Skin Diseases: Fungal Infections Overview

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Questions and Answers

What is the most common cause of vaginitis?

  • Trichomonas vaginalis
  • Bacterial vaginosis
  • Human papillomavirus
  • Candida albicans (correct)

Which of the following conditions can lead to an opportunistic infection by Candida albicans?

  • Uncontrolled diabetes (correct)
  • High protein intake
  • High-fat diet
  • Dehydration

What are the characteristics of the discharge associated with trichomoniasis?

  • Clear and odorless
  • Thin and watery
  • Thick, yellow, and cheesy
  • Profuse, greenish yellow with a foul odor (correct)

Which treatment is commonly used for skin and mucosal infections caused by Candida albicans?

<p>Topical applications of miconazole (A)</p> Signup and view all the answers

What is a common symptom of vulvovaginal candidiasis?

<p>Thick, yellow discharge (B)</p> Signup and view all the answers

Which statement about Trichomonas vaginalis is true?

<p>It can be part of normal flora. (A)</p> Signup and view all the answers

What factor might disturb the normal acidity of the vagina and promote Trichomonas vaginalis overgrowth?

<p>Hormonal fluctuation (C)</p> Signup and view all the answers

How does Leishmania donovani affect the human body if left untreated?

<p>It can lead to extensive damage to the liver, spleen, and kidneys. (C)</p> Signup and view all the answers

What is the role of the female Anopheles mosquito in the transmission of malaria?

<p>It injects the sporozoite stage of the protozoan into the human bloodstream. (D)</p> Signup and view all the answers

Why are individuals with sickle cell trait less susceptible to malaria?

<p>The sickle-shaped red blood cells provide a hostile environment for the parasite. (C)</p> Signup and view all the answers

Which stage of Plasmodium is responsible for infecting red blood cells?

<p>Trophozoite stage (A)</p> Signup and view all the answers

What specific symptoms characterize malaria episodes?

<p>Chills and fever alternating with asymptomatic periods. (B)</p> Signup and view all the answers

What symptom is NOT commonly associated with coccidioidomycosis?

<p>Weight gain (A)</p> Signup and view all the answers

Which factor contributes to the spread of Coccidioides immitis infection?

<p>Inhalation of arthroconidia (B)</p> Signup and view all the answers

What characteristic feature is formed by Coccidioides immitis in tissues during severe infections?

<p>Spherules filled with spores (D)</p> Signup and view all the answers

What is the primary habitat for Histoplasma capsulatum to thrive?

<p>Bird and bat droppings (B)</p> Signup and view all the answers

How does Histoplasma capsulatum survive and multiply in the human body?

<p>Inside macrophages (B)</p> Signup and view all the answers

What would increase the likelihood of severe infection by Coccidioides immitis?

<p>Having a compromised immune system (D)</p> Signup and view all the answers

In cases where Coccidioides immitis spreads systematically, how can it resemble a different disease?

<p>It can present similarly to tuberculosis. (B)</p> Signup and view all the answers

What aspect of birds allows them to provide nutrients for Histoplasma capsulatum without carrying the disease?

<p>Their high body temperature inhibits the fungus. (D)</p> Signup and view all the answers

Which group of individuals is most likely to show prior infection with Coccidioides immitis based on the skin test?

<p>Long-time residents of endemic regions (A)</p> Signup and view all the answers

What is a potential complication of a respiratory infection caused by the fungus carried by bats?

<p>Pneumonia (A)</p> Signup and view all the answers

How does Pneumocystis jirovecii primarily invade the body?

<p>Breathing in endospores (D)</p> Signup and view all the answers

Which population is at higher risk for severe infections caused by Pneumocystis jirovecii?

<p>Immunocompromised individuals (D)</p> Signup and view all the answers

What unique reproductive feature is associated with the lifecycle of Pneumocystis jirovecii?

<p>Sexual reproduction with cyst formation (D)</p> Signup and view all the answers

What is the typical entry point for Blastomyces dermatitidis in an infection?

<p>Through wounds (C)</p> Signup and view all the answers

What is a significant challenge in treating infections caused by Pneumocystis jirovecii?

<p>Lack of antifungal agents (B)</p> Signup and view all the answers

In which organ are significant microbial lesions found during a severe Pneumocystis infection?

<p>Lungs (A)</p> Signup and view all the answers

What characteristic of the fungus associated with bat feces makes it particularly concerning for cave explorers?

<p>It can airborne spread from the feces (B)</p> Signup and view all the answers

What might happen if a healthy individual's immune response to Pneumocystis jirovecii is inadequate?

<p>The infection can spread and become severe (B)</p> Signup and view all the answers

Why did hospitals notice an increase in lung fungal infections in the early 1980s among young people?

<p>Increase in HIV-related immunocompromised patients (D)</p> Signup and view all the answers

What is the primary method by which Cyclosporiasis is typically spread?

<p>Ingestion of contaminated water or uncooked foods (B)</p> Signup and view all the answers

Which condition can lead to more severe symptoms of Cyclosporiasis?

<p>Immunosuppression (D)</p> Signup and view all the answers

Which species primarily causes Cryptosporidiosis in humans?

<p>Cryptosporidium parvum (A)</p> Signup and view all the answers

How is Cryptosporidiosis primarily transmitted?

<p>Contaminated recreational and drinking water (A)</p> Signup and view all the answers

What type of diarrhea is most commonly associated with Cryptosporidiosis?

<p>Cholera-like diarrhea (C)</p> Signup and view all the answers

Which of the following organisms is known to cause life-threatening diarrhea in immunocompromised individuals?

<p>Cryptosporidium spp. (D)</p> Signup and view all the answers

What is a major environmental source of contamination for Cryptosporidiosis?

<p>Municipal drinking water (C)</p> Signup and view all the answers

What is the main vector responsible for spreading Visceral Leishmaniasis?

<p>Sand fly (C)</p> Signup and view all the answers

Which of the following is a common effect of Cyclospora infection?

<p>Watery diarrhea (D)</p> Signup and view all the answers

Which treatment method is typically needed to remove oocysts from drinking water?

<p>Filtration (A)</p> Signup and view all the answers

Flashcards

Vulvovaginal Candidiasis

A fungal infection affecting the vagina and vulva caused by Candida albicans, characterized by itching, thick cheesy discharge, and possibly a yeasty odor.

Candida albicans infection

An opportunistic infection that can occur due to factors like uncontrolled diabetes, pH changes, hormone fluctuations, and long-term antibiotic use.

Trichomoniasis

A sexually transmitted infection caused by the protozoan Trichomonas vaginalis, often asymptomatic but can cause a greenish-yellow, foul-smelling discharge, irritation, and itching.

Trichomonas vaginalis

An anaerobic protozoan found in the vagina and male urethra, often a harmless inhabitant but can overgrow and cause trichomoniasis due to changes in vaginal acidity.

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T. hominis

A type of Trichomonas found in the intestinal tract, often a harmless inhabitant.

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T. tenax

A type of Trichomonas found in the intestinal tract, often a harmless inhabitant.

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Gonorrhea

A common bacterial infection often co-occurring with trichomoniasis.

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Pneumocystis pneumonia (PCP)

A fungal infection caused by Pneumocystis jirovecii that primarily affects the lungs. It's often found in healthy individuals with minimal symptoms, but can cause severe complications in people with compromised immune systems, such as those with HIV/AIDS.

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Blastomycosis

A fungal infection caused by Blastomyces dermatitidis. It usually enters the body through wounds or inhalation of spores from soil, often causing skin infections or lung infections.

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Bat-Associated Fungal Infection

A fungal infection that is commonly associated with bat droppings and can cause respiratory problems, including pneumonia. It can spread to other organs causing severe complications, especially in individuals with weakened immune systems.

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PCP in Immunocompromised Individuals

A severe illness often associated with immunosuppression, such as in individuals with HIV/AIDS. This fungal infection can have a high fatality rate if untreated.

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Dissemination of Fungal Infection

The fungal pathogen can spread from the lungs to other organs through the bloodstream and lymph, causing lesions in various body parts.

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Coccidioidomycosis

A type of fungal infection that is common in the Southwest USA, often referred to as Valley Fever or San Joaquin fever. It is caused by the organism Coccidioides immitis and is typically spread through the inhalation of fungal spores found in the soil.

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Spores of Coccidioides immitis

A type of fungal cell that is part of the mating cycle of Coccidioides immitis. They are inhaled and usually cause mild flu-like symptoms or no symptoms at all.

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Filamentous form of Coccidioides immitis

The stage of Coccidioides immitis in the soil, where it forms filaments that reproduce by the formation of arthroconidia.

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Spherule of Coccidioides immitis

A thick-walled structure that forms in tissues during a Coccidioides immitis infection. It is filled with spores and can be used for diagnosis.

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Histoplasmosis

A fungal infection caused by Histoplasma capsulatum. It is common in the central and eastern US and often resembles tuberculosis.

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Conidia of Histoplasma capsulatum

A type of fungal cell produced by Histoplasma capsulatum. It is the form that is inhaled and infects humans.

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Yeast form of Histoplasma capsulatum

The stage of Histoplasma capsulatum that forms inside macrophages. It is a yeast-like form that can multiply and spread through the body.

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Macrophage

A type of immune cell that can engulf and contain Histoplasma capsulatum but can also contribute to the spread of the infection through the body.

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Bird and bat droppings and Histoplasmosis

Droppings from birds and bats provide nutrients, particularly a source of nitrogen, for the fungus Histoplasma capsulatum. They are a common source of infection.

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Leishmania donovani

A parasitic protozoan that causes Leishmaniasis, a disease spread through the bite of sandflies. It can survive and multiply within macrophages, which then circulate it throughout the body.

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Leishmaniasis

A disease caused by the protozoan Leishmania donovani, spread through the bite of sandflies. It can cause severe damage to the liver, spleen, and kidneys if left untreated, leading to death.

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Plasmodium vivax

A parasitic protozoan that causes malaria, a disease spread through the bite of infected mosquitos. It infects red blood cells (RBCs) and causes periodic fevers and chills.

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Malaria

A disease caused by the protozoan Plasmodium vivax, spread through the bite of infected mosquitos. It causes periodic fevers, chills, and other symptoms.

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Sporozoite stage

A stage in the life cycle of Plasmodium vivax where the protozoan is found in the saliva of infected mosquitoes. It is injected into the bloodstream when the mosquito bites a human.

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Cyclosporiasis

A protozoan infection causing intestinal disease, often spread through contaminated food like berries or uncooked meals.

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Cryptosporidium

A protozoan parasite causing diarrhea, usually transmitted through contaminated water sources.

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Cryptosporidium Oocysts

The infective stage of the protozoan Cryptosporidium, responsible for spreading the infection through ingestion.

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Cryptosporidiosis

A life-threatening diarrhea caused by Cryptosporidium infection, particularly severe in immunocompromised individuals like those with AIDS.

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Importance of Water Filtration

Water filtration is essential because it removes Cryptosporidium oocysts, ensuring safer drinking water.

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Visceral Leishmaniasis

A parasitic disease spread through the bite of infected sand flies, commonly found in tropical countries.

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Cyclospora Oocysts

The infective stage of Cyclospora, ingested through contaminated food and water.

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Cyclosporiasis

A parasitic infection characterized by watery diarrhea that can last for weeks, especially debilitating for people with compromised immune systems.

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Visceral Leishmaniasis

A type of Leishmaniasis characterized by involvement of internal organs like the liver, spleen, and bone marrow.

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Cryptosporidium Life Cycle

The life cycle of Cryptosporidium involves the release of sporozoites that invade intestinal cells, ultimately leading to the shedding of oocysts in feces.

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Study Notes

Skin Diseases

  • Fungi that invade keratinized tissue (epidermis) colonize hair, nails and outer layer (stratum corneal), causing dermatomycoses (fungal skin infections) also known as tinea or ringworm.
  • Mycoses refers to fungal cells targeting skin cells.
  • Fungal and protozoal organisms have complex life cycles, making them resistant to anti-fungal/protozoal drugs.
  • Immunocompromised individuals (like those with HIV) are more vulnerable to fungal infections.
  • Ringworm presents as circular lesions, commonly on the scalp.
  • Tinea corporis, cruris, capitis, and unguium are contagious and transmittable through unclean environments and inanimate objects (fomites).
  • Tinea capitis (scalp ringworm) is common in elementary school-aged children, potentially causing bald patches.
  • Dogs and cats can also get ringworm, which can spread to children.
  • Tinea cruris/jock itch affects the groin area
  • Tinea pedis/athlete's foot affects the feet, potentially leading to secondary bacterial infections in moist environments like shoes.
  • Tinea unguium/onychomycosis affects fingernails or toenails.
  • Antifungal drugs are used to treat these infections, but treatment may take several weeks due to the organism's complex life cycle.

Opportunistic Fungal Infections

  • Candida albicans is a part of normal flora in the mouth and vagina.
  • Antibiotics can disrupt normal flora, allowing Candida to overgrow and cause candidiasis, which can have no competition.
  • Fungal overgrowth in mucosal tissue due to antibiotic use can lead to candidiasis.
  • Changes in mucosal pH can also lead to candidiasis.
  • Candidiasis can cause thrush (oral cavity overgrowth), vaginitis, and infection of other tissues.
  • Candidiasis is one of the most common nosocomial (hospital-acquired) fungal infections.
  • Candida auris is a concerning emerging fungal infection, which is difficult to grow in normal media and is resistant to many common antifungal drugs.
  • Candida auris is highly resistant to antifungal drugs, and can cause serious bloodstream infections in hospitalized patients.

Vulvovaginal Candidiasis

  • Vulvovaginal candidiasis is a common vaginal infection caused by Candida albicans.
  • It can occur in individuals with uncontrolled diabetes, hormonal changes, or long-term antibiotic therapy.
  • The condition is characterized by itching, a thick, yellow discharge, and a yeasty odor.
  • Candida albicans infects mucous membranes of the mouth, intestinal tract, and genitourinary tract.
  • Treatment typically involves topical antifungal drugs like miconazole or clotrimazole.

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