community, spatial organization, local and systemic host-microbe interactions.

    Common Skin Fungi

    • Malassezia fungi are common skin fungi that can be opportunistic pathogens due to their need for lipids and presence on parts of the body with high sebaceous glands, like scalp, face, and upper body.
    • Malassezia can excessively grow causing dandruff, impacting the natural renewal of skin cells, leading to skin problems like eczema and dermatitis.
    • Malassezia can cause systemic infections in immunocompromised hosts.

    Staphylococcus epidermidis as a Pathogen

    • Staphylococcus epidermidis (gram-positive cocci) is usually harmless in the body but can cause infections, especially in hospitals, and can become problematic in wounds and invade deeper tissue like Staphylococcus aureus.

    • S. epidermidis can form biofilms.

    • It is not the primary pathogenic species, however; it can become pathogenic if it invades wounds or other parts of the body, causing infections in hospitals or other places where the skin has been breached.

    • Microorganisms can travel through different parts of the body from upper airways to the lungs and other sites,causing dysbiosis and various diseases.

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    Description

    Test your knowledge about the role of Cutibacterium acnes, Staphylococcus epidermidis, and Malassezia fungi in the skin microbiome. This quiz covers the mechanisms of how these microorganisms interact within the hair follicle environment and their impact on skin health. Dive into the diversity of the skin microbiome and its implications for pathogen growth.

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